Nanocarriers for the treatment of glioblastoma multiforme: Current state-of-the-art

Journal of Controlled Release

Volumn 227, Issue , 2016, Pages 23-37

  Karim, Reatul ^a   Palazzo, Claudio ^a   Evrard, Brigitte ^a   Piel, Geraldine ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Blood brain barrier; Glioblastoma; Lipid nanocapsule; Liposome; Polymeric nanoparticle

Indexed keywords

CHEMICAL MODIFICATION; DISEASES; FISH; LIPOSOMES; NANOCAPSULES; NANOPARTICLES; NANOSYSTEMS; POLYMERS; TUMORS;

BLOOD-BRAIN BARRIER; CONVECTION-ENHANCED DELIVERY; GLIOBLASTOMAS; HYDROPHILIC AND HYDROPHOBIC; LIPID NANOCAPSULES; POLYMERIC NANOPARTICLES; SITE-SPECIFIC DRUG DELIVERIES; STATE-OF-THE-ART TECHNOLOGY;

BLOOD;

ANTINEOPLASTIC AGENT; LIPID NANOCAPSULE; LIPOSOME; NANOCAPSULE; NANOCARRIER; NANOPARTICLE; POLYMER; POLYMERIC NANOPARTICLE; UNCLASSIFIED DRUG; DRUG CARRIER; LIPID;

BLOOD BRAIN BARRIER; BLOOD BRAIN TUMOR BARRIER; CANCER CHEMOTHERAPY; CENTRAL NERVOUS SYSTEM FUNCTION; CHEMICAL MODIFICATION; CRANIOTOMY; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TRANSPORT; GLIOBLASTOMA; HUMAN; LIPOSOMAL DELIVERY; NANOCHEMISTRY; NANOPHARMACEUTICS; NONHUMAN; ONCOGENESIS AND MALIGNANT TRANSFORMATION; PERMEABILITY BARRIER; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; REVIEW; TIGHT JUNCTION; ANIMAL; BRAIN; BRAIN NEOPLASMS; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN NEOPLASMS; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; GLIOBLASTOMA; HUMANS; LIPIDS; LIPOSOMES; NANOCAPSULES; NANOPARTICLES; POLYMERS;

EID: 84958965729     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2016.02.026     Document Type: Review

References (206)

1. O.O. Kanu, A. Mehta, C. Di, N. Lin, K. Bortoff, D.D. Bigner, H. Yan, and D.C. Adamson Glioblastoma multiforme: a review of therapeutic targets Expert Opin. Ther. Targets 13 2009 701 718
2. Q.T. Ostrom, H. Gittleman, P. Farah, A. Ondracek, Y. Chen, Y. Wolinsky, N.E. Stroup, C. Kruchko, and J.S. Barnholtz-Sloan CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010 Neuro-Oncology 15 Suppl. 2 2013 ii1 ii56
3. N. Sehati, and L.M. Liau Adjuvant treatment for gliomas Contemp. Neurosurg. 25 2003 1 9
4. D.N. Louis, H. Ohgaki, O.D. Wiestler, W.K. Cavenee, P.C. Burger, A. Jouvet, B.W. Scheithauer, and P. Kleihues The 2007 WHO classification of tumours of the central nervous system Acta Neuropathol. 114 2007 97 109
5. C. Adamson, O.O. Kanu, A.I. Mehta, C. Di, N. Lin, A.K. Mattox, and D.D. Bigner Glioblastoma multiforme: a review of where we have been and where we are going Expert Opin. Investig. Drugs 18 2009 1061 1083
6. X. Ying, H. Wen, W.L. Lu, J. Du, J. Guo, W. Tian, Y. Men, Y. Zhang, R.J. Li, T.Y. Yang, D.W. Shang, J.N. Lou, L.R. Zhang, and Q. Zhang Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals J. Control. Release 141 2010 183 192
7. H. Chen, L. Tang, Y. Qin, Y. Yin, J. Tang, W. Tang, X. Sun, Z. Zhang, J. Liu, and Q. He Lactoferrin-modified procationic liposomes as a novel drug carrier for brain delivery Eur. J. Pharm. Sci. 40 2010 94 102
8. M. Bragagni, N. Mennini, C. Ghelardini, and P. Mura Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting J. Pharm. Pharm. Sci. 15 2012 184 196
9. K.J. Lim, S. Bisht, E.E. Bar, A. Maitra, and C.G. Eberhart A polymeric nanoparticle formulation of curcumin inhibits growth, clonogenicity and stem-like fraction in malignant brain tumors Cancer Biol. Ther. 11 2011 464 473
10. E. Garcion, A. Lamprecht, B. Heurtault, A. Paillard, A. Aubert-Pouessel, B. Denizot, P. Menei, and J.P. Benoit A new generation of anticancer, drug-loaded, colloidal vectors reverses multidrug resistance in glioma and reduces tumor progression in rats Mol. Cancer Ther. 5 2006 1710 1722
11. D.J. Begley Delivery of therapeutic agents to the central nervous system: the problems and the possibilities Pharmacol. Ther. 104 2004 29 45
12. J. Bernacki, A. Dobrowolska, K. Nierwinska, and A. Malecki Physiology and pharmacological role of the blood-brain barrier Pharmacol. Rep. 60 2008 600 622
13. I. Wilhelm, C. Fazakas, and I.A. Krizbai In vitro models of the blood-brain barrier Acta Neurobiol. Exp. 71 2011 113 128
14. K. Matter, and M.S. Balda Signalling to and from tight junctions Nat. Rev. Mol. Cell Biol. 4 2003 225 236
15. B.T. Hawkins, and T.P. Davis The blood-brain barrier/neurovascular unit in health and disease Pharmacol. Rev. 57 2005 173 185
16. J. Correale, and A. Villa Cellular elements of the blood-brain barrier Neurochem. Res. 34 2009 2067 2077
17. H. Wolburg, and A. Lippoldt Tight junctions of the blood-brain barrier: development, composition and regulation Vasc. Pharmacol. 38 2002 323 337
18. A.M. Butt, H.C. Jones, and N.J. Abbott Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study J. Physiol. 429 1990 47 62
19. A.S. Yu, K.M. McCarthy, S.A. Francis, J.M. McCormack, J. Lai, R.A. Rogers, R.D. Lynch, and E.E. Schneeberger Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells Am. J. Physiol. Cell Physiol. 288 2005 C1231 C1241
20. + -dependent transport of large neutral amino acids occurs at the abluminal membrane of the blood-brain barrier Am. J. Physiol. Endocrinol. Metab. 285 2003 E1167 E1173
