메뉴 건너뛰기




Volumn 16, Issue 1, 2012, Pages

Clinical utility of biomarkers of endothelial activation in sepsis-a systematic review

Author keywords

Angiopoietin; Biomarker; Coagulation; Endothelium; Sepsis

Indexed keywords

ANGIOPOIETIN; BIOLOGICAL MARKER; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; PROTEIN TYROSINE KINASE; VASCULOTROPIN; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE;

EID: 84855816724     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11145     Document Type: Article
Times cited : (113)

References (103)
  • 1
    • 0026710191 scopus 로고
    • Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine
    • 10.1378/chest.101.6.1644, 1303622
    • Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
    • (1992) Chest , vol.101 , pp. 1644-1655
    • Bone, R.C.1    Balk, R.A.2    Cerra, F.B.3    Dellinger, R.P.4    Fein, A.M.5    Knaus, W.A.6    Schein, R.M.7    Sibbald, W.J.8
  • 3
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
    • 10.1097/00003246-200107000-00002, 11445675
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002, 11445675.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 4
    • 0035100888 scopus 로고    scopus 로고
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework
    • Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther 2001, 69:89-95.
    • (2001) Clin Pharmacol Ther , vol.69 , pp. 89-95
  • 5
    • 77956628404 scopus 로고    scopus 로고
    • Sepsis biomarkers: a review
    • 10.1186/cc8872, 2875530, 20144219
    • Pierrakos C, Vincent JL. Sepsis biomarkers: a review. Crit Care 2010, 14:R15. 10.1186/cc8872, 2875530, 20144219.
    • (2010) Crit Care , vol.14
    • Pierrakos, C.1    Vincent, J.L.2
  • 6
    • 1542404989 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in sepsis: a case of habeas corpus?
    • 10.1097/01.CCM.0000115264.93926.EC, 15090992
    • Hotchkiss RS, Karl IE. Endothelial cell apoptosis in sepsis: a case of habeas corpus?. Crit Care Med 2004, 32:901-902. 10.1097/01.CCM.0000115264.93926.EC, 15090992.
    • (2004) Crit Care Med , vol.32 , pp. 901-902
    • Hotchkiss, R.S.1    Karl, I.E.2
  • 7
    • 0036255814 scopus 로고    scopus 로고
    • Endothelial cell apoptosis in sepsis
    • 10.1097/00003246-200205001-00009, 12004240
    • Hotchkiss RS, Tinsley KW, Swanson PE, Karl IE. Endothelial cell apoptosis in sepsis. Crit Care Med 2002, 30:S225-228. 10.1097/00003246-200205001-00009, 12004240.
    • (2002) Crit Care Med , vol.30
    • Hotchkiss, R.S.1    Tinsley, K.W.2    Swanson, P.E.3    Karl, I.E.4
  • 8
    • 53049102247 scopus 로고    scopus 로고
    • Malaria and bacterial sepsis: similar mechanisms of endothelial apoptosis and its prevention in vitro
    • 10.1097/CCM.0b013e31818441ee, 18679107
    • Hemmer CJ, Vogt A, Unverricht M, Krause R, Lademann M, Reisinger EC. Malaria and bacterial sepsis: similar mechanisms of endothelial apoptosis and its prevention in vitro. Crit Care Med 2008, 36:2562-2568. 10.1097/CCM.0b013e31818441ee, 18679107.
    • (2008) Crit Care Med , vol.36 , pp. 2562-2568
    • Hemmer, C.J.1    Vogt, A.2    Unverricht, M.3    Krause, R.4    Lademann, M.5    Reisinger, E.C.6
  • 9
    • 0034918411 scopus 로고    scopus 로고
    • The endothelium in sepsis: source of and a target for inflammation
    • Hack CE, Zeerleder S. The endothelium in sepsis: source of and a target for inflammation. Crit Care Med 2001, 29:S21-27.
    • (2001) Crit Care Med , vol.29
    • Hack, C.E.1    Zeerleder, S.2
  • 10
    • 73549085373 scopus 로고    scopus 로고
    • Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA
    • 10.1152/ajpheart.00069.2009, 19855068
    • Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y. Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Am J Physiol Heart Circ Physiol 2010, 298:H92-101. 10.1152/ajpheart.00069.2009, 19855068.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Matsuda, N.1    Teramae, H.2    Yamamoto, S.3    Takano, K.4    Takano, Y.5    Hattori, Y.6
  • 11
    • 0036255482 scopus 로고    scopus 로고
    • Markers of endothelial damage in organ dysfunction and sepsis
    • 10.1097/00003246-200205001-00021, 12004252
    • Reinhart K, Bayer O, Brunkhorst F, Meisner M. Markers of endothelial damage in organ dysfunction and sepsis. Crit Care Med 2002, 30:S302-312. 10.1097/00003246-200205001-00021, 12004252.
    • (2002) Crit Care Med , vol.30
    • Reinhart, K.1    Bayer, O.2    Brunkhorst, F.3    Meisner, M.4
  • 13
    • 0037588986 scopus 로고    scopus 로고
    • The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    • 10.1182/blood-2002-06-1887, 12543869
    • Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003, 101:3765-3777. 10.1182/blood-2002-06-1887, 12543869.
    • (2003) Blood , vol.101 , pp. 3765-3777
    • Aird, W.C.1
  • 14
    • 0037389936 scopus 로고    scopus 로고
    • Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?
    • 10.1186/cc1864, 270612, 12720559
    • Vallet B. Bench-to-bedside review: endothelial cell dysfunction in severe sepsis: a role in organ dysfunction?. Crit Care 2003, 7:130-138. 10.1186/cc1864, 270612, 12720559.
