Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status

Journal of Pathology

Volumn 225, Issue 1, 2011, Pages 4-11

  Bardella, Chiara ^b   El Bahrawy, Mona ^c   Frizzell, Norma ^d   Adam, Julie ^a   Ternette, Nicola ^a   Hatipoglu, Emine ^a   Howarth, Kimberley ^b   O'Flaherty, Linda ^a   Roberts, Ian ^e   Turner, Gareth ^e   Taylor, Jennifer ^b   Giaslakiotis, Konstantinos ^e   MacAulay, Valentine M ^f   Harris, Adrian L ^f   Chandra, Ashish ^g   Lehtonen, Heli J ^h   Launonen, Virpi ^h   Aaltonen, Lauri A ^h   Pugh, Christopher W ^a   Mihai, Radu ^e   Trudgian, David ^a   Kessler, Benedikt ^a   Baynes, John W ^d   Ratcliffe, Peter J ^a   Tomlinson, Ian P ^b   Pollard, Patrick J ^a   more..

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c HAMMERSMITH HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SOUTH CAROLINA   (United States)

^e JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g ST THOMAS HOSPITAL   (United Kingdom)

^h UNIVERSITY OF HELSINKI   (Finland)

Author keywords

fumarate hydratase; HLRCC; immunhistochemistry; mitochondria; mouse models; renal cancer; succination

Indexed keywords

CYSTEINE; FUMARATE HYDRATASE; TUMOR MARKER;

ADULT; AGED; ANIMAL CELL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE MUTATION; GENETIC ANALYSIS; GENETIC SCREENING; HUMAN; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; KIDNEY CYST; LEIOMYOMATOSIS; MALE; MOUSE; MUTATION; NONHUMAN; PAPILLARY CARCINOMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN MODIFICATION; RETROSPECTIVE STUDY;

ADULT; AGED; ANIMALS; CARCINOMA, RENAL CELL; DISEASE MODELS, ANIMAL; FEMALE; FUMARATE HYDRATASE; GENETIC PREDISPOSITION TO DISEASE; GERM-LINE MUTATION; HUMANS; KIDNEY NEOPLASMS; LEIOMYOMATOSIS; LOSS OF HETEROZYGOSITY; MALE; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; MIDDLE AGED; NEOPLASTIC SYNDROMES, HEREDITARY; PROSPECTIVE STUDIES; SENSITIVITY AND SPECIFICITY; SUCCINIC ACID; TUMOR MARKERS, BIOLOGICAL;

EID: 79960916285     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2932     Document Type: Article

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