메뉴 건너뛰기




Volumn 27, Issue , 2016, Pages 81-92

Mechanisms of action of bone morphogenetic proteins in cancer

Author keywords

BMP; Cancer; EMT; Metastasis; TGF

Indexed keywords

BONE MORPHOGENETIC PROTEIN; CHORDIN; NOGGIN; SMAD PROTEIN; TUMOR PROTEIN;

EID: 84957426045     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2015.11.009     Document Type: Short Survey
Times cited : (84)

References (135)
  • 1
    • 21344434155 scopus 로고    scopus 로고
    • BMPs: from bone morphogenetic proteins to body morphogenetic proteins
    • Reddi A.H. BMPs: from bone morphogenetic proteins to body morphogenetic proteins. Cytokine Growth Factor Rev. 2005, 16:249-250.
    • (2005) Cytokine Growth Factor Rev. , vol.16 , pp. 249-250
    • Reddi, A.H.1
  • 2
    • 84879426981 scopus 로고    scopus 로고
    • Bi-directional roles of bone morphogenetic proteins in cancer: another molecular Jekyll and Hyde?
    • Ehata S., Yokoyama Y., Takahashi K., Miyazono K. Bi-directional roles of bone morphogenetic proteins in cancer: another molecular Jekyll and Hyde?. Pathol. Int. 2013, 63:287-296.
    • (2013) Pathol. Int. , vol.63 , pp. 287-296
    • Ehata, S.1    Yokoyama, Y.2    Takahashi, K.3    Miyazono, K.4
  • 4
    • 84906873948 scopus 로고    scopus 로고
    • The DAN family: modulators of TGF-beta signaling and beyond
    • Nolan K., Thompson T.B. The DAN family: modulators of TGF-beta signaling and beyond. Protein Sci. 2014, 23:999-1012.
    • (2014) Protein Sci. , vol.23 , pp. 999-1012
    • Nolan, K.1    Thompson, T.B.2
  • 5
    • 84924244580 scopus 로고    scopus 로고
    • Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche
    • Davis H., Irshad S., Bansal M., et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat. Med. 2015, 21:62-70.
    • (2015) Nat. Med. , vol.21 , pp. 62-70
    • Davis, H.1    Irshad, S.2    Bansal, M.3
  • 6
    • 79960841386 scopus 로고    scopus 로고
    • A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD)
    • Potti T.A., Petty E.M., Lesperance M.M. A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD). Hum. Mutat. 2011, 32:877-886.
    • (2011) Hum. Mutat. , vol.32 , pp. 877-886
    • Potti, T.A.1    Petty, E.M.2    Lesperance, M.M.3
  • 7
    • 84866985855 scopus 로고    scopus 로고
    • Targeting the TGF beta signalling pathway in disease
    • Akhurst R.J., Hata A. Targeting the TGF beta signalling pathway in disease. Nat. Rev. Drug Discov. 2012, 11:790-811.
    • (2012) Nat. Rev. Drug Discov. , vol.11 , pp. 790-811
    • Akhurst, R.J.1    Hata, A.2
  • 8
    • 84876817355 scopus 로고    scopus 로고
    • Beyond TGFb: roles of other TGFb superfamily members in cancer
    • Wakefield L.M., Hill C.S. Beyond TGFb: roles of other TGFb superfamily members in cancer. Nat. Rev. Cancer 2013, 13:328-341.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 328-341
    • Wakefield, L.M.1    Hill, C.S.2
  • 9
    • 0030716244 scopus 로고    scopus 로고
    • Growth regulation of human prostate cancer cells by bone morphogenetic protein-2
    • Ide H., Yoshida T., Matsumoto N., et al. Growth regulation of human prostate cancer cells by bone morphogenetic protein-2. Cancer Res. 1997, 57:5022-5027.
    • (1997) Cancer Res. , vol.57 , pp. 5022-5027
    • Ide, H.1    Yoshida, T.2    Matsumoto, N.3
  • 10
    • 11244256523 scopus 로고    scopus 로고
    • BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells
    • Miyazaki H., Watabe T., Kitamura T., Miyazono K. BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells. Oncogene 2004, 23:9326-9335.
    • (2004) Oncogene , vol.23 , pp. 9326-9335
    • Miyazaki, H.1    Watabe, T.2    Kitamura, T.3    Miyazono, K.4
  • 11
    • 0034698099 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells
    • Ghosh-Choudhury N., Ghosh-Choudhury G., Celeste A., et al. Bone morphogenetic protein-2 induces cyclin kinase inhibitor p21 and hypophosphorylation of retinoblastoma protein in estradiol-treated MCF-7 human breast cancer cells. Biochim. Biophys. Acta 2000, 1497:186-196.
    • (2000) Biochim. Biophys. Acta , vol.1497 , pp. 186-196
    • Ghosh-Choudhury, N.1    Ghosh-Choudhury, G.2    Celeste, A.3
  • 12
    • 0036148661 scopus 로고    scopus 로고
    • WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells
    • WAF1,Cip1 during bone morphogenetic protein-induced growth arrest in human breast cancer cells. J. Endocrinol. 2002, 172:187-198.
    • (2002) J. Endocrinol. , vol.172 , pp. 187-198
    • Pouliot, F.1    Labrie, C.2
  • 14
    • 33846559431 scopus 로고    scopus 로고
    • Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1
    • Qiu T., Grizzle W.E., Oelschlager D.K., Shen X., Cao X. Control of prostate cell growth: BMP antagonizes androgen mitogenic activity with incorporation of MAPK signals in Smad1. EMBO J. 2007, 26:346-357.
    • (2007) EMBO J. , vol.26 , pp. 346-357
    • Qiu, T.1    Grizzle, W.E.2    Oelschlager, D.K.3    Shen, X.4    Cao, X.5
  • 15
    • 42549158413 scopus 로고    scopus 로고
    • Bone morphogenetic protein-9 is a circulating vascular quiescence factor
    • David L., Mallet C., Keramidas M., et al. Bone morphogenetic protein-9 is a circulating vascular quiescence factor. Circ. Res. 2008, 102:914-922.
    • (2008) Circ. Res. , vol.102 , pp. 914-922
    • David, L.1    Mallet, C.2    Keramidas, M.3
  • 16
    • 34247331476 scopus 로고    scopus 로고
    • BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis
    • Scharpfenecker M., van Dinther M., Liu Z., et al. BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J. Cell Sci. 2007, 120:964-972.
    • (2007) J. Cell Sci. , vol.120 , pp. 964-972
    • Scharpfenecker, M.1    van Dinther, M.2    Liu, Z.3
  • 17
    • 39049131134 scopus 로고    scopus 로고
    • BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling
    • Suzuki Y., Montagne K., Nishihara A., Watabe T., Miyazono K. BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling. J. Biochem. 2008, 143:199-206.
    • (2008) J. Biochem. , vol.143 , pp. 199-206
    • Suzuki, Y.1    Montagne, K.2    Nishihara, A.3    Watabe, T.4    Miyazono, K.5
  • 18
    • 77952343641 scopus 로고    scopus 로고
    • BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo
    • Suzuki Y., Ohga N., Morishita Y., Hida K., Miyazono K., Watabe T. BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo. J. Cell Sci. 2010, 123:1684-1692.
