Microcirculatory oxygenation and shunting in sepsis and shock

Critical Care Medicine

Volumn 27, Issue 7, 1999, Pages 1369-1377

  Ince, Can ^a   Sinaasappel, Michiel ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Blood substitutes; Hemorrhage; Microcirculation; Optical spectroscopy; Palladium (Pd) porphyrin phosphorescence; Reduced nicotinamide adenine dinucleotide (NADH) fluorescence; Sepsis; Shock shunting; Tissue oxygenation

Indexed keywords

HEMOGLOBIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; OXYGEN; PALLADIUM; PORPHYRIN;

ARTICLE; BIOENERGY; BLEEDING; ENDOTOXEMIA; ERYTHROCYTE; HUMAN; MICROCIRCULATION; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN TENSION; PRIORITY JOURNAL; SEPSIS; SHOCK; SHUNTING; SPECTROSCOPY; TISSUE OXYGENATION;

ANOXEMIA; HUMANS; MICROCIRCULATION; OXYGEN; SEPSIS; SHOCK; SPECTRUM ANALYSIS;

EID: 0032790876     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-199907000-00031     Document Type: Article

References (75)

1. Dantzker DR: Adequacy of tissue oxygenation. Crit Care Med 1993; 21(Suppl): S40-S43
2. Johnson PC: Autoregulation of blood flow. Circ Res 1986; 59:483-495
3. Robin ED: Of men and mitochondria: Coping with hypoxic dysoxia. Am Rev Respir Dis 1980; 122:517-531
4. 2 Collaborative Group. N Engl J Med 1995; 333:1025-1032
5. Cain SM, Curtis SE: Experimental models of pathologic oxygen supply dependency. Crit Care Med 1991; 19:603-612
6. 2 uptake during endotoxemia. J Appl Physiol 1988; 64:2410-2419
7. Curtis SE, Cain SM: Regional and systemic oxygen delivery/uptake relations and lactate flux in hyperdynamic, endotoxin-treated dogs. Am Rev Respir Dis 1992; 145:348-354
8. van der Meer TJ, Wang H, Fink MP: Endotoxemia causes ileal mucosal acidosis in the absence of mucosal hypoxia in a normodynamic porcine model of septic shock. Crit Care Med 1995; 23:1217-1226
9. Walley KR: Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: Theory. J Appl Physiol 1996; 81: 885-894
10. Groeneveld AB, van Lambalgen AA, van den Bos GC, et al: Maldistribution of heterogeneous coronary blood flow during canine endotoxin shock. Cardiovasc Res 1991; 25: 80-88
11. Ruokonen E, Takala J, Kari A, et al: Regional blood flow and oxygen transport in septic shock. Crit Care Med 1993; 21:1296-1303
12. Friedman G, Berlot G, Kahn RJ, et al: Combined measurements of blood lactate concentrations and gastric intramucosal pH in patients with severe sepsis. Crit Care Med 1995; 23:1184-1193
13. Fiddian-Green RG, Baker S: Predictive value of the stomach wall pH for complications after cardiac operations: Comparison with other monitoring. Crit Care Med 1987; 15: 153-156
14. Vincent JL: End-points of resuscitation: Arterial blood pressure, oxygen delivery, blood lactate, or. . . ? Intensive Care Med 1996; 22:3-5
15. Marik PE: Gastric intramucosal pH: A better predictor of multiorgan dysfunction syndrome and death than oxygen-derived variables in patients with sepsis. Chest 1993; 104:225-229
16. Boekstegers P, Weidenhofer S, Kapsner T, et al: Skeletal muscle partial pressure of oxygen in patients with sepsis. Crit Care Med 1994; 22:640-650
17. 2 in endotoxemic dogs during shock and resuscitation. J Appl Physiol 1994; 76:793-800
18. Hasibeder W, Germann R, Wolf HJ, et al: Effects of short-term endotoxemia and dopamine on mucosal oxygenation in porcine jejunum. Am J Physiol 1996; 270:G667-G675
19. 2 during hypoxemia. J Appl Physiol 1989; 67: 1093-1099
20. Souba WW, Herskowitz K, Klimberg VS, et al: The effect of sepsis and endotoxemia on gut glutamine metabolism. Ann Surg 1990; 211:543-549
21. Lam C, Tyml K, Martin C, et al: Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 1994; 94: 2077-2083
22. Uusaro A, Ruokonen E, Takala J: Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery. Br J Anaesth 1995; 74:149-154
23. Cunnion RE, Schaer GL, Parker MM, et al: The coronary circulation in human septic shock. Circulation 1986; 73:637-644
