메뉴 건너뛰기




Volumn 7, Issue 12, 2007, Pages 3716-3722

Modeling the thermodynamics of the interaction of nanoparticles with cell membranes

Author keywords

[No Author keywords available]

Indexed keywords

MEMBRANE INTEGRITY; PHYSICOCHEMICAL FACTORS; SURFACE CHARGE DENSITY; THERAPEUTIC AGENTS;

EID: 38049125209     PISSN: 15306984     EISSN: None     Source Type: Journal    
DOI: 10.1021/nl072053l     Document Type: Article
Times cited : (240)

References (23)
  • 1
    • 2942577499 scopus 로고    scopus 로고
    • and references therein
    • Salata, O. J. Nanobiology 2004, 2, 3 and references therein.
    • (2004) Nanobiology , vol.2 , pp. 3
    • Salata, O.J.1
  • 2
    • 19944401541 scopus 로고    scopus 로고
    • El-Sayed, I. H.; Huang,'X.; El-Sayed, M. A. Nano Lett. 2005, 5, 829.
    • El-Sayed, I. H.; Huang,'X.; El-Sayed, M. A. Nano Lett. 2005, 5, 829.
  • 3
    • 14644439267 scopus 로고    scopus 로고
    • and references therein
    • Ferrari, M. Nat. Rev. Cancer 2005, 5, 161 and references therein.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 161
    • Ferrari, M.1
  • 20
    • 38049142536 scopus 로고    scopus 로고
    • Strictly speaking, introduction of charged groups onto the particle surfaces should change all three Flory-Huggins parameters, χPH, χPL, and χPW. To accurately calculate Flory-Huggins parameters, especially for charged systems, remains a daunting task requiring extensive molecular simulations and is beyond the scope of this study. We assumed here that the introduction of charged groups to functionalize the surface of the otherwise hydrophobic particles would have the strongest impact on the particle interaction with the headgroups; hence, this study maps out the phase diagram as function of χPH while leaving the other two parameters constant. More detailed analysis would be required to map out the phase diagram as function of all three parameters, χPH, χPL, and χpw
    • Strictly speaking, introduction of charged groups onto the particle surfaces should change all three Flory-Huggins parameters, χPH, χPL, and χPW. To accurately calculate Flory-Huggins parameters, especially for charged systems, remains a daunting task requiring extensive molecular simulations and is beyond the scope of this study. We assumed here that the introduction of charged groups to functionalize the surface of the otherwise hydrophobic particles would have the strongest impact on the particle interaction with the headgroups; hence, this study maps out the phase diagram as function of χPH while leaving the other two parameters constant. More detailed analysis would be required to map out the phase diagram as function of all three parameters, χPH, χPL, and χpw.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.