Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy

Cytokine

Volumn 56, Issue 2, 2011, Pages 481-488

  Napolioni, Valerio ^a,b,c   Carpi, Francesco M ^c   Giannì, Paola ^c   Sacco, Roberto ^a,b   Di Blasio, Luca ^c   Mignini, Fiorenzo ^c   Lucarini, Nazzareno ^c   Persico, Antonio M ^a,b  

^a UNIVERSITY CAMPUS BIO MEDICO   (Italy)

^b IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^c UNIVERSITY OF CAMERINO   (Italy)

Author keywords

Adenosine deaminase; Genetic polymorphism; Human longevity; Multifactor dimensionality reduction; Tumor necrosis factor

Indexed keywords

ADENOSINE DEAMINASE GENE; ADULT; AGE; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GENE INTERACTION; GENE LOCUS; GENERALIZED MULTIFACTOR DIMENSIONALITY REDUCTION; GENETIC EPISTASIS; GENOTYPE; HUMAN; ITALY; LIFE EXPECTANCY; LONGEVITY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; TUMOR NECROSIS FACTOR ALPHA GENE;

ADENOSINE DEAMINASE; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BASE SEQUENCE; DNA PRIMERS; EPISTASIS, GENETIC; FEMALE; HUMANS; LIFE EXPECTANCY; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 80053319751     PISSN: 10434666     EISSN: 10960023     Source Type: Journal    
DOI: 10.1016/j.cyto.2011.07.023     Document Type: Article

References (58)

