Recent advances in human gene-longevity association studies

Mechanisms of Ageing and Development

Volumn 122, Issue 9, 2001, Pages 909-920

  De Benedictis, G ^a   Tan, Qihua ^b   Jeune, B ^c   Christensen, K ^d   Ukraintseva, S V ^a   Bonafe M ^b   Franceschi, C ^c   Vaupel, J W ^d   Yashin, A I ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

^b MAX PLANCK INSTITUTE FOR DEMOGRAPHIC RESEARCH   (Germany)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Disease; Gene; Human longevity; Life span correlation

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN E; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; DIPEPTIDYL CARBOXYPEPTIDASE; FIBRINOGEN; FIBROLASE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; MITOCHONDRIAL DNA; PROTEIN P53; PROTEIN SUBUNIT; PROTHROMBIN;

AGING; DNA POLYMORPHISM; GENE; GENE FUNCTION; GENETIC RISK; HUMAN; LIFESPAN; LONGEVITY; MOLECULAR BIOLOGY; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SURVIVAL;

HUMANS; LONGEVITY; RISK FACTORS;

EID: 0035880002     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0047-6374(01)00247-0     Document Type: Review

References (71)

1. Agundez, J.A., et al., 1997. CYP2D6, NAT2 and CYP2E1 genetic polymorphisms in nonagenarians. Age Ageing 26, 147-151.
2. Akisaka, M., et al., 1997. Molecular genetic studies on DNA polymorphism of the HLA class II genes associated with human longevity. Tissue Antigens 50 (5), 489-493.
3. Bader, G., et al., 1998. Apolipoprotein E phenotype is not associated with longevity or disability in a sample of Italian octo-and nonagenarians. Gerontology 448, 293-299.
4. Bathum, L., et al., 1998. Genotypes for the cytochrome P450 enzymes CYP2D6 and CYP2C19 in human longevity. Role of CYP2D6 and CYP2C19 in longevity. Eur. J. Clin. Pharmacol. 54, 427-430.
5. Bladbjerg, E.M., et al., 1999. Longevity is independent of common variations in genes associated with cardiovascular risk. Thromb. Haemost. 82, 1100-1105.
6. Bonafè, M., et al., 1999a. P53 variants predisposing to cancer are present in healthy centenarians. Am. J. Hum. Genet. 64, 292-295.
7. Bonafè, M., et al., 1999b. P53 codon 72 polymorphism and longevity: additional data on centenarians from continental Italy and Sardinia. Am. J. Hum. Genet. 65, 1782-1785.
8. Brattstrom, L., et al., 1998. A common methylenetetrahydrofolate reductase gene mutation and longevity. Atherosclerosis 141, 315-319.
9. Carmelli, D., 1982. Intrapair comparisons of total life span in twins and pairs of sibs. Hum. Biol. 54, 525-537.
10. Caruso, C., et al., 2000. HLA, aging, and longevity: a critical reappraisal. Hum. Immunol. 61, 942-949.
11. Castellani, S., et al., 1998. Excessive vasoconstriction after stress by the aging kidney: inadequate prostaglandin modulation of increased endothelin activity. J. Lab. Clin. Med. 132, 186-194.
12. Castro, E., et al., 1999. Polymorphism at the Werner Locus: I. Newly Identified Polymorphisms, Ethnic Variability of 1637Cy/Arg, and its Stability in a Population of Finnish Centenarians. Am. J. Med. Genet. 82, 399-408.
13. Cottet, F., 2000. New polymorphisms in the human poly(ADP-ribose) polymerase-1 coding sequence: lack of association with longevity or with increased cellular poly(ADP-ribosyl)ation capacity. J. Mol. Med. 78, 431-440.
14. De Benedictis, G., et al., 1997. DNA multiallelic systems reveal gene/longevity associations not detected by diallelic systems: The APOB locus. Hum. Genet. 99, 312-318.
15. De Benedictis, G., et al., 1998a. Age-related changes of the 3'APOB-VNTR genotype pool in ageing cohorts. Ann. Hum. Genet. 62, 115-122.
16. De Benedictis, G., et al., 1998b. Gene/longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 6, 534-541.
17. De Benedictis, G., et al., 1999. Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans. FASEB J. 13, 1532-1536.
18. Dorak, M.T., et al., 1994. Homozygous MHC genotypes and longevity. Hum. Hered. 44, 271-278.
19. Faure-Delaneff, L., et al., 1997. Methylenetetrahydrofolate Reductase Thermolabile Variant and Human Longevity. Am. J. Hum. Genet. 60, 999-1001.
20. Faure-Delaneff, L., et al., 1998. Plasma concentration, kinetic constant and gene polymorphism of angiotensin I- converting enzyme in centenarians. Clin. Chem. 44, 2083-2087.
