Triclosan: A Widespread Environmental Toxicant with Many Biological Effects

Annual Review of Pharmacology and Toxicology

Volumn 56, Issue , 2016, Pages 251-272

  Yueh, Mei Fei ^a   Tukey, Robert H ^a  

^a San Diego   (United States)

Author keywords

Antibacterial; Antimicrobial resistance; Bioaccumulation; Environmental hazard; Hormone homeostasis; Liver pathogenesis; Precautionary principle

Indexed keywords

COSMETIC; SOAP; TRICLOSAN; ANTIINFECTIVE AGENT; DANGEROUS GOODS;

ARTICLE; BIOACCUMULATION; BODY FLUID; CELL PROLIFERATION; DEGRADATION; ENVIRONMENTAL EXPOSURE; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FIBROGENESIS; GENOTOXICITY; HEALTH HAZARD; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER DISEASE; MUTAGENICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SEWAGE DISPOSAL; WASTE DISPOSAL; ADVERSE EFFECTS; ANIMAL; DANGEROUS GOODS; ENVIRONMENT;

ANIMALS; ANTI-INFECTIVE AGENTS; ENVIRONMENT; HAZARDOUS SUBSTANCES; HUMANS; TRICLOSAN;

EID: 84954152889     PISSN: 03621642     EISSN: 15454304     Source Type: Book Series    
DOI: 10.1146/annurev-pharmtox-010715-103417     Document Type: Article

References (120)

