Surface-modified liposomes in gamma- and MR-imaging

Advanced Drug Delivery Reviews

Volumn 24, Issue 2-3, 1997, Pages 301-313

  Torchilin, Vladimir P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

diagnostics; drug carriers; drug targeting; gamma scintigraphy; imaging; liposomes; magnetic resonance; medical imaging

Indexed keywords

CONTROLLED DRUG DELIVERY; DIAGNOSIS; DRUG INTERACTIONS; DRUG PRODUCTS; IMMUNOLOGY; LIPIDS; MAGNETIC RESONANCE IMAGING; SURFACE TREATMENT;

DRUG CARRIERS; DRUG TARGETING; GAMMA SCINTIGRAPHY; SURFACE MODIFIED LIPOSOMES;

MEDICAL IMAGING;

CHELATING AGENT; CONTRAST MEDIUM; DIAGNOSTIC AGENT; DRUG CARRIER; GADOLINIUM; GADOLINIUM PENTETATE; IMAGING AGENT; IMMUNOLIPOSOME; INDIUM 111; LIPOSOME; LIPOSOME IN 111; LIPOSOME TC 99M; MACROGOL; MANGANESE; METAL; N ALPHA (PENTETIC ACID POLYLYSYL)GLUTARYL PHOSPHATIDYLETHANOLAMINE; PENTETIC ACID; POLYLYSINE; POLYMER; TECHNETIUM 99M; UNCLASSIFIED DRUG; VESCAN;

CARDIOVASCULAR SYSTEM; CHEMICAL MODIFICATION; CIRCULATION TIME; CONFERENCE PAPER; GAMMA SCINTIGRAPHY; HEART INFARCTION; HUMAN; INFECTION; INFLAMMATION; LIVER; LYMPH NODE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SPLEEN; TISSUE DISTRIBUTION; TUMOR;

EID: 0343051790     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00472-3     Document Type: Conference Paper

References (81)

