Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies

Biochemistry

Volumn 46, Issue 6, 2007, Pages 1534-1544

  Wakankar, Aditya A ^a   Borchardt, Ronald T ^b   Eigenbrot, Charles ^a   Shia, Steven ^a   Wang, Y John ^a   Shire, Steve J ^a   Liu, Jun L ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; GLYCEROL; HYDROPHOBIC CHROMATOGRAPHY; ISOMERIZATION; PHARMACOKINETICS; X RAY CRYSTALLOGRAPHY;

ASPARTIC ACID; BINDING AFFINITY; HYDROPHOBIC INTERACTION CHROMATOGRAPHY (HIC); PHARMACOLOGICAL RESPONSES; STRUCTURAL CHARACTERIZATION;

MONOCLONAL ANTIBODIES;

AMIDE; ASPARTIC ACID; GLYCINE; IMMUNOGLOBULIN E; ISOASPARTIC ACID; MONOCLONAL ANTIBODY; PENTAPEPTIDE;

AMINO ACID SEQUENCE; ANTIBODY AFFINITY; ANTIBODY ENGINEERING; ANTIBODY RESPONSE; ANTIBODY STRUCTURE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATOGRAPHY; CIRCULAR DICHROISM; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; HUMAN; ISOMERIZATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ASPARTIC ACID; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; COMPLEMENTARITY DETERMINING REGIONS; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN-ION CONCENTRATION; ISOMERISM; PEPTIDE FRAGMENTS;

EID: 33846967443     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi061500t     Document Type: Article

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