Postoperative bleeding in cardiac surgery: The role of tranexamic acid in patients homozygous for the 5G polymorphism of the plasminogen activator inhibitor-1 gene

Anesthesiology

Volumn 108, Issue 4, 2008, Pages 596-602

  Iribarren, Jose L ^a,b   Jimenez, Juan J ^a   Hernández, Domingo ^a   Brouard, Maitane ^a   Riverol, Debora ^a   Lorente, Leonardo ^a   De La Llana, Ramiro ^a   Nassar, Ibrahim ^a   Perez, Rosalia ^a   Martinez, Rafael ^a   Mora, Maria L ^a  

^a HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

^b NONE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANESTHETIC AGENT; HEPARIN; MUSCLE RELAXANT AGENT; OPIATE; PLACEBO; PROTAMINE; TRANEXAMIC ACID; VOLATILE AGENT;

ADULT; AGED; ARTICLE; BLOOD CLOTTING; BLOOD TRANSFUSION; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA POLYMORPHISM; DRUG EFFICACY; FEMALE; FIBRINOLYSIS; GENE; GENETIC ASSOCIATION; GENOTYPE; HEART SURGERY; HUMAN; INFORMATION PROCESSING; INTENSIVE CARE UNIT; MALE; PLASMINOGEN ACTIVATOR INHIBITOR 1 GENE; POSTOPERATIVE HEMORRHAGE; PRIORITY JOURNAL; TUBE;

EID: 41149083908     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/ALN.0b013e318167aecc     Document Type: Article

References (23)