1. Perls T., Kunkel L., Puca A. The genetics of aging. Curr Opin Genet Dev 2002, 12:362-369.
2. Bruunsgaard H., Pedersen M., Pedersen B.K. Aging and proinflammatory cytokines. Curr Opin Hematol 2001, 8:131-136.
3. Franceschi C., Bonafè M., Valensin S., Olivieri F., De Luca M., Ottaviani E., et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann NY Acad Sci 2000, 908:244-254.
4. Pawelec G., Effros R.B., Caruso C., Remarque E., Barnett Y., Solana R. T cells and aging. Front Biosci 1999, 4:216-269.
5. Franceschi C., Monti D., Sansoni P., Cossarizza A. The immunology of exceptional individuals: the lesson of centenarians. Immunol Today 1995, 16:12-16.
6. Caruso C., Candore G., Romano G.C., Lio D., Bonafè M., Valensin S., et al. Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data. Mech Ageing Dev 2001, 122:445-462.
7. Bayley J.P., Ottenhoff T.H., Verweij C.L. Is there a future for TNF promoter polymorphisms?. Genes Immun 2004, 5:315-329.
8. Cardelli M., Cavallone L., Marchegiani F., Oliveri F., Dato S., Montesanto A., et al. Genetic-demographic approach reveals male-specific association between survival and tumor necrosis factor (A/G) -308 polymorphism. J Gerontol A Biol Sci Med Sci. 2008, 63A:454-460.
9. Elahi M.M., Asotra K., Matata B.M., Mastana S.S. Tumor necrosis factor alpha -308 gene locus promoter polymorphism: an analysis of association with health and disease. Biochim Biophys Acta 2009, 1792:163-172.
10. Bruunsgaard H., Benfield T.L., Andersen-Ranberg K., Hjelmborg J.B., Pedersen A.N., Schroll M., et al. The tumor necrosis factor alpha -308G>A polymorphism is associated with dementia in the oldest old. J Am Geriatr Soc 2004, 52:1361-1366.
11. Khabour O.F., Barnawi J.M. Association of longevity with IL-10 -1082G/A and TNF-alpha -308G/A polymorphisms. Int J Immunogenet 2010, 37:293-298.
12. Lio D., Scola L., Crivello A., Colonna-Romano G., Candore G., Bonafé M., et al. Inflammation, genetics, and longevity: further studies on the protective effects in men of IL10 -1082 promoter SNP and its interaction with TNFa -308 promoter SNP. J Med Genet 2003, 40:296-299.
13. Ross O.A., Curran M.D., Rea I.M., Hyland P., Duggan O., Barnett C.R., et al. HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish. Mech Ageing Dev 2003, 124:563-567.
14. Soto-Vega E., Richaud-Patin Y., Llorente L. Human leukocyte antigen class I, class II and tumor necrosis factor-alpha polymorphisms in a healthy elder Mexican Mestizo population. Immun Ageing 2005, 3:2-13.
15. Wang X.Y., Hurme M., Jylha M., Hervonen A. Lack of association between human longevity and polymorphisms of IL-1 cluster, IL-6, IL-10 and TNF-alpha genes in Finnish nonagenarians. Mech Ageing Dev 2001, 123:29-38.
16. Pappachan J.V., Coulson T.G., Child N.J., Markham D.J., Nour S.M., Pulletz M.C., et al. Mortality in adult intensive care patients with severe systemic inflammatory response syndromes is strongly associated with the hypo-immune TNF -238A polymorphism. Immunogenetics 2009, 61:657-662.
17. Vassalli P. The pathophysiology of tumor necrosis factor. Ann Rev Immunol 1992, 10:411-452.
18. Eigler A., Greten T.F., Sinha B., Haslberger C., Sullivan G.W., Endres S. Endogenous adenosine curtails lipopolysaccharide-stimulated tumour necrosis factor synthesis. Scand J Immunol 1997, 45:132-139.
19. Cronstein B.N., Naime D., Firestein G. The anti-inflammatory effects of an adenosine kinase inhibitor are mediated by adenosine. Arthritis Rheum 1995, 38:1040-1045.
20. Levy O., Coughlin M., Cronstein B.N., Roy R.M., Desai A., Wessels M.R. The adenosine system selectively inhibits TLR-mediated TNF-a production in the human newborn. J Immunol 2006, 177:1956-1966.
21. Battistuzzi G., Iudicone P., Santolamazza P., Petrucci R. Activity of adenosine deaminase allelic forms in intact erythrocytes and in lymphocytes. Ann Hum Genet 1981, 45:15-19.
22. Napolioni V., Predazzi I.M. Age- and gender-specific association between ADA (22G>A) and TNF-α (-308G>A) genetic polymorphisms. Tissue Antigens 2010, 76:311-314.
23. Napolioni V., Lucarini N. Gender-specific association of ADA genetic polymorphism with human longevity. Biogerontology 2010, 11:457-462.
24. Cavalli-Sforza L.L., Menozzi P., Piazza A. The History and Geography of Human Genes 1994, Princeton University Press, Princeton.
25. Passarino G., Montesanto A., Dato S., Giordano S., Domma F., Mari V., et al. Sex and age specificity of susceptibility genes modulating survival at old age. Hum Hered 2006, 62:213-220.
26. Fargion S., Valenti L., Dongiovanni P., Scaccabarozzi A., Fracanzani A.L., Taioli E., et al. Tumor necrosis factor alpha promoter polymorphisms influence the phenotypic expression of hereditary hemochromatosis. Blood 2001, 97:3707-3712.
27. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genet Epidemiol 2003, 25:115-121.
28. Barrett J.C., Fry B., Maller J., Daly M.J. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005, 21:263-265.
29. Lou X.Y., Chen G.B., Yan L., Ma J.Z., Zhu J., Elston R.C., et al. A generalized combinatorial approach for detecting gene-by-gene and gene-by-environment interactions with application to nicotine dependence. Am J Hum Genet 2007, 80:1125-1137.
30. Hahn L.W., Ritchie M.D., Moore J.H. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 2003, 19:376-382.
