Isomerization and Oxidation in the Complementarity-Determining Regions of a Monoclonal Antibody: A Study of the Modification-Structure-Function Correlations by Hydrogen-Deuterium Exchange Mass Spectrometry

Analytical Chemistry

Volumn 88, Issue 4, 2016, Pages 2041-2050

  Yan, Yuetian ^a,b   Wei, Hui ^a   Fu, Ya ^a   Jusuf, Sutjano ^a   Zeng, Ming ^a   Ludwig, Richard ^a   Krystek, Stanley R ^a   Chen, Guodong ^a   Tao, Li ^a   Das, Tapan K ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BINS; CHEMICAL MODIFICATION; CONFORMATIONS; DEGRADATION; DEUTERIUM; ISOMERIZATION; ISOMERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OXIDATION; SPECTROMETRY;

BINDING AFFINITIES; COMPLEMENTARITY-DETERMINING REGIONS; CONFORMATIONAL CHANGE; DEGRADATION PATHWAYS; HYDROGEN-DEUTERIUM EXCHANGE; STRUCTURE-FUNCTION CORRELATION; THERAPEUTIC DRUGS; THERAPEUTIC MONOCLONAL ANTIBODIES;

ANTIBODIES;

ASPARTIC ACID; COMPLEMENTARITY DETERMINING REGION; DEUTERIUM; HYDROGEN; METHIONINE; MONOCLONAL ANTIBODY; RECOMBINANT PROTEIN;

ANIMAL; ANTIBODY AFFINITY; ANTIGEN ANTIBODY REACTION; BIOSYNTHESIS; CHEMISTRY; CHO CELL LINE; COMPLEMENTARITY DETERMINING REGION; CRICETULUS; DEUTERIUM HYDROGEN EXCHANGE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HAMSTER; ISOLATION AND PURIFICATION; ISOMERISM; KINETICS; MASS SPECTROMETRY; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY AFFINITY; ANTIGEN-ANTIBODY REACTIONS; ASPARTIC ACID; CHO CELLS; COMPLEMENTARITY DETERMINING REGIONS; CRICETINAE; CRICETULUS; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROGEN; ISOMERISM; KINETICS; MASS SPECTROMETRY; METHIONINE; OXIDATION-REDUCTION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 84958191421     PISSN: 00032700     EISSN: 15206882     Source Type: Journal    
DOI: 10.1021/acs.analchem.5b02800     Document Type: Article

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