Overexpression of the miR-34 family suppresses invasive growth of malignant melanoma with the wild-type p53 gene

Experimental and Therapeutic Medicine

Volumn 3, Issue 5, 2012, Pages 793-796

  Yamazaki, Hitoshi ^a   Chijiwa, Tsuyoshi ^b   Inoue, Yoshimasa ^c   Abe, Yoshiyuki ^d   Suemizu, Hiroshi ^e   Kawai, Kenji ^e   Wakui, Masatoshi ^f   Furukawa, Daisuke ^g   Mukai, Masaya ^c   Kuwao, Sadahito ^h   Saegusa, Makoto ^a   Nakamura, Masato ^g  

^a KITASATO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b Japan Self Def Force Naha Hospital   (Japan)

^c TOKAI UNIVERSITY HACHIOJI HOSPITAL   (Japan)

^d Tokorozawa PET Diagnostic Imaging Clinic   (Japan)

^e CENTRAL INSTITUTE FOR EXPERIMENTAL ANIMALS   (Japan)

^f KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^h Higashiyamato Hospital   (Japan)

Author keywords

Melanoma; MicroRNA 34; p53

Indexed keywords

MICRORNA; MICRORNA 31; PROTEIN P53; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CELL MIGRATION; CELL PROLIFERATION; DOWN REGULATION; GENE IDENTIFICATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MELANOMA; REAL TIME POLYMERASE CHAIN REACTION; RNA PROCESSING; WILD TYPE;

EID: 84858636221     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.497     Document Type: Article

References (34)

1. Hermeking H: p53 enters the microRNA world. Cancer Cell 12: 414-418, 2007.
2. Fabbri M, Croce CM and Calin GA: MicroRNAs. Cancer J 14: 1-6, 2008.
3. Mueller DW and Bosserhoff AK: Role of miRNAs in the progression of malignant melanoma. Br J Cancer 101: 551-556, 2009.
4. Yamashita T, Tokino T, Tonoki H, et al: Induction of apoptosis in melanoma cell lines by p53 and its related proteins. J Invest Dermatol 117: 914-919, 2001.
5. Min FL, Zhang H, Li WJ, Gao QX and Zhou GM: Effect of exogenous wild-type p53 on melanoma cell death pathways induced by irradiation at different linear energy transfer. In Vitro Cell Dev Biol Anim 41: 284-288, 2005.
6. Miyato Y and Ando K: Apoptosis of human melanoma cells by a combination of lonidamine and radiation. J Radiat Res (Tokyo) 45: 189-194, 2004.
7. Monney L, Sabatos CA, Gaglia JL, et al: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541, 2002.
8. Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 3: 1101-1108, 2008.
9. Chijiwa T, Abe Y, Ikoma N, et al: Thrombospondin 2 inhibits metastasis of human malignant melanoma through microenvironment-modification in NOD/SCID/γCnull (NOG) mice. Int J Oncol 34: 5-13, 2009.
10. Ikoma N, Yamazaki H, Abe Y, et al: S100A4 expression with reduced E-cadherin expression predicts distant metastasis of human malignant melanoma cell lines in the NOD/SCID/γCnull (NOG) mouse model. Oncol Rep 14: 633-637, 2005.
11. Dominguez-Sola D, Ying CY, Grandori C, et al: Non-transcriptional control of DNA replication by c-Myc. Nature 448: 445-451, 2007.
12. Ho J and Benchimol S: Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 10: 404-408, 2003.
13. Chen K and Rajewsky N: The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet 8: 93-103, 2007.
14. Kloosterman WP and Plasterk RH: The diverse functions of microRNAs in animal development and disease. Dev Cell 11: 441-450, 2006.
15. Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R: Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 20: 515-524, 2006.
16. Bommer GT, Gerin I, Feng Y, et al: p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17: 1298-1307, 2007.
17. Chang TC, Wentzel EA, Kent OA, et al: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26: 745-752, 2007.
18. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W and Nikitin AY: MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 67: 8433-8438, 2007.
19. He L, He X, Lim LP, et al: A microRNA component of the p53 tumour suppressor network. Nature 447: 1130-1134, 2007.
20. Raver-Shapira N, Marciano E, Meiri E, et al: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26: 731-743, 2007.
21. Tarasov V, Jung P, Verdoodt B, et al: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6: 1586-1593, 2007.
22. Tazawa H, Tsuchiya N, Izumiya M and Nakagama H: Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 104: 15472-15477, 2007.
23. Bagchi A and Mills AA: The quest for the 1p36 tumor suppressor. Cancer Res 68: 2551-2556, 2008.
24. Zhou Z, Flesken-Nikitin A, Corney DC, et al: Synergy of p53 and Rb deficiency in a conditional mouse model for metastatic prostate cancer. Cancer Res 66: 7889-7898, 2006.
25. Sun F, Fu H, Liu Q, et al: Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 582: 1564-1568, 2008.
26. Pigazzi M, Manara E, Baron E and Basso G: miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res 69: 2471-2478, 2009.
27. Bemis LT, Chen R, Amato CM, et al: MicroRNA-137 targets microphthalmia-associated transcription factor in melanoma cell lines. Cancer Res 68: 1362-1368, 2008.
28. Segura MF, Hanniford D, Menendez S, et al: Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor. Proc Natl Acad Sci USA 106: 1814-1819, 2009.
29. Lodygin D, Tarasov V, Epanchintsev A, et al: Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancer. Cell Cycle 7: 2591-2600, 2008.
30. Migliore C, Petrelli A, Ghiso E, et al: MicroRNAs impair MET-mediated invasive growth. Cancer Res 68: 10128-10136, 2008.
31. Yan D, Zhou X, Chen X, et al: MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci 50: 1559-1565, 2009.
32. Fujita Y, Kojima K, Hamada N, et al: Effects of miR-34a on cell growth and chemoresistance in prostate cancer PC3 cells. Biochem Biophys Res Commun 377: 114-119, 2008.
33. Kozaki K, Imoto I, Mogi S, Omura K and Inazawa J: Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 68: 2094-2105, 2008.
34. Toyota M, Suzuki H, Sasaki Y, et al: Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 68: 4123-4132, 2008