1. Fang JL, Stingley RL, Beland FA, Harrouk W, Lumpkins DL, Howard P. 2010. Occurrence, efficacy, metabolism, and toxicity of triclosan. J. Environ. Sci. Health C: Environ. Carcinog. Ecotoxicol. Rev. 28:147-71
2. Rodricks JV, Swenberg JA, Borzelleca JF, Maronpot RR, Shipp AM. 2010. Triclosan: A critical review of the experimental data and development of margins of safety for consumer products. Crit. Rev. Toxicol. 40:422-84
3. Dann AB, Hontela A. 2011. Triclosan: environmental exposure, toxicity and mechanisms of action. J. Appl. Toxicol. 31:285-311
4. WilcoxMH, Hall J, Pike H, Templeton PA, FawleyWN, et al. 2003. Use of perioperative mupirocin to prevent methicillin-resistant Staphylococcus aureus (MRSA) orthopaedic surgical site infections. J. Hosp. Infect. 54:196-201
5. Aiello AE, Larson EL, Levy SB. 2007. Consumer antibacterial soaps: effective or just risky? Clin. Infect. Dis. 45(Suppl. 2):S137-47
6. Heath RJ, Yu YT, Shapiro MA, Olson E, Rock CO. 1998. Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis. J. Biol. Chem. 273:30316-20
7. McMurry LM, Oethinger M, Levy SB. 1998. Triclosan targets lipid synthesis. Nature 394:531-32
8. Kampf G, Kramer A. 2004. Epidemiologic background of hand hygiene and evaluation of the most important agents for scrubs and rubs. Clin. Microbiol. Rev. 17:863-93
9. EscaladaMG, Russell AD, Maillard JY, Ochs D. 2005. Triclosan-bacteria interactions: single ormultiple target sites? Lett. Appl. Microbiol. 41:476-81
10. Crofton KM, Paul KB, DeVitoMJ, Hedge JM. 2007. Short-term in vivo exposure to the water contaminant triclosan: evidence for disruption of thyroxine. Environ. Toxicol. Pharmacol. 24:194-97
11. McAvoy DC, SchatowitzB, JacobM,HaukA,EckhoffWS. 2002. Measurement of triclosan inwastewater treatment systems. Environ. Toxicol. Chem. 21:1323-29
12. Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J. 2002. Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere 46:1485-89
13. Gómez MJ,Martnez BuenoMJ, Lacorte S, Fernández-Alba AR,Aguera A. 2007. Pilot survey monitoring pharmaceuticals and related compounds in a sewage treatment plant located on theMediterranean coast. Chemosphere 66:993-1002
14. KolpinDW,Furlong ET,MeyerMT,Thurman EM,Zaugg SD, et al. 2002. Pharmaceuticals, hormones, and other organic wastewater contaminants in U. S. streams, 1999-2000: A national reconnaissance. Environ. Sci. Technol. 36:1202-11
15. Bedoux G, Roig B, Thomas O, Dupont V, Le BB. 2012. Occurrence and toxicity of antimicrobial triclosan and by-products in the environment. Environ. Sci. Pollut. Res. Int. 19:1044-65
16. Singer H, Muller S, Tixier C, Pillonel L. 2002. Triclosan: occurrence and fate of a widely used biocide in the aquatic environment: field measurements in wastewater treatment plants, surface waters, and lake sediments. Environ. Sci. Technol. 36:4998-5004
17. OrvosDR, Versteeg DJ, Inauen J, Capdevielle M, Rothenstein A, Cunningham V. 2002. Aquatic toxicity of triclosan. Environ. Toxicol. Chem. 21:1338-49
18. Hanioka N, Jinno H, Nishimura T, Ando M. 1997. Effect of 2,4,4-trichloro-2-hydroxydiphenyl ether on cytochrome P450 enzymes in the rat liver. Chemosphere 34:719-30
19. Jacobs MN,Nolan GT,Hood SR. 2005. Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol. Appl. Pharmacol. 209:123-33
20. Wang LQ, Falany CN, JamesMO. 2004. Triclosan as a substrate and inhibitor of 3-phosphoadenosine 5-phosphosulfate-sulfotransferase and UDP-glucuronosyl transferase in human liver fractions. Drug Metab. Dispos. 32:1162-69
21. Yueh MF, Taniguchi K, Chen S, Evans RM, Hammock BD, et al. 2014. The commonly used antimicrobial additive triclosan is a liver tumor promoter. PNAS 111:17200-5
22. Balmer ME, Poiger T, Droz C, Romanin K, Bergqvist PA, et al. 2004. Occurrence of methyl triclosan, a transformation product of the bactericide triclosan, in fish from various lakes in Switzerland. Environ. Sci. Technol. 38:390-95
23. Kanetoshi A, Katsura E, Ogawa H, Ohyama T, Kaneshima H, Miura T. 1992. Acute toxicity, percutaneous absorption and effects on hepatic mixed function oxidase activities of 2,4,4-trichloro-2-hydroxydiphenyl ether (Irgasan DP300) and its chlorinated derivatives. Arch. Environ. Contam. Toxicol. 23:91-98
