Biodistribution of polysorbate 80-coated doxorubicin-loaded [14C]-poly(butyl cyanoacrylate) nanoparticles after intravenous administration to glioblastoma-bearing rats

Journal of Drug Targeting

Volumn 14, Issue 2, 2006, Pages 97-105

  Ambruosi, Alessandra ^a   Khalansky, Alexander S ^b   Yamamoto, Hiromitsu ^c   Gelperina, Svetlana E ^d   Begley, David J ^e   Kreuter, Jörg ^a  

^a GOETHE UNIVERSITY   (Germany)

^b RESEARCH INSTITUTE OF HUMAN MORPHOLOGY   (Russian Federation)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^d Research Center of Molecular Diagnostics and Therapy   (Russian Federation)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Blood brain barrier; Doxorubicin; Glioblastoma; Nanoparticles; Polysorbate 80

Indexed keywords

CARBON 14; CYANOACRYLATE DERIVATIVE; DOXORUBICIN; DRUG CARRIER; EVANS BLUE; NANOPARTICLE; POLY(ETHYL 2 CYANOACRYLATE); POLYSORBATE 80;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY DISTRIBUTION; CONTROLLED STUDY; DRUG COATING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG TARGETING; DRUG TISSUE LEVEL; GLIOBLASTOMA; INOCULATION; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; RAT STRAIN; RETICULOENDOTHELIAL SYSTEM;

ANIMALS; ANTI-BACTERIAL AGENTS; BLOOD-BRAIN BARRIER; BRAIN; BRAIN NEOPLASMS; DOXORUBICIN; ENBUCRILATE; EXCIPIENTS; GLIOBLASTOMA; INJECTIONS, INTRAVENOUS; MALE; NANOSTRUCTURES; NEOPLASM TRANSPLANTATION; PARTICLE SIZE; POLYSORBATES; RATS; RATS, WISTAR; SUSPENSIONS; TISSUE DISTRIBUTION;

EID: 33645863163     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.1080/10611860600636135     Document Type: Article

References (34)