1. G. Gregoriadis (Ed.) (1993) Liposome Technology, Vols. 1-3. CRC Press, Boca Raton, FL.
2. Lasic, D.D. (1993) Liposomes from Physics to Applications. Elsevier Science Publishers, Amsterdam.
3. Senior, J.H. (1987) Fate and behavior of liposomes in vivo: a review of controlling factors. Crit. Rev. Ther. Drug Carrier Syst., 3, 123-193.
4. Gregoriadis, G. (1988) Liposomes as Drug Carriers. John Wiley, Chichester.
5. Torchilin, V.P. (1985) Liposomes as targetable drug carriers. Crit. Rev. Ther. Drug Carriers Syst., 2, 65-115.
6. Torchilin, V.P., Zhou, F. and Huang, L. (1993) pH-Sensitive liposomes. J. Liposome Res., 3, 201-255.
7. Gregoriadis, G. (1977) Targeting of drigs. Nature, 165, 407-411.
8. Torchilin, V.P. (1984) Immobilization of specific proteins on liposome surface: systems for drug targeting. In: G. Gregoriadis (Ed.), Liposome Technology, 1st edn., Vol. 3. CRC Press, Boca Raton, FL, pp. 75-94.
9. Klibanov, A.L., Maruyama, K., Torchilin, V.P. and Huang, L. (1990) Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett., 268, 235-237.
10. Lasic, D. and Martin, F. (Eds.) (1995) Stealth Liposomes. CRC Press, Boca Raton, FL.
11. Torchilin, V.P. and Papisov, M.I. (1994) Why do polyethylene glycol-coated liposomes circulate so long? J. Liposome Res., 4, 725-739.
12. Seltzer, S.E. (1989) The role of liposomes in diagnostic imaging. Radiology, 171, 19-21.
13. Tilcock, C. (1995) Imaging tools: liposomal agents for nuclear medicine, computed tomography, magnetic resonance, and ultrasound. In: J.R. Philippot and F. Schuber (Eds.), Liposomes as Tools in Basic Research and Industry. CRC Press, Boca Raton, FL, pp. 225-240.
14. Phillips, W.T. and Goins, B. (1995) Targeted delivery of imaging agents by liposomes. In: V.P. Torchilin (Ed.), Handbook of Targeted Delivery of Imaging Agents. CRC Press. Boca Raton, FL. pp. 149-173.
15. Tilcock, C., Unger, E., Cullis, P. and MacDougall, P. (1989) Liposomal Gd-DTPA: preparation and characterization of relaxivity. Radiology, 171, 77-80.
16. Unger, E., Cardenas, D., Zerella, A., Fajardo, L.L. and Tilcock, C. (1990) Biodistribution and clearance of liposomal gadolinium-DTPA. Invest. Radiol., 25, 638-644.
17. Kabalka, G.W., Davis, M.A., Holmberg, E., Maruyama, K. and Huang, L. (1991) Gadolinium-labeled liposomes containing amphiphilic Gd-DTPA derivatives of varying chain length: targeted MRI contrast enhancement agents for the liver. Magn. Res. Imaging, 9, 373-377.
18. Schwendener, R.A., Wuethrich, R., Duewell, S., Westera, G. and Von-Schulthess, G.K. (1989) Small unilamellar liposomes as magnetic resonance contrast agents loaded with paramagnetic manganese-, gadolinium-, and iron-DTPA-stearate complexes. Int. J. Pharm., 49, 249-259.
19. Presant, C.A., Blayney, D., Proffitt, R.T., Turner, A.F., Williams, L.E., Nadel, H.I., Kennedy, P., Wiseman, C., Gala, K. and Cossley, R.J. (1990) Preliminary report: imaging of Kaposi sarcoma and lymphoma in AIDS with indium-111-labeled liposomes. Lancet, 335, 1307-1309.
20. Jaggi, M., Khar, R., Chauhan, U. and Gangal, S. (1991) Liposomes as carriers of technetium-99m glucoheptonate for liver imaging. Int. J. Pharm., 69, 77-79.
21. Unger, E., Fritz, T., Shen, D.K. and Wu, G. (1993) Manganese-based liposomes: comparative approaches. Invest. Radiol., 28, 933-938.
22. Trubetskoy, V.S. and Torchilin, V.P. (1994) New approaches in the chemical design of Gd-containing liposomes for use in magnetic resonance imaging of lymph nodes. J. Liposome Res., 4, 961-980.
23. Torchilin, V.P. Trubetskoy, V.S., Narula, J. and Khaw, B.A. (1995) PEG-Modified liposomes for gamma-and magnetic resonance imaging. In: F. Martin and D. Lasic (Eds.) Stealth Liposomes. CRC Press. Boca Raton, FL, pp. 225-231.
24. Phillips, W.T., Rudolph, A.S., Coins, B., Timmons, J.H., Klipper, R.T. and Blumhardt, R. (1992) A simple method for producing a technetium-99m-labeled liposome which is stable in vivo. Nucl. Med. Biol., 19, 539-547.