24. Fiss EM, Rule KL, Vikesland PJ. 2007. Formation of chloroform and other chlorinated byproducts by chlorination of triclosan-containing antibacterial products. Environ. Sci. Technol. 41:2387-94
25. Buth JM, Grandbois M, Vikesland PJ, McNeill K, Arnold WA. 2009. Aquatic photochemistry of chlorinated triclosan derivatives: potential source of polychlorodibenzo-p-dioxins. Environ. Toxicol. Chem. 28:2555-63
26. McMillan BJ, Bradfield CA. 2007. The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems. Mol. Pharmacol. 72:487-98
27. Reiss R,Mackay N, Habig C, Griffin J. 2002. An ecological risk assessment for triclosan in lotic systems following discharge from wastewater treatment plants in the United States. Environ. Toxicol. Chem. 21:2483-92
28. Halden RU, Paull DH. 2005. Co-occurrence of triclocarban and triclosan in U. S. water resources. Environ. Sci. Technol. 39:1420-26
29. Anger CT, Sueper C, Blumentritt DJ, McNeill K, Engstrom DR, Arnold WA. 2013. Quantification of triclosan, chlorinated triclosan derivatives, and their dioxin photoproducts in lacustrine sediment cores. Environ. Sci. Technol. 47:1833-43
30. Heidler J, Halden RU. 2007. Mass balance assessment of triclosan removal during conventional sewage treatment. Chemosphere 66:362-69
31. Chalew TE, Halden RU. 2009. Environmental exposure of aquatic and terrestrial biota to triclosan and triclocarban. J. Am. Water Works Assoc. 45:4-13
32. Coogan MA, La Point TW. 2008. Snail bioaccumulation of triclocarban, triclosan, and methyltriclosan in a North Texas, USA, stream affected by wastewater treatment plant runoff. Environ. Toxicol. Chem. 27:1788-93
33. Houtman CJ, Van Oostveen AM, Brouwer A, LamoreeMH, Legler J. 2004. Identification of estrogenic compounds in fish bile using bioassay-directed fractionation. Environ. Sci. Technol. 38:6415-23
34. Fair PA, Lee HB, Adams J, Darling C, Pacepavicius G, et al. 2009. Occurrence of triclosan in plasma of wild Atlantic bottlenose dolphins (Tursiops truncatus) and in their environment. Environ. Pollut. 157:2248-54
35. Wilson BA, Smith VH, deNoyelles F Jr, Larive CK. 2003. Effects of three pharmaceutical and personal care products on natural freshwater algal assemblages. Environ. Sci. Technol. 37:1713-19
36. Oliveira R, Domingues I, Koppe GC, Soares AM. 2009. Effects of triclosan on zebrafish early-life stages and adults. Environ. Sci. Pollut. Res. Int. 16:679-88
37. Yang LH, Ying GG, Su HC, Stauber JL, Adams MS, Binet MT. 2008. Growth-inhibiting effects of 12 antibacterial agents and their mixtures on the freshwater microalga Pseudokirchneriella subcapitata. Environ. Toxicol. Chem. 27:1201-8
38. Bester K. 2005. Fate of triclosan and triclosan-methyl in sewage treatment plants and surface waters. Arch. Environ. Contam. Toxicol. 49:9-17
39. Ying GG, Yu XY, Kookana RS. 2007. Biological degradation of triclocarban and triclosan in a soil under aerobic and anaerobic conditions and comparison with environmental fate modelling. Environ. Pollut. 150:300-5
40. Browne MA, Niven SJ, Galloway TS, Rowland SJ, Thompson RC. 2013. Microplastic moves pollutants and additives to worms, reducing functions linked to health and biodiversity. Curr. Biol. 23:2388-92
41. Calafat AM, Ye X,Wong LY, Reidy JA, Needham LL. 2008. Urinary concentrations of triclosan in the U. S. population: 2003-2004. Environ. Health Perspect. 116:303-7
42. Queckenberg C, Meins J, Wachall B, Doroshyenko O, Tomalik-Scharte D, et al. 2010. Absorption, pharmacokinetics, and safety of triclosan after dermal administration. Antimicrob. Agents Chemother. 54:570-72
43. Lin YJ. 2000. Buccal absorption of triclosan following topical mouthrinse application. Am. J. Dent. 13:215-17
44. Black JG, Howes D, Rutherford T. 1975. Percutaneous absorption and metabolism of Irgasan DP300. Toxicology 3:33-47
45. Moss T, Howes D, Williams FM. 2000. Percutaneous penetration and dermal metabolism of triclosan (2,4,4-trichloro-2-hydroxydiphenyl ether). Food Chem. Toxicol. 38:361-70
46. Fang JL, Vanlandingham M, da Costa GG, Beland FA. 2014. Absorption and metabolism of triclosan after application to the skin of B6C3F1 mice. Environ. Toxicol. In press. doi: 10. 1002/tox. 22074
47. Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J. 2006. Pharmacokinetics of triclosan following oral ingestion in humans. J. Toxicol. Environ. Health A 69:1861-73
