A study of the average effect of the 3′APOB-VNTR polymorphism on lipidemic parameters could explain why the short alleles (<35 repeats) are rare in centenarians

BMC Medical Genetics

Volumn 5, Issue , 2004, Pages

  Garasto, Sabrina ^a,b   Berardelli, Maurizio ^a,b   DeRango, Francesco ^a   Mari, Vincenzo ^b   Feraco, Emidio ^b   De Benedictis, Giovanna ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b INRCA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; AGING; ALLELE; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DISEASE PREDISPOSITION; FEMALE; GENDER; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; ITALY; LIPID BLOOD LEVEL; LONGEVITY; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NORMAL HUMAN; PHENOTYPE; PROTEIN POLYMORPHISM; TANDEM REPEAT; VARIABLE NUMBER OF TANDEM REPEAT;

3' FLANKING REGION; ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; APOLIPOPROTEINS B; ARTERIOSCLEROSIS; FEMALE; HUMANS; LIPIDS; MALE; MIDDLE AGED; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC;

EID: 2542476271     PISSN: 14712350     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2350-5-3     Document Type: Article

References (17)

1. Young SG: Recent progress in understanding apolipoprotein B. Circulation 1990, 82:1574-94.
2. Hallman DM, Visvikis S, Steinmetz J et al.: The effect of variation in the apolipoprotein B gene on plasmid lipid and apolipoprotein B levels. A likelihood-based approach to cladistic analysis. Ann Hum Genet 1994, 58:35-64.
3. Hegele RA, Huang LS, Herbert PN et al.: Apolipoprotein B-gene DNA polymorphisms associated with myocardial infarction. N Engl J Med 1986, 315:1509-15.
4. Friedl W, Ludwig EH, Paulweber B et al.: Hypervariability in a minisatellite 3′ of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls. J Lipid Res 1990, 31:659-65.
5. Chen B, Guo Z, He P et al.: Structure and function of alleles in the 3′ end region of human apoB gene. Chin Med J 1999, 112:221-3.
6. De Benedictis G, Falcone E, Rose G et al.: DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems. The APOB locus. Hum Genet 1997, 99:312-8.
7. De Benedictis G, Carotenuto L, Carrieri G et al.: Age-related changes of the 3′APOB-VNTR genotype pool in ageing cohorts. Ann Hum Genet 1998, 62:115-22.
8. Snieder H, van Doornen LJP, Boomsma DI: The age dependency of gene expression for plasma lipids, lipoproteins, and apolipoproteins. Am J Hum Genet 1997, 60:638-50.
9. Garasto S, Rose G, De Rango F et al.: The study of APOA1, APOC3 and APOA4 variability in healthy ageing people reveals another paradox in the oldest old subjects. Ann Hum Genet 2003, 67:54-62.
10. Franceschi C, Motta L, Valensin S, and the Italian Multicenter Study on Centenarians: Do men and women follow different trajectories to reach extreme longevity ? Aging Clin Exp Res 2000, 12:77-84.
11. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972, 18:499-502.
12. Christiansen FB, Feldman MW: Population Genetics Balckwell Sc Publ; 1986:130-134.
13. Alavantic D, Glisic S, Kandic I: APO B 3′ HVR polymorphism in healthy population: relationships to serum lipid levels. Genet Epidemiol 1998, 15:113-22.
14. Pritchard JK, Donnelly P: Case-control studies of association in structured or admixed populations. Theor Popul Biol 2001, 60:227-37.
15. Schatz IJ, Masaki K, Yano K et al.: Cholesterol and all-cause mortality in elderly people from the Honolulu Heart Program: a cohort study. Lancet 2001, 358:351-5.
16. Weverling-Rijnburger AVVE, Blauw GJ, Lagaay AM et al.: Total cholesterol and risk of mortality in the oldest old. Lancet 1997, 350:1119-23. Erratum in: Lancet 1998, 35: 70
17. Forette B: Are common risk factors relevant in the eldest old? In The Paradoxes of Longevity Edited by: Robine JM, Forette B, Franceschi C, Allard M. Berlin, Springer Verlag; 1999:73-80.