TDP-43-mediated neurodegeneration: Towards a loss-of-function hypothesis?

Trends in Molecular Medicine

Volumn 20, Issue 2, 2014, Pages 66-71

  Vanden Broeck, Lies ^a,b   Callaerts, Patrick ^a   Dermaut, Bart ^b  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIV LILLE   (France)

Author keywords

ALS; FTD; Loss of function; Neurodegeneration; Proteinopathy; TDP 43

Indexed keywords

TAR DNA BINDING PROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN;

AMYOTROPHIC LATERAL SCLEROSIS; CAENORHABDITIS ELEGANS; CELL INCLUSION; DROSOPHILA MELANOGASTER; FRONTOTEMPORAL DEMENTIA; GAIN OF FUNCTION MUTATION; GENE MUTATION; LOSS OF FUNCTION MUTATION; NERVE CELL DEGENERATION; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; NUCLEAR EXPORT SIGNAL; NUCLEAR LOCALIZATION SIGNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; RNA BINDING; RNA PROCESSING; RNA SPLICING; SYNAPTIC TRANSMISSION; ZEBRA FISH; ALTERNATIVE RNA SPLICING; CHROMOSOME 9; FISH; GENETIC CONSERVATION; GLIA CELL; HIGH THROUGHPUT SEQUENCING; HUMAN; LOCOMOTION; MUSCLE CELL; OPEN READING FRAME; PATHOGENESIS; PROTEIN DEPLETION; RODENT; TDP 43 PROTEINOPATHY; VENTRAL ROOT; WORM;

RODENTIA;

ALS; FTD; LOSS-OF-FUNCTION; NEURODEGENERATION; PROTEINOPATHY; TDP-43;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DNA-BINDING PROTEINS; FRONTOTEMPORAL DEMENTIA; HUMANS; MUTATION; NEURODEGENERATIVE DISEASES; NEURONS; RNA-BINDING PROTEINS;

EID: 84893669366     PISSN: 14714914     EISSN: 1471499X     Source Type: Journal    
DOI: 10.1016/j.molmed.2013.11.003     Document Type: Review

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