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Volumn 85, Issue 4, 2010, Pages 941-948

Production of individual ganoderic acids and expression of biosynthetic genes in liquid static and shaking cultures of Ganoderma lucidum

Author keywords

Ganoderma lucidum; Gene expression; Individual ganoderic acid; Liquid static culture; Medicinal mushroom fermentation

Indexed keywords

GANODERIC ACID; GANODERMA LUCIDUM; INDIVIDUAL GANODERIC ACID; MEDICINAL MUSHROOM; STATIC CULTURE;

EID: 76649132986     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-009-2106-5     Document Type: Article
Times cited : (90)

References (40)
  • 1
    • 12044254693 scopus 로고
    • Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes
    • 10.1021/cr00022a009 1:CAS:528:DyaK3sXlvVWjtLk%3D
    • I Abe M Rohmer GD Prestwich 1993 Enzymatic cyclization of squalene and oxidosqualene to sterols and triterpenes Chem Rev 93 2189 2206 10.1021/cr00022a009 1:CAS:528:DyaK3sXlvVWjtLk%3D
    • (1993) Chem Rev , vol.93 , pp. 2189-2206
    • Abe, I.1    Rohmer, M.2    Prestwich, G.D.3
  • 2
    • 33847745780 scopus 로고    scopus 로고
    • Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum
    • DOI 10.1002/cbdv.200790027
    • T Akihisa Y Nakamura M Tagata H Tokuda K Yasukawa E Uchiyama T Suzuki Y Kimura 2007 Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum Chem Biodivers 4 224 231 10.1002/cbdv.200790027 1:CAS:528:DC%2BD2sXisVyhu7k%3D (Pubitemid 46929192)
    • (2007) Chemistry and Biodiversity , vol.4 , Issue.2 , pp. 224-231
    • Akihisa, T.1    Nakamura, Y.2    Tagata, M.3    Tokuda, H.4    Yasukawa, K.5    Uchiyama, E.6    Suzuki, T.7    Kimura, Y.8
  • 3
    • 42549137378 scopus 로고    scopus 로고
    • Lovastatin biosynthetic genes of Aspergillus terreus are differentially expressed in solid-state and in liquid submerged fermentation
    • 10.1007/s00253-008-1409-2
    • J Barrios-González JG Baños AA Covarrubias A Garay-Arroyo 2008 Lovastatin biosynthetic genes of Aspergillus terreus are differentially expressed in solid-state and in liquid submerged fermentation Appl Microbiol Biotechnol 79 179 186 10.1007/s00253-008-1409-2
    • (2008) Appl Microbiol Biotechnol , vol.79 , pp. 179-186
    • Barrios-González, J.1    Baños, J.G.2    Covarrubias, A.A.3    Garay-Arroyo, A.4
  • 4
    • 55549103741 scopus 로고    scopus 로고
    • Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression
    • 10.1254/jphs.SC0080019 1:CAS:528:DC%2BD1cXhtlehs7%2FM
    • NH Chen JW Liu JJ Zhong 2008 Ganoderic acid Me inhibits tumor invasion through down-regulating matrix metalloproteinases 2/9 gene expression J Pharmacol Sci 108 212 216 10.1254/jphs.SC0080019 1:CAS:528:DC%2BD1cXhtlehs7%2FM
    • (2008) J Pharmacol Sci , vol.108 , pp. 212-216
    • Chen, N.H.1    Liu, J.W.2    Zhong, J.J.3
  • 5
    • 0032518190 scopus 로고    scopus 로고
    • Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor
    • DOI 10.1006/abbi.1997.0463
    • TP Devarenne DH Shin K Back SH Yin J Chappell 1998 Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor Arch Biochem Biophys 349 205 215 10.1006/abbi.1997.0463 1:CAS:528:DyaK1cXltlGntA%3D%3D (Pubitemid 28368663)
