BMP4, a strong better prognosis predictor, has a subtype preference and cell development association in gliomas

Journal of Translational Medicine

Volumn 11, Issue 1, 2013, Pages

  Bao, Zhaoshi ^a   Zhang, Chuanbao ^a   Yan, Wei ^a   Liu, Yanwei ^a   Li, Mingyang ^a   Zhang, Wei ^a   Jiang, Tao ^a,b  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

BMP4; Cell development; Glioma; Survival

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; ISOCITRATE DEHYDROGENASE 1; MESSENGER RNA;

ADULT; ARTICLE; BIOGENESIS; BRAIN NERVE CELL; CANCER GRADING; CANCER MORTALITY; CANCER PROGNOSIS; CANCER SURVIVAL; CELL CYCLE G1 PHASE; CELL DIFFERENTIATION; CELL MATURATION; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC CORRELATION; GLIOBLASTOMA; GLIOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; VALIDATION PROCESS;

ADULT; BIOLOGICAL MARKERS; BONE MORPHOGENETIC PROTEIN 4; BRAIN NEOPLASMS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC VARIATION; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MUTATION; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RNA, MESSENGER;

EID: 84876080879     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-11-100     Document Type: Article

References (27)

1. Wang Y, Jiang T. Understanding High Grade Glioma: Molecular Mechanism, Therapy and Comprehensive Management. Cancer Lett 2013, 331:139-46. 10.1016/j.canlet.2012.12.024, 23340179.
2. Ohgaki H, Dessen P, Jourde B, Horstmann S, Nishikawa T, Di Patre PL, Burkhard C, Schuler D, Probst-Hensch NM, Maiorka PC. Genetic pathways to glioblastoma: a population-based study. Cancer Res 2004, 64:6892-6899. 10.1158/0008-5472.CAN-04-1337, 15466178.
3. Katagiri T, Tsukamoto S. The unique activity of bone morphogenetic proteins in bone: a critical role of the Smad signaling pathway. Biol Chem 2013, pii: /j/bchm.just-accepted/hsz-2012-0310/hsz-2012-0310.xml. [Epub ahead of print] PubMed PMID: 23324379.
4. Li Z, Chen YG. Functions of BMP signaling in embryonic stem cell fate determination. Exp Cell Res 2013, 319:113-119.
5. Ma W, Ma J, Xu J, Qiao C, Branscum A, Cardenas A, Baron AT, Schwartz P, Maihle NJ, Huang Y. Lin28 regulates BMP4 and functions with Oct4 to affect ovarian tumor microenvironment. Cell Cycle 2013, 12:88-97. 10.4161/cc.23028, 23255092.
6. Fernandez-Rozadilla C, Palles C, Carvajal-Carmona L, Peterlongo P, Nici C, Veneroni S, Pinheiro M, Teixeira MR, Moreno V, Lamas MJ. BMP2/BMP4 colorectal cancer susceptibility loci in northern and southern European populations. Carcinogenesis 2013, 34:314-8. 10.1093/carcin/bgs357, 23161572.
7. Zhou Z, Chen ZW, Yang XH, Shen L, Ai XH, Lu S, Luo QQ. Establishment of a biomarker model for predicting bone metastasis in resected stage III non-small cell lung cancer. J Exp Clin Cancer Res 2012, 31:34. 10.1186/1756-9966-31-34, 3447731, 22537906.
8. Yan W, Zhang W, You G, Zhang J, Han L, Bao Z, Wang Y, Liu Y, Jiang C, Kang C. Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group. Neuro Oncol 2012, 14:1432-1440. 10.1093/neuonc/nos263, 23090983.
9. Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 2010, 17:98-110. 10.1016/j.ccr.2009.12.020, 2818769, 20129251.
10. Gravendeel LA, Kouwenhoven MC, Gevaert O, de Rooi JJ, Stubbs AP, Duijm JE, Daemen A, Bleeker FE, Bralten LB, Kloosterhof NK. Intrinsic gene expression profiles of gliomas are a better predictor of survival than histology. Cancer Res 2009, 69:9065-9072. 10.1158/0008-5472.CAN-09-2307, 19920198.