    • (2010) J. Cell Sci. , vol.123 , pp. 1684-1692
    • Suzuki, Y.1    Ohga, N.2    Morishita, Y.3    Hida, K.4    Miyazono, K.5    Watabe, T.6
  • 19
    • 84905989190 scopus 로고    scopus 로고
    • The balance of cell surface and soluble type III TGF-beta receptor regulates BMP signaling in normal and cancerous mammary epithelial cells
    • Gatza C.E., Elderbroom J.L., Oh S.Y., Starr M.D., Nixon A.B., Blobe G.C. The balance of cell surface and soluble type III TGF-beta receptor regulates BMP signaling in normal and cancerous mammary epithelial cells. Neoplasia 2014, 16:489-500.
    • (2014) Neoplasia , vol.16 , pp. 489-500
    • Gatza, C.E.1    Elderbroom, J.L.2    Oh, S.Y.3    Starr, M.D.4    Nixon, A.B.5    Blobe, G.C.6
  • 20
    • 84899442370 scopus 로고    scopus 로고
    • Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development
    • Holtzhausen A., Golzio C., How T., et al. Novel bone morphogenetic protein signaling through Smad2 and Smad3 to regulate cancer progression and development. FASEB J. 2014, 28:1248-1267.
    • (2014) FASEB J. , vol.28 , pp. 1248-1267
    • Holtzhausen, A.1    Golzio, C.2    How, T.3
  • 21
    • 0344845415 scopus 로고    scopus 로고
    • BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
    • Ying Q.L., Nichols J., Chambers I., Smith A. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003, 115:281-292.
    • (2003) Cell , vol.115 , pp. 281-292
    • Ying, Q.L.1    Nichols, J.2    Chambers, I.3    Smith, A.4
  • 22
    • 18744375483 scopus 로고    scopus 로고
    • And suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
    • Xu R.H., Peck R.M., Li D.S., Feng X., Ludwig T., Thomson J.A., Basic F.G.F. and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2005, 2:185-190.
    • (2005) Nat. Methods , vol.2 , pp. 185-190
    • Xu, R.H.1    Peck, R.M.2    Li, D.S.3    Feng, X.4    Ludwig, T.5    Thomson, J.A.6    Basic, F.G.F.7
  • 23
    • 84863012550 scopus 로고    scopus 로고
    • BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells
    • Li Z., Fei T., Zhang J., et al. BMP4 Signaling Acts via dual-specificity phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell. Stem Cell 2012, 10:171-182.
    • (2012) Cell. Stem Cell , vol.10 , pp. 171-182
    • Li, Z.1    Fei, T.2    Zhang, J.3
  • 24
    • 79952196280 scopus 로고    scopus 로고
    • Intrinsic transition of embryonic stem-cell differentiation into neural progenitors
    • Kamiya D., Banno S., Sasai N., et al. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature 2011, 470:503-509.
    • (2011) Nature , vol.470 , pp. 503-509
    • Kamiya, D.1    Banno, S.2    Sasai, N.3
  • 25
    • 84859539293 scopus 로고    scopus 로고
    • Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
    • Wang Z., Oron E., Nelson B., Razis S., Ivanova N. Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Cell. Stem Cell 2012, 10:440-454.
    • (2012) Cell. Stem Cell , vol.10 , pp. 440-454
    • Wang, Z.1    Oron, E.2    Nelson, B.3    Razis, S.4    Ivanova, N.5
  • 26
    • 84874492437 scopus 로고    scopus 로고
    • Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells
    • Li Q., Gu X., Weng H., et al. Bone morphogenetic protein-9 induces epithelial to mesenchymal transition in hepatocellular carcinoma cells. Cancer Sci. 2013, 104:398-408.
    • (2013) Cancer Sci. , vol.104 , pp. 398-408
    • Li, Q.1    Gu, X.2    Weng, H.3
  • 27
    • 0037947830 scopus 로고    scopus 로고
    • Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells
    • Mizuseki K., Sakamoto T., Watanabe K., et al. Generation of neural crest-derived peripheral neurons and floor plate cells from mouse and primate embryonic stem cells. Proc. Natl. Acad. Sci. U. S. A. 2003, 100:5828-5833.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 5828-5833
    • Mizuseki, K.1    Sakamoto, T.2    Watanabe, K.3
  • 28
    • 84938210397 scopus 로고    scopus 로고
    • A synthetic niche for nephron progenitor cells
    • Brown A.C., Muthukrishnan S.D., Oxburgh L. A synthetic niche for nephron progenitor cells. Dev. Cell 2015, 34:229-241.
    • (2015) Dev. Cell , vol.34 , pp. 229-241
    • Brown, A.C.1    Muthukrishnan, S.D.2    Oxburgh, L.3
  • 29
    • 84892149549 scopus 로고    scopus 로고
    • Efficient generation of lung and airway epithelial cells from human pluripotent stem cells
    • Huang S.X., Islam M.N., O'Neill J., et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells. Nat. Biotechnol. 2014, 32:84-91.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 84-91
    • Huang, S.X.1    Islam, M.N.2    O'Neill, J.3
  • 30
    • 84926356306 scopus 로고    scopus 로고
    • Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells
    • Iyer D., Gambardella L., Bernard W.G., et al. Robust derivation of epicardium and its differentiated smooth muscle cell progeny from human pluripotent stem cells. Development 2015, 142:1528-1541.
    • (2015) Development , vol.142 , pp. 1528-1541
    • Iyer, D.1    Gambardella, L.2    Bernard, W.G.3
  • 31
    • 34249036783 scopus 로고    scopus 로고
    • A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7
    • Alarmo E.L., Kuukasjarvi T., Karhu R., Kallioniemi A. A comprehensive expression survey of bone morphogenetic proteins in breast cancer highlights the importance of BMP4 and BMP7. Breast Cancer Res. Treat. 2007, 103:239-246.
    • (2007) Breast Cancer Res. Treat. , vol.103 , pp. 239-246
    • Alarmo, E.L.1    Kuukasjarvi, T.2    Karhu, R.3    Kallioniemi, A.4
  • 32
    • 82055175800 scopus 로고    scopus 로고
    • Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes
    • Rodriguez-Martinez A., Alarmo E.L., Saarinen L., et al. Analysis of BMP4 and BMP7 signaling in breast cancer cells unveils time-dependent transcription patterns and highlights a common synexpression group of genes. BMC Med. Genom. 2011, 4:80.
    • (2011) BMC Med. Genom. , vol.4 , pp. 80
    • Rodriguez-Martinez, A.1    Alarmo, E.L.2    Saarinen, L.3
  • 33
    • 21344473027 scopus 로고    scopus 로고
    • First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer
    • Helms M.W., Packeisen J., August C., et al. First evidence supporting a potential role for the BMP/SMAD pathway in the progression of oestrogen receptor-positive breast cancer. J. Pathol. 2005, 206:366-376.
