Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae

Biotechnology and Bioengineering

Volumn 109, Issue 11, 2012, Pages 2845-2853

  Dai, Zhubo ^a   Liu, Yi ^a,b   Huang, Luqi ^c   Zhang, Xueli ^a  

^a Chinese Academy of Sciences   (China)

^b TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

Author keywords

Fermentation; Isoprenoid precursors; Miltiradiene; Saccharomyces cerevisiae; Tanshinones; Terpenoids

Indexed keywords

AUXOTROPHIC MARKERS; BIOACTIVE COMPONENTS; CARDIO-VASCULAR DISEASE; DIPHOSPHATES; FARNESYL DIPHOSPHATE; FED-BATCH FERMENTATION; FUSION GENES; GERANYLGERANYL DIPHOSPHATE; ISOPRENOIDS; KAURENE; MICROBIAL PRODUCTION; MILTIRADIENE; OVER-EXPRESSION; PLASMID STABILITY; REGULATORY FACTORS; SYNERGETIC EFFECT; SYNTHASES; SYNTHETIC PATHWAYS; TANSHINONES; TERPENOIDS; TRADITIONAL CHINESE MEDICINE; YEAST STRAIN;

FERMENTATION; GENE EXPRESSION; LIPIDS;

YEAST;

3 HYDROXYL 3 METHYLGLUTARYL COENZYME A REDUCTASE; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; GERANYLTRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; ISOPRENOID; MILTIRADIENE; SQUALENE; TANSHINONE; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; FED BATCH FERMENTATION; FUNGAL STRAIN; FUSION GENE; GENE; GENE EXPRESSION; METABOLIC ENGINEERING; NONHUMAN; PLASMID; PROTEIN EXPRESSION; SACCHAROMYCES CEREVISIAE; SULFOLOBUS ACIDOCALDARIUS;

CULTURE MEDIA; DITERPENES; METABOLIC ENGINEERING; METABOLIC NETWORKS AND PATHWAYS; PLASMIDS; POLYISOPRENYL PHOSPHATES; SACCHAROMYCES CEREVISIAE; SULFOLOBUS ACIDOCALDARIUS;

SACCHAROMYCES CEREVISIAE; SALVIA; SULFOLOBUS ACIDOCALDARIUS;

EID: 84866744325     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24547     Document Type: Article

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