    • (1998) Archives of Biochemistry and Biophysics , vol.349 , Issue.2 , pp. 205-215
    • Devarenne, T.P.1    Shin, D.H.2    Back, K.3    Yin, S.4    Chappell, J.5
  • 6
    • 45849134086 scopus 로고    scopus 로고
    • Molecular cloning, characterization, and differential expression of a farnesyl-diphosphate synthase gene from the basidiomycetous fungus Ganoderma lucidum
    • DOI 10.1271/bbb.80067
    • YX Ding X Ou-Yang CH Shang A Ren L Shi YX Li MW Zhao 2008 Molecular cloning, characterization, and differential expression of a farnesyl-diphosphate synthase gene from the basidiomycetous fungus Ganoderma lucidum Biosci Biotechnol Biochem 72 1571 1579 10.1271/bbb.80067 1:CAS:528:DC%2BD1cXotlyks7c%3D (Pubitemid 351883788)
    • (2008) Bioscience, Biotechnology and Biochemistry , vol.72 , Issue.6 , pp. 1571-1579
    • Ding, Y.-X.1    Ou-Yang, X.2    Shang, C.-H.3    Ren, A.4    Shi, L.5    Li, Y.-X.6    Zhao, M.-W.7
  • 8
    • 0036007988 scopus 로고    scopus 로고
    • Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum
    • DOI 10.1021/bp010136g
    • QH Fang JJ Zhong 2002 Two-stage culture process for improved production of ganoderic acid by liquid fermentation of higher fungus Ganoderma lucidum Biotechnol Prog 18 51 54 10.1021/bp010136g 1:CAS:528:DC%2BD38XhtFahuw%3D%3D (Pubitemid 34147376)
    • (2002) Biotechnology Progress , vol.18 , Issue.1 , pp. 51-54
    • Fang, Q.-H.1    Zhong, J.-J.2
  • 9
    • 0000876133 scopus 로고
    • Effects of cultivation techniques and media on yields and morphology of the basidiomycete Armillaria mellea
    • 10.1007/BF00253534 1:CAS:528:DyaL2sXlsFarsrc%3D
    • G Hansson G Seifert 1987 Effects of cultivation techniques and media on yields and morphology of the basidiomycete Armillaria mellea Appl Microbiol Biotechnol 26 468 473 10.1007/BF00253534 1:CAS:528:DyaL2sXlsFarsrc%3D
    • (1987) Appl Microbiol Biotechnol , vol.26 , pp. 468-473
    • Hansson, G.1    Seifert, G.2
  • 10
    • 0010265954 scopus 로고
    • Changes of the triterpenoid patterns during formation of the fruit body in Ganoderma lucidum
    • 10.1016/0031-9422(90)85328-D 1:CAS:528:DyaK3MXlvV2htQ%3D%3D
    • M Hirotani T Furuya 1990 Changes of the triterpenoid patterns during formation of the fruit body in Ganoderma lucidum Phytochemistry 29 3767 3771 10.1016/0031-9422(90)85328-D 1:CAS:528:DyaK3MXlvV2htQ%3D%3D
    • (1990) Phytochemistry , vol.29 , pp. 3767-3771
    • Hirotani, M.1    Furuya, T.2
  • 11
    • 37049082521 scopus 로고
    • Investigation of the biosynthesis of 3-hydroxy triterpenoids, ganoderic acids T and S by application of a feeding experiment using [1, 2-13C2]acetate
    • 10.1039/p19900002751
    • M Hirotani I Asaka T Furuya 1990 Investigation of the biosynthesis of 3-hydroxy triterpenoids, ganoderic acids T and S by application of a feeding experiment using [1, 2-13C2]acetate J Chem Soc, Perkin Trans 1 2751 2754 10.1039/p19900002751
    • (1990) J Chem Soc, Perkin Trans , vol.1 , pp. 2751-2754
    • Hirotani, M.1    Asaka, I.2    Furuya, T.3
  • 12
    • 27844594899 scopus 로고    scopus 로고
    • Production of polysaccharides from Ganoderma lucidum (CCRC 36041) under limitations of nutrients