21. W.M. Pardridge Crossing the blood-brain barrier: are we getting it right? Drug Discov. Today 6 2001 1 2
22. R.S. El-Bacha, and A. Minn Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain Cell. Mol. Biol. 45 1999 15 23
23. R. Daneman, and M. Rescigno The gut immune barrier and the blood-brain barrier: are they so different? Immunity 31 2009 722 735
24. A. Aguzzi, B.A. Barres, and M.L. Bennett Microglia: scapegoat, saboteur, or something else? Science 339 2013 156 161
25. M.I. Borges-Walmsley, K.S. McKeegan, and A.R. Walmsley Structure and function of efflux pumps that confer resistance to drugs Biochem. J. 376 2003 313 338
26. F.J. Sharom The P-glycoprotein multidrug transporter Essays Biochem. 50 2011 161 178
27. Z.S. Chen, K. Lee, S. Walther, R.B. Raftogianis, M. Kuwano, H. Zeng, and G.D. Kruh Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system Cancer Res. 62 2002 3144 3150
28. T. Litman, M. Brangi, E. Hudson, P. Fetsch, A. Abati, D.D. Ross, K. Miyake, J.H. Resau, and S.E. Bates The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2) J. Cell Sci. 113 Pt 11 2000 2011 2021
29. H. Reiber Dynamics of brain-derived proteins in cerebrospinal fluid Clin. Chim. Acta 310 2001 173 186
30. F. Maher, S.J. Vannucci, and I.A. Simpson Glucose transporter proteins in brain FASEB J. 8 1994 1003 1011
31. H. Wolburg, S. Noell, A. Mack, K. Wolburg-Buchholz, and P. Fallier-Becker Brain endothelial cells and the glio-vascular complex Cell Tissue Res. 335 2009 75 96
32. R. Alyautdin, I. Khalin, M.I. Nafeeza, M.H. Haron, and D. Kuznetsov Nanoscale drug delivery systems and the blood-brain barrier Int. J. Nanomedicine 9 2014 795 811
33. K. Ulbrich, T. Hekmatara, E. Herbert, and J. Kreuter Transferrin- and transferrin-receptor-antibody-modified nanoparticles enable drug delivery across the blood-brain barrier (BBB) Eur. J. Pharm. Biopharm. 71 2009 251 256
34. W.M. Pardridge, J. Eisenberg, and J. Yang Human blood-brain barrier insulin receptor J. Neurochem. 44 1985 1771 1778
35. M.E. Halatsch, U. Schmidt, J. Behnke-Mursch, A. Unterberg, and C.R. Wirtz Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours Cancer Treat. Rev. 32 2006 74 89
36. S. Wagner, A. Zensi, S.L. Wien, S.E. Tschickardt, W. Maier, T. Vogel, F. Worek, C.U. Pietrzik, J. Kreuter, and H. von Briesen Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model PLoS One 7 2012 e32568
37. W.M. Pardridge Drug transport across the blood-brain barrier J. Cereb. Blood Flow Metab. 32 2012 1959 1972
38. D.R. Groothuis The blood-brain and blood-tumor barriers: a review of strategies for increasing drug delivery Neuro-Oncology 2 2000 45 59
39. K.E. Schlageter, P. Molnar, G.D. Lapin, and D.R. Groothuis Microvessel organization and structure in experimental brain tumors: microvessel populations with distinctive structural and functional properties Microvasc. Res. 58 1999 312 328
40. J.M. Squire, M. Chew, G. Nneji, C. Neal, J. Barry, and C. Michel Quasi-periodic substructure in the microvessel endothelial glycocalyx: a possible explanation for molecular filtering? J. Struct. Biol. 136 2001 239 255
41. I. Brigger, J. Morizet, G. Aubert, H. Chacun, M.J. Terrier-Lacombe, P. Couvreur, and G. Vassal Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting J. Pharmacol. Exp. Ther. 303 2002 928 936
42. K.H. Plate, A. Scholz, and D.J. Dumont Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited Acta Neuropathol. 124 2012 763 775
43. L. Juillerat-Jeanneret The targeted delivery of cancer drugs across the blood-brain barrier: chemical modifications of drugs or drug-nanoparticles? Drug Discov. Today 13 2008 1099 1106
44. O. van Tellingen, B. Yetkin-Arik, M.C. de Gooijer, P. Wesseling, T. Wurdinger, and H.E. de Vries Overcoming the blood-brain tumor barrier for effective glioblastoma treatment Drug Resist. Updat. 2015
45. S.I. Rapoport Effect of concentrated solutions on blood-brain barrier Am. J. Physiol. 219 1970 270 274
46. T. Siegal, R. Rubinstein, F. Bokstein, A. Schwartz, A. Lossos, E. Shalom, R. Chisin, and J.M. Gomori In vivo assessment of the window of barrier opening after osmotic blood-brain barrier disruption in humans J. Neurosurg. 92 2000 599 605
47. D. Regoli, and J. Barabe Pharmacology of bradykinin and related kinins Pharmacol. Rev. 32 1980 1 46
48. M.D. Prados, S.J.S. Schold, H.A. Fine, K. Jaeckle, F. Hochberg, L. Mechtler, M.R. Fetell, S. Phuphanich, L. Feun, T.J. Janus, K. Ford, and W. Graney A randomized, double-blind, placebo-controlled, phase 2 study of RMP-7 in combination with carboplatin administered intravenously for the treatment of recurrent malignant glioma Neuro-Oncology 5 2003 96 103
49. A. Saija, P. Princi, D. Trombetta, M. Lanza, and A. De Pasquale Changes in the permeability of the blood-brain barrier following sodium dodecyl sulphate administration in the rat Exp. Brain Res. 115 1997 546 551
50. T. Sakane, C. Tanaka, A. Yamamoto, M. Hashida, H. Sezaki, H. Ueda, and H. Takagi The effect of polysorbate 80 on brain uptake and analgesic effect of D-kyotorphin Int. J. Pharm. 57 1989 77 83