25. 67Ga-carrying liposomes. Eur. J. Nucl. Med., 11, 405-411.
26. 67Gallium-labeled liposomes with prolonged circulation: preparation and potential as nuclear imaging agents. Nucl. Med. Biol., 20, 149-155.
27. Barsky, D., Putz, B., Schulten, K. and Magin, R.L. (1992) Theory of paramagnetic contrast agents in liposome systems. Magn. Reson. Med., 21, 1-13.
28. Putz, B., Barsky, D. and Schulten, K. (1994) Mechanisms of liposomal contrast agents in magnetic resonance imaging. J. Liposome Res., 4, 771-808.
29. Tilcock, C.P., Ahkong, Q.F. and Parr, M. (1991) An improved method for the preparation of liposomal gadolinium-DTPA. Ionophore-mediated active entrapment of gadolinium. Invest. Radiol., 26, 242-247.
30. Khar, R.K. and Jaggi, M. (1994) Liposomes for liver scintigraphy. J. Liposome Res., 4, 939-958.
31. Unger, E.G., Winokur, T., MacDougall, P., Rosenblum. J., Clair, M., Gatenby, R. and Tilcock, C. (1989) Hepatic metastases: liposomal Gd-DTPA-enhanced MR imaging. Radiology, 171, 81-85.
32. Kabalka, G.W., Buonocore, K., Hubner, K., Davis, M. and Huang, L. (1988) Gadolinium-labeled liposomes containing paramagnetic amphipatic agents: targeted MRI contrast agents for the liver. Magn. Res. Med., 8, 89-95.
33. Kabalka, G., Davis, M., Moss, T., Buonocore, E., Hubner, K., Holmberg, E., Maruyama, K. and Huang, L. (1991) Gadolinium-labeled liposomes containing various amphiphilic gadolinium-DTPA derivatives: tsrgeted MRI contrast enhancement agents for the liver. Magn. Res. Med., 19, 406-415.
34. Schwendener, R.A. (1994) Liposomes as carriers for paramagnetic gadolinium chelates as organ specific contrast agents for magnetic resonance imaging (MRI). J. Liposome Res., 4, 837-855.
35. Basic, G., Niesman, M., Magin, R. and Swartz, H. (1990) NMR and ESR study of liposome delivery of manganese to murine liver. Magn. Reson. Med., 13, 44-61.
36. Palmer, T., Caride, V., Caldecourt, M., Twicjler, J. and Abdullah, V. (1984) The mechanism liposome accumulation in infarction. Biochim. Biophys. Acta, 797, 363-368.
37. Torchilin, V.P. Khaw, B.A., Smirnov, V.N. and Haber, E. (1979) Preservation of antimyosin antibody activity after covalent coupling to liposomes. Biochem. Biophys. Res. Commun., 89, 1114-1119.
38. Torchilin, V.P., Klibanov, A.L., Huang, L., O'Donnell, S., Nossiff, N.D. and Khaw, B.A. (1992) Targeted accumulation of polyethylene glycol-coated immunoliposomes in infarcted rabbit myocardium. FASEB J., 6, 2716-2719.
39. Torchilin, V.P. (1994) Immunoliposomes as targeted carriers of pharmaceuticals in the cardiovascular system. In: B.A. Khaw, J. Narula and H.W. Strauss (Eds.), Monoclonal Antibodies in Cardiovascular Diseases. Lea and Febiger, Malvern. PA, pp. 257-267.
40. Klibanov, A.L., Khaw, B.A., Nossiff, N., O'Donnel, S.M., Huang, L., Slinkin, M.A. and Torchilin, V.P. (1991) Targeting of macromolecular carriers and liposomes by antibodies to myosin heavy chain. Am. J. Physiol., 261 (Suppl. N4), 60-65.
41. Oku, N., Namba, Y., Takeda, A. and Okada, S. (1993) Tumor imaging with technetium-99m-DTPA incapsulated in RES-avoiding liposomes. Nucl. Med. Biol., 20, 407-412.
42. Tilcock, C., Ahkong, Q.F. and Fisher, D. (1993) Polymerderivatized technetium 99m-labeled liposomal blood pool agents for nuclear medicine applications. Biochim. Biophys. Acta, 1148, 77-84.
43. Yuan, F., Leunig, M., Huang, S.K., Berk, D.A., Papahadjopoulos, D. and Jain, R.K. (1994) Microvascular permeability and interstitial penetration of sterically stabilized (Stealth) liposomes in a human tumor xenograft. Cancer Res., 54, 3352-3356.
44. Presant, C.A., Turner, A.F. and Proffitl, R.T. (1994) Potential for improvement in clinical decision-making: tumor imaging with In-111 labeled liposomes. Results of a Phase II-III study. J. Liposome Res., 4, 985-1008.
