-
2
-
-
1442307970
-
Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells
-
Ameri, K., Lewis, C.E., Raida, M., Sowter, H., Hai, T. Harris, A.L. 2004. Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells. Blood 103, 1876 1882.
-
(2004)
Blood
, vol.103
, pp. 1876-1882
-
-
Ameri, K.1
Lewis, C.E.2
Raida, M.3
Sowter, H.4
Hai, T.5
Harris, A.L.6
-
3
-
-
33846256974
-
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway
-
Ameri, K., Hammond, E.M., Culmsee, C., Raida, M., Katschinski, D.M., Wenger, R.H., Wagner, E., Davis, R.J., Hai, T., Denko, N. Harris, A.L. 2007. Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene 26, 284 289.
-
(2007)
Oncogene
, vol.26
, pp. 284-289
-
-
Ameri, K.1
Hammond, E.M.2
Culmsee, C.3
Raida, M.4
Katschinski, D.M.5
Wenger, R.H.6
Wagner, E.7
Davis, R.J.8
Hai, T.9
Denko, N.10
Harris, A.L.11
-
4
-
-
27144458505
-
ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth
-
Bi, M., Naczki, C., Koritzinsky, M., Fels, D., Blais, J., Hu, N., Harding, H., Novoa, I., Varia, M., Raleigh, J. et al. 2005. ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth. EMBO J 24, 3470 3481.
-
(2005)
EMBO J
, vol.24
, pp. 3470-3481
-
-
Bi, M.1
Naczki, C.2
Koritzinsky, M.3
Fels, D.4
Blais, J.5
Hu, N.6
Harding, H.7
Novoa, I.8
Varia, M.9
Raleigh, J.10
-
5
-
-
43249108443
-
-/- mice
-
-/- mice. Mol Cell Biol 28, 3386 3400.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3386-3400
-
-
Bishop, T.1
Gallagher, D.2
Pascual, A.3
Lygate, C.A.4
De Bono, J.P.5
Nicholls, L.G.6
Ortega-Saenz, P.7
Oster, H.8
Wijeyekoon, B.9
Sutherland, A.I.10
-
6
-
-
0032581277
-
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
-
Carmeliet, P., Dor, Y., Herbert, J.M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P. et al. 1998. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485 490.
-
(1998)
Nature
, vol.394
, pp. 485-490
-
-
Carmeliet, P.1
Dor, Y.2
Herbert, J.M.3
Fukumura, D.4
Brusselmans, K.5
Dewerchin, M.6
Neeman, M.7
Bono, F.8
Abramovitch, R.9
Maxwell, P.10
-
7
-
-
4644329647
-
Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: A mechanism for hypoxia-dependent effect
-
Carriere, A., Carmona, M.C., Fernandez, Y., Rigoulet, M., Wenger, R.H., Penicaud, L. Casteilla, L. 2004. Mitochondrial reactive oxygen species control the transcription factor CHOP-10/GADD153 and adipocyte differentiation: a mechanism for hypoxia-dependent effect. J Biol Chem 279, 40462 40469.
-
(2004)
J Biol Chem
, vol.279
, pp. 40462-40469
-
-
Carriere, A.1
Carmona, M.C.2
Fernandez, Y.3
Rigoulet, M.4
Wenger, R.H.5
Penicaud, L.6
Casteilla, L.7
-
8
-
-
0032535483
-
The ubiquitin-proteasome pathway: On protein death and cell life
-
Ciechanover, A. 1998. The ubiquitin-proteasome pathway: On protein death and cell life. EMBO J 17, 7151 7160.
-
(1998)
EMBO J
, vol.17
, pp. 7151-7160
-
-
Ciechanover, A.1
-
9
-
-
34347350211
-
Degradation of Mcl-1 by β-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Ding, Q., He, X., Hsu, J.M., Xia, W., Chen, C.T., Li, L.Y., Lee, D.F., Liu, J.C., Zhong, Q., Wang, X. Hung, M.C. 2007. Degradation of Mcl-1 by β-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol 27, 4006 4017.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
He, X.2
Hsu, J.M.3
Xia, W.4
Chen, C.T.5
Li, L.Y.6
Lee, D.F.7
Liu, J.C.8
Zhong, Q.9
Wang, X.10
Hung, M.C.11
-
10
-
-
52749087157
-
Effects of hypoxia on transcription factor expression in human monocytes and macrophages
-
Elbarghati, L., Murdoch, C. Lewis, C.E. 2008. Effects of hypoxia on transcription factor expression in human monocytes and macrophages. Immunobiology 213, 899 908.