21. Forette, B., 1999. Are common risk factors relevant in the eldest old? In: Robine, JM, Franceschi, C, Forette, B, Allard, M. (Eds.), The Paradoxes of Longevity. Springer Verlag, Berlin, pp. 73-80.
22. Franceschi, C., et al., 2000a. Do men and women follow different trajectories to reach extreme longevity? Italian Multicenter Study on Centenarians. Aging Clin. Exp. Res. 12, 77-84.
23. Franceschi, C., et al., 2000b. The network and the remodeling theory of aging: historical background and new perspective. Exp. Gerontol. 35, 879-896.
24. Franceschi, C., et al., 2000c. Inflamm-aging: An evolutionary perspective on immunosenescence. Ann. NY Acad. Sci. 908, 244-254.
25. Galinsky, D., et al., 1997. Analysis of the apo E/apo C-I, angiotensin converting enzyme and methylenetetrahydrofolate reductase genes as candidates affecting human longevity. Atherosclerosis 129, 177-183.
26. Gerdes, L.U., et al., 2000. Estimation of apolipoprotein E genotype-specific relative mortality risks fromthe distribution of genotypes in centenarians and middle-aged men:apolipoprotein E gene is a "frailty gene", not a "longevity gene". Genet. Epidemiol. 19, 202-210.
27. Goldstein, J.L., et al., 1989. Familial hyper-cholesterolemia. In: Scriver, C.R., Blaudet, A.L., Sly, W.S., Valle, D. (Eds.), The Metabolic Basis of Inherited Disease, 6th ed. McGraw-Hill, New York, pp. 1215-1250.
28. Grube, K., et al., 1994. Poly (ADP-ribose) polymerase activity in mononuclear leucocytes of 13 mammalian species correlates with species specific life span. Proc. Natl. Acad. Sci. USA 99, 11759-11763.
29. Harmon, D.L., et al., 1997. MTHFR thermolabile genotype frequencies and longevity in northern Ireland. Atherosclerosis 131, 137-138.
30. Harris, J., 1992. Age differences in genetic and environmental influences for health from the Swedish adoption/twin study of aging. J. Gerontol. Psycholog. Sci. 47, 213-220.
31. Hayakawa, K., et al., 1992. Intrapair differences of phisical aging and longevity in identical twins. Acta Genet. Med. Gemellol. 41, 177-185.
32. Heijmans, B.T., et al., 1999a. Angiotensin I-converting enzyme and plasminogen activator inhibitor-1 gene variants: risk of mortality and fatal cardiovascular disease in an elderly population-based cohort. J. Am. Coll. Cardiol. 34, 1176-1183.
33. Heijmans, B.T., et al., 1999b. Mortality risk in men is associated with a common mutation in the méthylène-tetrahydrofolate reductase gene (MTHFR). Eur. J. Hum. Genet. 7, 197-204.
34. Heijmans, B.T., et al., 2000. Common gene variants, mortality and extreme longevity in humans. Exp. Gerontol. 35, 865-877.
35. Herskind, A.M., et al., 1996. The heritability of human longevity, a population-based study of 2872 Danish twin pairs born 1870-1900. Hum. Genet. 97, 319-323.
36. Ivanova, R., et al., 1998a. HLA-DR alleles display sex-dependent effects on survival and discriminate etween individual and familial longevity. Hum. Mol. Genet. 7, 187-194.
37. Ivanova, R., et al., 1998b. Mitochondrial genotype associated with French Caucasian centenarians. Gerontology 44, 349.
38. Izaks, G.J., et al., 1997. The association between human leucocyte antigens (HLA) and mortality in community residents aged 85 and older. J. Am. Geriatr. Soc. 45, 56-60.
39. Kervinen, K., et al., 1994. Apolipoprotein E and B polymorphisms-longevity factors assessed in nonagenarians. Atherosclerosis 105, 89-95.
40. Kluijtmans, L.A., et al., 1999. Reduced frequency of the thermolabile methylenetetrahydrofolate reductase genotype in the elderly. Atherosclerosis 146, 395-397.
41. Louhija, J., et al., 1994. Ageing and genetic variation of plasma apolipoproteins. Relative loss of the apolipoprotein E phanotype in centenarians. Arterioscler. Thromb. Vase. Biol. 14, 1084-1089.
42. Luciani, F. et al. 2001. A stochastic model for CD8 + T cell dynamics in human immunosenescence: implication for survival and longevity. J. Theoret. Biol., in press.
43. Ma, X.Y., et al., 1997. HLA and longevity or aging among Shanghai Chinese. Mech. Ageing Dev. 94, 191-198.
