Integrating an algal β-carotene hydroxylase gene into a designed carotenoid-biosynthesis pathway increases carotenoid production in yeast

Bioresource Technology

Volumn 184, Issue , 2015, Pages 2-8

  Chang, Jui Jen ^a,b   Thia, Caroline ^b   Lin, Hao Yeh ^b   Liu, Hsien Lin ^b   Ho, Feng Ju ^b   Wu, Jiunn Tzong ^b   Shih, Ming Che ^c   Li, Wen Hsiung ^b   Huang, Chieh Chen ^d  

^a CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b BIODIVERSITY RESEARCH CENTER   (Taiwan)

^c AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

Author keywords

Carotenoids; Green algae; Synthetic biology; Carotene hydroxylase

Indexed keywords

ALGAE; BIOCHEMISTRY; BIOSYNTHESIS; GENES; SYNTHETIC BIOLOGY; YEAST;

CAROTENOID BIOSYNTHESIS; CAROTENOID PRODUCTION; CAROTENOIDS; CHLAMYDOMONAS REINHARDTII; CHLORELLA ZOFINGIENSIS; GREEN ALGA; HAEMATOCOCCUS PLUVIALIS; HYDROXYLASES;

PIGMENTS;

BETA-CAROTENE HYDROXYLASE; CAROTENOID; MIXED FUNCTION OXIDASE;

BIOSYNTHESIS; ENZYMOLOGY; GENETIC ENGINEERING; GENETICS; GREEN ALGA; GROWTH, DEVELOPMENT AND AGING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; SACCHAROMYCES CEREVISIAE;

BIOSYNTHETIC PATHWAYS; CAROTENOIDS; CHLOROPHYTA; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GENETIC ENGINEERING; MIXED FUNCTION OXYGENASES; SACCHAROMYCES CEREVISIAE;

EID: 84939942575     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2014.11.097     Document Type: Article

References (29)

