Flavonoids inhibit melanoma lung metastasis by impairing tumor cells endothelium interactions

Journal of Cellular Physiology

Volumn 207, Issue 1, 2006, Pages 23-29

  Piantelli, Mauro ^a,c   Rossi, Cosmo ^a   Iezzi, Manuela ^a   La Sorda, Rossana ^a   Iacobelli, Stefano ^a   Alberti, Saverio ^a   Natali, Pier Giorgio ^b  

^a UNIVERSITY OF CHIETI   (Italy)

^b REGINA ELENA NATIONAL CANCER INSTITUTE   (Italy)

^c CESI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APIGENIN; FLAVONOID; QUERCETIN; TAMOXIFEN; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL ADHESION; CELL INTERACTION; CONTROLLED STUDY; DOSE RESPONSE; ENDOTHELIUM; EX VIVO STUDY; LUNG ENDOTHELIUM; LUNG METASTASIS; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; APIGENIN; ASCITIC FLUID; CELL ADHESION; CELL LINE; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; FLAVONOIDS; HUMANS; LUNG NEOPLASMS; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; QUERCETIN; RATS; RATS, SPRAGUE-DAWLEY; TAMOXIFEN; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR CELL ADHESION MOLECULE-1;

ANIMALIA; MURINAE;

EID: 33644926465     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20510     Document Type: Article

References (37)