    • DOI 10.1016/j.enzmictec.2005.05.004, PII S0141022905002024
    • C Hsieh MH Tseng CJ Liu 2006 Production of polysaccharides from Ganoderma lucidum (CCRC 36041) under limitation of nutrients Enzyme Microb Technol 38 109 117 10.1016/j.enzmictec.2005.05.004 1:CAS:528:DC%2BD2MXht1Giu7jP (Pubitemid 41660525)
    • (2006) Enzyme and Microbial Technology , vol.38 , Issue.1-2 , pp. 109-117
    • Hsieh, C.1    Tseng, M.-H.2    Liu, C.-J.3
  • 13
    • 4644290998 scopus 로고    scopus 로고
    • Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene
    • 10.1093/pcp/pch126 1:CAS:528:DC%2BD2cXns1SktLw%3D
    • MH Lee JH Jeong JW Seo CG Shin YS Kim JG In DC Yang JS Yi YE Choi 2004 Enhanced triterpene and phytosterol biosynthesis in Panax ginseng overexpressing squalene synthase gene Plant Cell Physiol 45 976 984 10.1093/pcp/pch126 1:CAS:528:DC%2BD2cXns1SktLw%3D
    • (2004) Plant Cell Physiol , vol.45 , pp. 976-984
    • Lee, M.H.1    Jeong, J.H.2    Seo, J.W.3    Shin, C.G.4    Kim, Y.S.5    In, J.G.6    Yang, D.C.7    Yi, J.S.8    Choi, Y.E.9
  • 14
    • 33846540736 scopus 로고    scopus 로고
    • Analysis of influence of environmental conditions on ganoderic acid content in Ganoderma lucidum using orthogonal design
    • 1:CAS:528:DC%2BD2sXhs1yrurc%3D
    • N Li XH Liu J Zhou YX Li MW Zhao 2006 Analysis of influence of environmental conditions on ganoderic acid content in Ganoderma lucidum using orthogonal design J Microbiol Biotechnol 16 1940 1946 1:CAS:528: DC%2BD2sXhs1yrurc%3D
    • (2006) J Microbiol Biotechnol , vol.16 , pp. 1940-1946
    • Li, N.1    Liu, X.H.2    Zhou, J.3    Li, Y.X.4    Zhao, M.W.5
  • 15
    • 33847155431 scopus 로고    scopus 로고
    • Enhancement of polysaccharides production in Ganoderma lucidum by the addition of ethyl acetate extracts from Eupolyphaga sinensis and Catharsius molossus
    • DOI 10.1007/s00253-006-0709-7
    • GQ Liu KC Zhang 2007 Enhancement of polysaccharides production in Ganoderma lucidum by the addition of ethyl acetate extracts from Eupolyphaga sinensis and Catharsius molossus Appl Microbiol Biotechnol 74 572 577 10.1007/s00253-006-0709-7 1:CAS:528:DC%2BD2sXhslSqtrw%3D (Pubitemid 46295013)
    • (2007) Applied Microbiology and Biotechnology , vol.74 , Issue.3 , pp. 572-577
    • Liu, G.-Q.1    Zhang, K.-C.2
  • 16
    • 0035710746 scopus 로고    scopus 로고
    • -ΔΔCT method
    • DOI 10.1006/meth.2001.1262
    • -CT method Methods 25 402 408 10.1006/meth.2001.1262 1:CAS:528:DC%2BD38XhtFelt7s%3D (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 17
    • 0031795507 scopus 로고    scopus 로고
    • Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV protease
    • 1:CAS:528:DyaK1cXntVSltL4%3D
    • BS Min N Nakamura H Mirashiro KW Bae M Hattori 1998 Triterpenes from the spores of Ganoderma lucidum and their inhibitory activity against HIV protease Chem Pharm Bull 46 1607 1612 1:CAS:528:DyaK1cXntVSltL4%3D
    • (1998) Chem Pharm Bull , vol.46 , pp. 1607-1612
    • Min, B.S.1    Nakamura, N.2    Mirashiro, H.3    Bae, K.W.4    Hattori, M.5
  • 18
    • 0026582193 scopus 로고
    • Enhanced glucan formation of filamentous fungi by effective mixing, oxygen limitation and fed-batch processing
