VEGF-initiated blood-retinal barrier breakdown in early diabetes

Investigative Ophthalmology and Visual Science

Volumn 42, Issue 10, 2001, Pages 2408-2413

  Qaum, T ^a   Xu, Q ^a   Joussen, A M ^a   Clemens, M W ^a   Qin, W ^a   Miyamoto, K ^a   Hassessian, H ^a   Wiegand, S J ^a   Rudge, J ^a   Yancopoulos, G D ^a   Adamis, A P ^a  

^a MASSACHUSETTS EYE AND EAR INFIRMARY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EVANS BLUE; IMMUNOGLOBULIN FC FRAGMENT; INTERLEUKIN 6 RECEPTOR; MESSENGER RNA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD RETINA BARRIER; BLOOD VESSEL PERMEABILITY; CONTROLLED STUDY; DIABETIC RETINOPATHY; FLUORESCENCE; MALE; NONHUMAN; ONSET AGE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RETINA BLOOD VESSEL; RETINA CAPILLARY; RIBONUCLEASE PROTECTION ASSAY; VENULE;

ANIMALS; BLOOD-RETINAL BARRIER; CAPILLARY PERMEABILITY; COLORING AGENTS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC RETINOPATHY; ENDOTHELIAL GROWTH FACTORS; EVANS BLUE; LYMPHOKINES; MALE; RATS; RATS, SPRAGUE-DAWLEY; RETINAL VESSELS; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034854865     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Preventative eye care in people with diabetes is cost-saving to the federal government. Implications for health care reform
2. The 14-year incidence of visual loss in a diabetic population
3. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
4. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
5. Vascular endothelial growth factor plays a role in hyperpermeability of diabetic retinal vessels
6. The relation between expression of vascular endothelial growth factor and breakdown of the blood retinal barrier in diabetic rat retinas
7. Upregulation of vascular endothelial growth factor in ischemic and non-ischemic human and experimental retinal disease
8. Upregulation of the vascular endothelial growth factor/vascular endothelial growth factor receptor system in experimental background diabetic retinopathy of the rat
9. Comparative analysis of vascular endothelial growth factor receptors on retinal and aortic vascular endothelial cells
10. Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues
11. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins
12. Breakdown of the inner and outer blood retinal barrier in streptozotocin-induced diabetes
13. Immunohistochemical localization of blood-retinal barrier breakdown in human diabetes
14. Constitutive expression of VEGF, VEGFR-1, and VEGFR-2 in normal eyes
15. Electron microscopic evidence for the mechanism of blood-retinal barrier breakdown in diabetic rabbits: Comparison with magnetic resonance imaging
16. Endothelial gaps and permeability of venules in rat tracheas exposed to inflammatory stimuli
17. Requirement for vascular endothelial growth factor in wound- and inflammation-related corneal neovascularization
18. Sensitive blood-retinal barrier breakdown quantitation using Evans blue
19. Neurally mediated increase in vascular permeability in the rat trachea: Onset, duration, and tachyphylaxis
20. Combinations of Evans blue with plasma protein: Its significance in capillary studies, blood dye disappearance curves and its use as a protein tag
21. Leukocyte-mediated endothelial cell injury and death in the diabetic retina
22. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition
23. VEGF increases retinal vascular ICAM-1 expression in vivo
24. Vascular endothelial growth factor-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1)
25. Polymorphonuclear leukocyte adhesion triggers the disorganization of endothelial cell-to-cell adherens junctions
26. Loss of tight junction proteins occludin and zonula occludens-1 from cerebral vascular endothelium during neutrophil-induced blood-brain barrier breakdown in vivo
27. Intracellular pool of vascular endothelial growth factor in human neutrophils
28. Human mesangial cells and peripheral blood mononuclear cells produce vascular permeability factor
29. Expression of vascular endothelial growth factor by human cosinophils: Upregulation by granulocyte macrophage colony-stimulating factor and interleukin-5
30. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: A potential role for T cells in angiogenesis
31. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets
32. Endothelial gaps as sites for plasma leakage in inflammation
33. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: Vascular endothelial growth factor decreases occludin in retinal endothelial cells