1. Al-Mehdi AB, Tozawa K, Fisher AB, Shientag L, Lee A, Muschel RJ. 2000. Intravascular origin of metastasis from the proliferation of the endothelium-attached tumor: A new model for metastasis. Nature Med 6:100-102.
2. Baril P, Neijari M, Scoazek J-Y, Boukerche H. 2002. Blocking a novel 55 kDa melanoma-associated cell surface antigen inhibits the development of spontaneous metastasis an interactions with frozen lung section. Int J Cancer 99: 315-322.
3. Bell JR, Donovan JL, Wong R, Waterhouse AL, German JB, Walzern RL, Kasim-Karakas SE. 2000. (+)-Catechin in human plasma after ingestion of a single serving of reconstituted red wine. Am J Clin Nutr 71:103-108.
4. Caltagirone S, Rossi C, Poggi A, Ranelletti FO, Natali PG, Aiello FB, Piantelli M. 2000. Flavonoids Apigenin and Quercetin inhibit melanoma growth and metastatic potential. Int J Cancer 87:595-600.
5. Choi JS, Choi YJ, Park SH, Kang JS, Kang YH. 2004. Flavones mitigate tumor necrosis factor-alpha-induced adhesion molecule upregulation in cultured human endothelial cells: Role of nuclear factor-kappa B. J Nutr 134:1013-1019.
6. De Caterina R, Libby P, Peng H-B, Thannickal VJ, Rajavashisth TB, Gimbrone MA, Shin WS, Liao JK. 1995. Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 96:60-68.
7. Dutcher JP. 2003. The prognostic role of detection of circulating melanoma cells in the blood. J Clin Oncol 21:757-759.
8. Ferry DR, Smith A, Malkhandi J, Fyfe DW, Detakats PG, Anderson D, Baker J Kerr DJ. 1996. Phase I clinical trial of the flavonoid Quercetin: Pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 2: 659-668.
9. Fidler IJ. 2003. The pathogenesis of cancer metastasis: The seed and soil hypothesis revisited. Nat Rev Cancer 3:453-458.
10. Folkman J. 1974. Tumor angiogenesis. Adv Cancer Res 19:331-358.
11. Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H, Wahala K, Montesano R, Schweigerer L. 1997. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Res 57:2916-2921.
12. Garofalo A, Chirivi R, Foglieni C, Pigott R, Mortarini R, Martin-Padura I, Anichini A, Gearing AJ, Dejana E, Giavazzi R. 1995. Involvement of the very late antigen 4 integrin on melanoma in interleukin1-augmented experimental metastases. Cancer Res 55:414-419.
13. Gerritsen ME, Carley WW, Ranges GE, Shen C-P, Phan SA, Ligon GF, Perry CA. 1995. Flavonoids inhibit cytokine-induced endothelial cell adhesion protein gene expression. Am J Pathol 147:278-292.
14. Gugler R, Leschik M, Dengler HJ. 1975. Disposition of Quercetin in man after single oral and intravenous doses. Europ J Clin Pharmacol 9:229-234.
15. Hanehan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100:57-70.
16. Hart IR. 1979. The selection and characterization of an invasive variant of the B16 melanoma. Am J Pathol 97:587-600.
17. Kobuchi H, Roy S, Sen CK, Nguyen HG, Packer L. 1999. Quercetin inhibits inducible ICAM-1 expression in human endothelial cells througk the JNK pathway. Am J Physiol 277:403-411.
18. Liotta LA, Kohn EC. 2001. The microenvironment of the tumor-host interface. Nature 411:375-379.
19. Krakauer T, Qun Li B, Young HA. 2001. The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines. FEBS Letts 500:52-55.
20. Kuroda Y, Hara Y. 1999. Antimutagenic and anticarcinogenic activity of tea polyphenol. Mutat Res 436:69-97.
21. Mendoza L, Carrascal T, De Luca M, Fuentes AM, Salado C, Bianco J, Vidal-Vanaclocha F. 2001. Hydrogen peroxyde mediates vascular cell adhesion molecule-1 expression from interleukin-18-activated hepatic sinusoidal endothelium: Implications for circulating cancer cell arrest in the murine liver. Hepathology 34:298-310.
22. Mendoza L, Valcarcel M, Carrascal T, Egilegor E, Salado C, Sim BK, Vidal-Vanaclocha F. 2004. Inhibition of cytokine-induced microvascular arrest of tumor cells by recombinant endostatin prevents experimental hepatic melanoma metastasis. Cancer Res 64:304-310.
23. Middleton E, Jr., Kandaswami C, Theoharides TC. 2000. The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol Rev 52:673-751.
24. Molino M, Barnathan ES, Numerof R, Clark J, Dreyer M, Cumashi A, Hoxie JA, Schechter N, Woolkalis M, Brass LF. 1997. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J Biol Chem 272:4043-4049.
25. Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE. 2002. Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression. J Biol Chem 277:34679-34691.
26. Nielsen BS, Lund LR, Christensen IJ, Johnsen M, Usher PA, Wulf-Andersen L, Frandsen TL, Dano K, Gundersen HJ. 2001. A precise and efficient stereological method for determining murine lung metastasis volumes. Am J Pathol 58:1997-2003.
27. Okahara H, Yagita H, Miyake K, Okomura K. 1994. Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis. Cancer Res 54:3233-3236.
28. Panes J, Gerritsen ME, Anderson DC, Miyasaka M, Granger DN. 1996. Apigenin inhibits tumor necrosis factor-induced intercellular adhesion molecule-1 upregulation in vivo. Microcirculation 3:279-286.
29. Ramelet AA. 2000. Pharmacological aspects of a phlebotropic drug in CVI-associated edema. Angiology 51:19-23.
30. Reiterer G, Toborek M, Hennig B. 2004. Quercetin protects against linoleic acid-induced porcine endothelial cell dysfunction. J Nutr 134:771-775.
31. Tokunaga T, Oshika Y, Abe Y, Ozeki Y, Sadahiro S, Kijima H, Tsuchida T, Yamazaki H, Ueyama Y, Tamaoki N, Nakamura M. 1998. Vascular endothelial growth factor (VEGF) mRNA isoform expression pattern is correlated with liver metastasis and poor prognosis in colon cancer. Br J Cancer 77:998-1002.
32. Tsai SH, Liang YC, Lin-Shiau SY, Lin JK. 1999. Suppression of TNF-α-mediated NFkB activity by myricetin and other flavonoids through downregulating the activity of IKK in ECV304 cells. J Cell Biochem 74:606-615.
33. Vidal-Vanaclocha F, Fantuzzi G, Mendoza L, Fuentes A, Anasagasti M, Martin J, Dinarello C. 2000. IL-18 regulates IL-1b-dependent hepatic melanoma metastasis via vascular cell adhesion molecole-1. Proc Natl Acad Sci USA 97: 734-739.
34. Vink J, Thomas L, Etoh T, Bruijin JA, Mihm MC, Gattoni-Celli S, Byers HR. 1993. Role of beta-1 integrins in organ specific adhesion of melanoma cells in vitro. Lab Invest 68:192-203.
35. Wadsworth TL, McDonald TL, Koop DR. 2001. Effects of Ginkgo biloba extract (Egb 761) and Quercetin on lipopolysaccaride-induced signaling pathways involved in the release of tumor necrosis factor-alpha. Biochem Pharmacol 62:963-974.
36. Wong CW, Song C, Grimes MM, Fu W, Dewhirst MW, Muschel RJ, Al-Mehdi AB. 2002. Intravascular location of breast cancer cells after spontaneous metastasis to the lung. Am J Pathol 161:749-753.
37. Xagorari A, Papapetropoulos A, Mauromatis A, Economou M, Fotsis T, Roussos C. 2001. Luteolin inhibits an endotoxin-stimulated phosphorylation cascade and proinflammatory cytokine production in macrophages. J Pharmacol Exp Ther 296:181-187.