메뉴 건너뛰기




Volumn 291, Issue 5, 2016, Pages 2181-2195

Acetoacetate accelerates muscle regeneration and ameliorates muscular dystrophy in mice

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CELLS; CYTOLOGY; KETONES; MAMMALS; METABOLITES; MUSCLE;

EID: 84957022178     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.676510     Document Type: Article
Times cited : (48)

References (87)
  • 1
    • 33144478944 scopus 로고    scopus 로고
    • Comparative in vitro activity of β-lactam/β-lactamase inhibitor combinations against Gram negative bacteria
    • Mohanty, S., Singhal, R., Sood, S., Dhawan, B., Das, B. K., and Kapil, A. (2005) Comparative in vitro activity of β-lactam/β-lactamase inhibitor combinations against Gram negative bacteria. Indian J. Med. Res. 122, 425-428
    • (2005) Indian J. Med. Res. , vol.122 , pp. 425-428
    • Mohanty, S.1    Singhal, R.2    Sood, S.3    Dhawan, B.4    Das, B.K.5    Kapil, A.6
  • 2
    • 84856096512 scopus 로고    scopus 로고
    • Satellite cells, the engines of muscle repair
    • Wang, Y. X., and Rudnicki, M. A. (2012) Satellite cells, the engines of muscle repair. Nat. Rev. Mol. Cell Biol. 13, 127-133
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 127-133
    • Wang, Y.X.1    Rudnicki, M.A.2
  • 3
    • 79957485838 scopus 로고    scopus 로고
    • Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis
    • Braun, T., and Gautel, M. (2011) Transcriptional mechanisms regulating skeletal muscle differentiation, growth and homeostasis. Nat. Rev. Mol. Cell Biol. 12, 349-361
    • (2011) Nat. Rev. Mol. Cell Biol. , vol.12 , pp. 349-361
    • Braun, T.1    Gautel, M.2
  • 4
    • 24144489118 scopus 로고    scopus 로고
    • Cellular and molecular signatures of muscle regeneration: Current concepts and controversies in adult myogenesis
    • Wagers, A. J., and Conboy, I. M. (2005) Cellular and molecular signatures of muscle regeneration: current concepts and controversies in adult myogenesis. Cell 122, 659-667
    • (2005) Cell , vol.122 , pp. 659-667
    • Wagers, A.J.1    Conboy, I.M.2
  • 5
    • 37548999686 scopus 로고    scopus 로고
    • Niche regulation of muscle satellite cell self-renewal and differentiation
    • Kuang, S., Gillespie, M. A., and Rudnicki, M. A. (2008) Niche regulation of muscle satellite cell self-renewal and differentiation. Cell Stem Cell 2, 22-31
    • (2008) Cell Stem Cell , vol.2 , pp. 22-31
    • Kuang, S.1    Gillespie, M.A.2    Rudnicki, M.A.3
  • 6
    • 27644531674 scopus 로고    scopus 로고
    • Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer
    • Kamrava, M., Simpkins, F., Alejandro, E., Michener, C., Meltzer, E., and Kohn, E. C. (2005) Lysophosphatidic acid and endothelin-induced proliferation of ovarian cancer cell lines is mitigated by neutralization of granulin-epithelin precursor (GEP), a prosurvival factor for ovarian cancer. Oncogene 24, 7084-7093
    • (2005) Oncogene , vol.24 , pp. 7084-7093
    • Kamrava, M.1    Simpkins, F.2    Alejandro, E.3    Michener, C.4    Meltzer, E.5    Kohn, E.C.6
  • 8
    • 52749083291 scopus 로고    scopus 로고
    • Stem cell based therapy for skeletal muscle diseases
    • Bhagavati, S. (2008) Stem cell based therapy for skeletal muscle diseases. Curr. Stem Cell Res. Ther. 3, 219-228
    • (2008) Curr. Stem Cell Res. Ther. , vol.3 , pp. 219-228
    • Bhagavati, S.1
  • 9
    • 34249825503 scopus 로고    scopus 로고