    • (2003) Crit Care , vol.7 , pp. 130-138
    • Vallet, B.1
  • 15
    • 43049113533 scopus 로고    scopus 로고
    • GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
    • 10.1136/bmj.39489.470347.AD, 2335261, 18436948
    • Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, Schünemann HJ. GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 2008, 336:924-926. 10.1136/bmj.39489.470347.AD, 2335261, 18436948.
    • (2008) BMJ , vol.336 , pp. 924-926
    • Guyatt, G.H.1    Oxman, A.D.2    Vist, G.E.3    Kunz, R.4    Falck-Ytter, Y.5    Alonso-Coello, P.6    Schünemann, H.J.7
  • 16
    • 77950269260 scopus 로고    scopus 로고
    • A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation
    • 10.1097/CCM.0b013e3181cf6fbc, 20124888, Emergency Medicine Shock Research Network (EMShockNet) investigators
    • Trzeciak S, Jones AE, Shapiro NI, Pusateri AE, Arnold RC, Rizzuto M, Arora T, Parrillo JE, Dellinger RP, . Emergency Medicine Shock Research Network (EMShockNet) investigators A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation. Crit Care Med 2010, 38:1092-1100. 10.1097/CCM.0b013e3181cf6fbc, 20124888, Emergency Medicine Shock Research Network (EMShockNet) investigators.
    • (2010) Crit Care Med , vol.38 , pp. 1092-1100
    • Trzeciak, S.1    Jones, A.E.2    Shapiro, N.I.3    Pusateri, A.E.4    Arnold, R.C.5    Rizzuto, M.6    Arora, T.7    Parrillo, J.E.8    Dellinger, R.P.9
  • 17
    • 38549109998 scopus 로고    scopus 로고
    • Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?
    • 10.1097/SLA.0b013e318162d616, 18216540
    • Ganter MT, Cohen MJ, Brohi K, Chesebro BB, Staudenmayer KL, Rahn P, Christiaans SC, Bir ND, Pittet JF. Angiopoietin-2, marker and mediator of endothelial activation with prognostic significance early after trauma?. Ann Surg 2008, 247:320-326. 10.1097/SLA.0b013e318162d616, 18216540.
    • (2008) Ann Surg , vol.247 , pp. 320-326
    • Ganter, M.T.1    Cohen, M.J.2    Brohi, K.3    Chesebro, B.B.4    Staudenmayer, K.L.5    Rahn, P.6    Christiaans, S.C.7    Bir, N.D.8    Pittet, J.F.9
  • 18
    • 34447635720 scopus 로고    scopus 로고
    • Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury
    • 10.1186/cc5037, 1751077, 16956410
    • Cepkova M, Brady S, Sapru A, Matthay MA, Church G. Biological markers of lung injury before and after the institution of positive pressure ventilation in patients with acute lung injury. Critical Care 2006, 10:R126. 10.1186/cc5037, 1751077, 16956410.
    • (2006) Critical Care , vol.10
    • Cepkova, M.1    Brady, S.2    Sapru, A.3    Matthay, M.A.4    Church, G.5
  • 20
    • 2442429636 scopus 로고    scopus 로고
    • Increased diffusion of soluble adhesion molecules in meningitis, severe sepsis and systemic inflammatory response without neurological infection is associated with intrathecal shedding in cases of meningitis
    • 10.1007/s00134-004-2253-1, 15067502
    • Megarbane B, Marchal P, Marfaing-Koka A, Belliard O, Jacobs F, Chary I, Brivet FG. Increased diffusion of soluble adhesion molecules in meningitis, severe sepsis and systemic inflammatory response without neurological infection is associated with intrathecal shedding in cases of meningitis. Intensive Care Med 2004, 30:867-874. 10.1007/s00134-004-2253-1, 15067502.
    • (2004) Intensive Care Med , vol.30 , pp. 867-874
    • Megarbane, B.1    Marchal, P.2    Marfaing-Koka, A.3    Belliard, O.4    Jacobs, F.5    Chary, I.6    Brivet, F.G.7
  • 21
    • 0036119842 scopus 로고    scopus 로고
    • Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis
    • 10.1097/00005373-200203000-00005, 11901317
    • Fujimi S, Ogura H, Tanaka H, Koh T, Hosotsubo H, Nakamori Y, Kuwagata Y, Shimazu T, Sugimoto H. Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis. J Trauma 2002, 52:443-448. 10.1097/00005373-200203000-00005, 11901317.
    • (2002) J Trauma , vol.52 , pp. 443-448
    • Fujimi, S.1    Ogura, H.2    Tanaka, H.3    Koh, T.4    Hosotsubo, H.5    Nakamori, Y.6    Kuwagata, Y.7    Shimazu, T.8    Sugimoto, H.9
  • 22
    • 0036596410 scopus 로고    scopus 로고
    • Increased hepatosplanchnic inflammation precedes the development of organ dysfunction after elective high-risk surgery
    • 10.1097/00024382-200206000-00002, 12069179
    • Poeze M, Ramsay G, Buurman WA, Greve JW, Dentener M, Takala J. Increased hepatosplanchnic inflammation precedes the development of organ dysfunction after elective high-risk surgery. Shock 2002, 17:451-458. 10.1097/00024382-200206000-00002, 12069179.
