Acute exposure of apigenin induces hepatotoxicity in Swiss mice

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Singh, Prabhat ^a   Mishra, Shrawan Kumar ^a   Noel, Sanjeev ^a   Sharma, Sharad ^a   Rath, Srikanta Kumar ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; APIGENIN; ASPARTATE AMINOTRANSFERASE; CATALASE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE; ENZYME;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER TOXICITY; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; SIGNAL TRANSDUCTION; TISSUE INJURY; TOXICITY TESTING; UPREGULATION; ANIMAL; BLOOD; DOSE RESPONSE; GENE EXPRESSION PROFILING; GENETICS; METABOLISM; TOXIC HEPATITIS;

ANIMALS; APIGENIN; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENZYMES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84863403861     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0031964     Document Type: Article

References (38)

1. Patel D, Shukla S, Gupta S, (2007) Apigenin and cancer chemoprevention: progress, potential and promise (review). Int J Oncol 30: 233-245.
2. Vargo MA, Voss OH, Poustka F, Cardounel AJ, Grotewold E, et al. (2006) Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 72: 681-692.
3. Xu L, Zhang L, Bertucci AM, Pope RM, Datta SK, (2008) Apigenin, a dietary flavonoid, sensitizes human T cells for activation-induced cell death by inhibiting PKB/Akt and NF-kappaB activation pathway. Immunol Lett 121: 74-83.
4. Kang HK, Ecklund D, Liu M, Datta SK, (2009) Apigenin, a non-mutagenic dietary flavonoid, suppresses lupus by inhibiting autoantigen presentation for expansion of autoreactive Th1 and Th17 cells. Arthritis Res Ther 11: R59.
5. Zhang YH, Park YS, Kim TJ, Fang LH, Ahn HY, et al. (2000) Endothelium-dependent vasorelaxant and antiproliferative effects of apigenin. Gen Pharmacol 35: 341-347.
6. Chuang CM, Monie A, Wu A, Hung CF, (2009) Combination of apigenin treatment with therapeutic HPV DNA vaccination generates enhanced therapeutic antitumor effects. J Biomed Sci 16: 49.
7. Galati G, Sabzevari O, Wilson JX, O'Brien PJ, (2002) Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 177: 91-104.
8. Morrissey C, O'Neill A, Spengler B, Christoffel V, Fitzpatrick JM, et al. (2005) Apigenin drives the production of reactive oxygen species and initiates a mitochondrial mediated cell death pathway in prostate epithelial cells. Prostate 63: 131-142.
9. Miyoshi N, Naniwa K, Yamada T, Osawa T, Nakamura Y, (2007) Dietary flavonoid apigenin is a potential inducer of intracellular oxidative stress: the role in the interruptive apoptotic signal. Arch Biochem Biophys 466: 274-282.
10. Tsuji PA, Walle T, (2008) Cytotoxic effects of the dietary flavones chrysin and apigenin in a normal trout liver cell line. Chem Biol Interact 171: 37-44.
11. Noel S, Kasinathan M, Rath SK, (2006) Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay. Toxicol In Vitro 20: 1168-1172.
12. Ohkawa H, Ohishi N, Yagi K, (1979) Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 95: 351-358.
13. Kakkar P, Das B, Viswanathan PN, (1984) A modified spectrophotometric assay of superoxide dismutase. Indian J Biochem Biophys 21: 130-132.
14. Sinha AK, (1972) Colorimetric assay of catalase. Anal Biochem 47: 389-394.
15. Wendel A, (1980) Glutathione peroxidase. In Enzymatic Basis of Detoxication. Edited by: Jakoby WB. pp. 333-348 Academic Press, New York.
16. Habig WH, Pabst MJ, Jakoby WB, (1974) Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.