    • Stem cells and plasticity of skeletal muscle cell differentiation: Potential application to cell therapy for degenerative muscular diseases
    • Endo, T. (2007) Stem cells and plasticity of skeletal muscle cell differentiation: potential application to cell therapy for degenerative muscular diseases. Regen. Med. 2, 243-256
    • (2007) Regen. Med. , vol.2 , pp. 243-256
    • Endo, T.1
  • 10
    • 33745625628 scopus 로고    scopus 로고
    • Muscle stem cells in development, regeneration, and disease
    • Shi, X., and Garry, D. J. (2006) Muscle stem cells in development, regeneration, and disease. Genes Dev. 20, 1692-1708
    • (2006) Genes Dev. , vol.20 , pp. 1692-1708
    • Shi, X.1    Garry, D.J.2
  • 11
    • 78149270788 scopus 로고    scopus 로고
    • Insulin-like 6 is induced by muscle injury and functions as a regenerative factor
    • Zeng, L., Akasaki, Y., Sato, K., Ouchi, N., Izumiya, Y., and Walsh, K. (2010) Insulin-like 6 is induced by muscle injury and functions as a regenerative factor. J. Biol. Chem. 285, 36060-36069
    • (2010) J. Biol. Chem. , vol.285 , pp. 36060-36069
    • Zeng, L.1    Akasaki, Y.2    Sato, K.3    Ouchi, N.4    Izumiya, Y.5    Walsh, K.6
  • 12
    • 0028807357 scopus 로고
    • Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes
    • Cantini, M., Massimino, M. L., Rapizzi, E., Rossini, K., Catani, C., Dalla Libera, L., and Carraro, U. (1995) Human satellite cell proliferation in vitro is regulated by autocrine secretion of IL-6 stimulated by a soluble factor(s) released by activated monocytes. Biochem. Biophys. Res. Commun. 216, 49-53
    • (1995) Biochem. Biophys. Res. Commun. , vol.216 , pp. 49-53
    • Cantini, M.1    Massimino, M.L.2    Rapizzi, E.3    Rossini, K.4    Catani, C.5    Dalla Libera, L.6    Carraro, U.7
  • 13
    • 84861207028 scopus 로고    scopus 로고
    • HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK-and myogenin-dependent repression of Pax7 transcription
    • Riuzzi, F., Sorci, G., Sagheddu, R., and Donato, R. (2012) HMGB1-RAGE regulates muscle satellite cell homeostasis through p38-MAPK-and myogenin-dependent repression of Pax7 transcription. J. Cell Sci. 125, 1440-1454
    • (2012) J. Cell Sci. , vol.125 , pp. 1440-1454
    • Riuzzi, F.1    Sorci, G.2    Sagheddu, R.3    Donato, R.4
  • 14
    • 77957122174 scopus 로고    scopus 로고
    • The engine driving the ship: Metabolic steering of cell proliferation and death
    • Buchakjian, M. R., and Kornbluth, S. (2010) The engine driving the ship: metabolic steering of cell proliferation and death. Nat. Rev. Mol. Cell Biol. 11, 715-727
    • (2010) Nat. Rev. Mol. Cell Biol. , vol.11 , pp. 715-727
    • Buchakjian, M.R.1    Kornbluth, S.2
  • 15
  • 16
    • 64849087954 scopus 로고    scopus 로고
    • Cancer. Puzzling patterns of predisposition
    • Pollard, P. J., and Ratcliffe, P. J. (2009) Cancer. Puzzling patterns of predisposition. Science 324, 192-194
    • (2009) Science , vol.324 , pp. 192-194
    • Pollard, P.J.1    Ratcliffe, P.J.2
  • 19
    • 84875804944 scopus 로고    scopus 로고
    • The emerging role of fumarate as an oncometabolite
    • Yang, M., Soga, T., Pollard, P. J., and Adam, J. (2012) The emerging role of fumarate as an oncometabolite. Front. Oncol. 2, 85
    • (2012) Front. Oncol. , vol.2 , pp. 85
    • Yang, M.1    Soga, T.2    Pollard, P.J.3    Adam, J.4
  • 25
