Pharmacologic targeting of sphingosine-1-phosphate receptor 1 improves the renal microcirculation during sepsis in the mouse

Journal of Pharmacology and Experimental Therapeutics

Volumn 352, Issue 1, 2015, Pages 61-66

  Wang, Zhen ^a   Sims, Clark R ^a   Patil, Naeem K ^a   Gokden, Neriman ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2,6 DICHLORO 4 PYRIDINYL) 1 (1,3 DIMETHYL 4 ISOPROPYL 1H PYRAZOLO[3,4 B]PYRIDIN 6 YL)SEMICARBAZIDE; 5 (4 PHENYL 5 TRIFLUOROMETHYL 2 THIENYL) 3 (3 TRIFLUOROMETHYLPHENYL) 1,2,4 OXADIAZOLE; CREATININE; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; UNCLASSIFIED DRUG; OXADIAZOLE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; THIOPHENE DERIVATIVE;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY PERMEABILITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG TARGETING; EVALUATION STUDY; HISTOPATHOLOGY; KIDNEY BLOOD FLOW; KIDNEY FUNCTION; KIDNEY PERFUSION; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MOUSE; NONHUMAN; RENAL CORTICAL CAPILLARY PERFUSION; SEPSIS; THERAPY DELAY; UREA NITROGEN BLOOD LEVEL; VIDEO MICROSCOPY; ADVERSE EFFECTS; ANIMAL; ANTAGONISTS AND INHIBITORS; CAPILLARY; DRUG EFFECTS; KIDNEY; LIGATION; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; PATHOPHYSIOLOGY; PERMEABILITY; PROCEDURES; PUNCTURE; TIME FACTOR; VASCULARIZATION;

ANIMALS; CAPILLARIES; DOSE-RESPONSE RELATIONSHIP, DRUG; KIDNEY; LIGATION; MALE; MICE; MICROCIRCULATION; MOLECULAR TARGETED THERAPY; OXADIAZOLES; PERMEABILITY; PUNCTURES; PYRAZOLES; PYRIDINES; RECEPTORS, LYSOSPHINGOLIPID; SEPSIS; THIOPHENES; TIME FACTORS;

EID: 84919712097     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.114.219394     Document Type: Article

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