    • (2005) J. Pathol. , vol.206 , pp. 366-376
    • Helms, M.W.1    Packeisen, J.2    August, C.3
  • 34
    • 84941247995 scopus 로고    scopus 로고
    • Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis
    • Pickup M.W., Hover L.D., Guo Y., et al. Deletion of the BMP receptor BMPR1a impairs mammary tumor formation and metastasis. Oncotarget 2015.
    • (2015) Oncotarget
    • Pickup, M.W.1    Hover, L.D.2    Guo, Y.3
  • 35
    • 0342657717 scopus 로고    scopus 로고
    • Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues
    • Kim I.Y., Lee D.H., Ahn H.J., et al. Expression of bone morphogenetic protein receptors type-IA, -IB and -II correlates with tumor grade in human prostate cancer tissues. Cancer Res. 2000, 60:2840-2844.
    • (2000) Cancer Res. , vol.60 , pp. 2840-2844
    • Kim, I.Y.1    Lee, D.H.2    Ahn, H.J.3
  • 36
    • 21344467705 scopus 로고    scopus 로고
    • Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells
    • Yang S., Zhong C., Frenkel B., Reddi A.H., Roy-Burman P. Diverse biological effect and Smad signaling of bone morphogenetic protein 7 in prostate tumor cells. Cancer Res. 2005, 65:5769-5777.
    • (2005) Cancer Res. , vol.65 , pp. 5769-5777
    • Yang, S.1    Zhong, C.2    Frenkel, B.3    Reddi, A.H.4    Roy-Burman, P.5
  • 37
    • 39149132827 scopus 로고    scopus 로고
    • A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer
    • Yang S., Pham L.K., Liao C.P., Frenkel B., Reddi A.H., Roy-Burman P. A novel bone morphogenetic protein signaling in heterotypic cell interactions in prostate cancer. Cancer Res. 2008, 68:198-205.
    • (2008) Cancer Res. , vol.68 , pp. 198-205
    • Yang, S.1    Pham, L.K.2    Liao, C.P.3    Frenkel, B.4    Reddi, A.H.5    Roy-Burman, P.6
  • 38
    • 84862012341 scopus 로고    scopus 로고
    • Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals
    • Nishimori H., Ehata S., Suzuki H.I., Katsuno Y., Miyazono K. Prostate cancer cells and bone stromal cells mutually interact with each other through bone morphogenetic protein-mediated signals. J. Biol. Chem. 2012, 287:20037-20046.
    • (2012) J. Biol. Chem. , vol.287 , pp. 20037-20046
    • Nishimori, H.1    Ehata, S.2    Suzuki, H.I.3    Katsuno, Y.4    Miyazono, K.5
  • 39
    • 31544464054 scopus 로고    scopus 로고
    • Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions
    • Feeley B.T., Krenek L., Liu N., et al. Overexpression of noggin inhibits BMP-mediated growth of osteolytic prostate cancer lesions. Bone 2006, 38:154-166.
    • (2006) Bone , vol.38 , pp. 154-166
    • Feeley, B.T.1    Krenek, L.2    Liu, N.3
  • 40
    • 79960834796 scopus 로고    scopus 로고
    • Bone morphogenetic protein -4 and -5 in pancreatic cancer-novel bidirectional players
    • Virtanen S., Alarmo E.L., Sandstrom S., Ampuja M., Kallioniemi A. Bone morphogenetic protein -4 and -5 in pancreatic cancer-novel bidirectional players. Exp. Cell Res. 2011, 317:2136-2146.
    • (2011) Exp. Cell Res. , vol.317 , pp. 2136-2146
    • Virtanen, S.1    Alarmo, E.L.2    Sandstrom, S.3    Ampuja, M.4    Kallioniemi, A.5
  • 41
    • 84885186411 scopus 로고    scopus 로고
    • Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis
    • Voorneveld P.W., Stache V., Jacobs R.J., et al. Reduced expression of bone morphogenetic protein receptor IA in pancreatic cancer is associated with a poor prognosis. Br. J. Cancer 2013, 109:1805-1812.
    • (2013) Br. J. Cancer , vol.109 , pp. 1805-1812
    • Voorneveld, P.W.1    Stache, V.2    Jacobs, R.J.3
  • 42
    • 84865133667 scopus 로고    scopus 로고
    • BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma
    • Zhang L., Sun H., Zhao F., et al. BMP4 administration induces differentiation of CD133+ hepatic cancer stem cells, blocking their contributions to hepatocellular carcinoma. Cancer Res. 2012, 72:4276-4285.
    • (2012) Cancer Res. , vol.72 , pp. 4276-4285
    • Zhang, L.1    Sun, H.2    Zhao, F.3
  • 43
    • 84921451313 scopus 로고    scopus 로고
    • Regulatory MiR-148a-ACVR1/BMP circuit defines a cancer stem cell-like aggressive subtype of hepatocellular carcinoma
    • Li L., Liu Y., Guo Y., et al. Regulatory MiR-148a-ACVR1/BMP circuit defines a cancer stem cell-like aggressive subtype of hepatocellular carcinoma. Hepatology 2015, 61:574-584.
    • (2015) Hepatology , vol.61 , pp. 574-584
    • Li, L.1    Liu, Y.2    Guo, Y.3
  • 44
    • 84880731862 scopus 로고    scopus 로고
    • BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells
    • Herrera B., Garcia-Alvaro M., Cruz S., et al. BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells. PLoS One 2013, 8:e69535.
    • (2013) PLoS One , vol.8 , pp. e69535
    • Herrera, B.1    Garcia-Alvaro, M.2    Cruz, S.3
  • 45
    • 73649125019 scopus 로고    scopus 로고
    • Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation
    • Herrera B., van D., inther M., Ten D., ijke P., Inman G.J. Autocrine bone morphogenetic protein-9 signals through activin receptor-like kinase-2/Smad1/Smad4 to promote ovarian cancer cell proliferation. Cancer Res. 2009, 69:9254-9262.
    • (2009) Cancer Res. , vol.69 , pp. 9254-9262
    • Herrera, B.1    van, D.2    Inther, M.3    Ten, D.4    Ijke, P.5    Inman, G.J.6
  • 46
    • 84969400983 scopus 로고    scopus 로고
    • SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma
    • Hernanda P.Y., Chen K., Das A.M., et al. SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma. Oncogene 2014.
    • (2014) Oncogene
    • Hernanda, P.Y.1    Chen, K.2    Das, A.M.3
  • 47
    • 33646362788 scopus 로고    scopus 로고
    • Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas
    • Wen X.Z., Akiyama Y., Baylin S.B., Yuasa Y. Frequent epigenetic silencing of the bone morphogenetic protein 2 gene through methylation in gastric carcinomas. Oncogene 2006, 25:2666-2673.
    • (2006) Oncogene , vol.25 , pp. 2666-2673
    • Wen, X.Z.1    Akiyama, Y.2    Baylin, S.B.3    Yuasa, Y.4
  • 48
    • 34548580322 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice
    • Bleuming S.A., He X.C., Kodach L.L., et al. Bone morphogenetic protein signaling suppresses tumorigenesis at gastric epithelial transition zones in mice. Cancer Res. 2007, 67:8149-8155.