    • 10.1007/BF01576364 1:CAS:528:DyaK38XitFaqs7Y%3D
    • U Rau E Gura E Olszewski F Wagner 1992 Enhanced glucan formation of filamentous fungi by effective mixing, oxygen limitation and fed-batch processing J Ind Microbiol 9 19 26 10.1007/BF01576364 1:CAS:528: DyaK38XitFaqs7Y%3D
    • (1992) J Ind Microbiol , vol.9 , pp. 19-26
    • Rau, U.1    Gura, E.2    Olszewski, E.3    Wagner, F.4
  • 19
    • 17444400413 scopus 로고    scopus 로고
    • Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation
    • DOI 10.1016/j.phytochem.2005.02.016
    • JW Seo JH Jeong CG Shin SC Lo SS Han KW Yu E Harada JY Han YE Choi 2005 Overexpression of squalene synthase in Eleutherococcus senticosus increases phytosterol and triterpene accumulation Phytochemistry 66 869 877 10.1016/j.phytochem.2005.02.016 1:CAS:528:DC%2BD2MXjsFCiu7Y%3D (Pubitemid 40545126)
    • (2005) Phytochemistry , vol.66 , Issue.8 , pp. 869-877
    • Seo, J.-W.1    Jeong, J.-H.2    Shin, C.-G.3    Lo, S.-C.4    Han, S.-S.5    Yu, K.-W.6    Harada, E.7    Han, J.-Y.8    Choi, Y.-E.9
  • 20
    • 45749107439 scopus 로고    scopus 로고
    • Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast
    • DOI 10.1271/bbb.80011
    • CH Shang F Zhu N Li X Ou-Yang L Shi MW Zhao YX Li 2008 Cloning and characterization of a gene encoding HMG-CoA reductase from Ganoderma lucidum and its functional identification in yeast Biosci Biotechnol Biochem 72 1333 1339 10.1271/bbb.80011 1:CAS:528:DC%2BD1cXnsVCmsrc%3D (Pubitemid 351872505)
    • (2008) Bioscience, Biotechnology and Biochemistry , vol.72 , Issue.5 , pp. 1333-1339
    • Shang, C.-H.1    Zhu, F.2    Li, N.3    Ou-Yang, X.4    Shi, L.5    Zhao, M.-W.6    Li, Y.-X.7
  • 21
    • 84986535294 scopus 로고
    • Triterpenoid natural products in the fungus Ganoderma lucidum
    • 1:CAS:528:DyaK3sXhtl2hsbk%3D
    • MS Shiao 1992 Triterpenoid natural products in the fungus Ganoderma lucidum J Chin Chem Soc 39 669 674 1:CAS:528:DyaK3sXhtl2hsbk%3D
    • (1992) J Chin Chem Soc , vol.39 , pp. 669-674
    • Shiao, M.S.1
  • 22
    • 0001609016 scopus 로고
    • Natural products and biological activities of the Chinese medicinal fungus Ganoderma lucidum
    • American Chemical Society: Washington, DC
    • Shiao MS, Lee KR, Lee JL, Cheng TW (1994) Natural products and biological activities of the Chinese medicinal fungus Ganoderma lucidum. Food Phytochemicals for Cancer Prevention II; ACS Symposium Series; American Chemical Society: Washington, DC, vol 547, pp 342-354
    • (1994) Food Phytochemicals for Cancer Prevention II; ACS Symposium Series , vol.547 , pp. 342-354
    • Shiao, M.S.1    Lee, K.R.2    Lee, J.L.3    Cheng, T.W.4
  • 23
    • 0036644167 scopus 로고    scopus 로고
    • Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid
    • DOI 10.1016/S0141-0229(02)00066-2, PII S0141022902000662
    • YJ Tang JJ Zhong 2002 Fed-batch fermentation of Ganoderma lucidum for hyperproduction of polysaccharide and ganoderic acid Enzyme Microb Technol 31 20 28 10.1016/S0141-0229(02)00066-2 1:CAS:528:DC%2BD38XksVansL0%3D (Pubitemid 34626812)
    • (2002) Enzyme and Microbial Technology , vol.31 , Issue.1-2 , pp. 20-28