51. N. Sheikov, N. McDannold, N. Vykhodtseva, F. Jolesz, and K. Hynynen Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles Ultrasound Med. Biol. 30 2004 979 989
52. R. Stam Electromagnetic fields and the blood-brain barrier Brain Res. Rev. 65 2010 80 97
53. R. Gabathuler Approaches to transport therapeutic drugs across the blood-brain barrier to treat brain diseases Neurobiol. Dis. 37 2010 48 57
54. N.H. Greig, S. Genka, E.M. Daly, D.J. Sweeney, and S.I. Rapoport Physicochemical and pharmacokinetic parameters of seven lipophilic chlorambucil esters designed for brain penetration Cancer Chemother. Pharmacol. 25 1990 311 319
55. J.M. Scherrmann Drug delivery to brain via the blood-brain barrier Vasc. Pharmacol. 38 2002 349 354
56. F. Lin, M.C. de Gooijer, D. Hanekamp, D. Brandsma, J.H. Beijnen, and O. van Tellingen Targeting core (mutated) pathways of high-grade gliomas: challenges of intrinsic resistance and drug efflux CNS Oncol. 2 2013 271 288
57. E.M. Kemper, A.E. van Zandbergen, C. Cleypool, H.A. Mos, W. Boogerd, J.H. Beijnen, and O. van Tellingen Increased penetration of paclitaxel into the brain by inhibition of P-glycoprotein Clin. Cancer Res. 9 2003 2849 2855
58. A.V. Kabanov, E.V. Batrakova, and D.W. Miller Pluronic® block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier Adv. Drug Deliv. Rev. 55 2003 151 164
59. C. Kuntner, J.P. Bankstahl, M. Bankstahl, J. Stanek, T. Wanek, G. Stundner, R. Karch, R. Brauner, M. Meier, X. Ding, M. Muller, W. Loscher, and O. Langer Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET Eur. J. Nucl. Med. Mol. Imaging 37 2010 942 953
60. E.F. Choo, D. Kurnik, M. Muszkat, T. Ohkubo, S.D. Shay, J.N. Higginbotham, H. Glaeser, R.B. Kim, A.J. Wood, and G.R. Wilkinson Differential in vivo sensitivity to inhibition of P-glycoprotein located in lymphocytes, testes, and the blood-brain barrier J. Pharmacol. Exp. Ther. 317 2006 1012 1018
61. E. Allard, C. Passirani, and J.P. Benoit Convection-enhanced delivery of nanocarriers for the treatment of brain tumors Biomaterials 30 2009 2302 2318
62. R.H. Bobo, D.W. Laske, A. Akbasak, P.F. Morrison, R.L. Dedrick, and E.H. Oldfield Convection-enhanced delivery of macromolecules in the brain Proc. Natl. Acad. Sci. U. S. A. 91 1994 2076 2080
63. D.W. Laske, P.F. Morrison, D.M. Lieberman, M.E. Corthesy, J.C. Reynolds, P.A. Stewart-Henney, S.S. Koong, A. Cummins, C.H. Paik, and E.H. Oldfield Chronic interstitial infusion of protein to primate brain: determination of drug distribution and clearance with single-photon emission computerized tomography imaging J. Neurosurg. 87 1997 586 594
64. M.T. Krauze, R. Saito, C. Noble, M. Tamas, J. Bringas, J.W. Park, M.S. Berger, and K. Bankiewicz Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents J. Neurosurg. 103 2005 923 929
65. K.B. Neeves, A.J. Sawyer, C.P. Foley, W.M. Saltzman, and W.L. Olbricht Dilation and degradation of the brain extracellular matrix enhances penetration of infused polymer nanoparticles Brain Res. 1180 2007 121 132
66. P. Hadaczek, Y. Yamashita, H. Mirek, L. Tamas, M.C. Bohn, C. Noble, J.W. Park, and K. Bankiewicz The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain Mol. Ther. 14 2006 69 78
67. W.M. Pardridge Drug and gene delivery to the brain: the vascular route Neuron 36 2002 555 558
68. Y.E. Koo, G.R. Reddy, M. Bhojani, R. Schneider, M.A. Philbert, A. Rehemtulla, B.D. Ross, and R. Kopelman Brain cancer diagnosis and therapy with nanoplatforms Adv. Drug Deliv. Rev. 58 2006 1556 1577
69. S. Bhaskar, F. Tian, T. Stoeger, W. Kreyling, J.M. de la Fuente, V. Grazu, P. Borm, G. Estrada, V. Ntziachristos, and D. Razansky Multifunctional nanocarriers for diagnostics, drug delivery and targeted treatment across blood-brain barrier: perspectives on tracking and neuroimaging Part. Fibre Toxicol. 7 2010 3
70. H. Harashima, K. Sakata, K. Funato, and H. Kiwada Enhanced hepatic uptake of liposomes through complement activation depending on the size of liposomes Pharm. Res. 11 1994 402 406
71. J. Senior, J.C. Crawley, and G. Gregoriadis Tissue distribution of liposomes exhibiting long half-lives in the circulation after intravenous injection Biochim. Biophys. Acta 839 1985 1 8
72. C.D. Oja, S.C. Semple, A. Chonn, and P.R. Cullis Influence of dose on liposome clearance: critical role of blood proteins Biochim. Biophys. Acta 1281 1996 31 37
73. T. Lian, and R.J. Ho Trends and developments in liposome drug delivery systems J. Pharm. Sci. 90 2001 667 680
74. F. Yuan, M. Leunig, S.K. Huang, D.A. Berk, D. Papahadjopoulos, and R.K. Jain Mirovascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft Cancer Res. 54 1994 3352 3356
75. A. Sharma, N.L. Straubinger, and R.M. Straubinger Modulation of human ovarian tumor cell sensitivity to N-(phosphonacetyl)-l-aspartate (PALA) by liposome drug carriers Pharm. Res. 10 1993 1434 1441
76. A. Gabizon, D.C. Price, J. Huberty, R.S. Bresalier, and D. Papahadjopoulos Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: biodistribution and imaging studies Cancer Res. 50 1990 6371 6378
77. C. He, Y. Hu, L. Yin, C. Tang, and C. Yin Effects of particle size and surface charge on cellular uptake and biodistribution of polymeric nanoparticles Biomaterials 31 2010 3657 3666