18. Noel S, Sharma S, Shanker R, Rath SK, (2007) Primaquine-induced differential gene expression analysis in mice liver using DNA microarrays. Toxicology 239: 96-107.
19. Ghribi O, DeWitt DA, Forbes MS, Herman MM, Savory J, (2001) Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits. Brain Res 903: 66-73.
20. Mullie P, Clarys P, Deriemaeker P, Hebbelinck M, (2007) Estimation of Daily Human Intake of Food Flavonoids. Plant Foods Hum Nutr 62: 93-98.
21. Freireich EJ, Gehan EA, Rall DP, Schmidt LH, Skipper HE, (1966) Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother Rep 50: 219-244.
22. Stroheker T, Picard K, Lhuguenot JC, Canivenc-Lavier MC, Chagnon MC, (2004) Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. Food Chem Toxicol 42: 887-897.
23. Ozer J, Ratner M, Shaw M, Bailey W, Schomaker S, (2008) The current state of serum biomarkers of hepatotoxicity. Toxicology 245: 194-205.
24. Galati G, Lin A, Sultan AM, O'Brien PJ, (2006) Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins. Free Radic Biol Med 40: 570-580.
25. de Zwart LL, Meerman JH, Commandeur JN, Vermeulen NP, (1999) Biomarkers of free radical damage applications in experimental animals and in humans. Free Radic Biol Med 26: 202-226.
26. Sugihara N, Arakawa T, Ohnishi M, Furuno K, (1999) Anti- and pro-oxidative effects of flavonoids on metal-induced lipid hydroperoxide-dependent lipid peroxidation in cultured hepatocytes loaded with alpha-linolenic acid. Free Radic Biol Med 27: 1313-1323.
27. Kachadourian R, Day BJ, (2006) Flavonoid-induced glutathione depletion: potential implications for cancer treatment. Free Radic Biol Med 41: 65-76.
28. Sahu SC, Gray GC, (1997) Lipid peroxidation and DNA damage induced by morin and naringenin in isolated rat liver nuclei. Food Chem Toxicol 35: 443-447.
29. Evans CG, Chang L, Gestwicki JE, (2010) Heat Shock Protein 70 (Hsp70) as an Emerging Drug Target. Journal of Med Chem 53: 4585-4602.
30. Hosokawa N, Hirayoshi K, Nakai A, Hosokawa Y, Marui N, et al. (1990) Flavonoids inhibit the expression of heat shock proteins. Cell Struct Funct 15: 393-401.
31. Elia G, Santoro MG, (1994) Regulation of heat shock protein synthesis by quercetin in human erythroleukaemia cells. Biochem J 300: 201-209.
32. Nylandsted J, Rohde M, Brand K, Bastholm L, Elling F, et al. (2000) Selective depletion of heat shock protein 70 (Hsp70) activates a tumor-specific death program that is independent of caspases and bypasses Bcl-2. Proc Natl Acad Sci U. S. A 97: 7871-7876.
33. Lee SM, Koh HJ, Park DC, Song BJ, Huh TL, et al. (2002) Cytosolic NADP(+)-dependent isocitrate dehydrogenase status modulates oxidative damage to cells. Free Radic Biol Med 32: 1185-1196.
34. Veech RL, Eggleston LV, Krebs HA, (1969) The redox state of free nicotinamide-adenine dinucleotide phosphate in the cytoplasm of rat liver. Biochem J 115: 609-619.
35. Vande VC, Cizeau J, Dubik D, Alimonti J, Brown T, et al. (2000) BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 20: 5454-5468.
36. Matsunaga E, Chedotal A, (2004) Repulsive guidance molecule/neogenin: a novel ligand-receptor system playing multiple roles in neural development. Dev Growth Differ 46: 481-486.
37. Poli M, Derosas M, Luscieti S, Cavadini P, Campanella A, et al. (2010) Pantothenate kinase-2 (Pank2) silencing causes cell growth reduction, cell-specific ferroportin upregulation and iron deregulation. Neurobiol Dis 39: 204-210.
38. Elble RC, Pauli BU, (2001) Tumor suppression by a proapoptotic calcium-activated chloride channel in mammary epithelium. J Biol Chem 276: 40510-40517.