Selective small molecule compounds increase BMP-2 responsiveness by inhibiting Smurf1-mediated Smad1/5 degradation

Scientific Reports

Volumn 4, Issue , 2014, Pages

  Cao, Yu ^a   Wang, Cheng ^a,b   Zhang, Xueli ^a   Xing, Guichun ^a   Lu, Kefeng ^a   Gu, Yongqing ^b   He, Fuchu ^a   Zhang, Lingqiang ^a,c  

^a BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^b SHIHEZI UNIVERSITY   (China)

^c DALIAN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN 2; SMAD1 PROTEIN; SMAD1 PROTEIN, HUMAN; SMAD5 PROTEIN; SMAD5 PROTEIN, HUMAN; SMURF1 PROTEIN, HUMAN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL CULTURE; DRUG EFFECT; HEK293 CELL LINE; HUMAN; METABOLISM; MOLECULAR LIBRARY; MYOBLAST; OSTEOBLAST; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; SIGNAL TRANSDUCTION; UBIQUITINATION;

BONE MORPHOGENETIC PROTEIN 2; CELLS, CULTURED; HEK293 CELLS; HUMANS; MYOBLASTS; OSTEOBLASTS; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS; SIGNAL TRANSDUCTION; SMAD1 PROTEIN; SMAD5 PROTEIN; SMALL MOLECULE LIBRARIES; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84901044965     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04965     Document Type: Article

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