Transferrin coupled liposomes as drug delivery carriers for brain targeting of 5-florouracil

Journal of Drug Targeting

Volumn 13, Issue 4, 2005, Pages 245-250

  Soni, Vandana ^a   Kohli, D V ^a   Jain, S K ^a  

^a DR H S GOUR UNIVERSITY   (India)

Author keywords

5 florouracil; Blood brain barrier; Brain delivery; Liposomes; Transferrin

Indexed keywords

BUFFER; CYANAMIDE; DRUG CARRIER; FLUOROURACIL; LIPID; LIPOSOME; PENTETATE TECHNETIUM TC 99M; PHOSPHATE; PHOSPHATIDYLCHOLINE; SEPHADEX; SODIUM CHLORIDE; TRANSFERRIN; TRITON X 100; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; BRAIN DISEASE; BRAIN TISSUE; CAPILLARY ENDOTHELIUM; CHOROID PLEXUS; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG TARGETING; DRUG TRANSPORT; DRUG UPTAKE; ENDOTHELIUM CELL; EPITHELIUM CELL; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PH; PRIORITY JOURNAL; RADIOACTIVITY; RAT; TIGHT JUNCTION;

ANIMALS; BRAIN; DRUG COMPOUNDING; DRUG STABILITY; FEMALE; FLUOROURACIL; LIGANDS; LIPOSOMES; MALE; PARTICLE SIZE; RATS; TECHNETIUM TC 99M PENTETATE; TISSUE DISTRIBUTION; TRANSFERRIN;

EID: 23144445489     PISSN: 1061186X     EISSN: None     Source Type: Journal    
DOI: 10.1080/10611860500107401     Document Type: Article

References (14)

1. Allen TM. 2002. Ligand targeted therapeutics in anticancer therapy. Nat Rev 2:750-763.
2. Bangham AD. 1968. Membrane model with phospholipids. Prog Biophys Mol Biol 18:29-39.
3. Bradford MA. 1976. Rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Cheng Y, Zak O, Alsen P, Harrison SC, Watz T. 2004. Structure of the human transferrin receptor-transferrin complex. Cell 116:565-576.
5. Fry DW, White JC, Goldman ID. 1978. Rapid separation of low molecular weight solutes from liposomes without dilution. J Anal Biochem 90:803-809.
6. Koukourakis MI, Koukouraki S, Giatromanolaki A, Archimandritis SC, Skarlatos J, Beroukas K, Bizakis JG, Retalis G, Karkavitsas N, Helidonis ES. 1999. Liposomal doxorubicin and conventionally fractionated radiotherapy in the treatment of locally advanced non-small-cell lung cancer and head and neck cancer. J Clin Oncol 17:3512-3521.
7. Krishniaiah YSR, Karthikeyan RS, Satyanarayana V. 2001. HPLC estimation of 5- fluorouracil in pharmaceutical dosage forms. Indian Drugs 39:23-26.
8. Litzinger DC, Buiting AM, van Rooijen N, Huang L. 1994. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim Biophys Acta 1190:99-107.
9. Pardridge WM. 1995. Blood brain barrier peptide transport and peptide drug delivery to brain. In: Taylor MD, Amidon GL, editors. Peptide based drug design. Washington DC: American chemical society. p 265-296.
10. Pardridge WM. 1998. Introduction to the blood-brain barrier. Methodology, biology and pathology. Cambridge: University Press. p 486.
11. Simoes S, Fonseca C, Pedroso de Lima MC, Duzgunes N. 2005. pH sensitive liposomes: From biophysics to therapeutic applications. In: Arshde R, editor. Trigger sensitive assembleies and peaticulates. London: Citus Books, in press.
12. Skarlatos S, Yoshikawa T, Pardridge WM. 1995. Transport of [125 I] transferrin through the rat blood brain barrier. Brain Res 683:161-166.
13. Strom G, Koppenhagen A, Heeremans A, Vingerhoeds M, Woodle MC, Crommelin DJA. 1995. Novel developments in liposomal delivery of peptides and proteins. J Control Release 36:19-24.
14. Zhong MQ, Hongyan L, Hongzhe U, Kwokping H. 2002. Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway. Pharmacol Rev 54:561-587.