    • Tang, Y.-J.1    Zhong, J.-J.2
  • 24
    • 0037416690 scopus 로고    scopus 로고
    • Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid
    • DOI 10.1016/S0141-0229(02)00338-1
    • YJ Tang JJ Zhong 2003 Role of oxygen supply in submerged fermentation of Ganoderma lucidum for production of Ganoderma polysaccharide and ganoderic acid Enzyme Microb Technol 32 478 484 10.1016/S0141-0229(02)00338-1 1:CAS:528:DC%2BD3sXmsFWgug%3D%3D (Pubitemid 36136068)
    • (2003) Enzyme and Microbial Technology , vol.32 , Issue.3-4 , pp. 478-484
    • Tang, Y.-J.1    Zhong, J.-J.2
  • 25
    • 0348044475 scopus 로고    scopus 로고
    • Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum
    • 1:CAS:528:DC%2BD2cXotleisLw%3D
    • YJ Tang JJ Zhong 2003 Scale-up of a liquid static culture process for hyperproduction of ganoderic acid by the medicinal mushroom Ganoderma lucidum Biotechnol Prog 18 51 54 1:CAS:528:DC%2BD2cXotleisLw%3D
    • (2003) Biotechnol Prog , vol.18 , pp. 51-54
    • Tang, Y.J.1    Zhong, J.J.2
  • 26
    • 33751015787 scopus 로고    scopus 로고
    • Separation of targeted ganoderic acids from Ganoderma lucidum by reversed phase liquid chromatography with ultraviolet and mass spectrometry detections
    • DOI 10.1016/j.bej.2006.09.026, PII S1369703X06002737
    • W Tang TY Gu JJ Zhong 2006 Separation of targeted ganoderic acids from Ganoderma lucidum by reversed phase liquid chromatography with ultraviolet and mass spectrometry detections Biochem Eng J 32 205 210 10.1016/j.bej.2006.09.026 1:CAS:528:DC%2BD28Xht1CisLrP (Pubitemid 44751583)
    • (2006) Biochemical Engineering Journal , vol.32 , Issue.3 , pp. 205-210
    • Tang, W.1    Gu, T.2    Zhong, J.-J.3
  • 27
    • 33845231348 scopus 로고    scopus 로고
    • Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells
    • DOI 10.1016/j.lfs.2006.09.001, PII S0024320506006801
    • W Tang JW Liu WM Zhao JJ Zhong 2006 Ganoderic acid T from Ganoderma lucidum mycelia induces mitochondria mediated apoptosis in lung cancer cells Life Sci 80 205 211 10.1016/j.lfs.2006.09.001 1:CAS:528:DC%2BD28Xht12qtLnJ (Pubitemid 44853986)
    • (2006) Life Sciences , vol.80 , Issue.3 , pp. 205-211
    • Tang, W.1    Liu, J.-W.2    Zhao, W.-M.3    Wei, D.-Z.4    Zhong, J.-J.5
  • 28
    • 57049144759 scopus 로고    scopus 로고
    • Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum
    • 10.1016/j.biortech.2008.10.005 1:CAS:528:DC%2BD1cXhsVyrs7nF
    • YJ Tang W Zhang JJ Zhong 2009 Performance analyses of a pH-shift and DOT-shift integrated fed-batch fermentation process for the production of ganoderic acid and Ganoderma polysaccharides by medicinal mushroom Ganoderma lucidum Bioresour Technol 100 1852 1859 10.1016/j.biortech.2008.10.005 1:CAS:528:DC%2BD1cXhsVyrs7nF
    • (2009) Bioresour Technol , vol.100 , pp. 1852-1859
    • Tang, Y.J.1    Zhang, W.2    Zhong, J.J.3
  • 29
    • 17444425679 scopus 로고    scopus 로고
    • Different control mechanisms regulate glucoamylase and protease gene transcription in Aspergillus oryzae in solid-state and submerged fermentation
    • 10.1007/s00253-004-1807-z