78. W. Lu, Y. Zhang, Y.Z. Tan, K.L. Hu, X.G. Jiang, and S.K. Fu Cationic albumin-conjugated pegylated nanoparticles as novel drug carrier for brain delivery J. Control. Release 107 2005 428 448
79. N.J. Abbott, L. Ronnback, and E. Hansson Astrocyte-endothelial interactions at the blood-brain barrier Nat. Rev. Neurosci. 7 2006 41 53
80. T.M. Allen, C. Hansen, F. Martin, C. Redemann, and A. Yau-Young Liposomes containing synthetic lipid derivatives of poly (ethylene glycol) show prolonged circulation half-lives in vivo Biochim. Biophys. Acta 1066 1991 29 36
81. V.P. Torchilin Immunoliposomes and PEGylated immunoliposomes: possible use for targeted delivery of imaging agents ImmunoMethods 4 1994 244 258
82. A.L. Klibanov, K. Maruyama, A.M. Beckerleg, V.P. Torchilin, and L. Huang Activity of amphipathic poly (ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target Biochim. Biophys. Acta 1062 1991 142 148
83. D.D. Lasic, F.J. Martin, A. Gabizon, S.K. Huang, and D. Papahadjopoulos Sterically stabilized liposomes: a hypothesis on the molecular origin of the extended circulation times Biochim. Biophys. Acta 1070 1991 187 192
84. M.C. Woodle, K.K. Matthay, M.S. Newman, J.E. Hidayat, L.R. Collins, C. Redemann, F.J. Martin, and D. Papahadjopoulos Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes Biochim. Biophys. Acta 1105 1992 193 200
85. F. Herve, N. Ghinea, and J.M. Scherrmann CNS delivery via adsorptive transcytosis AAPS J. 10 2008 455 472
86. W. Lu, J. Wan, Z. She, and X. Jiang Brain delivery property and accelerated blood clearance of cationic albumin conjugated pegylated nanoparticle J. Control. Release 118 2007 38 53
87. H. Wang, K. Xu, L. Liu, J.P. Tan, Y. Chen, Y. Li, W. Fan, Z. Wei, J. Sheng, and Y.-Y. Yang The efficacy of self-assembled cationic antimicrobial peptide nanoparticles against Cryptococcus neoformans for the treatment of meningitis Biomaterials 31 2010 2874 2881
88. Y. Qin, H. Chen, W. Yuan, R. Kuai, Q. Zhang, F. Xie, L. Zhang, Z. Zhang, J. Liu, and Q. He Liposome formulated with TAT-modified cholesterol for enhancing the brain delivery Int. J. Pharm. 419 2011 85 95
89. Y. Chen, and L. Liu Modern methods for delivery of drugs across the blood-brain barrier Adv. Drug Deliv. Rev. 64 2012 640 665
90. A. Beduneau, F. Hindre, A. Clavreul, J.C. Leroux, P. Saulnier, and J.P. Benoit Brain targeting using novel lipid nanovectors J. Control. Release 126 2008 44 49
91. A.D. Bangham, and R.W. Horne Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope J. Mol. Biol. 8 1964 660 668
92. A.D. Bangham, M.M. Standish, and J.C. Watkins Diffusion of univalent ions across the lamellae of swollen phospholipids J. Mol. Biol. 13 1965 238 252
93. A.D. Bangham, M.M. Standish, and G. Weissmann The action of steroids and streptolysin S on the permeability of phospholipid structures to cations J. Mol. Biol. 13 1965 253 259
94. D. Goren, A.T. Horowitz, D. Tzemach, M. Tarshish, S. Zalipsky, and A. Gabizon Nuclear delivery of doxorubicin via folate-targeted liposomes with bypass of multidrug-resistance efflux pump Clin. Cancer Res. 6 2000 1949 1957
95. R.I. Pakunlu, Y. Wang, M. Saad, J.J. Khandare, V. Starovoytov, and T. Minko In vitro and in vivo intracellular liposomal delivery of antisense oligonucleotides and anticancer drug J. Control. Release 114 2006 153 162
96. A. Sharma, and U.S. Sharma Liposomes in drug delivery: progress and limitations Int. J. Pharm. 154 1997 123 140
97. F. Yang, C. Jin, Y. Jiang, J. Li, Y. Di, Q. Ni, and D. Fu Liposome based delivery systems in pancreatic cancer treatment: from bench to bedside Cancer Treat. Rev. 37 2011 633 642
98. V.P. Torchilin Liposomes as delivery agents for medical imaging Mol. Med. Today 2 1996 242 249
99. V.P. Torchilin Surface-modified liposomes in gamma-and MR-imaging Adv. Drug Deliv. Rev. 24 1997 301 313
100. M. Matsuura, Y. Yamazaki, M. Sugiyama, M. Kondo, H. Ori, M. Nango, and N. Oku Polycation liposome-mediated gene transfer in vivo Biochim. Biophys. Acta 1612 2003 136 143
101. C. Brignole, G. Pagnan, D. Marimpietri, E. Cosimo, T.M. Allen, M. Ponzoni, and F. Pastorino Targeted delivery system for antisense oligonucleotides: a novel experimental strategy for neuroblastoma treatment Cancer Lett. 197 2003 231 235
102. E. Fattal, P. Couvreur, and C. Dubernet "Smart" delivery of antisense oligonucleotides by anionic pH-sensitive liposomes Adv. Drug Deliv. Rev. 56 2004 931 946
103. J.J. Sudimack, W. Guo, W. Tjarks, and R.J. Lee A novel pH-sensitive liposome formulation containing oleyl alcohol Biochim. Biophys. Acta 1564 2002 31 37
104. A. Asokan, and M.J. Cho Cytosolic delivery of macromolecules. II. Mechanistic studies with pH-sensitive morpholine lipids Biochim. Biophys. Acta 1611 2003 151 160
105. A.D. Frankel, and C.O. Pabo Cellular uptake of the tat protein from human immunodeficiency virus Cell 55 1988 1189 1193
106. Y. Kaneda Virosomes: evolution of the liposome as a targeted drug delivery system Adv. Drug Deliv. Rev. 43 2000 197 205