-
(2008)
Immunobiology
, vol.213
, pp. 899-908
-
-
Elbarghati, L.1
Murdoch, C.2
Lewis, C.E.3
-
11
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein, A.C., Gleadle, J.M., McNeill, L.A., Hewitson, K.S., O'Rourke, J., Mole, D.R., Mukherji, M., Metzen, E., Wilson, M.I., Dhanda, A. et al. 2001. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 107, 43 54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
Hewitson, K.S.4
O'Rourke, J.5
Mole, D.R.6
Mukherji, M.7
Metzen, E.8
Wilson, M.I.9
Dhanda, A.10
-
12
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
Harding, H.P., Zhang, Y., Zeng, H., Novoa, I., Lu, P.D., Calfon, M., Sadri, N., Yun, C., Popko, B., Paules, R., Stojdl, D.F., Bell, J.C., Hettmann, T., Leiden, J.M. Ron, D. 2003. An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Mol Cell 11, 619 633.
-
(2003)
Mol Cell
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
Stojdl, D.F.11
Bell, J.C.12
Hettmann, T.13
Leiden, J.M.14
Ron, D.15
-
14
-
-
0034213391
-
Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor
-
Hettmann, T., Barton, K. Leiden, J.M. 2000. Microphthalmia due to p53-mediated apoptosis of anterior lens epithelial cells in mice lacking the CREB-2 transcription factor. Dev Biol 222, 110 123.
-
(2000)
Dev Biol
, vol.222
, pp. 110-123
-
-
Hettmann, T.1
Barton, K.2
Leiden, J.M.3
-
15
-
-
34447651331
-
Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines
-
Igarashi, T., Izumi, H., Uchiumi, T., Nishio, K., Arao, T., Tanabe, M., Uramoto, H., Sugio, K., Yasumoto, K., Sasaguri, Y., Wang, K.Y., Otsuji, Y. Kohno, K. 2007. Clock and ATF4 transcription system regulates drug resistance in human cancer cell lines. Oncogene 26, 4749 4760.
-
(2007)
Oncogene
, vol.26
, pp. 4749-4760
-
-
Igarashi, T.1
Izumi, H.2
Uchiumi, T.3
Nishio, K.4
Arao, T.5
Tanabe, M.6
Uramoto, H.7
Sugio, K.8
Yasumoto, K.9
Sasaguri, Y.10
Wang, K.Y.11
Otsuji, Y.12
Kohno, K.13
-
16
-
-
0035917313
-
2 sensing
-
2 sensing. Science 292, 464 468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
Kim, W.4
Valiando, J.5
Ohh, M.6
Salic, A.7
Asara, J.M.8
Lane, W.S.9
Kaelin Jr., W.G.10
-
17
-
-
0035917808
-
2-regulated prolyl hydroxylation
-
2-regulated prolyl hydroxylation. Science 292, 468 472.
-
(2001)
Science
, vol.292
, pp. 468-472
-
-
Jaakkola, P.1
Mole, D.R.2
Tian, Y.M.3
Wilson, M.I.4
Gielbert, J.5
Gaskell, S.J.6
Von Kriegsheim, A.7
Hebestreit, H.F.8
Mukherji, M.9
Schofield, C.J.10
Maxwell, P.H.11
Pugh, C.W.12
Ratcliffe, P.J.13
-
18
-
-
33846879810
-
The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma
-
Kaelin, W.G., Jr. 2007. The von Hippel-Lindau tumor suppressor protein and clear cell renal carcinoma. Clin Cancer Res 13, 680s 684s.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Kaelin Jr., W.G.1
-
19
-
-
43649093915
-
Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway
-
Kaelin, W.G., Jr. Ratcliffe, P.J. 2008. Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway. Mol Cell 30, 393 402.
