Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles

Biomaterials

Volumn 33, Issue 32, 2012, Pages 8167-8176

  Xin, Hongliang ^a,b   Sha, Xianyi ^a   Jiang, Xinyi ^a   Zhang, Wei ^a   Chen, Liangcen ^a   Fang, Xiaoling ^a  

^a FUDAN UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Anti glioblastoma; Brain tumor; Dual target strategy; Glioma penetration; Nanoparticles; Toxicity

Indexed keywords

ACUTE TOXICITY; ANTI-GLIOBLASTOMA; BLOOD-BRAIN BARRIER; BRAIN TISSUE; BRAIN TUMORS; DELIVERY SYSTEMS; DRUG DELIVERY SYSTEM; DUAL TARGET STRATEGY; GLIOMA CELLS; GLIOMA PENETRATION; GLIOMA SPHEROIDS; IN-VIVO; INTRAVENOUS ADMINISTRATION; LOW DENSITY LIPOPROTEIN RECEPTORS; LOW PERMEABILITY; PACLITAXEL; THERAPEUTIC EFFECTS; TRANSCYTOSIS; TUMOR TISSUES;

BRAIN; DRUG DELIVERY; MOLECULAR BIOLOGY; NANOPARTICLES; TOXICITY; TUMORS;

LOADING;

ANGIOPEP; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MACROGOL; NANOPARTICLE; PACLITAXEL; PACLITAXEL ANGIOPEP CONJUGATE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG PENETRATION; DRUG SAFETY; DRUG SYNTHESIS; DRUG TARGETING; DRUG TRANSPORT; ENDOCYTOSIS; GLIOBLASTOMA; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCYTOSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BRAIN; BRAIN NEOPLASMS; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; GLIOBLASTOMA; HUMANS; MALE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; NANOPARTICLES; PACLITAXEL; PEPTIDES; POLYETHYLENE GLYCOLS;

EID: 84865558062     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.07.046     Document Type: Article

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