Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases

Cell Death and Differentiation

Volumn 17, Issue 11, 2010, Pages 1773-1784

  Li, B ^a   Hu, Q ^a   Wang, H ^a   Man, N ^a   Ren, H ^a   Wen, L ^a   Nukina, N ^b   Fei, E ^a   Wang, G ^a  

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

autophagy; Beclin 1; hax; neurodegeneration; OMI

Indexed keywords

ALPHA SYNUCLEIN; BECLIN 1; HUNTINGTIN; MUTANT PROTEIN; PROTEIN; PROTEIN HAX1; PROTEIN P62; PROTEINASE; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; BRAIN; CONTROLLED STUDY; CYTOSOL; DEGENERATIVE DISEASE; ENZYME ACTIVITY; GENE DELETION; MAMMAL; MOTONEURON; MOTOR NEURON DISEASE; MOUSE; MOUSE STRAIN; NERVE DEGENERATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TARGETING; QUALITY CONTROL; REGULATORY MECHANISM; YEAST;

ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOTTING, WESTERN; FLUORESCENT ANTIBODY TECHNIQUE; MICE; MITOCHONDRIA; MITOCHONDRIAL MEMBRANES; MITOCHONDRIAL PROTEINS; MUTANT PROTEINS; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NUCLEAR PROTEINS; POLYMERASE CHAIN REACTION; PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA, SMALL INTERFERING; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

MAMMALIA; MUS;

EID: 77957840160     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2010.55     Document Type: Article

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