1. Alyautdin, RN and Gothier, D and Petrov, V and Kharkevich, D and Kreuter, J. (1995) Analgesic activity of the hexapeptide dalargin absorbed on the surface of polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles Eur J Pharm Biopharm, 41, pp. 44-48.
2. Alyautdin, RN and Petrov, VE and Langer, K and Berthold, A and Kharkevich, DA and Kreuter, J. (1997) Delivery of loperamide across the blood-brain barrier with polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles Pharm Res, 14, pp. 325-328.
3. Alyautdin, RN and Tezikov, EB and Ramge, P and Kharkevich, DA and Begley, DJ and Kreuter, J. (1998) Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles: An in situ brain perfusion study J Microencapsul, 15, pp. 67-74.
4. 14C-poly(butyl cyanoacrylate) nanoparticles after i.v. administration in rats J Drug Target 13, pp. 535-542.
5. Araujo, L and Lobenberg, R and Kreuter, J. (1999) Influence of the surfactant concentration on the body distribution of nanoparticles J Drug Target, 6, pp. 373-385.
6. Begley, DJ. (1996) The blood-brain barrier: Principles for targeting peptides and drugs to the central nervous system J Pharm Pharmacol, 48, pp. 136-146.
7. Begley, DJ. (2004) Delivery of therapeutic agents to the central nervous system: The problems and the possibilities Pharm Ther, 104, pp. 29-45.
8. Buahin, KG and Brem, H. (1995) Interstitial chemotherapy of experimental brain tumors: Comparison of intratumoral injection versus polymeric controlled release J Neurooncol, 26, pp. 103 - 110.
9. Brandes AA, Pasetto LM, Monfardini S. 2000. New drugs in recurrent high grade gliomas. Anticancer Res 20: 1913-1920
10. Bonstelle, CT and Kori, SH and Rekate, H. (1983) Intracarotid chemotherapy of glioblastoma after induced blood-brain barrier disruption AJNR Am J Neuroradiol, 4, pp. 810-812.
11. Borchard, G and Kreuter, J. (1993) Interaction of serum components with poly(methylmethacrylate) nanoparticles and the resulting body distribution after intravenous injection in rats J Drug Target, 1, pp. 15-19.
12. Brigger, I and Morizet, J and Aubert, G and Chacun, H and Terrier-Lacombe, MJ and Couvreur, P and Vassal, G. (2002) Poly(ethylene glycol)-coated hexadecylcyanoacrylate nanospheres display a combined effect for brain tumor targeting J Pharmacol Exp Ther, 303, pp. 928-936.
13. Brigger, I and Morizet, J and Couvreur, P. (2004) Negative preclinical results with stealth nanospheres-encapsulated doxorubicin in an orthotopic murine brain tumor model J Control Release, 100, pp. 29-40.
14. Gelperina, SE and Khalansky, AS and Skidan, IN and Smirnova, ZS and Bobruskin, AI and Severin, SE and Turowski, B and Zanella, FE and Kreuter, J. (2002) Toxicological studies of doxorubicin bound to polysorbate 80-coated poly(butyl cyanoacrylate) nanoparticles in healthy rats and rats with intracranial glioblastoma Toxicol Lett, 126, pp. 131-141.
15. Granholm, AC and Albeck, D and Backman, C and Curtis, M and Ebendal, T and Friden, P and Henry, M and Hoffer, B and Kordower, J and Rose, GM and Soderstrom, S and Bartus, RT. (1998) A non-invasive system for delivering neural growth factors across the blood-brain barrier: A review Rev Neurosci, 9, pp. 31-55.
16. Gulyaev, AE and Gelperina, SE and Skidan, IN and Antropov, AS and Kivman, GY and Kreuter, J. (1999) Significant transport of doxorubicin into the brain with polysorbate 80-coated nanoparticles Pharm Res, 16, pp. 1564-1569.
17. Ji, Y and Powers, SK and Brown, JT and Miner, R. (1996) Characterization of the tumour invasion area in the rat intracerebral glioma J Neuro-Oncol, 30, pp. 189-197.
18. Kreuter, J. (1983) Physicochemical characterization of polyacrylic nanoparticles Int J Pharm, 14, pp. 43-58.
19. Kreuter, J. (2001) Nanoparticulate systems for brain delivery of drugs Adv Drug Deliv Rev, 47, pp. 65-81.
20. Kreuter, J and Ramge, P and Petrov, V and Hamm, S and Gelperina, SE and Engelhardt, B and Alyautdin, R and von Briesen, H and Begley, DJ. (2003) Direct evidence that polysorbate-80-coated poly(butyl cyanoacrylate) nanoparticles deliver drugs to the CNS via specific mechanisms requiring prior binding of drug to the nanoparticles Pharm Res, 20, pp. 409-416.
21. Lockman, PR and Mumper, RJ and Khan, MA and Allen, DD. (2002) Nanoparticle technology for drug delivery across the blood-brain barrier Drug Dev Ind Pharm, 28, pp. 1-13.
22. Maeda, H and Matsumura, Y. (1989) Tumoritropic and lymphotropic principles of macromolecular drugs Crit Rev Ther Drug Carrier Syst, 6, pp. 193-210.
23. Maeda, H. (2001) SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy Adv Drug Deliv Rev, 46, pp. 169-185.
24. Moos, T and Mølgård, K. (1993) Cerebrovascular permeability to azo dyes and plasma proteins Neuropath Appl Neurobiol, 19, pp. 120-127.
25. Neuwelt, E. (2004) Mechanisms of disease: The bloodbrain barrier Neurosurgery, 54, pp. 131-140.
26. Nomura, T and Inamura, T and Black, KL. (1994) Intracarotid infusion of bradykinin selectively increases blood-tumor permeability in 9L and C6 brain tumors Brain Res, 659, pp. 62-66.
27. Pardridge, WM. (2003) Blood-brain barrier drug targeting: The future of brain drug development Mol Interv, 3(90-105), pp. 51.
28. Prabhu, SS and Broaddus, WC and Oveissi, C and Berr, SS and Gillies, GT. (2000) Determination of intracranial tumor volumes in a rodent brain using magnetic resonance imaging, Evans Blue, and histology: A comparative study IEEE Trans Biomed Eng, 47, pp. 259-265.
29. Schaller, B. (2004) Usefulness of positron emission tomography in diagnosis and treatment follow-up of brain tumors Neurobiol Dis, 15, pp. 437-448.
30. Shimura, T and Teramoto, A and Nakazawa, S and Aihara, K. (1996) A clinicopathological study of malignant glioma done after local administration of chemotherapeutic agents Clin Neuropathol, 15, pp. 119-124.
31. Steiniger, SC and Kreuter, J and Khalansky, AS and Skidan, IN and Bobruskin, AI and Smirnova, ZS and Severin, SE and Uhl, R and Kock, M and Geiger, KD and Gelperina, SE. (2004) Chemotherapy of glioblastoma in rats using doxorubicin-loaded nanoparticles Int J Cancer, 109, pp. 759-767.
32. Tröster, SD and Müller, U and Kreuter, J. (1990) Modification of the body distribution of poly(methyl methacrylate) nanoparticles in rats by coating with surfactants Int J Pharm, 61, pp. 85-100.
33. Tsuji, A.(2000) Specific mechanism for transporting drugs into the brain. In The blood-brain barrier and the drug delivery to the CNS. (pp. 121-144). New York: Marcel Dekker.
34. Zagzag, D and Nomura, M and Friedlander, DR and Blanco, CY and Gagner, JP and Nomura, N and Newcomb, EW. (2003) Geldanamycin inhibits migration of glioma cells in vitro: A potential role for hypoxia-inducible factor (HIF-1alpha) in glioma cell invasion J Cell Physiol, 196, pp. 394-402.