48. Tukey RH, Strassburg CP. 2000. Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu. Rev. Pharmacol. Toxicol. 40:581-616
49. Long J, Zhang S, Fang X, Luo Y, Liu J. 2011. Association of neonatal hyperbilirubinemia with uridine diphosphate-glucuronosyltransferase 1A1 gene polymorphisms: meta-analysis. Pediatr. Int. 53:530-40
50. Nagar S, Remmel RP. 2006. Uridine diphosphoglucuronosyltransferase pharmacogenetics and cancer. Oncogene 25:1659-72
51. Ueda A, Hamadeh HK, Webb HK, Yamamoto Y, Sueyoshi T, et al. 2002. Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital. Mol. Pharmacol. 61:1-6
52. Sonoda J, Pei L, Evans RM. 2008. Nuclear receptors: decoding metabolic disease. FEBS Lett. 582:2-9
53. Johnson EF, Hsu MH, Savas U, Griffin KJ. 2002. Regulation of P450 4A expression by peroxisome proliferator activated receptors. Toxicology 181-82:203-6
54. Jinno H, Hanioka N, Onodera S, Nishimura T, Ando M. 1997. Irgasan R DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel. Xenobiotica 27:681-92
55. Paul KB, Thompson JT, Simmons SO, Vanden Heuvel JP, Crofton KM. 2013. Evidence for triclosaninduced activation of human and rodent xenobiotic nuclear receptors. Toxicol. In Vitro 27:2049-60
56. Paul KB, Hedge JM, DeVito MJ, Crofton KM. 2010. Short-term exposure to triclosan decreases thyroxine in vivo via upregulation of hepatic catabolism in young Long-Evans rats. Toxicol. Sci. 113:367-79
57. Pollock T, Tang B, deCatanzaro D. 2014. Triclosan exacerbates the presence of 14C-bisphenol A in tissues of female and male mice. Toxicol. Appl. Pharmacol. 278:116-23
58. Hovander L, Malmberg T, Athanasiadou M, Athanassiadis I, Rahm S, et al. 2002. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch. Environ. Contam. Toxicol. 42:105-17
59. Dayan AD. 2007. Risk assessment of triclosan [Irgasan R ] in human breast milk. Food Chem. Toxicol. 45:125-29
60. Arbuckle TE, Marro L, Davis K, FisherM, Ayotte P, et al. 2014. Exposure to free and conjugated forms of bisphenol A and triclosan among pregnant women in the MIREC cohort. Environ. Health Perspect. 123:277-84
61. Geens T, Neels H, Covaci A. 2012. Distribution of bisphenol-A, triclosan and n-nonylphenol in human adipose tissue, liver and brain. Chemosphere 87:796-802
62. Wolff MS, Teitelbaum SL, Windham G, Pinney SM, Britton JA, et al. 2007. Pilot study of urinary biomarkers of phytoestrogens, phthalates, and phenols in girls. Environ. Health Perspect. 115:116-21
63. Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G. 2006. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci. Total Environ. 372:87-93
64. Allmyr M, Panagiotidis G, Sparve E, Diczfalusy U, Sandborgh-Englund G. 2009. Human exposure to triclosan via toothpaste does not change CYP3A4 activity or plasma concentrations of thyroid hormones. Basic Clin. Pharmacol. Toxicol. 105:339-44
65. Philippat C, Botton J, Calafat AM, Ye X, Charles MA, Slama R. 2014. Prenatal exposure to phenols and growth in boys. Epidemiology 25:625-35
66. RotroffDM, WetmoreBA, Dix DJ, Ferguson SS, Clewell HJ, et al. 2010. Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. Toxicol. Sci. 117:348-58
67. Aylward LL, Hays SM. 2011. Consideration of dosimetry in evaluation of ToxCast data. J. Appl. Toxicol. 31:741-51
68. DeSalva SJ, Kong BM, Lin YJ. 1989. Triclosan: A safety profile. Am. J. Dent. 2(Spec. No.):185-96
69. Ciniglia C, Cascone C, Giudice RL, Pinto G, Pollio A. 2005. Application of methods for assessing the geno-and cytotoxicity of triclosan to C. ehrenbergii. J. Hazard. Mater. 122:227-32
70. Binelli A, Cogni D, Parolini M, Riva C, Provini A. 2009. In vivo experiments for the evaluation of genotoxic and cytotoxic effects of triclosan in zebra mussel hemocytes. Aquat. Toxicol. 91:238-44
71. Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, et al. 2006. The 2005 World Health Organization reevaluation of human and mammalian toxic equivalency factors for dioxins and dioxin-like compounds. Toxicol. Sci. 93:223-41
72. Latch DE, Packer JL, Stender BL, VanOverbeke J, Arnold WA,McNeill K. 2005. Aqueous photochemistry of triclosan: formation of 2,4-dichlorophenol, 2,8-dichlorodibenzo-p-dioxin, and oligomerization products. Environ. Toxicol. Chem. 24:517-25
73. Jaiswal AK. 2000. Regulation of genes encoding NAD(P)H:quinone oxidoreductases. Free Radic. Biol. Med. 29:254-62
