Myocardial hypoxia-inducible HIF-1α, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 293, Issue 1, 2007, Pages

  Bateman, Ryon M ^a   Tokunaga, Chiho ^a   Kareco, Thoma ^a   Dorscheid, Delbert R ^a   Walley, Keith R ^a,b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b ST PAUL S HOSPITAL   (Canada)

Author keywords

Heart; Inflammation; Microcirculation; Sepsis

Indexed keywords

GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERCELLULAR ADHESION MOLECULE 1; LIPOPOLYSACCHARIDE; OXYGEN; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CONTROLLED STUDY; ENDOTOXEMIA; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEART LEFT VENTRICLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HEART PROTECTION; INFLAMMATION; MALE; MICROVASCULARIZATION; MOLECULAR IMAGING; NONHUMAN; OXYGEN DIFFUSION; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEPSIS; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION; TISSUE OXYGENATION; UPREGULATION;

ANIMALS; ENDOTOXEMIA; GENE EXPRESSION; GLUCOSE TRANSPORTER TYPE 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INTERCELLULAR ADHESION MOLECULE-1; MALE; MICROCIRCULATION; MYOCARDITIS; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34547115685     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00035.2007     Document Type: Article

References (50)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29: 1303-1310, 2001.
2. Anning PB, Sair M, Winlove CP, Evans TW. Abnormal tissue oxygenation and cardiovascular changes in endotoxemia. Am J Respir Crit Care Med 159: 1710-1715, 1999.
3. Astiz M, Rackow EC, Weil MH, Schumer W. Early impairment of oxidative metabolism and energy production in severe sepsis. Circ Shock 26: 311-320, 1988.
4. Avontuur JA, Bruining HA, Ince C. Inhibition of nitric oxide synthesis causes myocardial ischemia in endotoxemic rats. Circ Res 76: 418-425, 1995.
5. Avontuur JA, Bruining HA, Ince C. Nitric oxide causes dysfunction of coronary autoregulation in endotoxemic rats. Cardiovasc Res 35: 368-376, 1997.
6. Barroso-Aranda J, Schmid-Schonbein GW, Zweifach BW, Mathison JC. Polymorphonuclear neutrophil contribution to induced tolerance to bacterial lipopolysaccharide. Circ Res 69: 1196-1206, 1991.
7. Bateman RM, Jagger JE, Sharpe MD, Ellsworth ML, Mehta S, Ellis CG. Erythrocyte deformability is a nitric oxide-mediated factor in decreased capillary density during sepsis. Am J Physiol Heart Circ Physiol 280: H2848-H2856, 2001.
8. Bateman RM, Sharpe MD, Ellis CG. Bench-to-bedside review: microvascular dysfunction in sepsis - hemodynamics, oxygen transport, and nitric oxide. Crit Care 7: 359-373, 2003.
9. Behrooz A, Ismail-Beigi F. Dual control of glut1 glucose transporter gene expression by hypoxia and by inhibition of oxidative phosphorylation. J Biol Chem 272: 5555-5562, 1997.
10. Blouin CC, Page EL, Soucy GM, Richard DE. Hypoxic gene activation by lipopolysaccharide in macrophages: implication of hypoxia-inducible factor 1alpha. Blood 103: 1124-1130, 2004.
11. Boczkowski J, Vicaut E, Aubier M. In vivo effects of Escherichia coli endotoxemia on diaphragmatic microcirculation in rats. J Appl Physiol 72: 2219-2224, 1992.
12. Bosan S, Kareco T, Ruehlmann D, Chen KY, Walley KR. Three-dimensional capillary geometry in gut tissue. Microsc Res Tech 61: 428-437, 2003.
13. Braun RD, Lanzen JL, Snyder SA, Dewhirst MW. Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. Am J Physiol Heart Circ Physiol 280: H2533-H2544, 2001.
14. Cunnion RE, Schaer GL, Parker MM, Natanson C, Parrillo JE. The coronary circulation in human septic shock. Circulation 73: 637-644, 1986.
15. Davani EY, Dorscheid DR, Lee CH, van Breemen C, Walley KR. Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton. Am J Physiol Heart Circ Physiol 287: H1013-H1022, 2004.
16. Dhainaut JF, Huyghebaert MF, Monsallier JF, Lefevre G, Dall'Ava-Santucci J, Brunet F, Villemant D, Carli A, Raichvarg D. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 75: 533-541, 1987.
17. 2 extraction in sepsis. Am J Physiol Heart Circ Physiol 282: H156-H164, 2002.
18. Frede S, Stockmann C, Freitag P, Fandrey J. Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-kappaB. Biochem J 396: 517-527, 2006.
19. Goddard CM, Allard MF, Hogg JC, Herbertson MJ, Walley KR. Prolonged leukocyte transit time in coronary microcirculation of endotoxemic pigs. Am J Physiol Heart Circ Physiol 269: H1389-H1397, 1995.
20. 2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am J Physiol Heart Circ Physiol 290: H2277-H2285, 2006.
21. Goldman D, Bateman RM, Ellis CG. Effect of sepsis on skeletal muscle oxygen consumption and tissue oxygenation: interpreting capillary oxygen transport data using a mathematical model. Am J Physiol Heart Circ Physiol 287: H2535-H2544, 2004.