    • (2002) Shock , vol.17 , pp. 451-458
    • Poeze, M.1    Ramsay, G.2    Buurman, W.A.3    Greve, J.W.4    Dentener, M.5    Takala, J.6
  • 23
    • 0033770708 scopus 로고    scopus 로고
    • Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies
    • 10.1159/000025758, 11025405
    • Bechard D, Meignin V, Scherpereel A, Oudin S, Kervoaze G, Bertheau P, Janin A, Tonnel A, Lassalle P. Characterization of the secreted form of endothelial-cell-specific molecule 1 by specific monoclonal antibodies. J Vasc Res 2000, 37:417-425. 10.1159/000025758, 11025405.
    • (2000) J Vasc Res , vol.37 , pp. 417-425
    • Bechard, D.1    Meignin, V.2    Scherpereel, A.3    Oudin, S.4    Kervoaze, G.5    Bertheau, P.6    Janin, A.7    Tonnel, A.8    Lassalle, P.9
  • 24
  • 25
    • 0031916636 scopus 로고    scopus 로고
    • Increased plasma von Willebrand factor in the systemic inflammatory response syndrome is derived from generalized endothelial cell activation
    • 10.1097/00003246-199802000-00031, 9468168
    • McGill SN, Ahmed NA, Christou NV. Increased plasma von Willebrand factor in the systemic inflammatory response syndrome is derived from generalized endothelial cell activation. Crit Care Med 1998, 26:296-300. 10.1097/00003246-199802000-00031, 9468168.
    • (1998) Crit Care Med , vol.26 , pp. 296-300
    • McGill, S.N.1    Ahmed, N.A.2    Christou, N.V.3
  • 26
    • 0030282223 scopus 로고    scopus 로고
    • Evaluation of a soluble E-selectin enzyme-linked immunosorbent assay under posttraumatic conditions
    • 10.1016/S0022-2143(96)90050-5, 8900296
    • Kneidinger R, Bahrami S, Redl H, Schlag G, Robinson M, Weichselbraun I, Cremer J. Evaluation of a soluble E-selectin enzyme-linked immunosorbent assay under posttraumatic conditions. J Lab Clin Med 1996, 128:520-523. 10.1016/S0022-2143(96)90050-5, 8900296.
    • (1996) J Lab Clin Med , vol.128 , pp. 520-523
    • Kneidinger, R.1    Bahrami, S.2    Redl, H.3    Schlag, G.4    Robinson, M.5    Weichselbraun, I.6    Cremer, J.7
  • 27
    • 0024334658 scopus 로고
    • Coagulation, fibrinolysis, and kallikrein systems in sepsis: relation to outcome
    • 10.1097/00003246-198908000-00002, 2502362
    • Hesselvik JF, Blomback M, Brodin B, Maller R. Coagulation, fibrinolysis, and kallikrein systems in sepsis: relation to outcome. Crit Care Med 1989, 17:724-733. 10.1097/00003246-198908000-00002, 2502362.
    • (1989) Crit Care Med , vol.17 , pp. 724-733
    • Hesselvik, J.F.1    Blomback, M.2    Brodin, B.3    Maller, R.4
  • 28
    • 77149131838 scopus 로고    scopus 로고
    • The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients
    • 10.1097/SHK.0b013e3181b2f978, 19543148
    • van der Heijden M, van Nieuw Amerongen GP, van Hinsbergh VW, Groeneveld AB. The interaction of soluble Tie2 with angiopoietins and pulmonary vascular permeability in septic and nonseptic critically ill patients. Shock 2010, 33:263-268. 10.1097/SHK.0b013e3181b2f978, 19543148.
    • (2010) Shock , vol.33 , pp. 263-268
    • van der Heijden, M.1    van Nieuw Amerongen, G.P.2    van Hinsbergh, V.W.3    Groeneveld, A.B.4
  • 29
    • 77951207233 scopus 로고    scopus 로고
    • Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome
    • 10.1007/s00134-009-1726-7, 19956923
    • Kumpers P, Hafer C, David S, Hecker H, Lukasz A, Fliser D, Haller H, Kielstein JT, Faulhaber-Walter R. Angiopoietin-2 in patients requiring renal replacement therapy in the ICU: relation to acute kidney injury, multiple organ dysfunction syndrome and outcome. Intensive Care Med 2010, 36:462-470. 10.1007/s00134-009-1726-7, 19956923.
    • (2010) Intensive Care Med , vol.36 , pp. 462-470
    • Kumpers, P.1    Hafer, C.2    David, S.3    Hecker, H.4    Lukasz, A.5    Fliser, D.6    Haller, H.7    Kielstein, J.T.8    Faulhaber-Walter, R.9
  • 30
    • 19344370093 scopus 로고    scopus 로고
    • Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation
    • 10.1016/j.thromres.2004.09.022, 15907522
    • Gando S, Kameue T, Matsuda N, Hayakawa M, Hoshino H, Kato H. Serial changes in neutrophil-endothelial activation markers during the course of sepsis associated with disseminated intravascular coagulation. Thromb Res 2005, 116:91-100. 10.1016/j.thromres.2004.09.022, 15907522.
    • (2005) Thromb Res , vol.116 , pp. 91-100
    • Gando, S.1    Kameue, T.2    Matsuda, N.3    Hayakawa, M.4    Hoshino, H.5    Kato, H.6
  • 31
    • 0036151361 scopus 로고    scopus 로고
    • Posttraumatic immune modulation in chronic alcoholics is associated with multiple organ dysfunction syndrome
    • 10.1097/00005373-200201000-00017, 11791058
    • von Heymann C, Langenkamp J, Dubisz N, von Dossow V, Schaffartzik W, Kern H, Kox WJ, Spies C. Posttraumatic immune modulation in chronic alcoholics is associated with multiple organ dysfunction syndrome. J Trauma 2002, 52:95-103. 10.1097/00005373-200201000-00017, 11791058.