    • (2007) Cancer Res. , vol.67 , pp. 8149-8155
    • Bleuming, S.A.1    He, X.C.2    Kodach, L.L.3
  • 49
    • 81255124262 scopus 로고    scopus 로고
    • Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma
    • Shirai Y.T., Ehata S., Yashiro M., Yanagihara K., Hirakawa K., Miyazono K. Bone morphogenetic protein-2 and -4 play tumor suppressive roles in human diffuse-type gastric carcinoma. Am. J. Pathol. 2011, 179:2920-2930.
    • (2011) Am. J. Pathol. , vol.179 , pp. 2920-2930
    • Shirai, Y.T.1    Ehata, S.2    Yashiro, M.3    Yanagihara, K.4    Hirakawa, K.5    Miyazono, K.6
  • 50
    • 39749092525 scopus 로고    scopus 로고
    • Current view: intestinal stem cells and signaling
    • Scoville D.H., Sato T., He X.C., Li L. Current view: intestinal stem cells and signaling. Gastroenterology 2008, 134:849-864.
    • (2008) Gastroenterology , vol.134 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 51
    • 34848868159 scopus 로고    scopus 로고
    • Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors
    • Kosinski C., Li V.S., Chan A.S., et al. Gene expression patterns of human colon tops and basal crypts and BMP antagonists as intestinal stem cell niche factors. Proc. Natl. Acad. Sci. U. S. A. 2007, 104:15418-15423.
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 15418-15423
    • Kosinski, C.1    Li, V.S.2    Chan, A.S.3
  • 53
    • 84861584357 scopus 로고    scopus 로고
    • Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1
    • Jaeger E., Leedham S., Lewis A., et al. Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1. Nat. Genet. 2012, 44:699-703.
    • (2012) Nat. Genet. , vol.44 , pp. 699-703
    • Jaeger, E.1    Leedham, S.2    Lewis, A.3
  • 54
    • 79959851441 scopus 로고    scopus 로고
    • Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer
    • Tomlinson I.P., Carvajal-Carmona L.G., Dobbins S.E., et al. Multiple common susceptibility variants near BMP pathway loci GREM1, BMP4, and BMP2 explain part of the missing heritability of colorectal cancer. PLoS Genet. 2011, 7:e1002105.
    • (2011) PLoS Genet. , vol.7 , pp. e1002105
    • Tomlinson, I.P.1    Carvajal-Carmona, L.G.2    Dobbins, S.E.3
  • 55
    • 38049029612 scopus 로고    scopus 로고
    • The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer
    • Kodach L.L., Bleuming S.A., Musler A.R., et al. The bone morphogenetic protein pathway is active in human colon adenomas and inactivated in colorectal cancer. Cancer 2008, 112:300-306.
    • (2008) Cancer , vol.112 , pp. 300-306
    • Kodach, L.L.1    Bleuming, S.A.2    Musler, A.R.3
  • 56
    • 42949160593 scopus 로고    scopus 로고
    • The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers
    • Kodach L.L., Wiercinska E., de Miranda N.F., et al. The bone morphogenetic protein pathway is inactivated in the majority of sporadic colorectal cancers. Gastroenterology 2008, 134:1332-1341.e3.
    • (2008) Gastroenterology , vol.134 , pp. 1332-1341.e3
    • Kodach, L.L.1    Wiercinska, E.2    de Miranda, N.F.3
  • 57
    • 6944224156 scopus 로고    scopus 로고
    • BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling
    • He X.C., Zhang J., Tong W.G., et al. BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat. Genet. 2004, 36:1117-1121.
    • (2004) Nat. Genet. , vol.36 , pp. 1117-1121
    • He, X.C.1    Zhang, J.2    Tong, W.G.3
  • 58
    • 80053557393 scopus 로고    scopus 로고
    • Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway
    • Kodach L.L., Jacobs R.J., Voorneveld P.W., et al. Statins augment the chemosensitivity of colorectal cancer cells inducing epigenetic reprogramming and reducing colorectal cancer cell 'stemness' via the bone morphogenetic protein pathway. Gut 2011, 60:1544-1553.
    • (2011) Gut , vol.60 , pp. 1544-1553
    • Kodach, L.L.1    Jacobs, R.J.2    Voorneveld, P.W.3
  • 59
    • 78650448449 scopus 로고    scopus 로고
    • Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice
    • Lombardo Y., Scopelliti A., Cammareri P., et al. Bone morphogenetic protein 4 induces differentiation of colorectal cancer stem cells and increases their response to chemotherapy in mice. Gastroenterology 2011, 140:297-309.e6.
    • (2011) Gastroenterology , vol.140 , pp. 297-309.e6
    • Lombardo, Y.1    Scopelliti, A.2    Cammareri, P.3
  • 60
    • 33847017335 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells
    • Deng H., Makizumi R., Ravikumar T.S., Dong H., Yang W., Yang W.L. Bone morphogenetic protein-4 is overexpressed in colonic adenocarcinomas and promotes migration and invasion of HCT116 cells. Exp. Cell Res. 2007, 313:1033-1044.
    • (2007) Exp. Cell Res. , vol.313 , pp. 1033-1044
    • Deng, H.1    Makizumi, R.2    Ravikumar, T.S.3    Dong, H.4    Yang, W.5    Yang, W.L.6
  • 61
    • 70349329766 scopus 로고    scopus 로고
    • Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion
    • Kang M.H., Kang H.N., Kim J.L., Kim J.S., Oh S.C., Yoo Y.A. Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion. Oncol. Rep. 2009, 22:525-534.
    • (2009) Oncol. Rep. , vol.22 , pp. 525-534
    • Kang, M.H.1    Kang, H.N.2    Kim, J.L.3    Kim, J.S.4    Oh, S.C.5    Yoo, Y.A.6
  • 62
    • 84952873854 scopus 로고    scopus 로고
    • BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation
    • Kim B.R., Oh S.C., Lee D.H., et al. BMP-2 induces motility and invasiveness by promoting colon cancer stemness through STAT3 activation. Tumour Biol. 2015.
    • (2015) Tumour Biol.
    • Kim, B.R.1    Oh, S.C.2    Lee, D.H.3
  • 64
    • 84920675634 scopus 로고    scopus 로고
    • The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC
    • Voorneveld P.W., Kodach L.L., Jacobs R.J., et al. The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. Br. J. Cancer 2015, 112:122-130.
    • (2015) Br. J. Cancer , vol.112 , pp. 122-130
    • Voorneveld, P.W.1    Kodach, L.L.2    Jacobs, R.J.3
  • 65
    • 84940185193 scopus 로고    scopus 로고
    • Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth
    • Shi Y., Chen G.B., Huang X.X., et al. Dragon (repulsive guidance molecule b, RGMb) is a novel gene that promotes colorectal cancer growth. Oncotarget 2015.
