Apolipoprotein E polymorphism is not associated with longevity or disability in a sample of Italian octo- and nonagenarians

Gerontology

Volumn 44, Issue 5, 1998, Pages 293-299

  Bader, G ^a   Zuliani, G ^a   Kostner, G M ^b   Fellin, R ^a,c  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF GRAZ   (Austria)

^c Arcispedale St Anna   (Italy)

Author keywords

Aging; Apoprotein E; Disability; Polymorphism

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; APOLIPOPROTEIN E; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID; LIPOPROTEIN; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

AGED; AGING; ALZHEIMER DISEASE; ARTICLE; CARDIOVASCULAR DISEASE; CHOLESTEROL BLOOD LEVEL; DISABILITY; GENE FREQUENCY; GENETIC POLYMORPHISM; HUMAN; HUMAN EXPERIMENT; ITALY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LONGEVITY; MULTIINFARCT DEMENTIA; NORMAL HUMAN; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0031716880     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000022030     Document Type: Article

References (30)

1. Davignon J, Gregg RE, Sing CF: Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988;8:1-21.
2. Dal longe ville J, Lussier-Cacan S, Davignon J: Modulation of plasma triglyceride levels by apo E phenotype: a meta-analysis. J Lipid Res 1I992;33:447-454.
3. Wilson C, Wardell MR, Weisgraber KH. Manley RW, Agard DA: Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E, Science 1991;252:1817-1822.
4. Gregg RE, Zech LA, Schaefer EJ, Stark D, Wilson D, Brewer HB: Abnormal in vivo metabolism of apolipoprotein E4 in humans. J Clin Invest 1986;78:815-821.
5. Ghiselli G, Schaefer EJ, Zech LA, Gregg RE, Brewer HB: Increased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia. J Clin Invest 1982;70:474-477.
6. Eichner JE, Kuller LH, Orchard TJ, Grandits GA, McCallum LM, Ferrel RE, Neaton JD: Relation of apolipoprotein E phenotype to myocardial infarction and mortality from coronary artery disease. Am J Cardiol 1993;171:160-165.
7. Boyles JK, Pitas RE, Wilson E, Mahley RW, Taylor JM: Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system. J Clin Invest 1985;76;1501-1513.
8. Boyles JK, Zoellner CD, Anderson LJ, Kosik LM, Pitas RE, Weisgraber KH, Hui DY, Mahley RW, Gebicke-Haerter PJ, Ignatius MJ, Shooter EM: A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. J Clin Invest 1989;83:1015-1031.
9. Saunders AM, Strittmatter WJ, Schmechel D, George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Grain B, Goldgaber D, Roses AD: Association of apolipoprotein E-4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-1472.
10. Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA: Gene dose of apolipoprotein E type 4 allele and risk of Alzheimer's disease in late onset families. Science 1993;261:921-923.
11. Frisoni GB, Bianchetti A, Govoni S, Trabucchi M, Calabresi L, Franceschini G: Association of apolipoprotein E E4 with vascular dementia (letter). J Am Med Assoc 1994;271:1317.
12. Davignon J, Bouthiller D, Nestruck AC, Sing CF: Apolipoprotein E polymorphism and ath- erosclerosis: Insight from a study in octogenarians. Trans Am Clin Climatol Assoc 1987;99:100-110.
13. Cauley JA, Eichner JE, Kamboch IM, Ferrel RE, Kuller LH: Apo E allele frequencies in younger (age 42-50) vs. older (age 65-90) women. Genet Epidemiol 1993;10:27-34.
