The "Perivascular Pump" Driven by Arterial Pulsation Is a Powerful Mechanism for the Distribution of Therapeutic Molecules within the Brain

Molecular Therapy

Volumn 14, Issue 1, 2006, Pages 69-78

  Hadaczek, Piotr ^a   Yamashita, Yoji ^a   Mirek, Hanna ^a   Tamas, Laszlo ^b   Bohn, Martha C ^c   Noble, Charles ^d   Park, John W ^d   Bankiewicz, Krystof ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CALIFORNIA PACIFIC MEDICAL CENTER   (United States)

^c CHILDREN S MEMORIAL RESEARCH CENTER   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AAV2; brain; convection enhanced delivery; liposomes; perivascular space; transport

Indexed keywords

BOVINE SERUM ALBUMIN; GENE PRODUCT; LIPOSOME; PARVOVIRUS VECTOR;

ANIMAL EUTHANASIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN CIRCULATION; BRAIN REGION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORPUS STRIATUM; DISTRIBUTION VOLUME; GENE DELIVERY SYSTEM; GLOBUS PALLIDUS; HEART CONTRACTION; HEART RATE; HEMISPHERE; HYPERTENSION; HYPOTENSION; MACROMOLECULE; MALE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PULSE WAVE; RAT; THERMODYNAMICS; TISSUE DISTRIBUTION; TRANSPORT KINETICS; VIRAL GENE DELIVERY SYSTEM; VIRUS CAPSID; VIRUS PARTICLE;

ANIMALS; BLOOD PRESSURE; BLOOD VESSELS; BRAIN; CONVECTION; DEPENDOVIRUS; DRUG DELIVERY SYSTEMS; GENETIC VECTORS; HEART RATE; LIPOSOMES; MAGNETIC RESONANCE ANGIOGRAPHY; MALE; MICROSCOPY, FLUORESCENCE; RATS; RATS, SPRAGUE-DAWLEY; SERUM ALBUMIN, BOVINE;

ADENO-ASSOCIATED VIRUS - 2; BOS TAURUS; MIRIDAE;

EID: 33745275175     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2006.02.018     Document Type: Article

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