    • (2002) J Trauma , vol.52 , pp. 95-103
    • von Heymann, C.1    Langenkamp, J.2    Dubisz, N.3    von Dossow, V.4    Schaffartzik, W.5    Kern, H.6    Kox, W.J.7    Spies, C.8
  • 32
    • 0031848006 scopus 로고    scopus 로고
    • Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn
    • 10.1515/CCLM.1998.064, 9711425
    • Grad S, Ertel W, Keel M, Infanger M, Vonderschmitt DJ, Maly FE. Strongly enhanced serum levels of vascular endothelial growth factor (VEGF) after polytrauma and burn. Clin Chem Lab Med 1998, 36:379-383. 10.1515/CCLM.1998.064, 9711425.
    • (1998) Clin Chem Lab Med , vol.36 , pp. 379-383
    • Grad, S.1    Ertel, W.2    Keel, M.3    Infanger, M.4    Vonderschmitt, D.J.5    Maly, F.E.6
  • 33
    • 34548218270 scopus 로고    scopus 로고
    • The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock
    • 10.1097/01.CCM.0000281637.08984.6E, 17855815
    • Rivers EP, Kruse JA, Jacobsen G, Shah K, Loomba M, Otero R, Childs EW. The influence of early hemodynamic optimization on biomarker patterns of severe sepsis and septic shock. Crit Care Med 2007, 35:2016-2024. 10.1097/01.CCM.0000281637.08984.6E, 17855815.
    • (2007) Crit Care Med , vol.35 , pp. 2016-2024
    • Rivers, E.P.1    Kruse, J.A.2    Jacobsen, G.3    Shah, K.4    Loomba, M.5    Otero, R.6    Childs, E.W.7
  • 34
    • 33749646870 scopus 로고    scopus 로고
    • [Effect of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis]
    • Fang XL, Fang Q, Cai GL, Yan J. [Effect of fluid resuscitation on adhesion molecule and hemodynamics in patients with severe sepsis]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2006, 18:539-541.
    • (2006) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue , vol.18 , pp. 539-541
    • Fang, X.L.1    Fang, Q.2    Cai, G.L.3    Yan, J.4
  • 35
    • 0032615701 scopus 로고    scopus 로고
    • Continuous heparinization and circulating adhesion molecules in the critically ill
    • Boldt J, Papsdorf M, Piper SN, Rothe A, Hempelmann G. Continuous heparinization and circulating adhesion molecules in the critically ill. Shock 1999, 11:13-18.
    • (1999) Shock , vol.11 , pp. 13-18
    • Boldt, J.1    Papsdorf, M.2    Piper, S.N.3    Rothe, A.4    Hempelmann, G.5
  • 36
    • 0038545471 scopus 로고    scopus 로고
    • [The significance of postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage in burn patients]
    • Kuang X, Ma K, Duan T. [The significance of postburn changes in plasma levels of ICAM-1, IL-10 and TNFalpha during early postburn stage in burn patients]. Zhonghua Shao Shang Za Zhi 2002, 18:302-304.
    • (2002) Zhonghua Shao Shang Za Zhi , vol.18 , pp. 302-304
    • Kuang, X.1    Ma, K.2    Duan, T.3
  • 37
    • 4644233671 scopus 로고    scopus 로고
    • [Clinical significance of soluble selectins and matrix metalloproteinases-9 in patients after successful cardiopulmonary resuscitation]
    • Li PJ, Yang XH, Zhang LP, Cao W, Qin J, Yao W. [Clinical significance of soluble selectins and matrix metalloproteinases-9 in patients after successful cardiopulmonary resuscitation]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 2004, 16:137-141.
    • (2004) Zhongguo Wei Zhong Bing Ji Jiu Yi Xue , vol.16 , pp. 137-141
    • Li, P.J.1    Yang, X.H.2    Zhang, L.P.3    Cao, W.4    Qin, J.5    Yao, W.6
  • 39
    • 64849117308 scopus 로고    scopus 로고
    • Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis
    • 10.1097/SHK.0b013e318188bd06, 18791490
    • Siner JM, Bhandari V, Engle KM, Elias JA, Siegel MD. Elevated serum angiopoietin 2 levels are associated with increased mortality in sepsis. Shock 2009, 31:348-353. 10.1097/SHK.0b013e318188bd06, 18791490.
    • (2009) Shock , vol.31 , pp. 348-353
    • Siner, J.M.1    Bhandari, V.2    Engle, K.M.3    Elias, J.A.4    Siegel, M.D.5
  • 40
    • 55749108506 scopus 로고    scopus 로고
    • Kinetics of angiopoietin-2 in serum of multi-trauma patients: correlation with patient severity
    • 10.1016/j.cyto.2008.09.003, 18952457
    • Giamarellos-Bourboulis EJ, Kanellakopoulou K, Pelekanou A, Tsaganos T, Kotzampassi K. Kinetics of angiopoietin-2 in serum of multi-trauma patients: correlation with patient severity. Cytokine 2008, 44:310-313. 10.1016/j.cyto.2008.09.003, 18952457.
    • (2008) Cytokine , vol.44 , pp. 310-313
    • Giamarellos-Bourboulis, E.J.1    Kanellakopoulou, K.2    Pelekanou, A.3    Tsaganos, T.4    Kotzampassi, K.5
  • 42
  • 43
    • 33645355399 scopus 로고    scopus 로고
    • Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans
    • 10.1371/journal.pmed.0030046, 1334221, 16417407
    • Parikh SM, Mammoto T, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP. Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006, 3:e46. 10.1371/journal.pmed.0030046, 1334221, 16417407.