-
(2008)
Mol Cell
, vol.30
, pp. 393-402
-
-
Kaelin Jr., W.G.1
Ratcliffe, P.J.2
-
20
-
-
36348936212
-
Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor
-
Köditz, J., Nesper, J., Wottawa, M., Stiehl, D.P., Camenisch, G., Franke, C., Myllyharju, J., Wenger, R.H. Katschinski, D.M. 2007. Oxygen-dependent ATF-4 stability is mediated by the PHD3 oxygen sensor. Blood 110, 3610 3617.
-
(2007)
Blood
, vol.110
, pp. 3610-3617
-
-
Köditz, J.1
Nesper, J.2
Wottawa, M.3
Stiehl, D.P.4
Camenisch, G.5
Franke, C.6
Myllyharju, J.7
Wenger, R.H.8
Katschinski, D.M.9
-
21
-
-
0342467925
-
ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase
-
Lassot, I., Segeral, E., Berlioz-Torrent, C., Durand, H., Groussin, L., Hai, T., Benarous, R. Margottin-Goguet, F. 2001. ATF4 degradation relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase. Mol Cell Biol 21, 2192 2202.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 2192-2202
-
-
Lassot, I.1
Segeral, E.2
Berlioz-Torrent, C.3
Durand, H.4
Groussin, L.5
Hai, T.6
Benarous, R.7
Margottin-Goguet, F.8
-
22
-
-
0032189348
-
Proteasome inhibitors: Valuable new tools for cell biologists
-
Lee, D.H. Goldberg, A.L. 1998. Proteasome inhibitors: valuable new tools for cell biologists. Trends Cell Biol 8, 397 403.
-
(1998)
Trends Cell Biol
, vol.8
, pp. 397-403
-
-
Lee, D.H.1
Goldberg, A.L.2
-
23
-
-
23644436667
-
Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer
-
Lee, S., Nakamura, E., Yang, H., Wei, W., Linggi, M.S., Sajan, M.P., Farese, R.V., Freeman, R.S., Carter, B.D., Kaelin, W.G., Jr. Schlisio, S. 2005. Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer. Cancer Cell 8, 155 167.
-
(2005)
Cancer Cell
, vol.8
, pp. 155-167
-
-
Lee, S.1
Nakamura, E.2
Yang, H.3
Wei, W.4
Linggi, M.S.5
Sajan, M.P.6
Farese, R.V.7
Freeman, R.S.8
Carter, B.D.9
Kaelin Jr., W.G.10
Schlisio, S.11
-
24
-
-
0035895928
-
SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons
-
Lipscomb, E.A., Sarmiere, P.D. Freeman, R.S. 2001. SM-20 is a novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent neurons. J Biol Chem 276, 5085 5092.
-
(2001)
J Biol Chem
, vol.276
, pp. 5085-5092
-
-
Lipscomb, E.A.1
Sarmiere, P.D.2
Freeman, R.S.3
-
25
-
-
0036464604
-
Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice
-
Masuoka, H.C. Townes, T.M. 2002. Targeted disruption of the activating transcription factor 4 gene results in severe fetal anemia in mice. Blood 99, 736 745.
-
(2002)
Blood
, vol.99
, pp. 736-745
-
-
Masuoka, H.C.1
Townes, T.M.2
-
26
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P.H., Wiesener, M.S., Chang, G.W., Clifford, S.C., Vaux, E.C., Cockman, M.E., Wykoff, C.C., Pugh, C.W., Maher, E.R. Ratcliffe, P.J. 1999. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271 275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
27
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari, S. Mori, M. 2004. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11, 381 389.
-
(2004)
Cell Death Differ
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
28
-
-
0026632457
-
Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins
-
Price, B.D. Calderwood, S.K. 1992. Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins. Cancer Res 52, 3814 3817.