24. Avontuur JA, Bruining HA, Ince C: Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. Cardiovasc Res 1997; 35:368-376
25. Drazenovic R, Samsel RW, Wylam ME, et al: Regulation of perfused capillary density in canine intestinal mucosa during endotoxemia. J Appl Physiol 1992; 72:259-265
26. Jourdain M, Tournoys A, Lero X, et al: Effects of N omega-nitro-L-arginine methyl ester on the endotoxin-induced disseminated intravascular coagulation in porcine septic shock. Crit Care Med 1997; 25:452-459
27. Ince C, Bruining HA: Optical spectroscopy for measurement of tissue hypoxia. In: Update in Intensive Care and Emergency Medicine: Update 1991. Vincent JL (Ed). New York, Springer-Verlag, 1991, pp 161-171
28. 2 during nonhypoxic and hypoxic ventilation. Am J Physiol 1993; 265:H537-H542
29. Wyatt JS, Cope M, Delpy DT, et al: Quantification of cerebral oxygenation and hemodynamics in sick newborn infants by near infra-red spectrophotometry. Lancet 1986; 1063-1066
30. Levy WJ, Levin S, Chance B: Near infra-red measurement of cerebral oxygenation. Anesthesiology 1995; 83:738-746
31. Ashruf JF, Coremans JM, Bruining HA, et al: Increase of cardiac work is associated with decrease of mitochondrial NADH. Am J Physiol 1995; 269:H856-H862
32. Chance B: Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondria. Circ Res 1976; 38(Suppl 1):I31-I38
33. Balaban RS: Regulation of oxidative phosphorylation in the mammalian cell. Am J Physiol 1990; 258:C377-C389
34. Coremans JMMC, Ince C, Bruining HA, et al: (Semi-)quantitative analysis of NADH fluorescence images of blood-perfused heart. Biophys J 1997; 72:1849-1860
35. Ince C, Ashruf JF, Avontuur JA, et al: Heterogeneity of the hypoxic state in rat heart is determined at the capillary level. Am J Physiol 1993; 264:H294-H301
36. 2 measurements in the intestinal microcirculation. Am J Physiol 1999; 276: G1515-G1520
37. Toth A, Pal M, Tischler ME, et al: Are there oxygen-deficient regions in resting skeletal muscle? Am J Physiol 1996; 270:H1933-H1939
38. Vetterlein F, Prange M, Lubrich D, et al: Capillary perfusion pattern and microvascular geometry in heterogeneous hypoxic areas of hypoperfused rat myocardium. Am J Physiol 1995; 268:H2183-H2194
39. Vanderkooi JM, Maniara G, Green TJ, et al: An optical method for measurement of dioxygen concentration based upon quenching of phosphorescence. J Biol Chem 1987; 262: 5476-5482
40. Wilson DF, Pastuszko A, DiGiacomo JE, et al: Effect of hyperventilation on oxygenation of the brain cortex of newborn piglets. J Appl Physiol 1991; 70:2691-2696
41. Sinaasappel M, Ince C: Calibration of Pd-porphyrin phosphorescence for oxygen concentration measurements in vivo. J Appl Physiol 1996; 81:2297-2303
42. Kerger H, Saltzman DJ, Menger MD, et al: Systemic and subcutaneous microvascular dissociation during 4-h hemorrhagic shock in conscious hamsters. Am J Physiol 1996; 270:H827-H836
43. Shonat RD, Johnson PC: Oxygen tension gradients and heterogeneity in venous microcirculation: A phosphorescence quenching study. Am J Physiol 1997; 272:H2233-H2240
44. 2 and its heterogeneity in single capillaries. Am J Physiol 1996; 271:H365-H372
45. Rumsey WL, Pawlowski M, Lejavardi N, et al: Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone." Am J Physiol 1994; 266:H1676-H1680
46. 2 in Models of Shock. PhD thesis. Amsterdam, University of Amsterdam, 1997
47. Krogh A: The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue. J Physiol 1919; 52: 409-415
48. Duling BR: Microvascular responses to alterations in oxygen tension. Circ Res 1972; 31: 481-489
49. Ellsworth ML, Pittman RN: Arterioles supply oxygen to capillaries by diffusion as well as by convection. Am J Physiol 1990; 258: H1240-H1243
50. Ellis CG, Wrigley SM, Groom AC: Heterogeneity of red blood cell perfusion in capillary networks supplied by a single arteriole in resting skeletal muscle. Circ Res 1994; 75: 357-368
51. Intaglietta M, Johnson PC, Winslow RM: Microvascular and tissue oxygen distribution. Cardiovasc Res 1996; 32:632-643