    • (2015) Oncotarget
    • Shi, Y.1    Chen, G.B.2    Huang, X.X.3
  • 66
    • 84903787162 scopus 로고    scopus 로고
    • The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
    • Whissell G., Montagni E., Martinelli P., et al. The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression. Nat. Cell Biol. 2014, 16:695-707.
    • (2014) Nat. Cell Biol. , vol.16 , pp. 695-707
    • Whissell, G.1    Montagni, E.2    Martinelli, P.3
  • 67
    • 39749112553 scopus 로고    scopus 로고
    • BMP suppresses PTEN expression via RAS/ERK signaling
    • Beck S.E., Carethers J.M. BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol. Ther. 2007, 6:1313-1317.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 1313-1317
    • Beck, S.E.1    Carethers, J.M.2
  • 68
    • 0032524069 scopus 로고    scopus 로고
    • Mutations in the SMAD4/DPC4 gene in juvenile polyposis
    • Howe J.R., Roth S., Ringold J.C., et al. Mutations in the SMAD4/DPC4 gene in juvenile polyposis. Science 1998, 280:1086-1088.
    • (1998) Science , vol.280 , pp. 1086-1088
    • Howe, J.R.1    Roth, S.2    Ringold, J.C.3
  • 69
    • 3142746721 scopus 로고    scopus 로고
    • The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations
    • Howe J.R., Sayed M.G., Ahmed A.F., et al. The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations. J. Med. Genet. 2004, 41:484-491.
    • (2004) J. Med. Genet. , vol.41 , pp. 484-491
    • Howe, J.R.1    Sayed, M.G.2    Ahmed, A.F.3
  • 70
    • 33646894742 scopus 로고    scopus 로고
    • Bmp signaling is required for intestinal growth and morphogenesis
    • Batts L.E., Polk D.B., Dubois R.N., Kulessa H. Bmp signaling is required for intestinal growth and morphogenesis. Dev. Dyn. 2006, 235:1563-1570.
    • (2006) Dev. Dyn. , vol.235 , pp. 1563-1570
    • Batts, L.E.1    Polk, D.B.2    Dubois, R.N.3    Kulessa, H.4
  • 71
    • 1542618115 scopus 로고    scopus 로고
    • De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine
    • Haramis A.P., Begthel H., van den Born M., et al. De novo crypt formation and juvenile polyposis on BMP inhibition in mouse intestine. Science 2004, 303:1684-1686.
    • (2004) Science , vol.303 , pp. 1684-1686
    • Haramis, A.P.1    Begthel, H.2    Van den Born, M.3
  • 72
    • 39149088615 scopus 로고    scopus 로고
    • Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    • Beppu H., Mwizerwa O.N., Beppu Y., et al. Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene 2008, 27:1063-1070.
    • (2008) Oncogene , vol.27 , pp. 1063-1070
    • Beppu, H.1    Mwizerwa, O.N.2    Beppu, Y.3
  • 74
    • 0034106184 scopus 로고    scopus 로고
    • Gastro-intestinal tumorigenesis in Smad4 mutant mice
    • Taketo M.M., Takaku K. Gastro-intestinal tumorigenesis in Smad4 mutant mice. Cytokine Growth Factor Rev. 2000, 11:147-157.
    • (2000) Cytokine Growth Factor Rev. , vol.11 , pp. 147-157
    • Taketo, M.M.1    Takaku, K.2
  • 75
    • 0035935996 scopus 로고    scopus 로고
    • Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members
    • Wach S., Schirmacher P., Protschka M., Blessing M. Overexpression of bone morphogenetic protein-6 (BMP-6) in murine epidermis suppresses skin tumor formation by induction of apoptosis and downregulation of fos/jun family members. Oncogene 2001, 20:7761-7769.
    • (2001) Oncogene , vol.20 , pp. 7761-7769
    • Wach, S.1    Schirmacher, P.2    Protschka, M.3    Blessing, M.4
  • 76
    • 12544259720 scopus 로고    scopus 로고
    • Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration
    • Rothhammer T., Poser I., Soncin F., Bataille F., Moser M., Bosserhoff A.K. Bone morphogenic proteins are overexpressed in malignant melanoma and promote cell invasion and migration. Cancer Res. 2005, 65:448-456.
    • (2005) Cancer Res. , vol.65 , pp. 448-456
    • Rothhammer, T.1    Poser, I.2    Soncin, F.3    Bataille, F.4    Moser, M.5    Bosserhoff, A.K.6
  • 77
    • 33749528535 scopus 로고    scopus 로고
    • Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation
    • Sneddon J.B., Zhen H.H., Montgomery K., et al. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:14842-14847.
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 14842-14847
    • Sneddon, J.B.1    Zhen, H.H.2    Montgomery, K.3
  • 78
    • 84929413484 scopus 로고    scopus 로고
    • Genomic Analysis of the BMP Family in Glioblastomas
    • Hover L.D., Abel T.W., Owens P. Genomic Analysis of the BMP Family in Glioblastomas. Transl. Oncogenomics 2015, 7:1-9.
    • (2015) Transl. Oncogenomics , vol.7 , pp. 1-9
    • Hover, L.D.1    Abel, T.W.2    Owens, P.3
  • 79
    • 84899570180 scopus 로고    scopus 로고
    • Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations
    • Buczkowicz P., Hoeman C., Rakopoulos P., et al. Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations. Nat. Genet. 2014, 46:451-456.
    • (2014) Nat. Genet. , vol.46 , pp. 451-456
    • Buczkowicz, P.1    Hoeman, C.2    Rakopoulos, P.3
  • 80
    • 84899539535 scopus 로고    scopus 로고
    • Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma
    • Fontebasso A.M., Papillon-Cavanagh S., Schwartzentruber J., et al. Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma. Nat. Genet. 2014, 46:462-466.
    • (2014) Nat. Genet. , vol.46 , pp. 462-466
    • Fontebasso, A.M.1    Papillon-Cavanagh, S.2    Schwartzentruber, J.3
  • 81
    • 84899559895 scopus 로고    scopus 로고
    • Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
    • Taylor K.R., Mackay A., Truffaux N., et al. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma. Nat. Genet. 2014, 46:457-461.
    • (2014) Nat. Genet. , vol.46 , pp. 457-461
    • Taylor, K.R.1    Mackay, A.2    Truffaux, N.3
  • 82
    • 84899526966 scopus 로고    scopus 로고
    • The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma
    • Wu G., Diaz A.K., Paugh B.S., et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat. Genet. 2014, 46:444-450.
    • (2014) Nat. Genet. , vol.46 , pp. 444-450
    • Wu, G.1    Diaz, A.K.2    Paugh, B.S.3
  • 83
    • 34547122001 scopus 로고    scopus 로고
    • The 2007 WHO classification of tumours of the central nervous system
    • Louis D.N., Ohgaki H., Wiestler O.D., et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol. 2007, 114:97-109.
    • (2007) Acta Neuropathol. , vol.114 , pp. 97-109
    • Louis, D.N.1    Ohgaki, H.2    Wiestler, O.D.3
  • 84
    • 9244241576 scopus 로고    scopus 로고
    • Identification of human brain tumour initiating cells
    • Singh S.K., Hawkins C., Clarke I.D., et al. Identification of human brain tumour initiating cells. Nature 2004, 432:396-401.