    • R Te Biesebeke N van Biezen WM de Vos CA van den Hondel PJ Punt 2004 Different control mechanisms regulate glucoamylase and protease gene transcription in Aspergillus oryzae in solid-state and submerged fermentation Appl Microbiol Biotechnol 67 75 82 10.1007/s00253-004-1807-z
    • (2004) Appl Microbiol Biotechnol , vol.67 , pp. 75-82
    • Te Biesebeke, R.1    Van Biezen, N.2    De Vos, W.M.3    Van Den Hondel, C.A.4    Punt, P.J.5
  • 30
    • 0348225923 scopus 로고    scopus 로고
    • Current techniques for the cultivation of Ganoderma lucidum for the production of biomass, ganoderic acid and polysaccharides
    • 1:CAS:528:DC%2BD2cXktVCqtA%3D%3D
    • R Wagner DA Mitchell GL Sassaki MAL De Almeida Amazonas M Berovic 2003 Current techniques for the cultivation of Ganoderma lucidum for the production of biomass, ganoderic acid and polysaccharides Food Technol Biotechnol 41 371 382 1:CAS:528:DC%2BD2cXktVCqtA%3D%3D
    • (2003) Food Technol Biotechnol , vol.41 , pp. 371-382
    • Wagner, R.1    Mitchell, D.A.2    Sassaki, G.L.3    De Almeida Amazonas, M.A.L.4    Berovic, M.5
  • 31
    • 0024433165 scopus 로고
    • The aggregation of human platelet induced by ganodermic acid S
    • DOI 10.1016/0005-2736(89)90285-X
    • CN Wang JC Chen MS Shiao CT Wang 1989 The aggregation of human platelet induced by ganoderic acid S Biochim Biophys Acta 986 151 160 10.1016/0005-2736(89)90285-X 1:CAS:528:DyaK3cXhvFaqtQ%3D%3D (Pubitemid 19281636)
    • (1989) Biochimica et Biophysica Acta - Biomembranes , vol.986 , Issue.1 , pp. 151-160
    • Wang, C.-N.1    Chen, J.-C.2    Shiao, M.-S.3    Wang, C.-T.4
  • 32
    • 33644768323 scopus 로고    scopus 로고
    • Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate
    • DOI 10.1007/s00253-005-0089-4
    • W Wang ZJ Zhao YF Xu XH Qian JJ Zhong 2006 Efficient induction of ginsenoside biosynthesis and alteration of ginsenoside heterogeneity in cell cultures of Panax notoginseng by using chemically synthesized 2-hydroxyethyl jasmonate Appl Microbiol Biotechnol 70 298 307 10.1007/s00253-005-0089-4 1:CAS:528:DC%2BD28XitV2qtr4%3D (Pubitemid 43345154)
    • (2006) Applied Microbiology and Biotechnology , vol.70 , Issue.3 , pp. 298-307
    • Wang, W.1    Zhao, Z.-J.2    Xu, Y.3    Qian, X.4    Zhong, J.-J.5
  • 33
    • 34247353700 scopus 로고    scopus 로고
    • Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo
    • DOI 10.1016/j.intimp.2007.02.006, PII S1567576907000574
    • G Wang J Zhao JW Liu Y Huang JJ Zhong W Tang 2007 Enhancement of IL-2 and IFN-γ expression and NK cells activity involved in the anti-tumor effect of ganoderic acid Me in vivo Int Immunopharmacol 7 864 870 10.1016/j.intimp. 2007.02.006 1:CAS:528:DC%2BD2sXkslKqsLc%3D (Pubitemid 46635284)
    • (2007) International Immunopharmacology , vol.7 , Issue.6 , pp. 864-870
    • Wang, G.1    Zhao, J.2    Liu, J.3    Huang, Y.4    Zhong, J.-J.5    Tang, W.6
  • 34
    • 39149097549 scopus 로고    scopus 로고
    • Improved production of mycelial biomass and ganoderic acid by submerged culture of Ganoderma lucidum SB97 using complex media
    • 10.1016/j.enzmictec.2007.10.016 1:CAS:528:DC%2BD1cXitVegsrc%3D
