High affinity heme binding to a heme regulatory motif on the nuclear receptor rev-erbβ leads to its degradation and indirectly regulates its interaction with nuclear receptor corepressor

Journal of Biological Chemistry

Volumn 291, Issue 5, 2016, Pages 2196-2222

  Carter, Eric L ^a   Gupta, Nirupama ^a   Ragsdale, Stephen W ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINS; GENE EXPRESSION; GENES; LIGANDS; PEPTIDES; PROTEINS; RATE CONSTANTS; TRANSCRIPTION;

CIRCADIAN RHYTHMS; CO-IMMUNOPRECIPITATIONS; CRYSTALLOGRAPHIC STUDIES; FULL-LENGTH PROTEINS; HEME REGULATORY MOTIFS; INTERACTION DOMAIN; LIGAND BINDING DOMAIN; NUCLEAR RECEPTORS;

PORPHYRINS;

HEMOPROTEIN; NUCLEAR RECEPTOR REV ERB BETA; REGULATOR PROTEIN; SILENCING MEDIATOR OF RETINOID AND THYROID HORMONE RECEPTOR; UNCLASSIFIED DRUG; APOMYOGLOBIN; APOPROTEIN; CELL RECEPTOR; CYCLOHEXIMIDE; HEME; ION; LIGAND; METAL; MYOGLOBIN; NCOR1 PROTEIN, HUMAN; NR1D2 PROTEIN, HUMAN; PROTEIN BINDING; RECEPTOR INTERACTING PROTEIN 140; REPRESSOR PROTEIN; UBIQUITIN;

ANISOTROPY; ARTICLE; BINDING AFFINITY; CELL FRACTIONATION; CIRCADIAN RHYTHM; CONTROLLED STUDY; DNA PROTEIN COMPLEX; FLUORESCENCE ANALYSIS; GEL MOBILITY SHIFT ASSAY; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HEK293 CELL LINE; HUMAN; INFLAMMATION; MASS SPECTROMETRY; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN PROCESSING;

AMINO ACID MOTIFS; APOPROTEINS; CIRCADIAN RHYTHM; CYCLOHEXIMIDE; GENE EXPRESSION REGULATION; HEK293 CELLS; HEME; HUMANS; INFLAMMATION; IONS; LIGANDS; MASS SPECTROMETRY; METALS; MYOGLOBIN; NUCLEAR RECEPTOR CO-REPRESSOR 1; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REPRESSOR PROTEINS; TRANSFECTION; UBIQUITIN;

EID: 84956999697     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.670281     Document Type: Article

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