    • (2004) Nature , vol.432 , pp. 396-401
    • Singh, S.K.1    Hawkins, C.2    Clarke, I.D.3
  • 85
    • 60849117508 scopus 로고    scopus 로고
    • PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells
    • Bleau A.M., Hambardzumyan D., Ozawa T., et al. PTEN/PI3K/Akt pathway regulates the side population phenotype and ABCG2 activity in glioma tumor stem-like cells. Cell. Stem Cell 2009, 4:226-235.
    • (2009) Cell. Stem Cell , vol.4 , pp. 226-235
    • Bleau, A.M.1    Hambardzumyan, D.2    Ozawa, T.3
  • 86
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno S., Chen J., Kwon C.H., et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 2009, 15:45-56.
    • (2009) Cancer Cell. , vol.15 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3
  • 87
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • Chen J., Li Y., Yu T.S., et al. A restricted cell population propagates glioblastoma growth after chemotherapy. Nature 2012, 488:522-526.
    • (2012) Nature , vol.488 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3
  • 88
    • 0034020459 scopus 로고    scopus 로고
    • Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice
    • Holland E.C., Celestino J., Dai C., Schaefer L., Sawaya R.E., Fuller G.N. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 2000, 25:55-57.
    • (2000) Nat. Genet. , vol.25 , pp. 55-57
    • Holland, E.C.1    Celestino, J.2    Dai, C.3    Schaefer, L.4    Sawaya, R.E.5    Fuller, G.N.6
  • 90
    • 33845610993 scopus 로고    scopus 로고
    • Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells
    • Piccirillo S.G., Reynolds B.A., Zanetti N., et al. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006, 444:761-765.
    • (2006) Nature , vol.444 , pp. 761-765
    • Piccirillo, S.G.1    Reynolds, B.A.2    Zanetti, N.3
  • 91
    • 84866116474 scopus 로고    scopus 로고
    • A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells
    • Tate C.M., Pallini R., Ricci-Vitiani L., et al. A BMP7 variant inhibits the tumorigenic potential of glioblastoma stem-like cells. Cell Death Differ. 2012, 19:1644-1654.
    • (2012) Cell Death Differ. , vol.19 , pp. 1644-1654
    • Tate, C.M.1    Pallini, R.2    Ricci-Vitiani, L.3
  • 92
    • 84888380939 scopus 로고    scopus 로고
    • Snail depletes the tumorigenic potential of glioblastoma
    • Savary K., Caglayan D., Caja L., et al. Snail depletes the tumorigenic potential of glioblastoma. Oncogene 2013, 32:5409-5420.
    • (2013) Oncogene , vol.32 , pp. 5409-5420
    • Savary, K.1    Caglayan, D.2    Caja, L.3
  • 93
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J., Son M.J., Woolard K., et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008, 13:69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 94
    • 84900796733 scopus 로고    scopus 로고
    • Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy
    • Yan K., Wu Q., Yan D.H., et al. Glioma cancer stem cells secrete Gremlin1 to promote their maintenance within the tumor hierarchy. Genes Dev. 2014, 28:1085-1100.
    • (2014) Genes Dev. , vol.28 , pp. 1085-1100
    • Yan, K.1    Wu, Q.2    Yan, D.H.3
  • 95
    • 84905700344 scopus 로고    scopus 로고
    • MiR-656 inhibits glioma tumorigenesis through repression of BMPR1A
    • Guo M., Jiang Z., Zhang X., et al. miR-656 inhibits glioma tumorigenesis through repression of BMPR1A. Carcinogenesis 2014, 35:1698-1706.
    • (2014) Carcinogenesis , vol.35 , pp. 1698-1706
    • Guo, M.1    Jiang, Z.2    Zhang, X.3
  • 96
    • 84876080879 scopus 로고    scopus 로고
    • BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas
    • Bao Z., Zhang C., Yan W., et al. BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas. J. Transl. Med. 2013, 11:100.
    • (2013) J. Transl. Med. , vol.11 , pp. 100
    • Bao, Z.1    Zhang, C.2    Yan, W.3
  • 97
    • 84955345763 scopus 로고    scopus 로고
    • Specific preferences in lineage choice and phenotypic plasticity of glioma stem cells under BMP4 and Noggin influence
    • Videla R., ichardson G.A., Garcia C.P., Roisman A., et al. Specific preferences in lineage choice and phenotypic plasticity of glioma stem cells under BMP4 and Noggin influence. Brain Pathol. 2015.
    • (2015) Brain Pathol.
    • Videla, R.1    ichardson, G.A.2    Garcia, C.P.3    Roisman, A.4
  • 98
    • 84896725037 scopus 로고    scopus 로고
    • BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells
    • Srikanth M., Kim J., Das S., Kessler J.A. BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells. Mol. Cancer Res. 2014, 12:283-294.
    • (2014) Mol. Cancer Res. , vol.12 , pp. 283-294
    • Srikanth, M.1    Kim, J.2    Das, S.3    Kessler, J.A.4
  • 99
    • 37549020350 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc
    • Alvarez-Rodriguez R., Barzi M., Berenguer J., Pons S. Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. J. Biol. Chem. 2007, 282:37170-37180.
    • (2007) J. Biol. Chem. , vol.282 , pp. 37170-37180
    • Alvarez-Rodriguez, R.1    Barzi, M.2    Berenguer, J.3    Pons, S.4
  • 100
    • 41149130332 scopus 로고    scopus 로고
    • Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development
    • Zhao H., Ayrault O., Zindy F., Kim J.H., Roussel M.F. Post-transcriptional down-regulation of Atoh1/Math1 by bone morphogenic proteins suppresses medulloblastoma development. Genes Dev. 2008, 22:722-727.
    • (2008) Genes Dev. , vol.22 , pp. 722-727
    • Zhao, H.1    Ayrault, O.2    Zindy, F.3    Kim, J.H.4    Roussel, M.F.5
  • 101
    • 79959663967 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma
    • Fiaschetti G., Castelletti D., Zoller S., et al. Bone morphogenetic protein-7 is a MYC target with prosurvival functions in childhood medulloblastoma. Oncogene 2011, 30:2823-2835.
    • (2011) Oncogene , vol.30 , pp. 2823-2835
    • Fiaschetti, G.1    Castelletti, D.2    Zoller, S.3
  • 102
    • 84930188532 scopus 로고    scopus 로고
    • Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma
    • Jones C., Baker S.J. Unique genetic and epigenetic mechanisms driving paediatric diffuse high-grade glioma. Nat. Rev. Cancer 2014, 14.
    • (2014) Nat. Rev. Cancer , vol.14
    • Jones, C.1    Baker, S.J.2
  • 103
    • 84948771699 scopus 로고    scopus 로고
    • Reprogramming during epithelial to mesenchymal transition under the control of TGFbeta
    • Tan E.J., Olsson A.K., Moustakas A. Reprogramming during epithelial to mesenchymal transition under the control of TGFbeta. Cell Adh. Migr. 2015, 9:233-246.