    • P Xu ZY Ding Z Qian CX Zhao KC Zhang 2008 Improved production of mycelial biomass and ganoderic acid by submerged culture of Ganoderma lucidum SB97 using complex media Enzyme Microb Technol 42 325 331 10.1016/j.enzmictec.2007.10.016 1:CAS:528:DC%2BD1cXitVegsrc%3D
    • (2008) Enzyme Microb Technol , vol.42 , pp. 325-331
    • Xu, P.1    Ding, Z.Y.2    Qian, Z.3    Zhao, C.X.4    Zhang, K.C.5
  • 35
    • 61849090801 scopus 로고    scopus 로고
    • A novel method to enhance the mycelia production of Ganoderma lucidum in submerged cultures by polymer additives and agitation strategies
    • 10.1016/j.jtice.2008.09.003 1:CAS:528:DC%2BD1MXmvFChtb0%3D
    • FC Yang MJ Yang SH Cheng 2009 A novel method to enhance the mycelia production of Ganoderma lucidum in submerged cultures by polymer additives and agitation strategies J Taiwan Inst Chem Eng 40 148 154 10.1016/j.jtice.2008.09. 003 1:CAS:528:DC%2BD1MXmvFChtb0%3D
    • (2009) J Taiwan Inst Chem Eng , vol.40 , pp. 148-154
    • Yang, F.C.1    Yang, M.J.2    Cheng, S.H.3
  • 36
    • 2342610689 scopus 로고
    • Biosynthesis of oxygenated triterpenoids in Ganoderma lucidum
    • 1:CAS:528:DyaK3cXhslGks7o%3D
    • SF Yeh CS Chou LJ Lin MS Shiao 1989 Biosynthesis of oxygenated triterpenoids in Ganoderma lucidum Proc Natl Sci Council B ROC 13 119 127 1:CAS:528:DyaK3cXhslGks7o%3D
    • (1989) Proc Natl Sci Council B ROC , vol.13 , pp. 119-127
    • Yeh, S.F.1    Chou, C.S.2    Lin, L.J.3    Shiao, M.S.4
  • 37
    • 33748582280 scopus 로고    scopus 로고
    • Determination of ergosterol in ganoderma spore lipid from the germinating spores of Ganoderma lucidum by high-performance liquid chromatography
    • DOI 10.1021/jf0617059
    • JP Yuan JH Wang X Liu HC Kuang XN Huang 2006 Determination of ergosterol in Ganoderma spore lipid from the germinating spores of Ganoderma lucidum by high-performance liquid chromatography J Agric Food Chem 54 6172 6176 10.1021/jf0617059 1:CAS:528:DC%2BD28XnsV2htr8%3D (Pubitemid 44367579)
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.17 , pp. 6172-6176
    • Yuan, J.-P.1    Wang, J.-H.2    Liu, X.3    Kuang, H.-C.4    Huang, X.-N.5
  • 39
    • 34547983158 scopus 로고    scopus 로고
    • Cloning and characterization of squalene synthase (SQS) gene from Ganoderma lucidum
    • 1:CAS:528:DC%2BD2sXhtVWgtLbI
    • MW Zhao WQ Liang DB Zhang N Wang CG Wang YJ Pan 2007 Cloning and characterization of squalene synthase (SQS) gene from Ganoderma lucidum J Microbiol Biotechnol 17 1106 1112 1:CAS:528:DC%2BD2sXhtVWgtLbI
    • (2007) J Microbiol Biotechnol , vol.17 , pp. 1106-1112
    • Zhao, M.W.1    Liang, W.Q.2    Zhang, D.B.3    Wang, N.4    Wang, C.G.5    Pan, Y.J.6
  • 40
    • 3142720623 scopus 로고    scopus 로고
    • Submerged cultivation of medicinal mushrooms for production of valuable bioactive metabolites
    • 1:CAS:528:DC%2BD2cXms1aju7k%3D
    • JJ Zhong YJ Tang 2004 Submerged cultivation of medicinal mushrooms for production of valuable bioactive metabolites Adv Biochem Eng Biotechnol 87 25 59 1:CAS:528:DC%2BD2cXms1aju7k%3D
    • (2004) Adv Biochem Eng Biotechnol , vol.87 , pp. 25-59
    • Zhong, J.J.1    Tang, Y.J.2


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