74. Ma H, Zheng L, Li Y, Pan S, Hu J, et al. 2013. Triclosan reduces the levels of global DNA methylation in HepG2 cells. Chemosphere 90:1023-29
75. Gou N, Yuan S, Lan J, Gao C, Alshawabkeh AN, Gu AZ. 2014. A quantitative toxicogenomics assay reveals the evolution and nature of toxicity during the transformation of environmental pollutants. Environ. Sci. Technol. 48:8855-63
76. LinD, ZhouQ,Xie X, Liu Y. 2010. Potential biochemical and genetic toxicity of triclosan as an emerging pollutant on earthworms (Eisenia fetida). Chemosphere 81:1328-33
77. Wang X, Liu Z, Wang W, Yan Z, Zhang C, et al. 2014. Assessment of toxic effects of triclosan on the terrestrial snail (Achatina fulica). Chemosphere 108:225-30
78. LinD, Xie X, Zhou Q, Liu Y. 2012. Biochemical and genotoxic effect of triclosan on earthworms (Eisenia fetida) using contact and soil tests. Environ. Toxicol. 27:385-92
79. Wilson AS, Power BE, Molloy PL. 2007. DNA hypomethylation and human diseases. Biochim. Biophys. Acta 1775:138-62
80. Winitthana T, Lawanprasert S, Chanvorachote P. 2014. Triclosan potentiates epithelial-tomesenchymal transition in anoikis-resistant human lung cancer cells. PLOS ONE 9:e110851
81. Lee HR, Hwang KA,NamKH,KimHC,Choi KC. 2014. Progression of breast cancer cells was enhanced by endocrine-disrupting chemicals, triclosan and octylphenol, via an estrogen receptor-dependent signaling pathway in cellular and mouse xenograft models. Chem. Res. Toxicol. 27:834-42
82. Kim JY, Yi BR, Go RE, Hwang KA, Nam KH, Choi KC. 2014. Methoxychlor and triclosan stimulates ovarian cancer growth by regulating cell cycle-and apoptosis-related genes via an estrogen receptordependent pathway. Environ. Toxicol. Pharmacol. 37:1264-74
83. Grivennikov SI, Greten FR, Karin M. 2010. Immunity, inflammation, and cancer. Cell 140:883-99
84. Clayton EM, Todd M, Dowd JB, Aiello AE. 2011. The impact of bisphenol A and triclosan on immune parameters in the U. S. population, NHANES 2003-2006. Environ. Health Perspect. 119:390-96
85. Tamura I, Kanbara Y, Saito M, Horimoto K, Satoh M, et al. 2012. Triclosan, an antibacterial agent, increases intracellular Zn2+ concentration in rat thymocytes: its relation to oxidative stress. Chemosphere 86:70-75
86. UdojiF,MartinT,EthertonR,WhalenMM. 2010. Immunosuppressive effects of triclosan, nonylphenol, and DDT on human natural killer cells in vitro. J. Immunotoxicol. 7:205-12
87. Foran CM, Bennett ER, Benson WH. 2000. Developmental evaluation of a potential non-steroidal estrogen: triclosan. Mar. Environ. Res. 50:153-56
88. Kumar V, Chakraborty A, Kural MR, Roy P. 2009. Alteration of testicular steroidogenesis and histopathology of reproductive system in male rats treated with triclosan. Reprod. Toxicol. 27:177-85
89. Gee RH, Charles A, Taylor N, Darbre PD. 2008. Oestrogenic and androgenic activity of triclosan in breast cancer cells. J. Appl. Toxicol. 28:78-91
90. Ahn KC, Zhao B, Chen J, Cherednichenko G, Sanmarti E, et al. 2008. In vitro biologic activities of the antimicrobials triclocarban, its analogs, and triclosan in bioassay screens: receptor-based bioassay screens. Environ. Health Perspect. 116:1203-10
91. Honkisz E, Zieba-Przybylska D,Wojtowicz AK. 2012. The effect of triclosan on hormone secretion and viability of human choriocarcinoma JEG-3 cells. Reprod. Toxicol. 34:385-92
92. Ishibashi H, Matsumura N, Hirano M, Matsuoka M, Shiratsuchi H, et al. 2004. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat. Toxicol. 67:167-79
93. Stoker TE,Gibson EK, Zorrilla LM. 2010. Triclosan exposuremodulates estrogen-dependent responses in the female Wistar rat. Toxicol. Sci. 117:45-53
94. Jung EM, An BS, Choi KC, Jeung EB. 2012. Potential estrogenic activity of triclosan in the uterus of immature rats and rat pituitary GH3 cells. Toxicol. Lett. 208:142-48
95. JamesMO, Li W, Summerlot DP, Rowland-Faux L, Wood CE. 2010. Triclosan is a potent inhibitor of estradiol and estrone sulfonation in sheep placenta. Environ. Int. 36:942-49
96. Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, et al. 2006. The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquat. Toxicol. 80:217-27
97. Helbing CC, van Aggelen G, Veldhoen N. 2011. Triclosan affects thyroid hormone-dependent metamorphosis in anurans. Toxicol. Sci. 119:417-18