    • (2015) Cell Adh. Migr. , vol.9 , pp. 233-246
    • Tan, E.J.1    Olsson, A.K.2    Moustakas, A.3
  • 104
    • 34548804505 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer
    • Buijs J.T., Henriquez N.V., van O., verveld P.G., et al. Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res. 2007, 67:8742-8751.
    • (2007) Cancer Res. , vol.67 , pp. 8742-8751
    • Buijs, J.T.1    Henriquez, N.V.2    van, O.3    Verveld, P.G.4
  • 105
    • 84860314217 scopus 로고    scopus 로고
    • The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation
    • Buijs J.T., der H., orst G., den H., oogen C., et al. The BMP2/7 heterodimer inhibits the human breast cancer stem cell subpopulation and bone metastases formation. Oncogene 2012, 31:2164-2174.
    • (2012) Oncogene , vol.31 , pp. 2164-2174
    • Buijs, J.T.1    der, H.2    Orst, G.3    Den, H.4    Oogen, C.5
  • 106
    • 84862917865 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
    • Kobayashi A., Okuda H., Xing F., et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J. Exp. Med. 2011, 208:2641-2655.
    • (2011) J. Exp. Med. , vol.208 , pp. 2641-2655
    • Kobayashi, A.1    Okuda, H.2    Xing, F.3
  • 107
    • 38849147900 scopus 로고    scopus 로고
    • BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells
    • Yang S., Du J., Wang Z., et al. BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. BMC Cancer 2007, 7:211.
    • (2007) BMC Cancer , vol.7 , pp. 211
    • Yang, S.1    Du, J.2    Wang, Z.3
  • 108
    • 84931056225 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors
    • Mock K., Preca B.T., Brummer T., Brabletz S., Stemmler M.P., Brabletz T. The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors. Oncotarget 2015, 6:14399-14412.
    • (2015) Oncotarget , vol.6 , pp. 14399-14412
    • Mock, K.1    Preca, B.T.2    Brummer, T.3    Brabletz, S.4    Stemmler, M.P.5    Brabletz, T.6
  • 109
    • 84862298985 scopus 로고    scopus 로고
    • Identification of NOG as a specific breast cancer bone metastasis-supporting gene
    • Tarragona M., Pavlovic M., Arnal-Estape A., et al. Identification of NOG as a specific breast cancer bone metastasis-supporting gene. J. Biol. Chem. 2012, 287:21346-21355.
    • (2012) J. Biol. Chem. , vol.287 , pp. 21346-21355
    • Tarragona, M.1    Pavlovic, M.2    Arnal-Estape, A.3
  • 110
    • 84865218588 scopus 로고    scopus 로고
    • The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites
    • Gao H., Chakraborty G., Lee-Lim A.P., et al. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. Cell 2012, 150:764-779.
    • (2012) Cell , vol.150 , pp. 764-779
    • Gao, H.1    Chakraborty, G.2    Lee-Lim, A.P.3
  • 111
    • 37549046846 scopus 로고    scopus 로고
    • Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice
    • Pangas S.A., Li X., Umans L., et al. Conditional deletion of Smad1 and Smad5 in somatic cells of male and female gonads leads to metastatic tumor development in mice. Mol. Cell Biol. 2008, 28:248-257.
    • (2008) Mol. Cell Biol. , vol.28 , pp. 248-257
    • Pangas, S.A.1    Li, X.2    Umans, L.3
  • 112
    • 54549102135 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway
    • Katsuno Y., Hanyu A., Kanda H., et al. Bone morphogenetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway. Oncogene 2008, 27:6322-6333.
    • (2008) Oncogene , vol.27 , pp. 6322-6333
    • Katsuno, Y.1    Hanyu, A.2    Kanda, H.3
  • 113
    • 84872573955 scopus 로고    scopus 로고
    • DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells
    • Balboni A.L., Hutchinson J.A., DeCastro A.J., et al. DeltaNp63alpha-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells. Cancer Res. 2013, 73:1020-1030.
    • (2013) Cancer Res. , vol.73 , pp. 1020-1030
    • Balboni, A.L.1    Hutchinson, J.A.2    DeCastro, A.J.3
  • 114
    • 84859717857 scopus 로고    scopus 로고
    • Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells
    • Sakai H., Furihata M., Matsuda C., et al. Augmented autocrine bone morphogenic protein (BMP) 7 signaling increases the metastatic potential of mouse breast cancer cells. Clin. Exp. Metastasis 2012, 29:327-338.
    • (2012) Clin. Exp. Metastasis , vol.29 , pp. 327-338
    • Sakai, H.1    Furihata, M.2    Matsuda, C.3
  • 115
    • 24944480253 scopus 로고    scopus 로고
    • Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism
    • Dai J., Keller J., Zhang J., Lu Y., Yao Z., Keller E.T. Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanism. Cancer Res. 2005, 65:8274-8285.
    • (2005) Cancer Res. , vol.65 , pp. 8274-8285
    • Dai, J.1    Keller, J.2    Zhang, J.3    Lu, Y.4    Yao, Z.5    Keller, E.T.6
  • 116
    • 79960960617 scopus 로고    scopus 로고
    • BMP4 promotes prostate tumor growth in bone through osteogenesis
    • Lee Y.C., Cheng C.J., Bilen M.A., et al. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res. 2011, 71:5194-5203.
    • (2011) Cancer Res. , vol.71 , pp. 5194-5203
    • Lee, Y.C.1    Cheng, C.J.2    Bilen, M.A.3
  • 117
    • 34548705794 scopus 로고    scopus 로고
    • BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo
    • Buijs J.T., Rentsch C.A., van der Horst G., et al. BMP7, a putative regulator of epithelial homeostasis in the human prostate, is a potent inhibitor of prostate cancer bone metastasis in vivo. Am. J. Pathol. 2007, 171:1047-1057.
    • (2007) Am. J. Pathol. , vol.171 , pp. 1047-1057
    • Buijs, J.T.1    Rentsch, C.A.2    van der Horst, G.3
  • 118
    • 84920383333 scopus 로고    scopus 로고
    • BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation
    • Pickup M.W., Hover L.D., Polikowsky E.R., et al. BMPR2 loss in fibroblasts promotes mammary carcinoma metastasis via increased inflammation. Mol. Oncol. 2015, 9:179-191.
    • (2015) Mol. Oncol. , vol.9 , pp. 179-191
    • Pickup, M.W.1    Hover, L.D.2    Polikowsky, E.R.3
  • 119
    • 84879541683 scopus 로고    scopus 로고
    • Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion
    • Owens P., Polikowsky H., Pickup M.W., et al. Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS One 2013, 8:e67533.
    • (2013) PLoS One , vol.8 , pp. e67533
    • Owens, P.1    Polikowsky, H.2    Pickup, M.W.3
  • 120
    • 84879089097 scopus 로고    scopus 로고
    • BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages
    • Lee J.H., Lee G.T., Woo S.H., et al. BMP-6 in renal cell carcinoma promotes tumor proliferation through IL-10-dependent M2 polarization of tumor-associated macrophages. Cancer Res. 2013, 73:3604-3614.
