-
1
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
Manolio, T.A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
-
(2009)
Nature
, vol.461
, pp. 747-753
-
-
Manolio, T.A.1
-
2
-
-
65949124249
-
Genomewide association studies-illuminating biologic pathways
-
Hirschhorn, J.N. Genomewide association studies-illuminating biologic pathways. N. Engl. J. Med. 360, 1699-1701 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1699-1701
-
-
Hirschhorn, J.N.1
-
3
-
-
65949107547
-
Common genetic variation and human traits
-
Goldstein, D.B. Common genetic variation and human traits. N. Engl. J. Med. 360, 1696-1698 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1696-1698
-
-
Goldstein, D.B.1
-
4
-
-
62549098116
-
Beyond odds ratios-communicating disease risk based on genetic profles
-
Kraft, P. et al. Beyond odds ratios-communicating disease risk based on genetic profles. Nat. Rev. Genet. 10, 264-269 (2009).
-
(2009)
Nat. Rev. Genet.
, vol.10
, pp. 264-269
-
-
Kraft, P.1
-
5
-
-
0036578764
-
Polygenic susceptibility to breast cancer and implications for prevention
-
Pharoah, P.D. et al. Polygenic susceptibility to breast cancer and implications for prevention. Nat. Genet. 31, 33-36 (2002).
-
(2002)
Nat. Genet.
, vol.31
, pp. 33-36
-
-
Pharoah, P.D.1
-
6
-
-
67649668769
-
Value of adding single-nucleotide polymorphism genotypes to a breast cancer risk model
-
Gail, M.H. Value of adding single-nucleotide polymorphism genotypes to a breast cancer risk model. J. Natl. Cancer Inst. 101, 959-963 (2009).
-
(2009)
J. Natl. Cancer Inst.
, vol.101
, pp. 959-963
-
-
Gail, M.H.1
-
7
-
-
47649099448
-
Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk
-
Gail, M.H. Discriminatory accuracy from single-nucleotide polymorphisms in models to predict breast cancer risk. J. Natl. Cancer Inst. 100, 1037-1041 (2008).
-
(2008)
J. Natl. Cancer Inst.
, vol.100
, pp. 1037-1041
-
-
Gail, M.H.1
-
8
-
-
69449098701
-
Estimation of absolute risk for prostate cancer using genetic markers and family history
-
Xu, J. et al. Estimation of absolute risk for prostate cancer using genetic markers and family history. Prostate 69, 1565-1572 (2009).
-
(2009)
Prostate
, vol.69
, pp. 1565-1572
-
-
Xu, J.1
-
9
-
-
56749101779
-
Genotype score in addition to common risk factors for prediction of type 2 diabetes
-
Meigs, J.B. et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N. Engl. J. Med. 359, 2208-2219 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2208-2219
-
-
Meigs, J.B.1
-
10
-
-
77949578084
-
Performance of common genetic variants in breast-cancer risk models
-
Wacholder, S. et al. Performance of common genetic variants in breast-cancer risk models. N. Engl. J. Med. 362, 986-993 (2010).
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 986-993
-
-
Wacholder, S.1
-
11
-
-
65949099120
-
Genetic risk prediction-are we there yet?
-
Kraft, P. & Hunter, D.J. Genetic risk prediction-are we there yet? N. Engl. J. Med. 360, 1701-1703 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 1701-1703
-
-
Kraft, P.1
Hunter, D.J.2
-
12
-
-
42649123990
-
Sizing up human height variation
-
Visscher, P.M. Sizing up human height variation. Nat. Genet. 40, 489-490 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 489-490
-
-
Visscher, P.M.1
-
13
-
-
42649118126
-
Many sequence variants affecting diversity of adult human height
-
Gudbjartsson, D.F. et al. Many sequence variants affecting diversity of adult human height. Nat. Genet. 40, 609-615 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 609-615
-
-
Gudbjartsson, D.F.1
-
14
-
-
42649092874
-
Identifcation of ten loci associated with height highlights new biological pathways in human growth
-
Lettre, G. et al. Identifcation of ten loci associated with height highlights new biological pathways in human growth. Nat. Genet. 40, 584-591 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 584-591
-
-
Lettre, G.1
-
15
-
-
42649139571
-
Genome-wide association analysis identifes 20 loci that infuence adult height
-
Weedon, M.N. et al. Genome-wide association analysis identifes 20 loci that infuence adult height. Nat. Genet. 40, 575-583 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 575-583
-
-
Weedon, M.N.1
-
16
-
-
56349100610
-
Reaching new heights: Insights into the genetics of human stature
-
Weedon, M.N. & Frayling, T.M. Reaching new heights: insights into the genetics of human stature. Trends Genet. 24, 595-603 (2008).