    • (2006) PLoS Med , vol.3
    • Parikh, S.M.1    Mammoto, T.2    Schultz, A.3    Yuan, H.T.4    Christiani, D.5    Karumanchi, S.A.6    Sukhatme, V.P.7
  • 44
    • 77952285642 scopus 로고    scopus 로고
    • Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity
    • 10.1186/cc9020, 2911723, 20482750
    • Davis JS, Yeo TW, Piera KA, Woodberry T, Celermajer DS, Stephens DP, Anstey NM. Angiopoietin-2 is increased in sepsis and inversely associated with nitric oxide-dependent microvascular reactivity. Crit Care 2010, 14:R89. 10.1186/cc9020, 2911723, 20482750.
    • (2010) Crit Care , vol.14
    • Davis, J.S.1    Yeo, T.W.2    Piera, K.A.3    Woodberry, T.4    Celermajer, D.S.5    Stephens, D.P.6    Anstey, N.M.7
  • 45
    • 53649099512 scopus 로고    scopus 로고
    • Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients
    • 10.1136/thx.2007.087387, 18559364
    • van der Heijden M, van Nieuw Amerongen GP, Koolwijk P, van Hinsbergh VW, Groeneveld AB. Angiopoietin-2, permeability oedema, occurrence and severity of ALI/ARDS in septic and non-septic critically ill patients. Thorax 2008, 63:903-909. 10.1136/thx.2007.087387, 18559364.
    • (2008) Thorax , vol.63 , pp. 903-909
    • van der Heijden, M.1    van Nieuw Amerongen, G.P.2    Koolwijk, P.3    van Hinsbergh, V.W.4    Groeneveld, A.B.5
  • 46
    • 0022256529 scopus 로고
    • APACHE II: a severity of disease classification system
    • 10.1097/00003246-198510000-00009, 3928249
    • Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13:818-829. 10.1097/00003246-198510000-00009, 3928249.
    • (1985) Crit Care Med , vol.13 , pp. 818-829
    • Knaus, W.A.1    Draper, E.A.2    Wagner, D.P.3    Zimmerman, J.E.4
  • 47
    • 0030015661 scopus 로고    scopus 로고
    • The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine
    • 10.1007/BF01709751, 8844239
    • Vincent JL, Moreno R, Takala J, Willatts S, De Mendonca A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239.
    • (1996) Intensive Care Med , vol.22 , pp. 707-710
    • Vincent, J.L.1    Moreno, R.2    Takala, J.3    Willatts, S.4    De Mendonca, A.5    Bruining, H.6    Reinhart, C.K.7    Suter, P.M.8    Thijs, L.G.9
  • 50
    • 79953902581 scopus 로고    scopus 로고
    • Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome
    • 10.1093/cid/cir125, 21460306
    • Page AV, Kotb M, McGeer A, Low DE, Kain KC, Liles WC. Systemic dysregulation of angiopoietin-1/2 in streptococcal toxic shock syndrome. Clin Infect Dis 2011, 52:e157-161. 10.1093/cid/cir125, 21460306.
    • (2011) Clin Infect Dis , vol.52
    • Page, A.V.1    Kotb, M.2    McGeer, A.3    Low, D.E.4    Kain, K.C.5    Liles, W.C.6
  • 51
    • 77957745203 scopus 로고    scopus 로고
    • The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    • 10.1186/cc9290, 3219288, 20942957
    • Shapiro N, Schuetz P, Yano K, Sorasaki M, Parikh SM, Jones AE, Trzeciak S, Ngo L, Aird WC. The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis. Crit Care 2010, 14:R182. 10.1186/cc9290, 3219288, 20942957.
    • (2010) Crit Care , vol.14
    • Shapiro, N.1    Schuetz, P.2    Yano, K.3    Sorasaki, M.4    Parikh, S.M.5    Jones, A.E.6    Trzeciak, S.7    Ngo, L.8    Aird, W.C.9
  • 52
    • 80051547246 scopus 로고    scopus 로고
    • Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension
    • 10.1097/SHK.0b013e31821e4e04, 21522043
    • Schuetz P, Jones AE, Aird WC, Shapiro NI. Endothelial cell activation in emergency department patients with sepsis-related and non-sepsis-related hypotension. Shock 2011, 36:104-108. 10.1097/SHK.0b013e31821e4e04, 21522043.
    • (2011) Shock , vol.36 , pp. 104-108
    • Schuetz, P.1    Jones, A.E.2    Aird, W.C.3    Shapiro, N.I.4
  • 56
    • 33748417281 scopus 로고    scopus 로고
    • Neutrophil-related inflammatory mediators in septic acute respiratory distress syndrome
    • Kinoshita M, Ono S, Mochizuki H. Neutrophil-related inflammatory mediators in septic acute respiratory distress syndrome. J Intensive Care Med 2002, 17:308-316.
    • (2002) J Intensive Care Med , vol.17 , pp. 308-316
    • Kinoshita, M.1    Ono, S.2    Mochizuki, H.3
  • 57
    • 0034113383 scopus 로고    scopus 로고
    • Increased nuclear factor kappa B activation in critically ill patients who die
    • 10.1097/00003246-200004000-00022, 10809280
    • Paterson RL, Galley HF, Dhillon JK, Webster NR. Increased nuclear factor kappa B activation in critically ill patients who die. Crit Care Med 2000, 28:1047-1051. 10.1097/00003246-200004000-00022, 10809280.