1. Aoi W., Naito Y., Sakuma K., Kuchide M., Tokuda H., Maoka T., Toyokuni S., Oka S., Yasuhara M., Yoshikawa T. Astaxanthin limits exercise-induced skeletal and cardiac muscle damage in mice. Antioxid. Redox Signal. 2003, 5:139-144.
2. Bartley G.E., Scolnik P.A. Plant carotenoids: pigments for photoprotection, visual attraction, and human health. Plant Cell 1995, 7:1027.
3. Chang J.J., Ho C.Y., Ho F.J., Tsai T.Y., Ke H.M., Wang C.H., Chen H.L., Shih M.C., Huang C.C., Li W.H. PGASO: a synthetic biology tool for engineering a cellulolytic yeast. Biotechnol. Biofuels 2012, 5:53.
4. Chang J.J., Ho F.J., Ho C.Y., Wu Y.C., Hou Y.H., Huang C.C., Shih M.C., Li W.H. Assembling a cellulase cocktail and a cellodextrin transporter into a yeast host for CBP ethanol production. Biotechnol. Biofuels 2013, 6:19-31.
5. Chang J.J., Ho C.Y., Mao C.T., Barham N., Huang Y.R., Ho F.J., Wu Y.C., Hou Y.H., Shih M.C., Li W.H., Huang C.C. A thermo-and toxin-tolerant kefir yeast for biorefinery and biofuel production. Appl. Energy 2014, 132:465-474.
6. de la Fuente J.L., Rodríguez-Sáiz M., Schleissner C., Díez B., Peiro E., Barredo J.L. High-titer production of astaxanthin by the semi-industrial fermentation of Xanthophyllomyces dendrorhous. J. Biotechnol. 2010, 148:144-146.
7. Dugo P., Herrero M., Giuffrida D., Ragonese C., Dugo G., Mondello L. Analysis of native carotenoid composition in orange juice using C30 columns in tandem. J. Sep. Sci. 2008, 31:2151-2160.
8. Gerjets T., Sandmann M., Zhu C., Sandmann G. Metabolic engineering of ketocarotenoid biosynthesis in leaves and flowers of tobacco species. Biotechnol. J. 2007, 2:1263-1269.
9. Gordon H.T., Bauernfeind J.C., Furia T.E. Carotenoids as food colorants. Crit. Rev. Food Sci. Nutr. 1982, 18:59-97.
10. Hussein G., Sankawa U., Goto H., Matsumoto K., Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J. Nat. Prod. 2006, 69:443-449.
11. Johnson E.A. Phaffia rhodozyma: colorful odyssey. Int. Microbiol. 2003, 6:169-174.
12. Kim J.H., Kang S.W., Kim S.W., Chang H.I. High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Biosci. Biotechnol. Biochem. 2005, 69:1743-1748.
13. Lemuth K., Steuer K., Albermann C. Engineering of a plasmid-free Escherichia coli strain for improved in vivo biosynthesis of astaxanthin. Microb. Cell Fact. 2011, 10:29.
14. Machlin L.J. Critical assessment of the epidemiological data concerning the impact of antioxidant nutrients on cancer and cardiovascular disease. Crit. Rev. Food Sci. Nutr. 1995, 35:41-50.
15. Mann V., Harker M., Pecker I., Hirschberg J. Metabolic engineering of astaxanthin production in tobacco flowers. Nat. Biotechnol. 2000, 18:888-892.
16. Miki W. Biological functions and activities of animal carotenoids. Pure Appl. Chem. 1991, 63:141-146.
17. Misawa N., Shimada H. Metabolic engineering for the production of carotenoids in non-carotenogenic bacteria and yeasts. J. Biotechnol. 1997, 59:169-181.
18. Miyawaki H., Takahashi J., Tsukahara H., Takehara I. Effects of astaxanthin on human blood rheology. J. Clin. Biochem. Nutr. 2008, 43:69-74.
19. Niklitschek M., Alcaíno J., Barahona S., Sepúlveda D., Lozano C., Carmona M., Marcoleta A., Martínez C., Lodato P., Baeza M., Cifuentes V. Genomic organization of the structural genes controlling the astaxanthin biosynthesis pathway of Xanthophyllomyces dendrorhous. Biol. Res. 2008, 41:93-108.
20. Nishizaki T., Tsuge K., Itaya M., Doi N., Yanagawa H. Metabolic engineering of carotenoid biosynthesis in Escherichia coli by ordered gene assembly in Bacillus subtilis. Appl. Environ. Microbiol. 2007, 73:1355-1361.
21. Palozza P., Krinsky N.I. Astaxanthin and canthaxanthin are potent antioxidants in a membrane model. Arch. Biochem. Biophys. 1992, 297:291-295.
22. Paniagua-Michel J., Olmos-Soto J., Ruiz M.A. Pathways of carotenoid biosynthesis in bacteria and microalgae. Methods Mol. Biol. 2012, 892:1-12.
23. Rodríguez-Sáiz M., de la Fuente J.L., Barredo J.L. Xanthophyllomyces dendrorhous for the industrial production of astaxanthin. Appl. Microbiol. Biotechnol. 2010, 88:645-658.
24. Sandmann G. Carotenoid biosynthesis in microorganisms and plants. Eur. J. Biochem. 1994, 223:7-24.
25. Türlerinde F.Ç.K.B.A., Klorofil-A B., Saptanmasi I.S. Spectrophotometric determination of chlorophyll-A, B and total carotenoid contents of some algae species using different solvents. Tr. J. Bot. 1998, 22:13-17.
26. Ukibe K., Hashida K., Yoshida N., Takagi H. Metabolic engineering of Saccharomyces cerevisiae for astaxanthin production and oxidative stress tolerance. Appl. Environ. Microbiol. 2009, 75:7205-7211.
27. Verwaal R., Wang J., Meijnen J.P., Visser H., Sandmann G., van den Berg J.A., van Ooyen A.J. High-level production of beta-carotene in Saccharomyces cerevisiae by successive transformation with carotenogenic genes from Xanthophyllomyces dendrorhous. Appl. Environ. Microbiol. 2007, 73:4342-4350.
28. Visser H., Ooyen A.J., Verdoes J.C. Metabolic engineering of the astaxanthin-biosynthetic pathway of Xanthophyllomyces dendrorhous. FEMS Yeast Res. 2003, 4:221-231.
29. Zhong Y.J., Huang J.C., Liu J., Li Y., Jiang Y., Xu Z.F., Sandmann G., Chen F. Functional characterization of various algal carotenoid ketolases reveals that ketolating zeaxanthin efficiently is essential for high production of astaxanthin in transgenic Arabidopsis. J. Exp. Bot. 2011, 62:3659-3669.