107. H. Nobuto, T. Sugita, T. Kubo, S. Shimose, Y. Yasunaga, T. Murakami, and M. Ochi Evaluation of systemic chemotherapy with magnetic liposomal doxorubicin and a dipole external electromagnet Int. J. Cancer 109 2004 627 635
108. S.H. Park, S.G. Oh, J.Y. Mun, and S.S. Han Loading of gold nanoparticles inside the DPPC bilayers of liposome and their effects on membrane fluidities Colloids Surf. B Biointerfaces 48 2006 112 118
109. M.L. Immordino, F. Dosio, and L. Cattel Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential Int. J. Nanomedicine 1 2006 297 315
110. H.I. Chang, and M.K. Yeh Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy Int. J. Nanomedicine 7 2012 49 60
111. Y. Liu, and W. Lu Recent advances in brain tumor-targeted nano-drug delivery systems Expert Opin. Drug Deliv. 9 2012 671 686
112. M.I. Koukourakis, S. Koukouraki, I. Fezoulidis, N. Kelekis, G. Kyrias, S. Archimandritis, and N. Karkavitsas High intratumoural accumulation of stealth® liposomal doxorubicin (Caelyx®) in glioblastomas and in metastatic brain tumours Br. J. Cancer 83 2000 1281 1286
113. V.P. Torchilin Recent advances with liposomes as pharmaceutical carriers Nat. Rev. Drug Discov. 4 2005 145 160
114. T.M. Allen Long-circulating (sterically stabilized) liposomes for targeted drug delivery Trends Pharmacol. Sci. 15 1994 215 220
115. V. Soni, D. Kohli, and S. Jain Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil J. Drug Target. 13 2005 245 250
116. J. Huwyler, D. Wu, and W.M. Pardridge Brain drug delivery of small molecules using immunoliposomes Proc. Natl. Acad. Sci. U. S. A. 93 1996 14164 14169
117. F. Re, I. Cambianica, C. Zona, S. Sesana, M. Gregori, R. Rigolio, B. La Ferla, F. Nicotra, G. Forloni, A. Cagnotto, M. Salmona, M. Masserini, and G. Sancini Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model Nanomedicine 7 2011 551 559
118. A.B. Madhankumar, B. Slagle-Webb, A. Mintz, J.M. Sheehan, and J.R. Connor Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme Mol. Cancer Ther. 5 2006 3162 3169
119. G. Charest, L. Sanche, D. Fortin, D. Mathieu, and B. Paquette Glioblastoma treatment: bypassing the toxicity of platinum compounds by using liposomal formulation and increasing treatment efficiency with concomitant radiotherapy Int. J. Radiat. Oncol. Biol. Phys. 84 2012 244 249
120. Y. Zhang, H. Jeong Lee, R.J. Boado, and W.M. Pardridge Receptor-mediated delivery of an antisense gene to human brain cancer cells J. Gene Med. 4 2002 183 194
121. P. Ponka, and C.N. Lok The transferrin receptor: role in health and disease Int. J. Biochem. Cell Biol. 31 1999 1111 1137
122. W.M. Pardridge Non-invasive drug delivery to the human brain using endogenous blood-brain barrier transport systems Pharm. Sci. Technol. Today 2 1999 49 59
123. A.G. de Boer, and P.J. Gaillard Drug targeting to the brain Annu. Rev. Pharmacol. Toxicol. 47 2007 323 355
124. M.J. Coloma, H.J. Lee, A. Kurihara, E.M. Landaw, R.J. Boado, S.L. Morrison, and W.M. Pardridge Transport across the primate blood-brain barrier of a genetically engineered chimeric monoclonal antibody to the human insulin receptor Pharm. Res. 17 2000 266 274
125. M. Zucchetti, A. Boiardi, A. Silvani, I. Parisi, S. Piccolrovazzi, and M. D'Incalci Distribution of daunorubicin and daunorubicinol in human glioma tumors after administration of liposomal daunorubicin Cancer Chemother. Pharmacol. 44 1999 173 176
126. K. Fabel, J. Dietrich, P. Hau, C. Wismeth, B. Winner, S. Przywara, A. Steinbrecher, W. Ullrich, and U. Bogdahn Long-term stabilization in patients with malignant glioma after treatment with liposomal doxorubicin Cancer 92 2001 1936 1942
127. P. Hau, K. Fabel, U. Baumgart, P. Rummele, O. Grauer, A. Bock, C. Dietmaier, W. Dietmaier, J. Dietrich, C. Dudel, F. Hubner, T. Jauch, E. Drechsel, I. Kleiter, C. Wismeth, A. Zellner, A. Brawanski, A. Steinbrecher, J. Marienhagen, and U. Bogdahn Pegylated liposomal doxorubicin-efficacy in patients with recurrent high-grade glioma Cancer 100 2004 1199 1207
128. S.L. Chua, M.A. Rosenthal, S.S. Wong, D.M. Ashley, A.M. Woods, A. Dowling, and L.M. Cher Phase 2 study of temozolomide and Caelyx in patients with recurrent glioblastoma multiforme Neuro-Oncology 6 2004 38 43
129. S. Ananda, A.K. Nowak, L. Cher, A. Dowling, C. Brown, J. Simes, M.A. Rosenthal, and N.-O. Cooperative Trials Group for Phase 2 trial of temozolomide and pegylated liposomal doxorubicin in the treatment of patients with glioblastoma multiforme following concurrent radiotherapy and chemotherapy J. Clin. Neurosci. 18 2011 1444 1448
130. C.P. Beier, C. Schmid, T. Gorlia, C. Kleinletzenberger, D. Beier, O. Grauer, A. Steinbrecher, B. Hirschmann, A. Brawanski, C. Dietmaier, T. Jauch-Worley, O. Kolbl, T. Pietsch, M. Proescholdt, P. Rummele, A. Muigg, G. Stockhammer, M. Hegi, U. Bogdahn, and P. Hau RNOP-09: pegylated liposomal doxorubicine and prolonged temozolomide in addition to radiotherapy in newly diagnosed glioblastoma - a phase II study BMC Cancer 9 2009 308
131. P. Couvreur, C. Dubernet, and F. Puisieux Controlled drug delivery with nanoparticles: current possibilities and future trends Eur. J. Pharm. Biopharm. 41 1995 2 13