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • Yu, F., White, S. B., Zhao, Q., and Lee, F. S. (2001) HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation. Proc. Natl. Acad. Sci. U.S.A. 98, 9630-9635
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 31
    • 69249247037 scopus 로고    scopus 로고
    • SDH5 mutations and familial paraganglioma: Somewhere Warburg is smiling
    • Kaelin, W. G., Jr. (2009) SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling. Cancer Cell 16, 180-182
    • (2009) Cancer Cell , vol.16 , pp. 180-182
    • Kaelin, W.G.1
  • 34
    • 84862776612 scopus 로고    scopus 로고
    • Alterations of metabolic genes and metabolites in cancer
    • Oermann, E. K., Wu, J., Guan, K. L., and Xiong, Y. (2012) Alterations of metabolic genes and metabolites in cancer. Semin. Cell Dev. Biol. 23, 370-380
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 370-380
    • Oermann, E.K.1    Wu, J.2    Guan, K.L.3    Xiong, Y.4
  • 35
    • 33746930794 scopus 로고    scopus 로고
    • Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
    • King, A., Selak, M. A., and Gottlieb, E. (2006) Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 25, 4675-4682
    • (2006) Oncogene , vol.25 , pp. 4675-4682
    • King, A.1    Selak, M.A.2    Gottlieb, E.3
  • 36
    • 84862632865 scopus 로고    scopus 로고
    • Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
    • Xiao, M., Yang, H., Xu, W., Ma, S., Lin, H., Zhu, H., Liu, L., Liu, Y., Yang, C., Xu, Y., Zhao, S., Ye, D., Xiong, Y., and Guan, K. L. (2012) Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors. Genes Dev. 26, 1326-1338
    • (2012) Genes Dev. , vol.26 , pp. 1326-1338
    • Xiao, M.1    Yang, H.2    Xu, W.3    Ma, S.4    Lin, H.5    Zhu, H.6    Liu, L.7    Liu, Y.8    Yang, C.9    Xu, Y.10    Zhao, S.11    Ye, D.12    Xiong, Y.13    Guan, K.L.14
  • 37
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • Menendez, J. A., and Lupu, R. (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat. Rev. Cancer 7, 763-777
    • (2007) Nat. Rev. Cancer , vol.7 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 38
    • 30544433533 scopus 로고    scopus 로고
    • ATP citrate lyase is an important component of cell growth and transformation
    • Bauer, D. E., Hatzivassiliou, G., Zhao, F., Andreadis, C., and Thompson, C. B. (2005) ATP citrate lyase is an important component of cell growth and transformation. Oncogene 24, 6314-6322
    • (2005) Oncogene , vol.24 , pp. 6314-6322
    • Bauer, D.E.1    Hatzivassiliou, G.2    Zhao, F.3    Andreadis, C.4    Thompson, C.B.5
  • 41
    • 0018876377 scopus 로고
    • Physiological roles of ketone bodies as substrates and signals in mammalian tissues
    • Robinson, A. M., and Williamson, D. H. (1980) Physiological roles of ketone bodies as substrates and signals in mammalian tissues. Physiol. Rev. 60, 143-187
    • (1980) Physiol. Rev. , vol.60 , pp. 143-187
    • Robinson, A.M.1    Williamson, D.H.2
  • 42
    • 44649195062 scopus 로고    scopus 로고
    • Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion
    • Macdonald, M. J., Hasan, N. M., and Longacre, M. J. (2008) Studies with leucine, β-hydroxybutyrate and ATP citrate lyase-deficient beta cells support the acetoacetate pathway of insulin secretion. Biochim. Biophys. Acta 1780, 966-972
    • (2008) Biochim. Biophys. Acta , vol.1780 , pp. 966-972