45. Nakamura, K., Kuba, A., Katayama, M., Hashimoto, S., Takatoku, K., Wakui, Y. and Bando, K. (1993) Indium-111-labeled liposomes: quality and biodistribution in mice bearing human tumor xenografts. Drug Delivery, 1, 69-74.
46. Tonthat, T., Taillefer, R., Duranceau, A., Lafontaine, E., Deschamps, C., Lambert, R., Labonte, C. and Norman, L. (1991) Indium-111-labeled phospholipid vesicles liposomes imaging in detection of primary lung cancer: preliminary results. J. Nucl. Med., 32 (Suppl. 5), 1085.
47. Briele, B., Graefen, M., Bockisch, A., Hartlapp, J.P., Roedel, W., Hotze, A. and Biersack, H.J. (1990) Indium(111) labeled liposomes as a tumor imaging agent: first clinical results. Eur. J. Nucl. Med., 16, 411-416.
48. Goto, R., Kubo, H. and Okada, S. (1991) Effect of reticuloendothelial blockade on tissue distribution of technetium-99-labeled synthetic liposomes in Ehrlich solid tumor-bearing mice. Chem. Pharm. Bull., 39, 230-232.
49. Goto, R. (1994) Tissue distribution of 99m-Tc-labeled liposomes prepared from synthetic amphiphiles containing amino acid residues. J. Liposome Res., 4, 877-906.
50. Goins, B., Klipper, R., Rudolph, A.S. and Phillips, W.T. (1994) Use of technetium-99m-liposomes in tumor imaging. J. Nucl. Med., 35, 1491-1498.
51. Gabizon, A., Price, D.C., Huberty, J., Bresalier, R.S. and Papahadjopoulos, D. (1990) Effect of liposome composition and other factors on the targeting of liposomes to experimental tumors: biodistribution and imaging studies. Cancer. Res., 50, 6371-6378.
52. Patel, H., Boodle, C. and Vaugn-Jones, R. (1984) Assesment of the potential uses of liposomes for lymphoscintigraphy and lymphatic drug delivery. Biochim. Biophys. Acta, 801, 76-86.
53. Goins, B., Klipper, R., Rudolph, A.S., Cliff, R.O., Blumhardt, R. and Phillips, W.T. (1993) Biodistribution and imaging studies of technetium-99m-labeled liposomes in rats with focal infection. J. Nucl. Med., 34, 2160-2168.
54. Kasi, L.P., Lamki, L.M. and Podoloff, D.A. (1988) The potential of imaging abscesses with technetium-99m multilamellar liposomes. J. Nucl. Med., 29 (Suppl. 5), 888.
55. Chan, T.W., Eley, C., Liberty, P., So, A. and Kressel, H.Y. (1992) Magnetic resonance imaging of abscesses using lipidcoated iron oxide particles. Invest. Radiol., 27, 443-449.
56. Turski, P., Kalinke, T., Strother, L., Perman, W., Scott, G. and Kornguth, S. (1988) Magnetic resonance imaging of rabbit brain after intracarotid of large multivesicular liposomes containing paramagnetic metals and DTPA. Magn. Res. Med., 7, 184-196.
57. Love, W.G., Amos, N., Kellaway, I.W. and Williams, B.D. (1989) Specific accumulation of technetium-99m radiolabelled, negative liposomes in the inflamed paws of rats with adjuvant induced arthritis: effect of liposome size. Ann. Rheum. Dis., 48, 143-148.
58. Shermatova, S.Z. (1990) Using labeled liposomes for the visualisation of bone marrow. Med. Radiol., 35 (8). 36.
59. Shetty, H.G.M., Williams, B.D., Facey, P.E., Hayward, M.H., Evans, W., Williams, K. and Morgan, J. (1988) Fate of intra-articular Technetium-99m-labelled liposomes [abstract]. Br. J. Rheumatol., 27 (Suppl. 2), 118.
60. Niesman, M.R., Khoobehi, B., Magin, R.L. and Webb, A.G. (1994) Liposomes and diagnostic imaging: the potential to visualize both structure and function. J. Liposome Res., 4, 741-768.
61. Torchilin, V.P. and Trubetskoy, V.S. (1995) Which polymers can make nanoparticulate drug carriers long-circulating? Adv. Drug Delivery Rev., 16, 141-155.
62. Woodle, M.C. (1995) Sterically stabilized liposome therapeutics. Adv. Drug Delivery Rev., 16, 249-265.
63. Allen, T.M., Hansen, C.B. and de Menezes, D.E.L. (1995) Pharmacokinetics of long-circulating liposomes. Adv. Drug Delivery Rev., 16, 267-284.