31. Ritchie M.D., Hahn L.W., Roodi N., Bailey L.R., Dupont W.D., Parl F.F., et al. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 2001, 69:138-147.
32. Pernerger T.V. What's wrong with Bonferroni adjustments?. BMJ 1998, 316:1236-1238.
33. Huxley V.H., Wang J.J., Whitt S.P. Sexual dimorphism in the permeability response of coronary microvessels to adenosine. Am J Physiol Heart Circ Physiol 2005, 288:2006-2013.
34. Viña J., Borrás C., Gambini J., Sastre J., Pallardó F.V. Why females live longer than males: control of longevity by sex hormones. Sci Aging Knowledge Environ 2005, 23:pe17.
35. Naumova A.K., Greenwood C.M., Morgan K. Imprinting and deviation from Mendelian transmission ratios. Genome 2001, 44:311-320.
36. Friedrichs F., Brescianini S., Annese V., Latiano A., Berger K., Kugathasan S., et al. Evidence of transmission ratio distortion of DLG5 R30Q variant in general and implication of an association with Crohn disease in men. Hum Genet 2006, 119:305-311.
37. Hirschhorn R., Yang D.R., Israni A. An Asp8Asn substitution results in the adenosine deaminase (ADA) genetic polymorphism (ADA 2 allozyme): occurrence on different chromosomal backgrounds and apparent intragenic crossover. Ann Hum Genet 1994, 58:1-9.
38. Hall J.G. Genomic imprinting: review and relevance to human diseases. Am J Hum Genet 1990, 46:857-873.
39. Napolioni V. ADA (22G>A) polymorphism: a possible genetic marker for predictive medicine of human reproduction?. Metabolism 2010, 59:e9-e10.
40. Banci M., Saccucci P., D'Annibale F., Dofcaci A., Trionfera G., Magrini A., et al. Adenosine deaminase genetic polymorphism and coronary artery disease. Cardiology 2009, 112:74-75.
41. Willems L., Ashton K.J., Headrick J.P. Adenosine-mediated cardioprotection in the aging myocardium. Cardiovasc Res 2005, 66:245-255.
42. Sun Y., Wu F., Sun F., Huang P. Adenosine promotes IL-6 release in airway epithelia. J Immunol 2008, 180:4173-4181.
43. Sansoni P., Vescovini R., Fagnoni F., Biasini C., Zanni F., Zanlari L., et al. The immune system in extreme longevity. Exp Gerontol 2008, 43:61-65.
44. Franco R., Pacheco R., Gatell J.M., Gallart T., Lluis C. Enzymatic and extraenzymatic role of adenosine deaminase 1 in T-cell-dendritic cell contacts and in alterations of the immune function. Crit Rev Immunol 2007, 27:495-509.
45. Parish S.T., Kim S., Sekhon R.K., Wu J.E., Kawakatsu Y., Effros R.B. Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes. J Immunol 2010, 184:2847-2854.
46. Temple S.E., Pham K., Glendenning P., Phillips M., Waterer G.W. Endotoxin induced TNF and IL-10 mRNA production is higher in male than female donors: correlation with elevated expression of TLR4. Cell Immunol 2008, 251:69-71.
47. Knöferl M.W., Angele M.K., Diodato M.D., Schwacha M.G., Ayala A., Cioffi W.G., et al. Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg 2002, 235:105-112.
48. Wang M., Tsai B.M., Kher A., Baker L.B., Wairiuko G.M., Meldrum D.R. Role of endogenous testosterone in myocardial proinflammatory and proapoptotic signaling after acute ischemia-reperfusion. Am J Physiol Heart Circ Physiol 2005, 288:221-226.
49. Huovinen E., Kaprio J., Vesterinen E., Koskenvou M. Mortality of adults with asthma: a propective cohort study. Thorax 1997, 52:49-54.
50. Oganov R.G., Maslennikova G.Ya. Asthma mortality in Russia between 1980-89. Eur Respir J 1998, 13:287-289.
51. Antonicelli R., Olivieri F., Cavallone L., Spazzafumo L., Bonafè M., Marchegiani F., et al. Tumor necrosis factoralpha gene -308G>A polymorphism is associated with ST-elevation myocardial infarction and with high plasma levels of biochemical ischemia markers. Coron Artery Dis 2005, 16:489-493.
52. Bellizzi D., Rose G., Cavalcante P., Covello G., Dato S., De Rango F., et al. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 2005, 85:258-263.
53. De Luca M., Rose G., Bonafè M., Garasto S., Greco V., Weir B.S., et al. Sex-specific longevity associations defined by tyrosine hydroxylase-insulin-insulin growth factor 2 haplotypes on the 11p15.5 chromosomal region. Exp Gerontol 2001, 36:1663-1671.
54. Ivanova R., Hénon N., Lepage V., Charron D., Vicaut E., Schächter F. HLA-DR alleles display sex-dependent effects on survival and discriminate between individual and familial longevity. Hum Mol Genet 1998, 7:187-194.
55. Tan Q., De Benedictis G., Yashi A.I., Bonafe M., DeLuca M., Valensin S., et al. Measuring the genetic influence in modulating the human life span: gene-environment interaction and the sex-specific genetic effect. Biogerontology 2001, 2:141-153.
56. Albani D., Batelli S., Polito L., Prato F., Pesaresi M., Gajo G.B., et al. Interleukin-6 plasma level increases with age in an Italian elderly population (" The Treviso Longeva" -Trelong-study) with a sex-specific contribution of rs1800795 polymorphism. Age (Dordr) 2009, 31:155-162.
57. Albani D., Batelli S., Polito L., Vittori A., Pesaresi M., Gajo G.B., et al. A polymorphic variant of the insulin-like growth factor 1 (IGF-1) receptor correlates with male longevity in the Italian population: a genetic study and evaluation of circulating IGF-1 from the " Treviso Longeva (TRELONG)" study. BMC Geriatr 2009, 9:19.
58. Di Bona D., Vasto S., Capurso C., Christiansen L., Deiana L., Franceschi C., et al. Effect of interleukin-6 polymorphisms on human longevity: a systematic review and meta-analysis. Ageing Res Rev 2009, 8:36-42.