PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

PLoS Biology

Volumn 14, Issue 2, 2016, Pages

  Jiang, Kai ^a   Liu, Yajuan ^a   Fan, Junkai ^a   Zhang, Jie ^a   Li, Xiang An ^a   Evers, B Mark ^a   Zhu, Haining ^a   Jia, Jianhang ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; ARGININE; G PROTEIN COUPLED RECEPTOR KINASE 2; PHOSPHATIDYLINOSITOL 4 PHOSPHATE; PLECKSTRIN; PROTEIN PATCHED; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SMOOTHENED PROTEIN; CELL SURFACE RECEPTOR; DROSOPHILA PROTEIN; G PROTEIN COUPLED RECEPTOR; GPRK2 PROTEIN, DROSOPHILA; HEDGEHOG PROTEIN, DROSOPHILA; PHOSPHATIDYLINOSITOL 4-PHOSPHATE; POLYPHOSPHOINOSITIDE; PTCH1 PROTEIN, MOUSE; SMOOTHENED PROTEIN, DROSOPHILA; SONIC HEDGEHOG PROTEIN;

ARTICLE; BIOACCUMULATION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVITY; LIPOGENESIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; 3T3 CELL LINE; ANIMAL; DROSOPHILA; EUKARYOTIC FLAGELLUM; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALS; CILIA; DROSOPHILA; DROSOPHILA PROTEINS; G-PROTEIN-COUPLED RECEPTOR KINASE 2; HEDGEHOG PROTEINS; MICE; NIH 3T3 CELLS; PATCHED RECEPTORS; PATCHED-1 RECEPTOR; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SMOOTHENED RECEPTOR;

EID: 84957556796     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002375     Document Type: Article

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