22. Herbertson MJ, Werner HA, Russell JA, Iversen K, Walley KR. Myocardial oxygen extraction ratio is decreased during endotoxemia in pigs. J Appl Physiol 79: 479-486, 1995.
23. 18F]fluoromisonidazole. Am J Physiol Regul Integr Comp Physiol 261: R965-R972, 1991.
24. 2 tension. Am J Physiol Cell Physiol 271: C1172-C1180, 1996.
25. Jurgensen JS, Rosenberger C, Wiesener MS, Warnecke C, Horstrup JH, Grafe M, Philipp S, Griethe W, Maxwell PH, Frei U, Bachmann S, Willenbrock R, Eckardt KU. Persistent induction of HIF-1alpha and -2alpha in cardiomyocytes and stromal cells of ischemic myocardium. FASEB J 18: 1415-1417, 2004.
26. Lam C, Tyml K, Martin C, Sibbald W. Microvascular perfusion is impaired in a rat model of normotensive sepsis. J Clin Invest 94: 2077-2083, 1994.
27. Lang CH, Bagby GJ, Ferguson JL, Spitzer JJ. Cardiac output and redistribution of organ blood flow in hypermetabolic sepsis. Am J Physiol Regul Integr Comp Physiol 246: R331-R337, 1984.
28. Levy RJ, Piel DA, Acton PD, Zhou R, Ferrari VA, Karp JS, Deutschman CS. Evidence of myocardial hibernation in the septic heart. Crit Care Med 33: 2752-2756, 2005.
29. McKinnon RL, Lidington D, Bolon M, Ouellette Y, Kidder GM, Tyml K. Reduced arteriolar conducted vasoconstriction in septic mouse cremaster muscle is mediated by nNOS-derived NO. Cardiovasc Res 69: 236-244, 2006.
30. Otsu N. A threshold selection method from gray-level histograms. IEEE Trans Sys Man Cyber 9: 62-66, 1979.
31. Peng T, Lu X, Lei M, Moe GW, Feng Q. Inhibition of p38 MAPK decreases myocardial TNF-alpha expression and improves myocardial function and survival in endotoxemia. Cardiovasc Res 59: 893-900, 2003.
32. Rumsey WL, Kilpatrick L, Wilson DF, Erecinska M. Myocardial metabolism and coronary flow: effects of endotoxemia. Am J Physiol Heart Circ Physiol 255: H1295-H1304, 1988.
33. Rumsey WL, Pawlowski M, Lejavardi N, Wilson DF. Oxygen pressure distribution in the heart in vivo and evaluation of the ischemic "border zone". Am J Physiol Heart Circ Physiol 266: H1676-H1680, 1994.
34. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 32: 1825-1831, 2004.
35. Scharte M, Han X, Uchiyama T, Tawadrous Z, Delude RL, Fink MP. LPS increases hepatic HIF-1alpha protein and expression of the HIF-1-dependent gene aldolase A in rats. J Surg Res 135: 262-267, 2006.
36. 2, and the 3 PHDs: how animal cells signal hypoxia to the nucleus. Cell 107: 1-3, 2001.
37. Semenza GL, Agani F, Iyer N, Kotch L, Laughner E, Leung S, Yu A. Regulation of cardiovascular development and physiology by hypoxia-inducible factor 1. Ann NY Acad Sci 874: 262-268, 1999.
38. Suga H. Cardiac energetics: from E(max) to pressure-volume area. Clin Exp Pharmacol Physiol 30: 580-585, 2003.
39. Sutter CH, Laughner E, Semenza GL. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci USA 97: 4748-4753, 2000.
40. van Lambalgen AA, van Kraats AA, Mulder MF, van den Bos GC, Teerlink T, Thijs LG. Organ blood flow and distribution of cardiac output in dopexamine- or dobutamine-treated endotoxemic rats. J Crit Care 8: 117-127, 1993.
41. Walley KR. Heterogeneity of oxygen delivery impairs oxygen extraction by peripheral tissues: theory. J Appl Physiol 81: 885-894, 1996.
42. Walley KR, Becker CJ, Hogan RA, Teplinsky K, Wood LD. Progressive hypoxemia limits left ventricular oxygen consumption and contractility. Circ Res 63: 849-859, 1988.
43. 2 tension. Proc Natl Acad Sci USA 92: 5510-5514, 1995.
44. Wang GL, Jiang BH, Semenza GL. Effect of altered redox states on expression and DNA-binding activity of hypoxia-inducible factor 1. Biochem Biophys Res Commun 212: 550-556, 1995.
45. Wenger RH, Kvietikova I, Rolfs A, Gassmann M, Marti HH. Hypoxia-inducible factor-1 alpha is regulated at the post-mRNA level. Kidney Int 51: 560-563, 1997.
46. Wenger RH, Stiehl DP, Camenisch G. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005: re12, 2005.
47. Wright G, Higgin JJ, Raines RT, Steenbergen C, Murphy E. Activation of the prolyl hydroxylase oxygen-sensor results in induction of GLUT1, heme oxygenase-1, and nitric-oxide synthase proteins and confers protection from metabolic inhibition to cardiomyocytes. J Biol Chem 278: 20235-20239, 2003.
48. Yamakawa M, Liu LX, Date T, Belanger AJ, Vincent KA, Akita GY, Kuriyama T, Cheng SH, Gregory RJ, Jiang C. Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors. Circ Res 93: 664-673, 2003.
49. Zhao X, He G, Chen YR, Pandian RP, Kuppusamy P, Zweier JL. Endothelium-derived nitric oxide regulates postischemic myocardial oxygenation and oxygen consumption by modulation of mitochondrial electron transport. Circulation 111: 2966-2972, 2005.
50. Zuurbier CJ, van Iterson M, Ince C. Functional heterogeneity of oxygen supply-consumption ratio in the heart. Cardiovasc Res 44: 488-497, 1999.