44. Mannucci, P.M., et al., 1997. Gene polymorphisms predicting high plasma levels of coagulation and fibrinolysis proteins: A study in centenarians. Arterioscler. Thromb. Vase. Biol. 17, 755-759.
45. Mari, D., et al., 1996. Mutant factor V (Arg506Gln) in healthy centenarians. Lancet 347, 1044.
46. Matsushita, S., et al., 1997. The frequency of the methylenetetrahydrofolate reductase-gene mutation varies wth age in the normal population. Am. J. Hum. Genet. 61, 1459-1460.
47. McGue, M., et al., 1993. Longevity is moderately heritable in a sample of Danish twins born 1870-1880. J. Gerontol. 48, B237-B244.
48. Meiklejohn, D.J., et al., 2000. The contribution of factor VII gene polymorphisms to longevity in Scottish nonagenarians. Thromb. Haemost. 83, 519.
49. Merched, A., et al., 1998. Apolipoprotein AIV codon 360 mutation increases with human aging and is not associated with Alzheimer's disease. Neurosci. Lett. 242, 117-119.
50. Muiras, M.L., et al., 1998a. Lack of association between human longevity and genetic polymorphsims in drug-metabolizing enzymes at the NAT2, GSTM1 and CYP2D6 loci. Hum. Genet. 102, 526-532.
51. Muiras, M.L., et al., 1998b. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines fromcentenarians. J. Mol. Med. 76, 346-354.
52. Pepe, G., et al., 1998. In search of a biological pattern for human longevity: impact of apo A-IV genetic polymorphisms on lipoproteins and the hyper-Lp(a) in centenarians. Atherosclerosis 137, 407-417.
53. Proust, J., 1982. HLA and longevity. Tissue Antigens 19, 68-73.
54. Rea, I.M., et al., 2000. Community living nonagenarians in northern Ireland have lower plasma homocysteine but similar methylenetetrahydrofolate reductase thermolabile genotype prevalence compared to 70-89-year-old subjects. Atherosclerosis 149, 207-214.
55. Ricci, G., et al., 1998. Association between longevity and allelic forms of human leukocyte antigens (HLA): population study of aged Italian human subjects. Arch. Immunol. Ther. Exp. (Warsz) 46, 31-34.
56. Satoh, M.S., et al., 1992. Role of poly (ADP-ribose) formation in DNA repair. Nature 356, 356-358.
57. Schachter, F., et al., 1994. Genetic associations with human longevity at the APOE and ACE loci. Nature Genet. 6, 29-32.
58. Takata, H., et al., 1987. Influence of major histocompatibility complex region genes on human longevity among Okinawan-Japanese centenarians and nonagenarians. Lancet 2 (8563), 824-826.
59. Tan, Q. et al. (2001). Measuring the genetic influence in modulating human life span: Gene-environment and gene-sex interactions. Biogerontology 2 (3), in press.
60. Tanaka, M., et al., 1998. Mitochondrial genotype associated with longevity. Lancet 351, 185-186.
61. Todesco, L., et al., 1999. Methylenetetrahydrofolate reductase polymorphism, plasma homocysteine and age. Eur. Clin. Invest. 29, 1003-1009.
62. Toupance, B., et al., 1998. A model for antagonistic pleiotropic gene action for mortality and advanced age. Am. J. Hum. Genet. 62, 1525-1534.
63. Vaupel, J.W., et al., 1998. Biodemographic trajectories of longevity. Science 280, 855-860.
64. Wilmoth, J.R., et al., 2000. Increase of maximum life-span in Sweden, 1861-1999. Science 289 (5488), 2366-2368.
65. Yamada, H., et al., 1998. CYP2D6 and CYP2C19 genotypes in an elderly Swedish population. Eur. J. Clin. Pharmacol. 54, 479-481.
66. Yang, Y.L., et al., 1999. Heat shock protein expression protects against cerebral ischemia and monoamine overload in rat heatstroke. Am. J. Physiol. 276, H1961-1967.
67. Yashin, A.I., et al., 1998. Combining genetic and demographic information in population studies of aging and longevity. J. Epidemiol. Biostatist. 3, 289-294.
68. Yashin, A.I., et al., 1999a. Half of the variation in susceptibility to mortality is genetic: findings from Swedish twin survival data. Behav. Genet. 29, 11-19.
69. Yashin, A.I., et al., 1999b. Genes, demography, and life span: the contribution of demographic data in genetic studies on aging and longevity. Am. J. Hum. Genet. 65, 1178-1193.
70. Yashin, et al. (2000) Genes and longevity: lessons from studies of centenarians. J. Gerontol. A Biol. Sci. Med. Sci. 55 (7), B319-28.
71. Zhang, J.G., et al., 1998. Apolipoprotein E and longevity among Han Chinese population. Mech. Ageing Dev. 104, 159-167.