    • Macdonald, M.J.1    Hasan, N.M.2    Longacre, M.J.3
  • 43
    • 77953809888 scopus 로고    scopus 로고
    • Mitochondrial fatty acid oxidation and oxidative stress: Lack of reverse electron transfer-associated production of reactive oxygen species
    • Schönfeld, P., Wieckowski, M. R., Lebiedzińska, M., and Wojtczak, L. (2010) Mitochondrial fatty acid oxidation and oxidative stress: lack of reverse electron transfer-associated production of reactive oxygen species. Biochim. Biophys. Acta 1797, 929-938
    • (2010) Biochim. Biophys. Acta , vol.1797 , pp. 929-938
    • Schönfeld, P.1    Wieckowski, M.R.2    Lebiedzińska, M.3    Wojtczak, L.4
  • 44
    • 77953167776 scopus 로고    scopus 로고
    • Acetoacetate as regulator of palmitic acid-induced uncoupling involving liver mitochondrial ADP/ATP antiporter and aspartate/glutamate antiporter
    • Samartsev, V. N., and Kozhina, O. V. (2010) Acetoacetate as regulator of palmitic acid-induced uncoupling involving liver mitochondrial ADP/ATP antiporter and aspartate/glutamate antiporter. Biochemistry 75, 598-605
    • (2010) Biochemistry , vol.75 , pp. 598-605
    • Samartsev, V.N.1    Kozhina, O.V.2
  • 45
    • 3342967630 scopus 로고    scopus 로고
    • Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: Role of oxidative stress
    • Abdelmegeed, M. A., Kim, S. K., Woodcroft, K. J., and Novak, R. F. (2004) Acetoacetate activation of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in primary cultured rat hepatocytes: role of oxidative stress. J. Pharmacol. Exp. Ther. 310, 728-736
    • (2004) J. Pharmacol. Exp. Ther. , vol.310 , pp. 728-736
    • Abdelmegeed, M.A.1    Kim, S.K.2    Woodcroft, K.J.3    Novak, R.F.4
  • 46
    • 0032832864 scopus 로고    scopus 로고
    • Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients
    • Jain, S. K., and McVie, R. (1999) Hyperketonemia can increase lipid peroxidation and lower glutathione levels in human erythrocytes in vitro and in type 1 diabetic patients. Diabetes 48, 1850-1855
    • (1999) Diabetes , vol.48 , pp. 1850-1855
    • Jain, S.K.1    McVie, R.2
  • 47
    • 21844440290 scopus 로고    scopus 로고
    • Ketone bodies stimulate chaperonemediated autophagy
    • Finn, P. F., and Dice, J. F. (2005) Ketone bodies stimulate chaperonemediated autophagy. J. Biol. Chem. 280, 25864-25870
    • (2005) J. Biol. Chem. , vol.280 , pp. 25864-25870
    • Finn, P.F.1    Dice, J.F.2
  • 49
    • 0842264588 scopus 로고    scopus 로고
    • Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes
    • Jain, S. K., Kannan, K., Lim, G., Matthews-Greer, J., McVie, R., and Bocchini, J. A., Jr. (2003) Elevated blood interleukin-6 levels in hyperketonemic type 1 diabetic patients and secretion by acetoacetate-treated cultured U937 monocytes. Diabetes Care 26, 2139-2143
    • (2003) Diabetes Care , vol.26 , pp. 2139-2143
    • Jain, S.K.1    Kannan, K.2    Lim, G.3    Matthews-Greer, J.4    McVie, R.5    Bocchini, J.A.6
  • 51
    • 0037073574 scopus 로고    scopus 로고
    • Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells
    • Hoffman, W. H., Cheng, C., Passmore, G. G., Carroll, J. E., and Hess, D. (2002) Acetoacetate increases expression of intercellular adhesion molecule-1 (ICAM-1) in human brain microvascular endothelial cells. Neurosci. Lett. 334, 71-74
    • (2002) Neurosci. Lett. , vol.334 , pp. 71-74
    • Hoffman, W.H.1    Cheng, C.2    Passmore, G.G.3    Carroll, J.E.4    Hess, D.5
