Nuclear receptor Rev-erbα is a critical lithium-sensitive component of the circadian clock

Science

Volumn 311, Issue 5763, 2006, Pages 1002-1005

  Yin, Lei ^a   Wang, Jing ^a   Klein, Peter S ^a   Lazar, Mitchell A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATOMIC CLOCKS; BIOMEDICAL ENGINEERING; DEGRADATION; ENZYMES; GENES; LITHIUM; SYNTHESIS (CHEMICAL);

CIRCADIAN RHYTHM; GLYCOGEN SYNTHASE KINASE 3 (GSK3); PHOSPHORYLATES; PROTEASOMAL DEGRADATION;

PROTEINS;

CELL NUCLEUS RECEPTOR; CELL NUCLEUS RECEPTOR REV ERB ALPHA; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM; PER1 PROTEIN; PROTEASOME; TRANSCRIPTION FACTOR CLOCK; UNCLASSIFIED DRUG;

BIOLOGY;

ANIMAL CELL; ARTICLE; BMAL1 GENE; CELL STRAIN 3T3; CELL STRAIN HEPG2; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE; GENE ACTIVATION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOLOGICAL CLOCKS; CELL LINE; CELL LINE, TUMOR; CIRCADIAN RHYTHM; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LITHIUM CHLORIDE; MICE; MOLECULAR SEQUENCE DATA; NIH 3T3 CELLS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEASOME ENDOPEPTIDASE COMPLEX; RECEPTORS, CYTOPLASMIC AND NUCLEAR;

ANIMALIA;

EID: 33144465537     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1121613     Document Type: Article

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