-
(2008)
Trends Genet.
, vol.24
, pp. 595-603
-
-
Weedon, M.N.1
Frayling, T.M.2
-
17
-
-
48349136889
-
Genome-wide association defnes more than 30 distinct susceptibility loci for Crohn's disease
-
Barrett, J.C. et al. Genome-wide association defnes more than 30 distinct susceptibility loci for Crohn's disease. Nat. Genet. 40, 955-962 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 955-962
-
-
Barrett, J.C.1
-
18
-
-
0034644185
-
Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden Denmark, and Finland
-
Lichtenstein, P. et al. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. N. Engl. J. Med. 343, 78-85 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 78-85
-
-
Lichtenstein, P.1
-
19
-
-
34250006413
-
Genome-wide association study identifes novel breast cancer susceptibility loci
-
Easton, D.F. et al. Genome-wide association study identifes novel breast cancer susceptibility loci. Nature 447, 1087-1093 (2007).
-
(2007)
Nature
, vol.447
, pp. 1087-1093
-
-
Easton, D.F.1
-
20
-
-
39749129053
-
Multiple newly identifed loci associated with prostate cancer susceptibility
-
Eeles, R.A. et al. Multiple newly identifed loci associated with prostate cancer susceptibility. Nat. Genet. 40, 316-321 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 316-321
-
-
Eeles, R.A.1
-
21
-
-
56749176944
-
Meta-analysis of genome-wide association data identifes four new susceptibility loci for colorectal cancer
-
Houlston, R.S. et al. Meta-analysis of genome-wide association data identifes four new susceptibility loci for colorectal cancer. Nat. Genet. 40, 1426-1435 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 1426-1435
-
-
Houlston, R.S.1
-
22
-
-
67349158067
-
A multistage genome-wide association study in breast cancer identifes two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)
-
Thomas, G. et al. A multistage genome-wide association study in breast cancer identifes two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat. Genet. 41, 579-584 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 579-584
-
-
Thomas, G.1
-
23
-
-
39749118602
-
Multiple loci identifed in a genome-wide association study of prostate cancer
-
Thomas, G. et al. Multiple loci identifed in a genome-wide association study of prostate cancer. Nat. Genet. 40, 310-315 (2008).
-
(2008)
Nat. Genet.
, vol.40
, pp. 310-315
-
-
Thomas, G.1
-
24
-
-
70349545839
-
Identifcation of seven new prostate cancer susceptibility loci through a genome-wide association study
-
Eeles, R.A. et al. Identifcation of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat. Genet. 41, 1116-1121 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 1116-1121
-
-
Eeles, R.A.1
-
25
-
-
0031714655
-
The population genetics of adaptation: The distribution of factors fxed during adaptive evolution
-
Orr, H.A. The population genetics of adaptation: The distribution of factors fxed during adaptive evolution. Evolution 52, 935-949 (1998).
-
(1998)
Evolution
, vol.52
, pp. 935-949
-
-
Orr, H.A.1
-
26
-
-
35948953262
-
Power to detect risk alleles using genome-wide tag SNP panels
-
Eberle, M.A. et al. Power to detect risk alleles using genome-wide tag SNP panels. PLoS Genet. 3, 1827-1837 (2007).
-
(2007)
PLoS Genet.
, vol.3
, pp. 1827-1837
-
-
Eberle, M.A.1
-
27
-
-
0036094731
-
Power calculations for genetic association studies using estimated probability distributions
-
Schork, N.J. Power calculations for genetic association studies using estimated probability distributions. Am. J. Hum. Genet. 70, 1480-1489 (2002).