  • 52
    • 0031456506 scopus 로고    scopus 로고
    • Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart.Athree tracer study of glycolysis, glycogen metabolism, and glucose oxidation
    • Russell, R. R., 3rd, Cline, G. W., Guthrie, P. H., Goodwin, G. W., Shulman, G. I., and Taegtmeyer, H. (1997) Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart.Athree tracer study of glycolysis, glycogen metabolism, and glucose oxidation. J. Clin. Invest. 100, 2892-2899
    • (1997) J. Clin. Invest. , vol.100 , pp. 2892-2899
    • Russell, R.R.1    Cline, G.W.2    Guthrie, P.H.3    Goodwin, G.W.4    Shulman, G.I.5    Taegtmeyer, H.6
  • 53
    • 0033142036 scopus 로고    scopus 로고
    • Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T
    • Pan, J. W., Bebin, E. M., Chu, W. J., and Hetherington, H. P. (1999) Ketosis and epilepsy: 31P spectroscopic imaging at 4.1 T. Epilepsia 40, 703-707
    • (1999) Epilepsia , vol.40 , pp. 703-707
    • Pan, J.W.1    Bebin, E.M.2    Chu, W.J.3    Hetherington, H.P.4
  • 55
    • 0015523712 scopus 로고
    • Ato Operon: A highly inducible system for acetoacetate and butyrate degradation in Escherichia coli
    • Pauli, G., and Overath, P. (1972) ato Operon: a highly inducible system for acetoacetate and butyrate degradation in Escherichia coli. Eur. J. Biochem./FEBS 29, 553-562
    • (1972) Eur. J. Biochem./FEBS , vol.29 , pp. 553-562
    • Pauli, G.1    Overath, P.2
  • 56
    • 69249246978 scopus 로고    scopus 로고
    • Signal transduction and adaptive regulation through bacterial two-component systems: The Escherichia coli AtoSC paradigm
    • Kyriakidis, D. A., and Tiligada, E. (2009) Signal transduction and adaptive regulation through bacterial two-component systems: the Escherichia coli AtoSC paradigm. Amino Acids 37, 443-458
    • (2009) Amino Acids , vol.37 , pp. 443-458
    • Kyriakidis, D.A.1    Tiligada, E.2
  • 58
    • 0014972144 scopus 로고
    • Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues
    • Williamson, D. H., Bates, M. W., Page, M. A., and Krebs, H. A. (1971) Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues. Biochem. J. 121, 41-47
    • (1971) Biochem. J. , vol.121 , pp. 41-47
    • Williamson, D.H.1    Bates, M.W.2    Page, M.A.3    Krebs, H.A.4
  • 59
    • 78149282298 scopus 로고    scopus 로고
    • Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells
    • Chen, Y., Ye, J., Cao, L., Zhang, Y., Xia, W., and Zhu, D. (2010) Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells. Int. J. Biochem. Cell Biol. 42, 2072-2081
    • (2010) Int. J. Biochem. Cell Biol. , vol.42 , pp. 2072-2081
    • Chen, Y.1    Ye, J.2    Cao, L.3    Zhang, Y.4    Xia, W.5    Zhu, D.6
  • 61
    • 0032531254 scopus 로고    scopus 로고
    • MyoD, myogenin, and desmin-nls-lacZ transgene emphasize the distinct patterns of satellite cell activation in growth and regeneration
    • Creuzet, S., Lescaudron, L., Li, Z., and Fontaine-Pérus, J. (1998) MyoD, myogenin, and desmin-nls-lacZ transgene emphasize the distinct patterns of satellite cell activation in growth and regeneration. Exp. Cell Res. 243, 241-253
    • (1998) Exp. Cell Res. , vol.243 , pp. 241-253
    • Creuzet, S.1    Lescaudron, L.2    Li, Z.3    Fontaine-Pérus, J.4
  • 62
    • 55049103095 scopus 로고    scopus 로고
    • All muscle satellite cells are equal, but are some more equal than others?
