Inactivation of renal mitochondrial respiratory complexes and manganese superoxide dismutase during sepsis: Mitochondria-targeted antioxidant mitigates injury

American Journal of Physiology - Renal Physiology

Volumn 306, Issue 7, 2014, Pages

  Patil, Naeem K ^a   Parajuli, Nirmala ^a   Macmillan Crow, Lee Ann ^a   Mayeux, Philip R ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Kidney; Mitochondria; Mitochondrial antioxidant; Oxidative stress; Sepsis

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTIOXIDANT; MANGANESE SUPEROXIDE DISMUTASE; MITO TEMPO; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVITY; GLOMERULUS FILTRATION RATE; KIDNEY CIRCULATION; KIDNEY FUNCTION; MALE; MITOCHONDRIAL RESPIRATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RESPIROMETRY; SEPSIS; SURVIVAL RATE; THERAPY DELAY;

KIDNEY; MITOCHONDRIA; MITOCHONDRIAL ANTIOXIDANT; OXIDATIVE STRESS; SEPSIS;

ACUTE KIDNEY INJURY; ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIOXIDANTS; BODY TEMPERATURE REGULATION; CELL RESPIRATION; DISEASE MODELS, ANIMAL; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ELECTRON TRANSPORT COMPLEX I; ELECTRON TRANSPORT COMPLEX II; ELECTRON TRANSPORT COMPLEX III; ELECTRON TRANSPORT COMPLEX IV; KIDNEY; MALE; MICE; MICE, INBRED C57BL; MICROCIRCULATION; MITOCHONDRIA; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; PIPERIDINES; RENAL CIRCULATION; SEPSIS; SUPEROXIDE DISMUTASE; TIME FACTORS;

EID: 84900558112     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00643.2013     Document Type: Article

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