14. Kervinen K, Savolainen MJ, Salokannel J, Hynninen A, Heikkinen J, Ehnolm C, Koistinen MJ, Kesaniemi YA: Apolipoprotein E and B polymorphisms: Longevity factors assessed in nonagenarians. Atherosclerosis 1994;10:89-95.
15. Zuliani G, Bader G, Imbastaro T, Mezzetti A, Taddeo U, Kostner GM, Fellin R, Associazione Medica Sabin: Lipoprotein (a) plasma levels and apo (a) isoform s are not associated with longevity or disability in a sample of Italian octo-nonagenarians, Aging Clin Exp Res 1995;7:385-391.
16. Mezzetti A, Lapcnna D, Costantini F, Pierdomenico SD, De Cesare D, Cuccurullo F, Romano F, Riario-Sforza G, Zuliani G, Fellin R, Associazione Medica Sabin: Systemic oxidative stress and its relationship with aging: A cross-sectional study. JAGS 1996;44:823-827.
17. Katz S, Downs TD, Cash HR, Grotz RC: Progress in the development of the index of ADL. Gerontologist 1970;10:20-30.
18. Hackler R, Schefer JR, Motzny S, Brand S, Kleine TO, Kaffarnik H, Steinmetz A: Rapid determination of apolipoprotein E phenotypes from whole plasma by automated isoelectric focusing using PhastSystem™ and immunofixation. J Lipid Res 1994;35:153-158.
19. Gerdes LU, Klausen IC, Sihm I, Faegeman O: Apolipoprotein E polymorphism in a Danish population compared to findings in 45 other study populations around the world. Genet Epidemiol 1992;9:155-167.
20. Hallman DM, Boerwinkle E, Saha N, Sandholzer C, Menzel HJ, Csázár A, Utermann G: The apolipoprotein E polymorphism: A comparison of allele frequencies and effects in nine populations. Am J Hum Genet 1991;49:338-349.
21. Eggensen G, Tegelman R, Ericsson S, Angelin B, Berglund L: Apolipoprotein E polymorphism in a healthy Swedish population: Variation of allele frequency with age and relation to serum lipid concentrations. Clin Chem 1993;39:2125-2129.
22. Muros M, Rodriguez-Ferrer CR: Apolipoprotein E polymorphism influence on lipids, apolipoproteins and Lp(a) in a Spanish population underexpressing apo E4. Atherosclerosis 1996;121:13-21.
23. James RW, Boemi M, Giansanti R, Fumeili P, Pometta D: Underexpression of the apolipoprotein E4 isoform in an Italian population. Arterioscler Thromb 1993;13:1456-1459.
24. Xu CF, Talmud PJ, Angelico F, Del Ben M, Savill J, Humphries SE: Apolipoprotein E polymorphism and plasma lipid, lipoprotein, and apolipoprotein levels in Italian children. Genet Epidemiol 1991;8:389-398.
25. Ruiu G, Cassader M, Gambino R, Alemanno N, Demichieli F, Pagano A, Veglia F, Pagano G: Apolipoprotein E allele frequencies in an Italian population: Relation to age and lipid profile. Aging Clin Exp Res 1995;7:185-189.
26. Stamler J, Shekelle RB: Dietary cholesterol and human coronary heart disease: the epidemiologic evidence. Arch Pathol Lab Med 1988;112:1032-1040.
27. Rimm EB, Ascherio A, Giovannucci E, Spiegelman D, Stampfer MJ, Willett WC: Vegetable, fruit and cereal fiber intake and risk of coronary heart disease among men. JAMA 1996;275:447-451.
28. Gey KF, Puske P, Jordan P, Moser UK: Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. Am J Clin Nutr 1991;53:326S-334S.
29. Scacchi R, De Bernardini L, Mantuano E, Donini LM, Vilardo T, Corbo RM: Apolipoprotein E (APO E) allele frequencies in lateonset sporadic Alzheimer's disease (AD), mixed dementia and vascular dementia: Lack of association of ε4 allele with AD in Italian octogenarian patients. Neurosci Lett 1995;201:231-234.
30. Utermann G: Apolipoprotein polymorphism and multifactorial hyperlipidaemia. J Inherit Metab Dis 1988;11(suppl 1):74-86.