    • Zammit, P. S. (2008) All muscle satellite cells are equal, but are some more equal than others? J. Cell Sci. 121, 2975-2982
    • (2008) J. Cell Sci. , vol.121 , pp. 2975-2982
    • Zammit, P.S.1
  • 65
    • 48949083339 scopus 로고    scopus 로고
    • Liver-specific silencing of the human gene encoding succinyl-CoA:3-ketoacid CoA transferase
    • Orii, K. E., Fukao, T., Song, X. Q., Mitchell, G. A., and Kondo, N. (2008) Liver-specific silencing of the human gene encoding succinyl-CoA:3-ketoacid CoA transferase. Tohoku J. Exp. Med. 215, 227-236
    • (2008) Tohoku J. Exp. Med. , vol.215 , pp. 227-236
    • Orii, K.E.1    Fukao, T.2    Song, X.Q.3    Mitchell, G.A.4    Kondo, N.5
  • 66
    • 0016280296 scopus 로고
    • Substrate specificity and mechanism of action of acetoacetate coenzyme A transferase from rat heart
    • Fenselau, A., and Wallis, K. (1974) Substrate specificity and mechanism of action of acetoacetate coenzyme A transferase from rat heart. Biochemistry 13, 3884-3888
    • (1974) Biochemistry , vol.13 , pp. 3884-3888
    • Fenselau, A.1    Wallis, K.2
  • 68
    • 84859465080 scopus 로고    scopus 로고
    • Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1
    • Garedew, A., Andreassi, C., and Moncada, S. (2012) Mitochondrial dynamics, biogenesis, and function are coordinated with the cell cycle by APC/C CDH1. Cell Metab. 15, 466-479
    • (2012) Cell Metab. , vol.15 , pp. 466-479
    • Garedew, A.1    Andreassi, C.2    Moncada, S.3
  • 69
    • 32944477055 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression
    • Yang, W., Chen, Y., Zhang, Y., Wang, X., Yang, N., and Zhu, D. (2006) Extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase pathway is involved in myostatin-regulated differentiation repression. Cancer Res. 66, 1320-1326
    • (2006) Cancer Res. , vol.66 , pp. 1320-1326
    • Yang, W.1    Chen, Y.2    Zhang, Y.3    Wang, X.4    Yang, N.5    Zhu, D.6
  • 70
    • 84858796367 scopus 로고    scopus 로고
    • A two-way street: Reciprocal regulation of metabolism and signalling
    • Wellen, K. E., and Thompson, C. B. (2012) A two-way street: reciprocal regulation of metabolism and signalling. Nat. Rev. Mol. Cell Biol. 13, 270-276
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 270-276
    • Wellen, K.E.1    Thompson, C.B.2
  • 72
    • 84856702223 scopus 로고    scopus 로고
    • Inhibition of GSK3 by lithium, from single molecules to signaling networks
    • Freland, L., and Beaulieu, J. M. (2012) Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front. Mol. Neurosci. 5, 14
    • (2012) Front. Mol. Neurosci. , vol.5 , pp. 14
    • Freland, L.1    Beaulieu, J.M.2
  • 73
    • 0033400713 scopus 로고    scopus 로고
    • Ketone bodies: A review of physiology, pathophysiology and application of monitoring to diabetes
    • Laffel, L. (1999) Ketone bodies: a review of physiology, pathophysiology and application of monitoring to diabetes. Diabetes Metab. Res. Rev. 15, 412-426
    • (1999) Diabetes Metab. Res. Rev. , vol.15 , pp. 412-426
    • Laffel, L.1
  • 76
    • 0035880453 scopus 로고    scopus 로고
    • Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability
    • Jorquera, R., and Tanguay, R. M. (2001) Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability. Hum. Mol. Genet. 10, 1741-1752
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 1741-1752
    • Jorquera, R.1    Tanguay, R.M.2
  • 77
    • 0015691789 scopus 로고
    • The role of acetoacetate in the transfer of acetyl units outside the mitochondria in liver and adipose tissue of rats or mice
    • Rous, S., and Favarger, P. (1973) The role of acetoacetate in the transfer of acetyl units outside the mitochondria in liver and adipose tissue of rats or mice. FEBS Lett. 37, 231-234
    • (1973) FEBS Lett. , vol.37 , pp. 231-234
    • Rous, S.1    Favarger, P.2
  • 78
    • 0018959353 scopus 로고
    • Contribution of leucine in the fatty acid synthesis and ketogenesis in mice adipose tissue
