Comparisons of the Intraocular Tissue Distribution, Pharmacokinetics, and Safety of 125I-Labeled Full-Length and Fab Antibodies in Rhesus Monkeys Following Intravitreal Administration

Toxicologic Pathology

Volumn 27, Issue 5, 1999, Pages 536-544

  Mordenti, Joyce ^a   Cuthbertson, R Andrew ^a   Ferrara, Napoleone ^a   Thomsen, Karen ^a   Berleau, Lea ^a   Licko, Vojtech ^a   Allen, Philip C ^b   Valverde, Celia R ^b   Meng, Y Gloria ^a   Fei, David T w ^a   Fourre, Kathleen M ^a   Ryan, Anne M ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

immunogenicity; intraocular; intravitreal; microautoradiography; monoclonal antibody; pharmacokinetics; Recombinant protein; retinal drug delivery

Indexed keywords

IMMUNOGLOBULIN F(AB) FRAGMENT; IODINE 125; MONOCLONAL ANTIBODY;

ANIMAL EXPERIMENT; ARTICLE; AUTORADIOGRAPHY; INTRAOCULAR PRESSURE; INTRAVITREAL DRUG ADMINISTRATION; MALE; NONHUMAN; OPHTHALMOSCOPY; PRIORITY JOURNAL; RETINA; RHESUS MONKEY; TISSUE DISTRIBUTION;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTORADIOGRAPHY; ENDOTHELIAL GROWTH FACTORS; EYE; EYE DISEASES; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; INFLAMMATION; INJECTIONS; INTRAOCULAR PRESSURE; IODINE RADIOISOTOPES; LYMPHOKINES; MACACA MULATTA; MALE; RECOMBINANT PROTEINS; TISSUE DISTRIBUTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VITREOUS BODY; WEIGHT GAIN;

ANIMALIA; MACACA MULATTA;

EID: 0032864292     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339902700507     Document Type: Article

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