132. P. Couvreur Polyalkylcyanoacrylates as colloidal drug carriers Crit. Rev. Ther. Drug Carrier Syst. 5 1987 1 20
133. J. Kreuter Nanoparticles-a historical perspective Int. J. Pharm. 331 2007 1 10
134. G. Tosi, L. Costantino, B. Ruozi, F. Forni, and M.A. Vandelli Polymeric nanoparticles for the drug delivery to the central nervous system Expert Opin. Drug Deliv. 5 2008 155 174
135. S. Ganesh, A.K. Iyer, F. Gattacceca, D.V. Morrissey, and M.M. Amiji In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles J. Control. Release 172 2013 699 706
136. S.G. Schwartz, I.U. Scott, H.W. Flynn Jr., and M.W. Stewart Drug delivery techniques for treating age-related macular degeneration Expert Opin. Drug Deliv. 11 2014 61 68
137. A.E. Gulyaev, S.E. Gelperina, I.N. Skidan, A.S. Antropov, G.Y. Kivman, and J. Kreuter Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles Pharm. Res. 16 1999 1564 1569
138. D. Shenoy, S. Little, R. Langer, and M. Amiji Poly(ethylene oxide)-modified poly(beta-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs: part 2. In vivo distribution and tumor localization studies Pharm. Res. 22 2005 2107 2114
139. K. Andrieux, E. Garcia-Garcia, H.R. Kim, and P. Couvreur Colloidal carriers: a promising way to treat central nervous system diseases J. Nanoneurosci. 1 2009 17 34
140. S. Wohlfart, S. Gelperina, and J. Kreuter Transport of drugs across the blood-brain barrier by nanoparticles J. Control. Release 161 2012 264 273
141. J.C. Olivier Drug transport to brain with targeted nanoparticles NeuroRx 2 2005 108 119
142. M. Fazil, S. Md, S. Haque, M. Kumar, S. Baboota, J.K. Sahni, and J. Ali Development and evaluation of rivastigmine loaded chitosan nanoparticles for brain targeting Eur. J. Pharm. Sci. 47 2012 6 15
143. T.H. Kim, H.H. Jiang, Y.S. Youn, C.W. Park, K.K. Tak, S. Lee, H. Kim, S. Jon, X. Chen, and K.C. Lee Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity Int. J. Pharm. 403 2011 285 291
144. F. Zheng, X.-W. Shi, G.-F. Yang, L.-L. Gong, H.-Y. Yuan, Y.-J. Cui, Y. Wang, Y.-M. Du, and Y. Li Chitosan nanoparticle as gene therapy vector via gastrointestinal mucosa administration: results of an in vitro and in vivo study Life Sci. 80 2007 388 396
145. G. Lukowski, R. Müller, B. Müller, and M. Dittgen Acrylic acid copolymer nanoparticles for drug delivery: I. Characterization of the surface properties relevant for in vivo organ distribution Int. J. Pharm. 84 1992 23 31
146. G. Griffiths, B. Nystrom, S.B. Sable, and G.K. Khuller Nanobead-based interventions for the treatment and prevention of tuberculosis Nat. Rev. Microbiol. 8 2010 827 834
147. N. Denora, A. Trapani, V. Laquintana, A. Lopedota, and G. Trapani Recent advances in medicinal chemistry and pharmaceutical technology-strategies for drug delivery to the brain Curr. Top. Med. Chem. 9 2009 182 196
148. K. Li, and B. Liu Polymer encapsulated conjugated polymer nanoparticles for fluorescence bioimaging J. Mater. Chem. 22 2012 1257 1264
149. C. Wu, S.J. Hansen, Q. Hou, J. Yu, M. Zeigler, Y. Jin, D.R. Burnham, J.D. McNeill, J.M. Olson, and D.T. Chiu Design of highly emissive polymer dot bioconjugates for in vivo tumor targeting Angew. Chem. 50 2011 3430 3434
150. X. Liu, K.A. Howard, M. Dong, M.O. Andersen, U.L. Rahbek, M.G. Johnsen, O.C. Hansen, F. Besenbacher, and J. Kjems The influence of polymeric properties on chitosan/siRNA nanoparticle formulation and gene silencing Biomaterials 28 2007 1280 1288
151. T. Jung, W. Kamm, A. Breitenbach, E. Kaiserling, J.X. Xiao, and T. Kissel Biodegradable nanoparticles for oral delivery of peptides: is there a role for polymers to affect mucosal uptake? Eur. J. Pharm. Biopharm. 50 2000 147 160
152. A. Vila, A. Sanchez, M. Tobio, P. Calvo, and M.J. Alonso Design of biodegradable particles for protein delivery J. Control. Release 78 2002 15 24
153. J.H. Park, S. Kwon, J.O. Nam, R.W. Park, H. Chung, S.B. Seo, I.S. Kim, I.C. Kwon, and S.Y. Jeong Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery J. Control. Release 95 2004 579 588
154. S. Yadav, L.E. van Vlerken, S.R. Little, and M.M. Amiji Evaluations of combination MDR-1 gene silencing and paclitaxel administration in biodegradable polymeric nanoparticle formulations to overcome multidrug resistance in cancer cells Cancer Chemother. Pharmacol. 63 2009 711 722
155. P. Calvo, B. Gouritin, H. Chacun, D. Desmaële, J. D'Angelo, J.-P. Noel, D. Georgin, E. Fattal, J.P. Andreux, and P. Couvreur Long-circulating PEGylated polycyanoacrylate nanoparticles as new drug carrier for brain delivery Pharm. Res. 18 2001 1157 1166
156. J. Kreuter, V. Petrov, D. Kharkevich, and R. Alyautdin Influence of the type of surfactant on the analgesic effects induced by the peptide dalargin after its delivery across the blood-brain barrier using surfactant-coated nanoparticles J. Control. Release 49 1997 81 87
157. R.N. Alyautdin, V.E. Petrov, K. Langer, A. Berthold, D.A. Kharkevich, and J. Kreuter Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated polybutylcyanoacrylate nanoparticles Pharm. Res. 14 1997 325 328