    • Rous, S., Bas, S., and Sengupta, S. (1980) Contribution of leucine in the fatty acid synthesis and ketogenesis in mice adipose tissue. Int. J. Biochem. 11, 337-340
    • (1980) Int. J. Biochem. , vol.11 , pp. 337-340
    • Rous, S.1    Bas, S.2    Sengupta, S.3
  • 80
    • 67349278470 scopus 로고    scopus 로고
    • β-Hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways
    • Kornasio, R., Riederer, I., Butler-Browne, G., Mouly, V., Uni, Z., and Halevy, O. (2009)β-Hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways. Biochim. Biophys. Acta 1793, 755-763
    • (2009) Biochim. Biophys. Acta , vol.1793 , pp. 755-763
    • Kornasio, R.1    Riederer, I.2    Butler-Browne, G.3    Mouly, V.4    Uni, Z.5    Halevy, O.6
  • 81
    • 84855829095 scopus 로고    scopus 로고
    • Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation
    • Averous, J., Gabillard, J. C., Seiliez, I., and Dardevet, D. (2012) Leucine limitation regulates myf5 and myoD expression and inhibits myoblast differentiation. Exp. Cell Res. 318, 217-227
    • (2012) Exp. Cell Res. , vol.318 , pp. 217-227
    • Averous, J.1    Gabillard, J.C.2    Seiliez, I.3    Dardevet, D.4
  • 82
    • 84922397301 scopus 로고    scopus 로고
    • Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells
    • Areta, J. L., Hawley, J. A., Ye, J. M., Chan, M. H., and Coffey, V. G. (2014) Increasing leucine concentration stimulates mechanistic target of rapamycin signaling and cell growth in C2C12 skeletal muscle cells. Nutr. Res. 34, 1000-1007
    • (2014) Nutr. Res. , vol.34 , pp. 1000-1007
    • Areta, J.L.1    Hawley, J.A.2    Ye, J.M.3    Chan, M.H.4    Coffey, V.G.5
  • 83
    • 78149498161 scopus 로고    scopus 로고
    • Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses
    • Li, X., Gianoulis, T. A., Yip, K. Y., Gerstein, M., and Snyder, M. (2010) Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses. Cell 143, 639-650
    • (2010) Cell , vol.143 , pp. 639-650
    • Li, X.1    Gianoulis, T.A.2    Yip, K.Y.3    Gerstein, M.4    Snyder, M.5
  • 84
    • 79959230308 scopus 로고    scopus 로고
    • Metabolites as global regulators: A new view of protein regulation: Systematic investigation of metabolite-protein interactions may help bridge the gap between genome-wide association studies and small molecule screening studies
    • Li, X., and Snyder, M. (2011) Metabolites as global regulators: a new view of protein regulation: systematic investigation of metabolite-protein interactions may help bridge the gap between genome-wide association studies and small molecule screening studies. BioEssays 33, 485-489
    • (2011) BioEssays , vol.33 , pp. 485-489
    • Li, X.1    Snyder, M.2
  • 85
    • 0015044489 scopus 로고
    • Evidence for an effect of inulin on the peripheral utilization of ketone bodies in dogs
    • Balasse, E. O., and Havel, R. J. (1971) Evidence for an effect of inulin on the peripheral utilization of ketone bodies in dogs. J. Clin. Invest. 50, 801-813
    • (1971) J. Clin. Invest. , vol.50 , pp. 801-813
    • Balasse, E.O.1    Havel, R.J.2
  • 86
    • 0015038748 scopus 로고
    • Incorporation of label from D-β-hydroxy (14C)butyrate and (3-14C)acetoacetate into amino acids in rat brain in vivo
    • Cremer, J. E. (1971) Incorporation of label from D-β-hydroxy (14C)butyrate and (3-14C)acetoacetate into amino acids in rat brain in vivo. Biochem. J. 122, 135-138
    • (1971) Biochem. J. , vol.122 , pp. 135-138
    • Cremer, J.E.1
  • 87
    • 84884742752 scopus 로고    scopus 로고
    • Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): Role of ketone bodies
    • Nakagawa, T., Ge, Q., Pawlosky, R., Wynn, R. M., Veech, R. L., and Uyeda, K. (2013) Metabolite regulation of nucleo-cytosolic trafficking of carbohydrate response element-binding protein (ChREBP): role of ketone bodies. J. Biol. Chem. 288, 28358-28367
    • (2013) J. Biol. Chem. , vol.288 , pp. 28358-28367
    • Nakagawa, T.1    Ge, Q.2    Pawlosky, R.3    Wynn, R.M.4    Veech, R.L.5    Uyeda, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.