Puzzling role of genetic risk factors in human longevity: “risk alleles” as pro-longevity variants

Biogerontology

Volumn 17, Issue 1, 2016, Pages 109-127

  Ukraintseva, Svetlana ^a,b   Yashin, Anatoliy ^a,b   Arbeev, Konstantin ^a   Kulminski, Alexander ^a   Akushevich, Igor ^a   Wu, Deqing ^a   Joshi, Gaurang ^c   Land, Kenneth C ^a   Stallard, Eric ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE CANCER INSTITUTE   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Age specific influence; Aging; Complex disease; Conditional effects; Epistasis; Genetic risk factors; Gene environment interaction; Longevity; Physical senescence; Trade offs

Indexed keywords

APOLIPOPROTEIN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; PROTEIN P53;

AGING; ALZHEIMER DISEASE; APOE GENE; CARDIOVASCULAR DISEASE; CTLA 4 GENE; DIABETES MELLITUS; EPISTASIS; FOXO1A GENE; FOXO3A GENE; GENE; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE ENVIRONMENT INTERACTION; HEREDITY; HETEROZYGOTE; HUMAN; LIFESPAN; LONGEVITY; MORTALITY; MTHFR GENE; NONHUMAN; NRDE2 GENE; PAI 1 GENE; PRIORITY JOURNAL; REVIEW; SENESCENCE; TP53 GENE; VULNERABLE POPULATION; AGE DISTRIBUTION; ALLELE; BIOLOGICAL MODEL; EPIDEMIOLOGY; GENETIC PREDISPOSITION; GENETIC VARIATION; GENETICS; RISK FACTOR; SURVIVAL RATE;

AGE DISTRIBUTION; AGING; ALLELES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; LONGEVITY; MODELS, GENETIC; RISK FACTORS; SURVIVAL RATE;

EID: 84955421696     PISSN: 13895729     EISSN: 15736768     Source Type: Journal    
DOI: 10.1007/s10522-015-9600-1     Document Type: Review

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