-
(1992)
Cancer Res
, vol.52
, pp. 3814-3817
-
-
Price, B.D.1
Calderwood, S.K.2
-
29
-
-
48249154559
-
Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation
-
Rantanen, K., Pursiheimo, J., Hogel, H., Himanen, V., Metzen, E. Jaakkola, P.M. 2008. Prolyl hydroxylase PHD3 activates oxygen-dependent protein aggregation. Mol Biol Cell 19, 2231 2240.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 2231-2240
-
-
Rantanen, K.1
Pursiheimo, J.2
Hogel, H.3
Himanen, V.4
Metzen, E.5
Jaakkola, P.M.6
-
30
-
-
41649116940
-
The kinesin KIF1Bb acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor
-
Schlisio, S., Kenchappa, R.S., Vredeveld, L.C., George, R.E., Stewart, R., Greulich, H., Shahriari, K., Nguyen, N.V., Pigny, P., Dahia, P.L. et al. 2008. The kinesin KIF1Bb acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor. Genes Dev 22, 884 893.
-
(2008)
Genes Dev
, vol.22
, pp. 884-893
-
-
Schlisio, S.1
Kenchappa, R.S.2
Vredeveld, L.C.3
George, R.E.4
Stewart, R.5
Greulich, H.6
Shahriari, K.7
Nguyen, N.V.8
Pigny, P.9
Dahia, P.L.10
-
31
-
-
33748521536
-
E3 ubiquitin ligases as cancer targets and biomarkers
-
Sun, Y. 2006. E3 ubiquitin ligases as cancer targets and biomarkers. Neoplasia 8, 645 654.
-
(2006)
Neoplasia
, vol.8
, pp. 645-654
-
-
Sun, Y.1
-
32
-
-
0038282482
-
The hypoxia-inducible factor-1 a is a negative factor for tumor therapy
-
Unruh, A., Ressel, A., Mohamed, H.G., Johnson, R.S., Nadrowitz, R., Richter, E., Katschinski, D.M. Wenger, R.H. 2003. The hypoxia-inducible factor-1 a is a negative factor for tumor therapy. Oncogene 22, 3213 3220.
-
(2003)
Oncogene
, vol.22
, pp. 3213-3220
-
-
Unruh, A.1
Ressel, A.2
Mohamed, H.G.3
Johnson, R.S.4
Nadrowitz, R.5
Richter, E.6
Katschinski, D.M.7
Wenger, R.H.8
-
33
-
-
32544446451
-
Coping with stress: EIF2 kinases and translational control
-
Wek, R.C., Jiang, H.Y. Anthony, T.G. 2006. Coping with stress: eIF2 kinases and translational control. Biochem Soc Trans 34, 7 11.
-
(2006)
Biochem Soc Trans
, vol.34
, pp. 7-11
-
-
Wek, R.C.1
Jiang, H.Y.2
Anthony, T.G.3
-
34
-
-
31444444162
-
Integration of oxygen signaling at the consensus HRE
-
Wenger, R.H., Stiehl, D.P. Camenisch, G. 2005. Integration of oxygen signaling at the consensus HRE. Sci STKE 2005, re12.
-
(2005)
Sci STKE
, vol.2005
, pp. 12
-
-
Wenger, R.H.1
Stiehl, D.P.2
Camenisch, G.3
-
35
-
-
57349157684
-
Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 a-deficient mouse embryonic fibroblasts
-
Wirthner, R., Wrann, S., Balamurugan, K., Wenger, R.H. Stiehl, D.P. 2008. Impaired DNA double-strand break repair contributes to chemoresistance in HIF-1 a-deficient mouse embryonic fibroblasts. Carcinogenesis 29, 2306 2316.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2306-2316
-
-
Wirthner, R.1
Wrann, S.2
Balamurugan, K.3
Wenger, R.H.4
Stiehl, D.P.5
-
36
-
-
8744224520
-
ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells
-
Yang, X. Karsenty, G. 2004. ATF4, the osteoblast accumulation of which is determined post-translationally, can induce osteoblast-specific gene expression in non-osteoblastic cells. J Biol Chem 279, 47109 47114.
-
(2004)
J Biol Chem
, vol.279
, pp. 47109-47114
-
-
Yang, X.1
Karsenty, G.2
|