    • (2000) Crit Care Med , vol.28 , pp. 1047-1051
    • Paterson, R.L.1    Galley, H.F.2    Dhillon, J.K.3    Webster, N.R.4
  • 58
    • 0033397528 scopus 로고    scopus 로고
    • Circulating intercellular adhesion molecule-1 as an early predictor of hepatic failure in patients with septic shock
    • 10.1097/00003246-199912000-00008, 10628605
    • Weigand MA, Schmidt H, Pourmahmoud M, Zhao Q, Martin E, Bardenheuer HJ. Circulating intercellular adhesion molecule-1 as an early predictor of hepatic failure in patients with septic shock. Crit Care Med 1999, 27:2656-2661. 10.1097/00003246-199912000-00008, 10628605.
    • (1999) Crit Care Med , vol.27 , pp. 2656-2661
    • Weigand, M.A.1    Schmidt, H.2    Pourmahmoud, M.3    Zhao, Q.4    Martin, E.5    Bardenheuer, H.J.6
  • 59
    • 0031945765 scopus 로고    scopus 로고
    • Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection
    • Kayal S, Jais JP, Aguini N, Chaudiere J, Labrousse J. Elevated circulating E-selectin, intercellular adhesion molecule 1, and von Willebrand factor in patients with severe infection. Am J Respir Crit Care Med 1998, 157:776-784.
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 776-784
    • Kayal, S.1    Jais, J.P.2    Aguini, N.3    Chaudiere, J.4    Labrousse, J.5
  • 60
    • 0031012703 scopus 로고    scopus 로고
    • Does age influence circulating adhesion molecules in the critically ill?
    • 10.1097/00003246-199701000-00019, 8989183
    • Boldt J, Muller M, Heesen M, Papsdorf M, Hempelmann G. Does age influence circulating adhesion molecules in the critically ill?. Crit Care Med 1997, 25:95-100. 10.1097/00003246-199701000-00019, 8989183.
    • (1997) Crit Care Med , vol.25 , pp. 95-100
    • Boldt, J.1    Muller, M.2    Heesen, M.3    Papsdorf, M.4    Hempelmann, G.5
  • 61
    • 0030800048 scopus 로고    scopus 로고
    • The circulating adhesion molecules sICAM-1 and sE-selection in patients with sepsis
    • 10.1007/s001010050442, 9304360
    • Egerer K, Rohr U, Krausch D, Kox W. The circulating adhesion molecules sICAM-1 and sE-selection in patients with sepsis. Anaesthesist 1997, 46:592-598. 10.1007/s001010050442, 9304360.
    • (1997) Anaesthesist , vol.46 , pp. 592-598
    • Egerer, K.1    Rohr, U.2    Krausch, D.3    Kox, W.4
  • 62
    • 0031467638 scopus 로고    scopus 로고
    • Assessment of inflammatory cytokines, nitrate/nitrite, type II phospholipase A2, and soluble adhesion molecules in systemic inflammatory response syndrome
    • Takakuwa T, Endo S, Inada K, Kasai T, Yamada Y, Ogawa M. Assessment of inflammatory cytokines, nitrate/nitrite, type II phospholipase A2, and soluble adhesion molecules in systemic inflammatory response syndrome. Res Commun Mol Pathol Pharmacol 1997, 98:43-52.
    • (1997) Res Commun Mol Pathol Pharmacol , vol.98 , pp. 43-52
    • Takakuwa, T.1    Endo, S.2    Inada, K.3    Kasai, T.4    Yamada, Y.5    Ogawa, M.6
  • 63
    • 0029928498 scopus 로고    scopus 로고
    • Circulating adhesion molecules in the critically ill: a comparison between trauma and sepsis patients
    • 10.1007/BF01720718, 8857119
    • Boldt J, Muller M, Kuhn D, Linke LC, Hempelmann G. Circulating adhesion molecules in the critically ill: a comparison between trauma and sepsis patients. Intensive Care Med 1996, 22:122-128. 10.1007/BF01720718, 8857119.
    • (1996) Intensive Care Med , vol.22 , pp. 122-128
    • Boldt, J.1    Muller, M.2    Kuhn, D.3    Linke, L.C.4    Hempelmann, G.5
  • 65
    • 0028256113 scopus 로고
    • Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study
    • 10.1097/00003246-199404000-00022, 7511496
    • Cowley HC, Heney D, Gearing AJ, Hemingway I, Webster NR. Increased circulating adhesion molecule concentrations in patients with the systemic inflammatory response syndrome: a prospective cohort study. Crit Care Med 1994, 22:651-657. 10.1097/00003246-199404000-00022, 7511496.
    • (1994) Crit Care Med , vol.22 , pp. 651-657
    • Cowley, H.C.1    Heney, D.2    Gearing, A.J.3    Hemingway, I.4    Webster, N.R.5
  • 66
    • 0029800805 scopus 로고    scopus 로고
    • Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome
    • 10.1097/00003246-199611000-00004, 8917025
    • Moss M, Gillespie MK, Ackerson L, Moore FA, Moore EE, Parsons PE. Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome. Crit Care Med 1996, 24:1782-1786. 10.1097/00003246-199611000-00004, 8917025.
    • (1996) Crit Care Med , vol.24 , pp. 1782-1786
    • Moss, M.1    Gillespie, M.K.2    Ackerson, L.3    Moore, F.A.4    Moore, E.E.5    Parsons, P.E.6
  • 70
    • 0033031968 scopus 로고    scopus 로고
    • Interleukin 1 receptor antagonist and E-selectin concentrations: a comparison in patients with severe acute pancreatitis and severe sepsis
    • 10.1016/S0883-9441(99)90015-1, 10382785
    • Hynninen M, Valtonen M, Markkanen H, Vaara M, Kuusela P, Jousela I, Piilonen A, Takkunen O. Interleukin 1 receptor antagonist and E-selectin concentrations: a comparison in patients with severe acute pancreatitis and severe sepsis. J Crit Care 1999, 14:63-68. 10.1016/S0883-9441(99)90015-1, 10382785.