158. A. Ambruosi, S. Gelperina, A. Khalansky, S. Tanski, A. Theisen, and J. Kreuter Influence of surfactants, polymer and doxorubicin loading on the anti-tumour effect of poly (butyl cyanoacrylate) nanoparticles in a rat glioma model J. Microencapsul. 23 2006 582 592
159. B. Petri, A. Bootz, A. Khalansky, T. Hekmatara, R. Muller, R. Uhl, J. Kreuter, and S. Gelperina Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants J. Control. Release 117 2007 51 58
160. S.C. Steiniger, J. Kreuter, A.S. Khalansky, I.N. Skidan, A.I. Bobruskin, Z.S. Smirnova, S.E. Severin, R. Uhl, M. Kock, K.D. Geiger, and S.E. Gelperina Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles Int. J. Cancer 109 2004 759 767
161. T. Hekmatara, C. Bernreuther, A.S. Khalansky, A. Theisen, J. Weissenberger, J. Matschke, S. Gelperina, J. Kreuter, and M. Glatzel Efficient systemic therapy of rat glioblastoma by nanoparticle-bound doxorubicin is due to antiangiogenic effects Clin. Neuropathol. 28 2009 153 164
162. S. Wohlfart, C. Bernreuther, A. Khalansky, A. Theisen, J. Weissenberger, S. Gelperina, M. Glatzel, and J. Kreuter Increased numbers of injections of doxorubicin bound to nanoparticles lead to enhanced efficacy against rat glioblastoma 101/8 J. Nanoneurosci. 1 2009 144 151
163. A. Ambruosi, A.S. Khalansky, H. Yamamoto, S.E. Gelperina, D.J. Begley, and J. Kreuter Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats J. Drug Target. 14 2006 97 105
164. S. Wohlfart, A.S. Khalansky, S. Gelperina, D. Begley, and J. Kreuter Kinetics of transport of doxorubicin bound to nanoparticles across the blood-brain barrier J. Control. Release 154 2011 103 107
165. C.X. Wang, L.S. Huang, L.B. Hou, L. Jiang, Z.T. Yan, Y.L. Wang, and Z.L. Chen Antitumor effects of polysorbate-80 coated gemcitabine polybutylcyanoacrylate nanoparticles in vitro and its pharmacodynamics in vivo on C6 glioma cells of a brain tumor model Brain Res. 1261 2009 91 99
166. E. Pereverzeva, I. Treschalin, D. Bodyagin, O. Maksimenko, K. Langer, S. Dreis, B. Asmussen, J. Kreuter, and S. Gelperina Influence of the formulation on the tolerance profile of nanoparticle-bound doxorubicin in healthy rats: focus on cardio- and testicular toxicity Int. J. Pharm. 337 2007 346 356
167. B. Sanchez De Juan, H. Von Briesen, S.E. Gelperina, and J. Kreuter Cytotoxicity of doxorubicin bound to poly (butyl cyanoacrylate) nanoparticles in rat glioma cell lines using different assays J. Drug Target. 14 2006 614 622
168. S. Gelperina, O. Maksimenko, A. Khalansky, L. Vanchugova, E. Shipulo, K. Abbasova, R. Berdiev, S. Wohlfart, N. Chepurnova, and J. Kreuter Drug delivery to the brain using surfactant-coated poly (lactide-co-glycolide) nanoparticles: influence of the formulation parameters Eur. J. Pharm. Biopharm. 74 2010 157 163
169. S. Wohlfart, A.S. Khalansky, S. Gelperina, O. Maksimenko, C. Bernreuther, M. Glatzel, and J. Kreuter Efficient chemotherapy of rat glioblastoma using doxorubicin-loaded PLGA nanoparticles with different stabilizers PLoS One 6 2011 e19121
170. H. Gao, Z. Yang, S. Zhang, S. Cao, S. Shen, Z. Pang, and X. Jiang Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization Sci. Rep. 3 2013 2534
171. N. Shah, K. Chaudhari, P. Dantuluri, R.S. Murthy, and S. Das Paclitaxel-loaded PLGA nanoparticles surface modified with transferrin and Pluronic((R))P85, an in vitro cell line and in vivo biodistribution studies on rat model J. Drug Target. 17 2009 533 542
172. Y.-I. Jeong, S.-G. Jin, I.-Y. Kim, J. Pei, M. Wen, T.-Y. Jung, K.-S. Moon, and S. Jung Doxorubicin-incorporated nanoparticles composed of poly (ethylene glycol)-grafted carboxymethyl chitosan and antitumor activity against glioma cells in vitro Colloids Surf. B 79 2010 149 155
173. H. Xin, X. Sha, X. Jiang, W. Zhang, L. Chen, and X. Fang Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles Biomaterials 33 2012 8167 8176
174. B. Heurtault, P. Saulnier, B. Pech, J.E. Proust, and J.P. Benoit A novel phase inversion-based process for the preparation of lipid nanocarriers Pharm. Res. 19 2002 875 880
175. A. Lamprecht, Y. Bouligand, and J.P. Benoit New lipid nanocapsules exhibit sustained release properties for amiodarone J. Control. Release 84 2002 59 68
176. B. Heurtault, P. Saulnier, B. Pech, M.-C. Venier-Julienne, J.-E. Proust, R. Phan-Tan-Luu, and J.-P. Benoît The influence of lipid nanocapsule composition on their size distribution Eur. J. Pharm. Sci. 18 2003 55 61
177. N.T. Huynh, C. Passirani, P. Saulnier, and J.P. Benoit Lipid nanocapsules: a new platform for nanomedicine Int. J. Pharm. 379 2009 201 209
178. B. Heurtault, P. Saulnier, B. Pech, J. Proust, J. Richard, and J. Benoit Lipidic Nanocapsules: Preparation Process and Use as Drug Delivery Systems, Patent No. WO02688000 2000
179. N. Anton, J.P. Benoit, and P. Saulnier Design and production of nanoparticles formulated from nano-emulsion templates - a review J. Control. Release 128 2008 185 199
180. D. Hoarau, P. Delmas, S. David, E. Roux, and J.C. Leroux Novel long-circulating lipid nanocapsules Pharm. Res. 21 2004 1783 1789
181. A. Lamprecht, J.-L. Saumet, J. Roux, and J.-P. Benoit Lipid nanocarriers as drug delivery system for ibuprofen in pain treatment Int. J. Pharm. 278 2004 407 414
