In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles

Journal of Controlled Release

Volumn 172, Issue 3, 2013, Pages 699-706

  Ganesh, Shanthi ^a,b   Iyer, Arun K ^a   Gattacceca, Florence ^a,c   Morrissey, David V ^b   Amiji, Mansoor M ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c UNIV MONTPELLIER   (France)

Author keywords

Cisplatin; Hyaluronic acid; Multidrug resistance; Nanoparticles; siRNA; Tumor targeting

Indexed keywords

ACID RESISTANCE; BEARINGS (MACHINE PARTS); CONTROLLED DRUG DELIVERY; DISEASES; DRUG PRODUCTS; HYALURONIC ACID; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; INFRARED DEVICES; MAMMALS; NANOPARTICLES; ORGANIC ACIDS; POLYMERASE CHAIN REACTION; TUMORS;

CIS-PLATIN; CLINICAL MANAGEMENT; COMBINATION TREATMENTS; DISTRIBUTION PATTERNS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRIES (ICPMS); MULTIDRUG RESISTANCE; SIRNA; TUMOR TARGETING;

TARGETED DRUG DELIVERY;

CISPLATIN; HERMES ANTIGEN; HYALURONIC ACID; NANOPARTICLE; SMALL INTERFERING RNA;

ARTICLE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG RESISTANCE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VIVO STUDY; LOW DRUG DOSE; LUNG TUMOR; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RADIATION DOSE DISTRIBUTION;

CISPLATIN; HYALURONIC ACID; MULTIDRUG RESISTANCE; NANOPARTICLES; SIRNA; TUMOR TARGETING;

ANIMALS; ANTIGENS, CD44; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CISPLATIN; DRUG DELIVERY SYSTEMS; HUMANS; HYALURONIC ACID; MICE; NANOPARTICLES; NEOPLASMS; RNA, SMALL INTERFERING; TISSUE DISTRIBUTION;

EID: 84887138119     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2013.10.016     Document Type: Article

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