-
(2002)
Am. J. Hum. Genet.
, vol.70
, pp. 1480-1489
-
-
Schork, N.J.1
-
28
-
-
1842435224
-
Power for genetic association studies with random allele frequencies and genotype distributions
-
Ambrosius, W.T., Lange, E.M. & Langefeld, C.D. Power for genetic association studies with random allele frequencies and genotype distributions. Am. J. Hum. Genet. 74, 683-693 (2004).
-
(2004)
Am. J. Hum. Genet.
, vol.74
, pp. 683-693
-
-
Ambrosius, W.T.1
Lange, E.M.2
Langefeld, C.D.3
-
29
-
-
67149095078
-
Designing genome-wide association studies: Sample size, power, imputation, and the choice of genotyping chip
-
Spencer, C.C., Su, Z., Donnelly, P. & Marchini, J. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet. 5, e1000477 (2009).
-
(2009)
PLoS Genet.
, vol.5
-
-
Spencer, C.C.1
Su, Z.2
Donnelly, P.3
Marchini, J.4
-
30
-
-
77249134594
-
Rare variants create synthetic genome-wide associations
-
Dickson, S.P., Wang, K., Krantz, I., Hakonarson, H. & Goldstein, D.B. Rare variants create synthetic genome-wide associations. PLoS Biol. 8, e1000294 (2010).
-
(2010)
PLoS Biol.
, vol.8
-
-
Dickson, S.P.1
Wang, K.2
Krantz, I.3
Hakonarson, H.4
Goldstein, D.B.5
-
31
-
-
34548219537
-
Flexible design for following up positive fndings
-
Yu, K. et al. Flexible design for following up positive fndings. Am. J. Hum. Genet. 81, 540-551 (2007).
-
(2007)
Am. J. Hum. Genet.
, vol.81
, pp. 540-551
-
-
Yu, K.1
-
32
-
-
42749087766
-
Estimating odds ratios in genome scans: An approximate conditional likelihood approach
-
Ghosh, A., Zou, F. & Wright, F.A. Estimating odds ratios in genome scans: an approximate conditional likelihood approach. Am. J. Hum. Genet. 82, 1064-1074 (2008).
-
(2008)
Am. J. Hum. Genet.
, vol.82
, pp. 1064-1074
-
-
Ghosh, A.1
Zou, F.2
Wright, F.A.3
-
33
-
-
67149117126
-
Discovery of rare variants via sequencing: Implications for the design of complex trait association studies
-
Li, B. & Leal, S.M. Discovery of rare variants via sequencing: implications for the design of complex trait association studies. PLoS Genet. 5, e1000481 (2009).
-
(2009)
PLoS Genet.
, vol.5
-
-
Li, B.1
Leal, S.M.2
-
34
-
-
50949095168
-
Methods for detecting associations with rare variants for common diseases: Application to analysis of sequence data
-
Li, B. & Leal, S.M. Methods for detecting associations with rare variants for common diseases: application to analysis of sequence data. Am. J. Hum. Genet. 83, 311-321 (2008).
-
(2008)
Am. J. Hum. Genet.
, vol.83
, pp. 311-321
-
-
Li, B.1
Leal, S.M.2
-
35
-
-
52449107055
-
Bias-reduced estimators and confdence intervals for odds ratios in genome-wide association studies
-
Zhong, H. & Prentice, R.L. Bias-reduced estimators and confdence intervals for odds ratios in genome-wide association studies. Biostatistics 9, 621-634 (2008).
-
(2008)
Biostatistics
, vol.9
, pp. 621-634
-
-
Zhong, H.1
Prentice, R.L.2
-
36
-
-
75649147432
-
"Winner's curse" in odds ratios from genomewide association fndings for major complex human diseases
-
Zhong, H. & Prentice, R.L. Correcting "winner's curse" in odds ratios from genomewide association fndings for major complex human diseases. Genet. Epidemiol. 34, 78-91 (2009).
-
(2009)
Genet. Epidemiol.
, vol.34
, pp. 78-91
-
-
Zhong, H.1
Correcting, L.P.R.2
|