11. Hanzelmann S, Castelo R, Guinney J. GSVA: gene set variation analysis for microarray and RNA-Seq data. BMC Bioinforma 2013, 14:7.
12. R Core Team A language and environment for statistical computing 2012, Vienna, Austria: R Foundation for Statistical Computing, R Core Team.
13. Castelo R. GSVAdata: Data employed in the vignette of the GSVA package
14. Kelleher FC, Fennelly D, Rafferty M. Common critical pathways in embryogenesis and cancer. Acta Oncol 2006, 45:375-388. 10.1080/02841860600602946, 16760173.
15. Houlston RS, Webb E, Broderick P, Pittman AM, Di Bernardo MC, Lubbe S, Chandler I, Vijayakrishnan J, Sullivan K, Penegar S. Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer. Nat Genet 2008, 40:1426-1435. 10.1038/ng.262, 2836775, 19011631.
16. Sneddon JB, Zhen HH, Montgomery K, van de Rijn M, Tward AD, West R, Gladstone H, Chang HY, Morganroth GS, Oro AE, Brown PO. Bone morphogenetic protein antagonist gremlin 1 is widely expressed by cancer-associated stromal cells and can promote tumor cell proliferation. Proc Natl Acad Sci USA 2006, 103:14842-14847. 10.1073/pnas.0606857103, 1578503, 17003113.
17. Kwak C, Park YH, Kim IY, Moon KC, Ku JH. Expression of bone morphogenetic proteins, the subfamily of the transforming growth factor-beta superfamily, in renal cell carcinoma. J Urol 2007, 178:1062-1067. 10.1016/j.juro.2007.05.005, 17644140.
18. Hjertner O, Hjorth-Hansen H, Borset M, Seidel C, Waage A, Sundan A. Bone morphogenetic protein-4 inhibits proliferation and induces apoptosis of multiple myeloma cells. Blood 2001, 97:516-522. 10.1182/blood.V97.2.516, 11154231.
19. Virtanen S, Alarmo EL, Sandstrom S, Ampuja M, Kallioniemi A. Bone morphogenetic protein -4 and -5 in pancreatic cancer-novel bidirectional players. Exp Cell Res 2011, 317:2136-2146. 10.1016/j.yexcr.2011.06.001, 21704030.
20. Ketolainen JM, Alarmo EL, Tuominen VJ, Kallioniemi A. Parallel inhibition of cell growth and induction of cell migration and invasion in breast cancer cells by bone morphogenetic protein 4. Breast Cancer Res Treat 2010, 124:377-386. 10.1007/s10549-010-0808-0, 20182795.
21. Theriault BL, Shepherd TG, Mujoomdar ML, Nachtigal MW. BMP4 induces EMT and Rho GTPase activation in human ovarian cancer cells. Carcinogenesis 2007, 28:1153-1162. 10.1093/carcin/bgm015, 17272306.
22. Piccirillo SG, Reynolds BA, Zanetti N, Lamorte G, Binda E, Broggi G, Brem H, Olivi A, Dimeco F, Vescovi AL. Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells. Nature 2006, 444:761-765. 10.1038/nature05349, 17151667.
23. Piccirillo SG, Vescovi AL. Bone morphogenetic proteins regulate tumorigenicity in human glioblastoma stem cells. Ernst Schering Found Symp Proc 2006, 6:59-81.
24. Altaner C. Glioblastoma and stem cells. Neoplasma 2008, 55:369-374.
25. Zhou Z, Sun L, Wang Y, Wu Z, Geng J, Miu W, Pu Y, You Y, Yang Z, Liu N. Bone morphogenetic protein 4 inhibits cell proliferation and induces apoptosis in glioma stem cells. Cancer Biother Radiopharm 2011, 26:77-83. 10.1089/cbr.2010.0857, 21355779.
26. Liu B, Tian D, Yi W, Wu L, Cai Q, Dong H, Shen H, Ji B, Wang L, Zhang S. Effect of bone morphogenetic protein 4 in the human brain glioma cell line U251. Cell Biochem Biophys 2010, 58:91-96. 10.1007/s12013-010-9095-y, 20730570.
27. Kallioniemi A. Bone morphogenetic protein 4-a fascinating regulator of cancer cell behavior. Cancer Genet 2012, 205:267-277. 10.1016/j.cancergen.2012.05.009, 22749032.