1. Laffey JG: The systemic inflammatory response to cardiac surgery. ANESTHESIOLOGY 2002; 97:215-52
2. Karkouti K, Wijeysundera DN, Yau TM, Beattie WS, Abdelnaem E, McCluskey SA, Ghannam M, Yeo E, Djaiani G, Karski J: The independent association of massive blood loss with mortality in cardiac surgery. Transfusion 2004; 44:1453-62
3. Koch CG, Li L, Duncan AI, Mihaljevic T, Loop FD, Starr NJ, Blackstone EH: Transfusion in coronary artery bypass grafting is associated with reduced long-term survival. Ann Thorac Surg 2006; 81:1650-7
4. Dacey LJ, Munoz JJ, Baribeau YR, Johnson ER, Lahey SJ, Leavitt BJ, Quinn RD, Nugent WC, Birkmeyer JD, O'Connor GT: Re-exploration for hemorrhage following coronary artery bypass grafting: Incidence and risk factors. Northern New England Cardiovascular Disease Study Group. Arch Surg 1998; 133:442-7
5. Jiménez JJ, Iribarren JL, Raya JM, Nassar I, Lorente L, Pérez R, Brouard M, Lorenzo JM, Alarcó B, Martínez R, Mora ML: Factors associated with excessive bleeding in cardiopulmonary bypass patients: A nested case-control study. J Cardiothorac Surg 2007; 2:17
6. Dawson S, Hamsten A, Wiman B, Henney A, Humphries S: Genetic variation at the plasminogen activator inhibitor-1 locus is associated with altered levels of plasma plasminogen activator inhibitor-1 activity. Arterioscler Thromb 1991; 11:183-90
7. Sequi R, Estelles A, Mira Y, España F, Villa P, Falco C, Vaya A, Grancha S, Ferrando F, Aznar J: PAI-1 promoter 4G/5G genotype as an additional risk factor for venous thrombosis in subjects with genetic thrombophilic defects. Br J Haematol 2000; 111:122-8
8. Engles L: Review and application of serine protease inhibition in coronary artery bypass graft surgery. Am J Health Syst Pharm 2005; (suppl 62):9-14
9. Jiménez JJ, Iribarren JL, Lorente L, Rodriguez JM, Hernandez D, Nassar MI, Perez R, Brouard M, Milena A, Martinez R, Mora ML: Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: A case control study followed by a randomized double-blind controlled trial. Critical Care 2007; 11:R117
10. Falk G, Almqvist A, Nordenhem A, Svensson H, Wiman B: Allele specific PCR for detection of a sequence polymorphism in the promoter region of the plasminogen activator inhibitor-1 (PAI-1) gene. Fibrinolysis 1995; 9:170-4
11. Burzotta F, Iacoviello L, Di Castelnuovo A, Zamparelli R, D'Orazio A, Amore C, Schiavello R, Donati MB, Maseri A, Possati G, Andreotti F: Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children. J Pediatr Endocrinol Metab 2006; 19:741-8
12. Moulton MJ, Creswell LL, Mackey ME, Cox JL, Rosenbloom M: Reexploration for bleeding is a risk factor for adverse outcomes after cardiac operations. J Thorac Cardiovasc Surg 1996; 111:1037-46
13. Setakis E, Stirnadel H, Balding DJ: Logistic regression protects against population structure in genetic association studies. Genome Res 2006; 16: 290-6
14. Welsby IJ, Podgoreanu MV, Phillips-Bute B, Mathew JP, Smith PK, Newman MF, Schwinn DA, Stafford-Smith M: Genetic factors contribute to bleeding after cardiac surgery. J Thromb Haemost 2005; 3:1206-12
15. Nuttall GA, Henderson N, Quinn M, Blair C, Summers L, Williams BA, Oliver WC, Santrach PJ: Excessive bleeding and transfusion in a prior cardiac surgery is associated with excessive bleeding and transfusion in the next surgery. Anesth Analg 2006; 102:1012-7
16. Leng HM, Brouwers E, Knockaert I, Declerck PJ: Immunoassays for the quantitation of porcine PAI-1 antigen and activity in biological fluid samples. Thromb Haemost 2000; 84:1082-6
17. Grebenchtchikov N, Maguire TM, Riisbro R, Geurts-Moespot A, O'Donovan N, Schmitt M, McGreal G, McDermott E, O'Higgins N, Brunner N, Sweep CG, Duffy MJ: Measurement of plasminogen activator system components in plasma and tumor tissue extracts obtained from patients with breast cancer: An EORTC Receptor and Biomarker Group collaboration. Oncol Rep 2005; 14:235-9
18. Duggan E, O'Dwyer MJ, Caraher E, Diviney D, McGovern E, Kelleher D, McManus R, Ryan T: Coagulopathy after cardiac surgery may be influenced by a functional plasminogen activator inhibitor polymorphism. Anesth Analg 2007; 104:1343-7
19. Levi M, Cromheecke ME, de Jonge E, Prins MH, de Mol BJ, Briet E, Buller HR: Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints. Lancet 1999; 354:1940-7
20. Carless PA, Moxey AJ, Stokes BJ, Henry DA: Are antifibrinolytic drugs equivalent in reducing blood loss and transfusion in cardiac surgery? A meta-analysis of randomized head-to-head trials. Cardiovasc Disord 2005; 5:19
21. Carroll RC, Chavez JJ, Snider CC, Meyers DS, Muenchen RA: Correlation of perioperative platelet function and coagulation tests with bleeding after cardiopulmonary bypass surgery. J Lab Clin Med 2006; 147:197-204
22. Sartori MT, Vettor R, De Pergola G, De Mitrio V, Saggiorato G, Della Mea P, Patrassi GM, Lombardi AM, Fabris R, Girolami A: Role of the 4G/5G polymorphism of PAI-1 gene promoter on PAI-1 levels in obese patients: Influence of fat distribution and insulin-resistance. Thromb Haemost 2001; 86:1161-9
23. Berberoglu M, Evliyaoglu O, Adiyaman P, Ocal G, Ulukol B, Simsek F, Siklar Z, Torel A, Ozel D, Akar N: Plasminogen activator inhibitor-1 (PAI-1) gene polymorphism (-675 4G/5G) associated with obesity and vascular risk in children. J Pediatr Endocrinol Metab 2006; 19:741-8