    • (1999) J Crit Care , vol.14 , pp. 63-68
    • Hynninen, M.1    Valtonen, M.2    Markkanen, H.3    Vaara, M.4    Kuusela, P.5    Jousela, I.6    Piilonen, A.7    Takkunen, O.8
  • 71
    • 0032751042 scopus 로고    scopus 로고
    • Markers of systemic inflammation predicting organ failure in community-acquired septic shock
    • 10.1042/CS19990073, 10545303
    • Takala A, Jousela I, Jansson SE, Olkkola KT, Takkunen O, Orpana A, Karonen SL, Repo H. Markers of systemic inflammation predicting organ failure in community-acquired septic shock. Clin Sci 1999, 97:529-538. 10.1042/CS19990073, 10545303.
    • (1999) Clin Sci , vol.97 , pp. 529-538
    • Takala, A.1    Jousela, I.2    Jansson, S.E.3    Olkkola, K.T.4    Takkunen, O.5    Orpana, A.6    Karonen, S.L.7    Repo, H.8
  • 72
  • 75
    • 0029858536 scopus 로고    scopus 로고
    • Elevated selectin levels after severe trauma: a marker for sepsis and organ failure and a potential target for immunomodulatory therapy
    • 10.1097/00005373-199610000-00010, 8858024
    • Simons RK, Hoyt DB, Winchell RJ, Rose RM, Holbrook T. Elevated selectin levels after severe trauma: a marker for sepsis and organ failure and a potential target for immunomodulatory therapy. J Trauma 1996, 41:653-662. 10.1097/00005373-199610000-00010, 8858024.
    • (1996) J Trauma , vol.41 , pp. 653-662
    • Simons, R.K.1    Hoyt, D.B.2    Winchell, R.J.3    Rose, R.M.4    Holbrook, T.5
  • 77
    • 40949123909 scopus 로고    scopus 로고
    • A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis
    • 10.1097/SHK.0b013e31815072c1, 18598002
    • Shapiro NI, Yano K, Okada H, Fischer C, Howell M, Spokes KC, Ngo L, Angus DC, Aird WC. A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis. Shock 2008, 29:452-457. 10.1097/SHK.0b013e31815072c1, 18598002.
    • (2008) Shock , vol.29 , pp. 452-457
    • Shapiro, N.I.1    Yano, K.2    Okada, H.3    Fischer, C.4    Howell, M.5    Spokes, K.C.6    Ngo, L.7    Angus, D.C.8    Aird, W.C.9
  • 79
    • 0030854053 scopus 로고    scopus 로고
    • Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction
    • Cummings CJ, Sessler CN, Beall LD, Fisher BJ, Best AM, Fowler AA. Soluble E-selectin levels in sepsis and critical illness. Correlation with infection and hemodynamic dysfunction. Am J Resp Crit Care Med 1997, 156:431-437.
    • (1997) Am J Resp Crit Care Med , vol.156 , pp. 431-437
    • Cummings, C.J.1    Sessler, C.N.2    Beall, L.D.3    Fisher, B.J.4    Best, A.M.5    Fowler, A.A.6
  • 81
    • 37549028378 scopus 로고    scopus 로고
    • Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis
    • 10.1080/10623320701678326, 2430170, 18080871
    • Schuetz P, Christ-Crain M, Morgenthaler NG, Struck J, Bergmann A, Muller B. Circulating precursor levels of endothelin-1 and adrenomedullin, two endothelium-derived, counteracting substances, in sepsis. Endothelium 2007, 14:345-351. 10.1080/10623320701678326, 2430170, 18080871.
    • (2007) Endothelium , vol.14 , pp. 345-351
    • Schuetz, P.1    Christ-Crain, M.2    Morgenthaler, N.G.3    Struck, J.4    Bergmann, A.5    Muller, B.6
  • 86
    • 0025904585 scopus 로고
    • Elevated plasma levels of endothelin in patients with sepsis syndrome
    • Weitzberg E, Lundberg JM, Rudehill A. Elevated plasma levels of endothelin in patients with sepsis syndrome. Circ Shock 1991, 33:222-227.
    • (1991) Circ Shock , vol.33 , pp. 222-227
    • Weitzberg, E.1    Lundberg, J.M.2    Rudehill, A.3
  • 87
    • 0026101534 scopus 로고
    • Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis
    • 10.1097/00000658-199103000-00014, 1358338, 1998407
    • Pittet JF, Morel DR, Hemsen A, Gunning K, Lacroix JS, Suter PM, Lundberg JM. Elevated plasma endothelin-1 concentrations are associated with the severity of illness in patients with sepsis. Ann Surg 1991, 213:261-264. 10.1097/00000658-199103000-00014, 1358338, 1998407.
    • (1991) Ann Surg , vol.213 , pp. 261-264
    • Pittet, J.F.1    Morel, D.R.2    Hemsen, A.3    Gunning, K.4    Lacroix, J.S.5    Suter, P.M.6    Lundberg, J.M.7
  • 88
    • 78650989117 scopus 로고    scopus 로고
    • Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study
    • 10.1186/cc9412, 3222041, 21219633
    • Yang K-Y, Liu K-T, Chen Y-C, Chen C-S, Lee Y-C, Perng R-P, Feng J-Y. Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study. Critical Care 2011, 15:R11. 10.1186/cc9412, 3222041, 21219633.
