Inhibition of ultraviolet light induced skill carcinogenesis in SKH-1 mice by apigenin, a plant flavonoid

Anticancer Research

Volumn 17, Issue 1 A, 1997, Pages 85-91

  Birt, Diane F ^a,b,c   Mitchell, David ^d   Gold, Barry ^a,c   Pour, Parviz ^a   Pinch, Heather Conway ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Apigenin; Flavonoid; Mice; Skin; Ultraviolet light

Indexed keywords

APIGENIN; DNA; FLAVONOID; ORNITHINE DECARBOXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INCIDENCE; CANCER SURVIVAL; CELL FREE SYSTEM; COMPARATIVE STUDY; CONTROLLED STUDY; DNA DAMAGE; ENZYME INDUCTION; ENZYME INHIBITION; FEMALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CARCINOGENESIS; ULTRAVIOLET A RADIATION; ULTRAVIOLET B RADIATION;

ANIMALS; ANTICARCINOGENIC AGENTS; CHAMOMILE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FLAVONOIDS; MICE; NEOPLASMS, RADIATION-INDUCED; OILS, VOLATILE; ORNITHINE DECARBOXYLASE; PLANTS, MEDICINAL; SKIN NEOPLASMS; ULTRAVIOLET RAYS;

EID: 0031057115     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Scotto J, Fears TR and Fraumani JF: Incidence of non-melanoma skin cancer in the United States. Publ. No NH-2433 ed. USPHS, Bethesda, MD, 1981.
2. Pierceall WE, Mukhopadhyay T, Goldberg LH and Ananthaswamy HN: Mutations in the p53 tumor suppressor gene in human cutaneous squamous cell carcinomas. Mol Carcinog 4: 445-449, 1991.
3. Ziegler A, Jonason AS, Leffell DJ, Simon JA, Sharma HW, Kimmelman J, Remington L, Jacks T and Brash DE: Sunburn and p53 in the onset of skin cancer. Nature 372: 773-776, 1994.
4. Kripke ML, Cox PA, Alas LG and Yarosh DB: Pyrimidine dimers in DNA initiate systemic immunosupression in UV-irradiated mice. Proc Natl Acad Sci USA 89: 7516-7520, 1992.
5. Flindt-Hansen H: Photocarcinogenesis in mice and the effect of a sunscreen, para-aminobenzoic acid. Dan Med Bull 39: 355-362, 1992.
6. Birt DF, Walker B, Tibbels MG and Bresnick E: Anti-mutagenesis and anti-promotion by apigenin, robinetin and indole-3-carbinol. Carcinogenesis 7: 959-963, 1986.
7. Wei H, Tye L, Bresnick E and Birt DF: Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res 50: 499-502, 1990.
8. Wang Z-Y, Huang M-T, Ferraro T, Wong C-Q, Lou Y-R, Reuhl K, Iatropoulos M, Yang CS and Conney AH: Inhibitory effect of green tea in the drinking water on tumorigenesis by ultraviolet light and 12-O-tetradecanoylphorbol-13-acetate in the skin of SKH-1 mice. Cancer Res 52: 1162-1170, 1992.
9. Madronich S and De Gruijl FR: Stratospheric ozone depletion between 1979 and 1992: Implications for biologically active ultraviolet-B radiation and non-melanoma skin cancer incidence. Photochem Photobiol 59: 541-546, 1994.
10. Birt DF, White LT, Choi B and Pelling JC: Dietary fat effects on the initiation and promotion of two-stage skin tumorigenesis in the SENCAR mouse. Cancer Res 49: 4170-4174, 1989.
11. Peto R, Pike MC, Day NE, Gray RG, Lee PN, Parish S, Peto J, Richards S and Wahrendorf J: Guidelines for simple, sensitive significance tests for carcinogenic effects in long-term animal experiments. In: Long Term and Short Term Screening for Carcinogenesis: A Critical Appraisal. Anonymous IARC, Lyon, 1980, pp 301-426.
12. Mitchell DL, Haipek CA and Clarkson JM: (6-4) photoproducts are removed from the DNA of UV-irradiated mammalian cells more efficiently than cyclobutane pyrimidine dimers. Mutat Res 143: 109-112, 1985.
13. Lamola AA and Yamane Y: Sensitized photodimerization of thymine in DNA. Proc Natl Acad Sci USA 58: 443-446, 1967.
14. Ghosh R, Johnston D and Mitchell DL: Generation of oligonucleotides containing site-specific cyclobutane pyrimidine dimers and pyrimidine (6-4) pyrimidinone photoproducts by immunoprecipitation. Nucl Acids Res 23: 4934-4937, 1995.
15. Birt DF and Bresnick E: Chemoprevention by nonnutrient components of vegetables and fruits. In: Human Nutrition: A Comprehensive Treatise. (Alfin-Slater R, Kritchevsky D, eds). Plenum, New York, NY, 1991, pp 221-61.
16. Middleton E: The flavonoids. Trends Pharmac Sci 5: 335-338, 1984.
17. Koone MD and Black HS: A mode of action for butylated hydroxytoluene-mediated photoprotection. J Invest Dermatol 87: 343-347, 1986.
18. Gensler HL, Aickin M and Peng YM: Cumulative reduction of primary skin tumor growth in UV-irradiated mice by the combination of retinyl palmitate and canthaxanthin. Cancer Lett 53: 27-31, 1990.
19. Wang ZY, Huang M-T, Lou Y-R, Xie J-G, Reuhl KR, Newmark HL, Ho C-T, Yang CS and Conney AH: Inhibitory effects of black tea, green tea, decaffeinated black tea, and decaffeinated green tea on ultraviolet B light-induced skin carcinogenesis in 7,12-dimethylbenz[a]anthracene-initiated SKH-1 mice. Cancer Res 54: 3428-3435, 1994.
20. Wang ZY, Agarwal R, Bickers DR and Mukhtar H: Protection against ultraviolet B radiation-induced photocarcinogenesis in hairless mice by green tea polyphenols. Carcinogenesis 12: 1527-1530, 1991.
21. Mondon P and Shahin MM: Protective effect of two sunscreens against lethal and genotoxic effects of UVB in V79 Chinese hamster cells and Saccharomyces cerevisiae strains XV185-14C and D5. Mutat Res Genet Toxicol Testing 279: 121-128, 1992.
22. Tornaletti S, Rozek D and Pfeifer GP: The distribution of UV photoproducts along the human p53 gene and its relation to mutations in skin cancer. Oncogene 8: 2051-2057, 1993.
23. Lepley DM, Li B, Birt DF and Pelling JC: The chemopreventive flavonoid apigenin induces G2/M arrest in keratinocytes. [In Press] Carcinogenesis 1996.
24. Sato F, Matsukawa Y, Matsumoto K, Nishino H and Sakai T: Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem Biophys Res Commun 204: 578-584, 1994.
25. Matsukawa Y, Marui N, Sakai T, Satomi Y, Yoshida M, Matsumoto K, Nishino H and Aoike A: Genistein arrests cell cycle progression at G2-M. Cancer Res 53: 1328-1331, 1993.
26. Losiewicz M, Carlson B, Kaur G, Sausville E and Worland P: Potent inhibition of cdc2 kinase activity by the flavonoid L86-8275. Biochem Biophys Res Commun 201: 589-595, 1995.
27. Wei Y, Zhao X, Kariya Y, Fukata H, Teshigawara K and Uchida A: Induction of apoptosis by quercetin: Involvement of heat shock protein. Cancer Res 54: 4952-4957, 1994.