52. Wieringa PA, Spaan JAE, Stassen HG, et al: Heterogeneous flow distribution in a three dimensional network stimulation of the myocardial microcirculation: A hypothesis. Microcirculation 1982; 2:195-216
53. Eerbeek O, Ince C: Weak spots inside the myocardium of a Langendorff rat heart observed by NADH videofluorometry. Adv Exp Med Biol 1997; 411:347-351
54. Avontuur JA, Bruining HA, Ince C: Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 1995; 76:418-425
55. Shepherd AP, Kiel JW: A model of counter-current shunting of oxygen in the intestinal villus. Am J Physiol 1992; 262:H1136-H1142
56. van Lambalgen AA, van Kraats AA, van den Bos GC, et al: Renal function and metabolism during endotoxemia in rats: Role of hypoperfusion. Circ Shock 1991; 35:164-173
57. Sinaasappel M, van Iterson M, Ince C: Microvascular oxygen pressure in the pig intestine during haemorhagic shock and resuscitation. J Physiol (Lond) 1999; 514:245-253
58. 2 measured by Pd-porphine quenching of phosphorescence in a porcine model of slowly developing sepsis. In: Proceedings of the 9th European Conference on Intensive Care Medicine. Bennett D (Ed). Bologna, Italy, Monduzzi, 1996, pp 133-139
59. 2 in the gut measured by quenching of phosphorescence in a porcine model of developing sepsis. Abstr. Intensive Care Med 1996; 22(Suppl 3):S331
60. Cicutti N, Rakusan K, Downey HF: Coronary artery occlusion extends perfusion territory boundaries through microvascular collaterals. Basic Res Cardiol 1994; 89:427-437
61. Menger MD, Vollmar B: In vivo documentation of an arteriovenous shunt in rat pancreatic acinar tissue. Pancreas 1996; 13:125-129
62. Cronenwett JL, Lindenauer SM: Direct measurement of arteriovenous anastomotic blood flow in the septic canine hindlimb. Surgery 1979; 85:275-282
63. Piiper J, Meyer M, Scheid P: Dual role of diffusion in tissue gas exchange: Blood-tissue equilibration and diffusion shunt. Respir Physiol 1984; 56:131-144
64. Roth AC, Feigl EO: Diffusional shunting in the canine myocardium. Circ Res 1981; 48: 470-480
65. Yipintsoi T, Bassingthwaighte JB: Circulatory transport of iodoantipyrine and water in the isolated dog heart. Circ Res 1970; 27:461-477
66. Humer MF, Phang PT, Friesen BP, et al: Heterogeneity of gut capillary transit times and impaired gut oxygen extraction in endotoxemic pigs. J Appl Physiol 1996; 81:895-904
67. 2 tension: A mathematical analysis. Respir Physiol 1986; 63:79-96
68. Lash JM, Bohlen HG: Excess oxygen delivery during muscle contractions in spontaneously hypertensive rats. J Appl Physiol 1995; 78:101-111
69. Steeb GD, Wilson MA, Garrison RN: Pentoxifylline preserves small-intestine microvascular blood flow during bacteremia. Surgery 1992; 112:756-763
70. Lund N, de Asla RJ, Cladis F, et al: Dopexamine hydrochloride in septic shock: Effects on oxygen delivery and oxygenation of gut, liver, and muscle. J Trauma 1995; 38:767-775
71. Zhang H, Vincent JL: Nitric oxide does not influence tissue oxygen extraction capabilities in low cardiac output. Crit Care Med 1997; 25:205
72. Nolte D, Steinhauser P, Pickelmann S, et al: Effect of diaspirin-cross-linked hemoglobin (DCLHb) on local tissue oxygen tension in striated skin muscle: An efficacy study in the hamster. J Lab Clin Med 1997; 130:328-338
73. Bone HG, Schenarts PJ, Booke M, et al: Oxalated pyridoxilated hemoglobin polyoxyethylene conjugate normalizes the hyperdynamic circulation in septic sheep. Crit Care Med 1997; 25:1010-1018
74. 2 measured by Pd-porphyrin quenching of phosphorescence in shock, sepsis and in resuscitation with a Hb-based blood substitute (DCLHB). In: Intensive Care Capita Selecta 1997. Bakker J (Ed). Utrecht, The Netherlands Stichting Venti-Care, 1997, p 77-84
75. van Iterson M, Sinaasappel M, Burhop K, et al: Microvascular gut oxygenation measured by Pd-porphyrin phosphorescence during severe hemorrhagic shock and resuscitation with DCLHb in pigs. J Lab Clin Med In Press