98. Zorrilla LM, Gibson EK, Jeffay SC, Crofton KM, Setzer WR, et al. 2009. The effects of triclosan on puberty and thyroid hormones in male Wistar rats. Toxicol. Sci. 107:56-64
99. Rodriguez PE, SanchezMS. 2010. Maternal exposure to triclosan impairs thyroid homeostasis and female pubertal development inWistar rat offspring. J. Toxicol. Environ. Health A 73:1678-88
100. Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, et al. 2012. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action. Toxicology 300:31-45
101. Axelstad M, Boberg J, Vinggaard AM, Christiansen S, Hass U. 2013. Triclosan exposure reduces thyroxine levels in pregnant and lactating rat dams and in directly exposed offspring. Food Chem. Toxicol. 59:534-40
102. Qatanani M, Zhang J, Moore DD. 2005. Role of the constitutive androstane receptor in xenobioticinduced thyroid hormone metabolism. Endocrinology 146:995-1002
103. Cullinan MP, Palmer JE, Carle AD, West MJ, Seymour GJ. 2012. Long term use of triclosan toothpaste and thyroid function. Sci. Total Environ. 416:75-79
104. Cookson BD, Farrelly H, Stapleton P, Garvey RP, Price MR. 1991. Transferable resistance to triclosan in MRSA. Lancet 337:1548-49
105. Yazdankhah SP, Scheie AA, Høiby EA, Lunestad BT, Heir E, et al. 2006. Triclosan and antimicrobial resistance in bacteria: An overview. Microb. Drug Resist. 12:83-90
106. Beier RC, Duke SE, Ziprin RL, Harvey RB, Hume ME, et al. 2008. Antibiotic and disinfectant susceptibility profiles of vancomycin-resistant Enterococcus faecium (VRE) isolated from community wastewater in Texas. Bull. Environ. Contam. Toxicol. 80:188-94
107. Seaman PF, Ochs D, Day MJ. 2007. Small-colony variants: A novel mechanism for triclosan resistance in methicillin-resistant Staphylococcus aureus. J. Antimicrob. Chemother. 59:43-50
108. Bayston R, Ashraf W, Smith T. 2007. Triclosan resistance in methicillin-resistant Staphylococcus aureus expressed as small colony variants: A novel mode of evasion of susceptibility to antiseptics. J. Antimicrob. Chemother. 59:848-53
109. BirosováL,MikulásováM. 2009. Development of triclosan and antibiotic resistance in Salmonella enterica serovar Typhimurium. J. Med. Microbiol. 58:436-41
110. Aiello AE, Marshall B, Levy SB, Della-Latta P, Larson E. 2004. Relationship between triclosan and susceptibilities of bacteria isolated from hands in the community. Antimicrob. Agents Chemother. 48:2973-79
111. Cole EC, Addison RM, Rubino JR, Leese KE, Dulaney PD, et al. 2003. Investigation of antibiotic and antibacterial agent cross-resistance in target bacteria from homes of antibacterial product users and nonusers. J. Appl. Microbiol. 95:664-76
112. Braoudaki M, Hilton AC. 2004. Adaptive resistance to biocides in Salmonella enterica and Escherichia coli O157 and cross-resistance to antimicrobial agents. J. Clin. Microbiol. 42:73-78
113. Brenwald NP, Fraise AP. 2003. Triclosan resistance inmethicillin-resistant Staphylococcus aureus (MRSA). J. Hosp. Infect. 55:141-44
114. Drury B, Scott J, Rosi-Marshall EJ, Kelly JJ. 2013. Triclosan exposure increases triclosan resistance and influences taxonomic composition of benthic bacterial communities. Environ. Sci. Technol. 47:8923-30
115. Cherednichenko G, ZhangR,Bannister RA,Timofeyev V, Li N, et al. 2012. Triclosan impairs excitationcontraction coupling and Ca2+ dynamics in striated muscle. PNAS 109:14158-63
116. Schultz MM, Bartell SE, Schoenfuss HL. 2012. Effects of triclosan and triclocarban, two ubiquitous environmental contaminants, on anatomy, physiology, and behavior of the fathead minnow (Pimephales promelas). Arch. Environ. Contam. Toxicol. 63:114-24
117. Pugliese G, Favero MS. 1998. EPA charges illegal claim for antibacterial-impregnated consumer products. Infect. Control Hosp. Epidemiol. 19:140
118. Kriebel D, Tickner J, Epstein P, Lemons J, Levins R, et al. 2001. The precautionary principle in environmental science. Environ. Health Perspect. 109:871-76
119. Yueh MF, Nguyen N, Famourzadeh M, Strassburg CP, Oda Y, et al. 2001. The contribution of UDPglucuronosyltransferase 1A9 on CYP1A2-mediated genotoxicity by aromatic and heterocyclic amines. Carcinogenesis 22:943-50
120. Raffensperger C, Tickner J, eds. 1999. Protecting Public Health and the Environment: Implementing the Precautionary Principle. Washington, DC: Island Press