Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan

Aging Cell

Volumn 10, Issue 3, 2011, Pages 533-541

  Kulminski, Alexander M ^a   Culminskaya, Irina ^a   Ukraintseva, Svetlana V ^a   Arbeev, Konstantin G ^a   Arbeeva, Liubov ^a   Wu, Deqing ^a   Akushevich, Igor ^a   Land, Kenneth C ^a   Yashin, Anatoli I ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Aging; Disease; Genetics; Lifespan; Longevity regulation; Mortality; Trade offs

Indexed keywords

APOLIPOPROTEIN E; LIPID;

ADULT; ADVERSE OUTCOME; AGING; ALLELE; ARTICLE; BIOLOGICAL ACTIVITY; CARDIOVASCULAR DISEASE; CONTROLLED STUDY; FEMALE; GENE ACTIVITY; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETIC REGULATION; GENOTYPE; HEREDITY; HOMOZYGOTE; HUMAN; LIFESPAN; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NEOPLASM; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; REGULATORY MECHANISM; SURVIVAL;

ADULT; AGE OF ONSET; ALLELES; APOLIPOPROTEINS E; CARDIOVASCULAR DISEASES; COHORT STUDIES; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; KAPLAN-MEIER ESTIMATE; LIPIDS; LONGEVITY; NEOPLASMS; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS;

EID: 79955965569     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2011.00689.x     Document Type: Article

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