    • (2013) Cancer Res. , vol.73 , pp. 3604-3614
    • Lee, J.H.1    Lee, G.T.2    Woo, S.H.3
  • 121
    • 27644508801 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis
    • Raida M., Clement J.H., Leek R.D., et al. Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J. Cancer Res. Clin. Oncol. 2005, 131:741-750.
    • (2005) J. Cancer Res. Clin. Oncol. , vol.131 , pp. 741-750
    • Raida, M.1    Clement, J.H.2    Leek, R.D.3
  • 122
    • 84931425495 scopus 로고    scopus 로고
    • MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling
    • Xiao F., Qiu H., Cui H., et al. MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. Oncogene 2015, 34:1968-1978.
    • (2015) Oncogene , vol.34 , pp. 1968-1978
    • Xiao, F.1    Qiu, H.2    Cui, H.3
  • 123
    • 84888084861 scopus 로고    scopus 로고
    • Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
    • Yoshimatsu Y., Lee Y.G., Akatsu Y., et al. Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:18940-18945.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , pp. 18940-18945
    • Yoshimatsu, Y.1    Lee, Y.G.2    Akatsu, Y.3
  • 124
    • 84941736038 scopus 로고    scopus 로고
    • Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer
    • Cunha S.I., Bocci M., Lovrot J., et al. Endothelial ALK1 Is a Therapeutic Target to Block Metastatic Dissemination of Breast Cancer. Cancer Res. 2015, 75:2445-2456.
    • (2015) Cancer Res. , vol.75 , pp. 2445-2456
    • Cunha, S.I.1    Bocci, M.2    Lovrot, J.3
  • 125
    • 84930380645 scopus 로고    scopus 로고
    • Transforming growth factor beta and bone morphogenetic protein actions in brain tumors
    • Caja L., Bellomo C., Moustakas A. Transforming growth factor beta and bone morphogenetic protein actions in brain tumors. FEBS Lett. 2015, 589:1588-1597.
    • (2015) FEBS Lett. , vol.589 , pp. 1588-1597
    • Caja, L.1    Bellomo, C.2    Moustakas, A.3
  • 126
    • 77954368572 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells
    • Chirasani S.R., Sternjak A., Wend P., et al. Bone morphogenetic protein-7 release from endogenous neural precursor cells suppresses the tumourigenicity of stem-like glioblastoma cells. Brain 2010, 133:1961-1972.
    • (2010) Brain , vol.133 , pp. 1961-1972
    • Chirasani, S.R.1    Sternjak, A.2    Wend, P.3
  • 127
    • 84938152098 scopus 로고    scopus 로고
    • Inhibition of BMP signaling suppresses metastasis in mammary cancer
    • Owens P., Pickup M.W., Novitskiy S.V., et al. Inhibition of BMP signaling suppresses metastasis in mammary cancer. Oncogene 2015, 34:2437-2449.
    • (2015) Oncogene , vol.34 , pp. 2437-2449
    • Owens, P.1    Pickup, M.W.2    Novitskiy, S.V.3
  • 128
    • 84940467157 scopus 로고    scopus 로고
    • Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth
    • Hover L.D., Young C.D., Bhola N.E., et al. Small molecule inhibitor of the bone morphogenetic protein pathway DMH1 reduces ovarian cancer cell growth. Cancer Lett. 2015.
    • (2015) Cancer Lett.
    • Hover, L.D.1    Young, C.D.2    Bhola, N.E.3
  • 129
    • 84938917325 scopus 로고    scopus 로고
    • Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations
    • Wang Z., Shen Z., Li Z., et al. Activation of the BMP-BMPR pathway conferred resistance to EGFR-TKIs in lung squamous cell carcinoma patients with EGFR mutations. Proc. Natl. Acad. Sci. U. S. A. 2015, 112:9990-9995.
    • (2015) Proc. Natl. Acad. Sci. U. S. A. , vol.112 , pp. 9990-9995
    • Wang, Z.1    Shen, Z.2    Li, Z.3
  • 130
    • 76149089505 scopus 로고    scopus 로고
    • Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis
    • Cunha S.I., Pardali E., Thorikay M., et al. Genetic and pharmacological targeting of activin receptor-like kinase 1 impairs tumor growth and angiogenesis. J. Exp. Med. 2010, 207:85-100.
    • (2010) J. Exp. Med. , vol.207 , pp. 85-100
    • Cunha, S.I.1    Pardali, E.2    Thorikay, M.3
  • 131
    • 79951828866 scopus 로고    scopus 로고
    • Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies
    • Hu-Lowe D.D., Chen E., Zhang L., et al. Targeting activin receptor-like kinase 1 inhibits angiogenesis and tumorigenesis through a mechanism of action complementary to anti-VEGF therapies. Cancer Res. 2011, 71:1362-1373.
    • (2011) Cancer Res. , vol.71 , pp. 1362-1373
    • Hu-Lowe, D.D.1    Chen, E.2    Zhang, L.3
  • 132
    • 84901044965 scopus 로고    scopus 로고
    • Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation
    • Cao Y., Wang C., Zhang X., et al. Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation. Sci. Rep. 2014, 4(4965).
    • (2014) Sci. Rep. , vol.4 , Issue.4965
    • Cao, Y.1    Wang, C.2    Zhang, X.3
  • 133
    • 84879214694 scopus 로고    scopus 로고
    • Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival
    • Duggal R., Geissinger U., Zhang Q., et al. Vaccinia virus expressing bone morphogenetic protein-4 in novel glioblastoma orthotopic models facilitates enhanced tumor regression and long-term survival. J. Transl. Med. 2013, 11:155.
    • (2013) J. Transl. Med. , vol.11 , pp. 155
    • Duggal, R.1    Geissinger, U.2    Zhang, Q.3
  • 134
    • 84894963068 scopus 로고    scopus 로고
    • Implantable controlled release devices for BMP-7 delivery and suppression of glioblastoma initiating cells
    • Reguera-Nunez E., Roca C., Hardy E., de la Fuente M., Csaba N., Garcia-Fuentes M. Implantable controlled release devices for BMP-7 delivery and suppression of glioblastoma initiating cells. Biomaterials 2014, 35:2859-2867.
    • (2014) Biomaterials , vol.35 , pp. 2859-2867
    • Reguera-Nunez, E.1    Roca, C.2    Hardy, E.3    de la Fuente, M.4    Csaba, N.5    Garcia-Fuentes, M.6
  • 135
    • 84870481111 scopus 로고    scopus 로고
    • BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1alpha stability and MGMT expression
    • Persano L., Pistollato F., Rampazzo E., et al. BMP2 sensitizes glioblastoma stem-like cells to Temozolomide by affecting HIF-1alpha stability and MGMT expression. Cell Death Dis. 2012, 3:e412.
    • (2012) Cell Death Dis. , vol.3 , pp. e412
    • Persano, L.1    Pistollato, F.2    Rampazzo, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.