182. A. Lamprecht, and J.P. Benoit Etoposide nanocarriers suppress glioma cell growth by intracellular drug delivery and simultaneous P-glycoprotein inhibition J. Control. Release 112 2006 208 213
183. F. Lacoeuille, F. Hindré, F. Moal, J. Roux, C. Passirani, O. Couturier, P. Calès, J.-J. Le Jeune, A. Lamprecht, and J.-P. Benoit In vivo evaluation of lipid nanocapsules as a promising colloidal carrier for paclitaxel Int. J. Pharm. 344 2007 143 149
184. E. Jestin, M. Mougin-Degraef, A. Faivre-Chauvet, P. Remaud-Le Saec, F. Hindre, J.P. Benoit, J.F. Chatal, J. Barbet, and J.F. Gestin Radiolabeling and targeting of lipidic nanocapsules for applications in radioimmunotherapy Q. J. Nucl. Med. Mol. Imaging 51 2007 51 60
185. 188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution Eur. J. Nucl. Med. Mol. Imaging 33 2006 602 607
186. N. Anton, P. Saulnier, C. Gaillard, E. Porcher, S. Vrignaud, and J.-P. Benoit Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules Langmuir 25 2009 11413 11419
187. A. Paillard, F. Hindre, C. Vignes-Colombeix, J.P. Benoit, and E. Garcion The importance of endo-lysosomal escape with lipid nanocapsules for drug subcellular bioavailability Biomaterials 31 2010 7542 7554
188. J. Hureaux, F. Lagarce, F. Gagnadoux, M.-C. Rousselet, V. Moal, T. Urban, and J.-P. Benoit Toxicological study and efficacy of blank and paclitaxel-loaded lipid nanocapsules after iv administration in mice Pharm. Res. 27 2010 421 430
189. E. Allard, C. Passirani, E. Garcion, P. Pigeon, A. Vessieres, G. Jaouen, and J.P. Benoit Lipid nanocapsules loaded with an organometallic tamoxifen derivative as a novel drug-carrier system for experimental malignant gliomas J. Control. Release 130 2008 146 153
190. E. Allard, N.T. Huynh, A. Vessieres, P. Pigeon, G. Jaouen, J.P. Benoit, and C. Passirani Dose effect activity of ferrocifen-loaded lipid nanocapsules on a 9L-glioma model Int. J. Pharm. 379 2009 317 323
191. A.-L. Lainé, A. Clavreul, A. Rousseau, C. Tétaud, A. Vessieres, E. Garcion, G. Jaouen, L. Aubert, M. Guilbert, and J.-P. Benoit Inhibition of ectopic glioma tumor growth by a potent ferrocenyl drug loaded into stealth lipid nanocapsules Nanomedicine 10 2014 1667 1677
192. A. Vessieres, S. Top, P. Pigeon, E. Hillard, L. Boubeker, D. Spera, and G. Jaouen Modification of the estrogenic properties of diphenols by the incorporation of ferrocene. generation of antiproliferative effects in vitro J. Med. Chem. 48 2005 3937 3940
193. A. Zanotto-Filho, E. Braganhol, M.I. Edelweiss, G.A. Behr, R. Zanin, R. Schroder, A. Simoes-Pires, A.M. Battastini, and J.C. Moreira The curry spice curcumin selectively inhibits cancer cells growth in vitro and in preclinical model of glioblastoma J. Nutr. Biochem. 23 2012 591 601
194. M.C. Perry, M. Demeule, A. Regina, R. Moumdjian, and R. Beliveau Curcumin inhibits tumor growth and angiogenesis in glioblastoma xenografts Mol. Nutr. Food Res. 54 2010 1192 1201
195. A. Zanotto-Filho, K. Coradini, E. Braganhol, R. Schroder, C.M. de Oliveira, A. Simoes-Pires, A.M. Battastini, A.R. Pohlmann, S.S. Guterres, C.M. Forcelini, R.C. Beck, and J.C. Moreira Curcumin-loaded lipid-core nanocapsules as a strategy to improve pharmacological efficacy of curcumin in glioma treatment Eur. J. Pharm. Biopharm. 83 2013 156 167
196. A.L. Laine, N.T. Huynh, A. Clavreul, J. Balzeau, J. Bejaud, A. Vessieres, J.P. Benoit, J. Eyer, and C. Passirani Brain tumour targeting strategies via coated ferrociphenol lipid nanocapsules Eur. J. Pharm. Biopharm. 81 2012 690 693
197. A. Elsaesser, and C.V. Howard Toxicology of nanoparticles Adv. Drug Deliv. Rev. 64 2012 129 137
198. V.V. Ginzburg, and S. Balijepalli Modeling the thermodynamics of the interaction of nanoparticles with cell membranes Nano Lett. 7 2007 3716 3722
199. W.T. Godbey, K.K. Wu, and A.G. Mikos Tracking the intracellular path of poly(ethylenimine)/DNA complexes for gene delivery Proc. Natl. Acad. Sci. U. S. A. 96 1999 5177 5181
200. N. Panté, and M. Kann Nuclear pore complex is able to transport macromolecules with diameters of ∼ 39 nm Mol. Biol. Cell 13 2002 425 434
201. N. Gou, A. Onnis-Hayden, and A.Z. Gu Mechanistic toxicity assessment of nanomaterials by whole-cell-array stress genes expression analysis Environ. Sci. Technol. 44 2010 5964 5970
202. G. Bhabra, A. Sood, B. Fisher, L. Cartwright, M. Saunders, W.H. Evans, A. Surprenant, G. Lopez-Castejon, S. Mann, and S.A. Davis Nanoparticles can cause DNA damage across a cellular barrier Nat. Nanotechnol. 4 2009 876 883
203. P. Myllynen Nanotoxicology: damaging DNA from a distance Nat. Nanotechnol. 4 2009 795 796
204. I. Lynch, T. Cedervall, M. Lundqvist, C. Cabaleiro-Lago, S. Linse, and K.A. Dawson The nanoparticle-protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century Adv. Colloid Interf. Sci. 134-135 2007 167 174
205. W. Jiang, B.Y. Kim, J.T. Rutka, and W.C. Chan Nanoparticle-mediated cellular response is size-dependent Nat. Nanotechnol. 3 2008 145 150
206. A.M. Nyström, and B. Fadeel Safety assessment of nanomaterials: implications for nanomedicine J. Control. Release 161 2012 403 408