Kinetics of transport of doxorubicin bound to nanoparticles across the blood-brain barrier

Journal of Controlled Release

Volumn 154, Issue 1, 2011, Pages 103-107

  Wohlfart, Stefanie ^a   Khalansky, Alexander S ^b   Gelperina, Svetlana ^c   Begley, David ^d   Kreuter, Jörg ^a  

^a GOETHE UNIVERSITY   (Germany)

^b RESEARCH INSTITUTE OF HUMAN MORPHOLOGY   (Russian Federation)

^c Nanosystem LTD   (Russian Federation)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain barrier; Capillary depletion; Drug targeting; Nanoparticles

Indexed keywords

BLOOD-BRAIN BARRIER; BODY WEIGHT; BRAIN PARENCHYMA; BRAIN TISSUE; CAPILLARY DEPLETION; CENTRAL NERVOUS SYSTEMS; DEPLETION TECHNIQUE; DOXORUBICIN; DRUG DISTRIBUTION; DRUG SOLUTIONS; DRUG TARGETING; EFFECTIVE CONCENTRATION; INTRAVENOUS INJECTIONS; LOW CONCENTRATIONS; N-BUTYL CYANOACRYLATE; POLYSORBATE 80; RAT BRAIN; TAIL VEINS; TIME-DEPENDENT; TRANSCYTOSIS;

BLOOD; BLOOD VESSELS; CENTRIFUGATION; DRUG DELIVERY; RATS; SURFACE ACTIVE AGENTS; TISSUE;

NANOPARTICLES;

DOXORUBICIN; NANOPARTICLE; POLY(N BUTYL CYANOACRYLATE); UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CENTRIFUGATION; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG TRANSPORT; HOMOGENATE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; RAT; SUPERNATANT;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD-BRAIN BARRIER; BRAIN; DOXORUBICIN; DRUG CARRIERS; ENBUCRILATE; KINETICS; MALE; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, WISTAR; SURFACE PROPERTIES; TISSUE DISTRIBUTION;

EID: 79960901437     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.05.010     Document Type: Article

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