Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability

Human Molecular Genetics

Volumn 10, Issue 17, 2001, Pages 1741-1752

  Jorquera, Rossana ^a   Tanguay, Robert M ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETOACETIC ACID DERIVATIVE; B 581; CELL PROTEIN; ENZYME INHIBITOR; FUMARYLACETOACETASE; FUMARYLACETOACETATE; GLUTATHIONE; GLUTATHIONE ETHYL ESTER; GROWTH FACTOR RECEPTOR; MUTAGENIC AGENT; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RAS PROTEIN; SPINDLE POLE ASSOCIATED PROTEIN; THIOL DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG;

ANAPHASE; ANIMAL CELL; APOPTOSIS; ARTICLE; BIOACCUMULATION; BIOCHEMISTRY; CELL ORGANELLE; CHROMATIN; CHROMOSOME ABERRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINESIS; ENZYME ACTIVATION; GENETIC DISORDER; GENETIC STABILITY; GOLGI COMPLEX; HIGH RISK PATIENT; HUMAN; HUMAN CELL; KARYOKINESIS; LIVER CANCER; METABOLIC DISORDER; METABOLITE; MICRONUCLEUS; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MULTINUCLEAR CELL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; RODENT; SIGNAL TRANSDUCTION; SKIN FIBROBLAST; TELOPHASE; TYROSINEMIA;

ANIMALIA; RODENTIA;

EID: 0035880453     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/10.17.1741     Document Type: Article

References (74)

1. Hypertyrosinemia
2. The occurrence of hepatoma in the chronic form of hereditary tyrosinemia
3. On the enzymic defects in hereditary tyrosinemia
4. Type 1 hereditary tyrosinemia. Evidence for molecular heterogeneity and identification of a causal mutation in a French Canadian patient
5. Homogentisate metabolism: The isomerization of maleylacetoacetate by an enzyme which requires glutathione
6. Hereditary tyrosinemias (type 1): A new vista on tyrosine toxicity and cancer
7. Tyrosinaemia type 1 and glutathione synthetase deficiency: Two disorders with reduced hepatic thiol group concentrations and a liver 4-fumarylacetoacetate hydrolase deficiency
8. Tyrosine and its catabolites: From disease to cancer
9. The mutagenicity of the tyrosine metabolite, fumarylacetoacetate, is enhanced by glutathione depletion
10. Cyclin B-dependent kinase and caspase-1 activation precedes mitochondrial dysfunction in fumaryl-acetoacetate-induced apoptosis
11. Hepatocyte injury in tyrosinemia type 1 is induced by fumarylacetoacetate and is inhibited by caspase inhibitors
12. Complete rescue of lethal albino c14CoS mice by null mutation of 4-hydroxyphenylpyruvate dioxygenase and induction of apoptosis of hepatocytes in these mice by in vivo retrieval of the tyrosine catabolic pathway
13. Chromosomal instability in hereditary tyrosinemia type I
14. DNA ploidy abnormalities in the liver of children with hereditary tyrosinemia type I. Correlation with histopathologic features
15. Mechanistic aspects on chemical induction of spindle disturbances and abnormal chromosome numbers
16. The detection and evaluation of aneugenic chemicals
17. Cellular thiols and redox-regulated signal transduction
18. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
19. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase
20. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
21. Raf-1/MEK/MAPK pathway is necessary for the G2/M transition induced by nocodazole
22. Signal transduction through MAP kinase cascades
23. How MAP kinases are regulated
24. Signal-transducing protein phosphorylation cascades mediated by Ras/Rho proteins in the mammalian cell: The potential for multiplex signalling
25. Okadaic acid activates microtubule-associated protein kinase in quiescent fibroblastic cells
26. Protein kinase C α activates RAF-1 by direct phosphorylation
27. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and transformation of NIH 3T3 cells
28. Transformation of mammalian cells by constitutively active MAP kinase kinase
29. Increased MAPK expression and activity in primary human hepatocellular carcinoma
30. MAPK mediates RAS-induced chromosome instability
31. Mos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle
32. Role of microtubules in the organization of the Golgi complex
33. Molecular cloning of a novel 97-kd Golgi complex autoantigen associated with Sjogren's syndrome
34. Vacuolar system-associated protein-60: A protein characterized from bovine granulosa and luteal cells that is associated with intracellular vesicles and related to human 80K-H and murine β-glucosidase II
35. Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability
36. N-Ras induces alterations in Golgi complex architecture and in constitutive protein transport
37. A p53-independent pathway for activation of WAF1/CIP1 expression following oxidative stress
38. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle
39. Spindle disturbances in mammalian cells. IV. The action of some glutathione-specific agents in V79 Chinese hamster cells, changes in levels of free sulfhydryls and ATP, c-mitosis and effects on DNA metabolism
40. Role of PI3K in cell transformation and control of the actin cytoskeleton by ras
41. p53-dependent effects of RAS oncogene on chromosome stability and cell cycle checkpoints
42. Thiol depletion induces apoptosis in cultured lung fibroblasts
43. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
44. Distinct pathways of Gi- and Gq-mediated mitogen-activated protein kinase activation
45. Receptor-tyrosine-kinase- and Gβγ-mediated MAP kinase activation by a common signalling pathway
46. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
47. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc
48. 2+ levels
49. Mitotic aberrations induced by carbaryl reflect tyrosine kinase inhibition with coincident up-regulation of serine/threonine protein phosphatase activity: Implications for coordination of karyokinesis and cytokinesis
50. Accessory protein regulation of microtubule dynamics throughout the cell cycle
51. Microtubule motors in mitosis
52. Direct interaction of pericentrin with cytoplasmic dynein light intermediate chain contributes to mitotic spindle organization
53. CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment
54. Opposing motor activities are required for the organization of the mammalian mitotic spindle pole
55. 2+ store depletion in rat liver epithelial cells
56. Extracellular signal-regulated kinase 1/2-mediated phosphorylation of JunD and FosB is required for okadaic acid-induced activator protein 1 activation
57. The regulation of AP-1 activity by mitogen-activated protein kinases
58. Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade
59. Stimulation of Elk1 transcriptional activity by mitogen-activated protein kinases is negatively regulated by protein phosphatase 2B (calcineurin)
60. 2+-calmodulin-dependent protein kinase cascade
61. Variable gene expression within human tyrosinemia type 1 liver may reflect region-specific dysplasia
62. Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice
63. Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice
64. Rescue of mice homozygous for lethal albino deletions: Implications for an animal model for the human liver disease tyrosinemia type 1
65. Inositol trisphosphate and calcium signalling
66. 2+ store, with functional properties distinct from those of the endoplasmic reticulum
67. Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization
68. Cytosolic phospholipase A2 is required for macrophage arachidonic acid release by agonists that Do and Do not mobilize calcium. Novel role of mitogen-activated protein kinase pathways in cytosolic phospholipase A2 regulation
69. Microtubule-interfering agents stimulate the transcription of cyclo-oxygenase-2. Evidence for involvement of ERK1/2 AND p38 mitogen-activated protein kinase pathways
70. cPLA2 is phosphorylated and activated by MAP kinase
71. Enzymes involved in conversion of tyrosine to acetoacetate
72. Assays for the detection of chemically-induced chromosome damage in cultured mammalian cells
73. Microtubule disruption induced in vivo by alkylation of β-tubulin by 1-aryl-3-(2-chloroethyl)ureas, a novel class of soft alkylating agents
74. Synchronization of normal diploid and transformed mammalian cells