Characterization of heme-regulated eIF2α kinase: Roles of the N-terminal domain in the oligomeric state, heme binding, catalysis, and inhibition

Biochemistry

Volumn 45, Issue 32, 2006, Pages 9894-9905

  Miksanova, Marketa ^a   Igarashi, Jotaro ^a   Minami, Masahiro ^a   Sagami, Ikuko ^a,b   Yamauchi, Seigo ^a   Kurokawa, Hirofumi ^a   Shimizu, Toru ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; ENZYME INHIBITION; HEMOGLOBIN; LIGHT ABSORPTION; LIGHT SCATTERING; PARAMAGNETIC RESONANCE; PROTEINS; REACTION KINETICS; SYNTHESIS (CHEMICAL);

C-TERMINAL DOMAIN; KINETIC PARAMETERS; OLIGOMERIC STATE; PROTEIN SYNTHESIS;

OLIGOMERS;

ADENOSINE TRIPHOSPHATE; BILIRUBIN; CYSTEINE; FERRIC ION; FERROUS ION; HEME; HEME DERIVATIVE; HEME REGULATED EUKARYOTIC INITIATION FACTOR 2ALPHA KINASE; HEME REGULATED INHIBITOR; HEMOGLOBIN A; HYDROXIDE; INITIATION FACTOR 2ALPHA; IRON; LIGAND; MUTANT PROTEIN; MYOGLOBIN; OLIGOMER; PROTEIN INHIBITOR; PROTEIN KINASE R; PROTEIN SUBUNIT; PROTOPORPHYRIN; UNCLASSIFIED DRUG; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); DISSOCIATION CONSTANT; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; LIGHT SCATTERING; MICHAELIS MENTEN KINETICS; MOUSE; NONHUMAN; OPTICAL ROTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN SYNTHESIS; STRUCTURAL PROTEOMICS;

ANIMALS; CATALYSIS; EIF-2 KINASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HEMIN; KINETICS; MICE; MOLECULAR WEIGHT; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; PHOSPHORYLATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; PROTOPORPHYRINS; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747513241     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi060556k     Document Type: Article

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