64. Gabizon, A.A. (1995) Liposome circulation time and tumor targeting: implications for cancer chemotherapy. Adv. Drug Delivery Rev., 16, 285-294.
65. Torchilin, V.P. (1994) Immunoliposomes and PEGylated immunoliposomes: possible use for targeted delivery of imaging agents. Immunomethods, 4, 244-258.
66. Torchilin, V.P., Trubetskoy, V.S., Milshteyn, A.M., Cannillo, J., Wolf, G.L., Papisov, M.I., Bogdanov, A.A., Jr., Narula, J., Khaw, B.A. and Omelyanenko, V.G. (1994) Targeted delivery of diagnostic agents by surface-modified liposomes. J. Control. Release, 26, 45-58.
67. Trubetskoy, V.S. and Torchilin, V.P. (1994) New approaches in the chemical design of Gd-containing liposomes for use in magnetic resonance imaging of lymph nodes. J. Liposome Res., 4, 961-980.
68. Trubetskoy, V. Cannillo, J., Milstern, A., Wolf, G. and Torchilin, V. (1995) Controlled delivery of Gd-containing liposomes to lymph nodes: surface modification may enhance MRI contrast properties. Magn. Res. Imaging, 13, 31-37.
69. Torchilin, V.P., Klibanov, A.L., Nossiff, N.D., Slinkin, M.A., Strauss, H.W., Haber, E. and Khaw, B.A. (1987) Monoclonal antibody modification with chelate-linked high-molecular-weight polymers: major increase in polyvalent cation binding without loss of antigen binding. Hybridoma, 6, 229-240.
70. Torchilin, V.P. and Klibanov, A.L (1991) The antibody-linked chelating polymers for nuclear therapy and diagnostics. Crit. Rev. Ther. Drug Carrier Syst., 7, 275-308.
71. Slinkin, M., Klibanov, A. and Torchilin, V. (1991) Terminal-modified polylysine-based chelating polymers: highly efficient coupling to antibody with minimal loss in immunoreactivity. Bioconjugate Chem., 2, 342-348.
72. Trubetskoy, V.S., Torchilin, V.P., Kennel, S.J. and Huang, L. (1992) Use of N-terminal modified poly (L-lysine)-antibody conjugate as a carrier for targeted gene delivery in mouse lung endothelial cells. Bioconjugate Chem., 3, 323-327.
73. Stoll, M., Mizuochi, T., Childs, R. and Feizi, T. (1988) Improved procedure for the construction of neoglycolipids having antigenic and lectin-binding activities, from reducing oligosaccharides. Biochem J., 256, 661-667.
74. Tilcock, C. (1993) Liposomal paramagnetic MR contrast agents. In: G. Gregoriadis (Ed.), Liposome Technology, 2nd edn., Vol. 2, CRC Press. Boca Raton, FL, pp. 65-87.
75. Torchilin, V.P. and Trubetskoy, V.S. (1995) Magnetic resonance imaging of lymph nodes with Gd-containing liposomes. In: V.P. Torchilin (Ed.), Handbook on Targeted Delivery of Imaging Agents. CRC Press. Boca Raton, FL, pp. 403-413.
76. O'Driscoll, C. (1992) Anatomy and physiology of the lymphatics. In: W.N. Charman and V.J. Stella (Eds.) Lymphatic Transport of Drugs. CRC Press, Boca Raton, FL, pp. 1-35.
77. Yasuda, T., Palasios, I.F., Dec, G.W., Fallon, J.T., Gold, H.K., Leinbach, R.C., Strauss, H.W., Khaw, B.A. and Haber, E. (1987) Indium 111-monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis. Circulation. 76, 306-311.
78. Trubetskoy, V.S., Narula, J., Khaw, B.A. and Torchilin, V.P. (1993) Chemically optimised antimyosin Fab conjugate with chelating polymers: inportance of the nature of the protein-polymer single site covalent bond for biodistribution and infarction localization. Bioconj. Chem., 4, 251-255.
79. Khaw, B.A., Klibanov, A.L., O'Donnell, S.M., Saito, T., Nossiff, N., Slinkin, M.A., Newell, J.B., Strauss, H.W. and Torchilin, V.P. (1991) Gamma imaging with negatively charge-modified monoclonal antibody: modification with synthetic polymers. J. Nucl. Med., 32, 1742-1751.
80. Narula, J., Khaw, B.A. and Yasuda, T. (1994) Antimyosin imaging for acute myocarditis. In: B.A. Khaw, J. Narula and H.W. Strauss (Eds.), Monoclonal Antibodies in Cardiovascular Diseases. Lea and Febiger, Malvern, pp. 67-78.
81. Torchilin, V.P. (1996) Liposomes as delivery agents for medical imaging. Mol. Med. Today, 2, 242-249.