    • (2011) Critical Care , vol.15
    • Yang, K.-Y.1    Liu, K.-T.2    Chen, Y.-C.3    Chen, C.-S.4    Lee, Y.-C.5    Perng, R.-P.6    Feng, J.-Y.7
  • 91
    • 34748855578 scopus 로고    scopus 로고
    • Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure
    • 10.1097/01.CCM.0000284508.05247.B3, 17944029
    • Martin K, Borgel D, Lerolle N, Feys HB, Trinquart L, Vanhoorelbeke K, Deckmyn H, Legendre P, Diehl JL, Baruch D. Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure. Crit Care Med 2007, 35:2375-2382. 10.1097/01.CCM.0000284508.05247.B3, 17944029.
    • (2007) Crit Care Med , vol.35 , pp. 2375-2382
    • Martin, K.1    Borgel, D.2    Lerolle, N.3    Feys, H.B.4    Trinquart, L.5    Vanhoorelbeke, K.6    Deckmyn, H.7    Legendre, P.8    Diehl, J.L.9    Baruch, D.10
  • 92
    • 0034306680 scopus 로고    scopus 로고
    • Hemostatic disturbances in patients with systemic inflammatory response syndrome (SIRS) and associated acute renal failure (ARF)
    • 10.1016/S0049-3848(00)00306-6, 11053612
    • Garcia-Fernandez N, Montes R, Purroy A, Rocha E. Hemostatic disturbances in patients with systemic inflammatory response syndrome (SIRS) and associated acute renal failure (ARF). Thromb Res 2000, 100:19-25. 10.1016/S0049-3848(00)00306-6, 11053612.
    • (2000) Thromb Res , vol.100 , pp. 19-25
    • Garcia-Fernandez, N.1    Montes, R.2    Purroy, A.3    Rocha, E.4
  • 93
    • 0027214771 scopus 로고
    • Time course of hemostatic abnormalities in sepsis and its relation to outcome
    • 10.1378/chest.103.5.1536, 8486040
    • Lorente JA, Garcia-Frade LJ, Landin L, de Pablo R, Torrado C, Renes E, Garcia-Avello A. Time course of hemostatic abnormalities in sepsis and its relation to outcome. Chest 1993, 103:1536-1542. 10.1378/chest.103.5.1536, 8486040.
    • (1993) Chest , vol.103 , pp. 1536-1542
    • Lorente, J.A.1    Garcia-Frade, L.J.2    Landin, L.3    de Pablo, R.4    Torrado, C.5    Renes, E.6    Garcia-Avello, A.7
  • 94
    • 0035671508 scopus 로고    scopus 로고
    • Von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury
    • 10.1097/00003246-200112000-00016, 11801836
    • Ware LB, Conner ER, Matthay MA. von Willebrand factor antigen is an independent marker of poor outcome in patients with early acute lung injury. Crit Care Med 2001, 29:2325-2331. 10.1097/00003246-200112000-00016, 11801836.
    • (2001) Crit Care Med , vol.29 , pp. 2325-2331
    • Ware, L.B.1    Conner, E.R.2    Matthay, M.A.3
  • 97
    • 0032707329 scopus 로고    scopus 로고
    • Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome
    • 10.1007/s001340051054, 10654210
    • Bajaj MS, Tricomi SM. Plasma levels of the three endothelial-specific proteins von Willebrand factor, tissue factor pathway inhibitor, and thrombomodulin do not predict the development of acute respiratory distress syndrome. Intensive Care Med 1999, 25:1259-1266. 10.1007/s001340051054, 10654210.
    • (1999) Intensive Care Med , vol.25 , pp. 1259-1266
    • Bajaj, M.S.1    Tricomi, S.M.2
  • 99
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • 10.1056/NEJMoa022139, 12700374
    • Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 100
    • 59649097493 scopus 로고    scopus 로고
    • Management of septic shock: where do we stand?
    • 10.1007/S12098-008-0241-0, 19132319
    • Sankar J, Lodha R, Kabra SK. Management of septic shock: where do we stand?. Indian J Pediatr 2008, 75:1167-1169. 10.1007/S12098-008-0241-0, 19132319.
    • (2008) Indian J Pediatr , vol.75 , pp. 1167-1169
    • Sankar, J.1    Lodha, R.2    Kabra, S.K.3
  • 101
    • 78650989117 scopus 로고    scopus 로고
    • Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study
    • 10.1186/cc9412, 3222041, 21219633
    • Yang KY, Liu KT, Chen YC, Chen CS, Lee YC, Perng RP, Feng JY. Plasma soluble vascular endothelial growth factor receptor-1 levels predict outcomes of pneumonia-related septic shock patients: a prospective observational study. Crit Care 2011, 15:R11. 10.1186/cc9412, 3222041, 21219633.
    • (2011) Crit Care , vol.15
    • Yang, K.Y.1    Liu, K.T.2    Chen, Y.C.3    Chen, C.S.4    Lee, Y.C.5    Perng, R.P.6    Feng, J.Y.7
  • 102
    • 0024333745 scopus 로고
    • Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group
    • 10.1097/00003246-198905000-00002, 2651003
    • Bone RC, Fisher CJ, Clemmer TP, Slotman GJ, Metz CA, Balk RA. Sepsis syndrome: a valid clinical entity. Methylprednisolone Severe Sepsis Study Group. Crit Care Med 1989, 17:389-393. 10.1097/00003246-198905000-00002, 2651003.
    • (1989) Crit Care Med , vol.17 , pp. 389-393
    • Bone, R.C.1    Fisher, C.J.2    Clemmer, T.P.3    Slotman, G.J.4    Metz, C.A.5    Balk, R.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.