Nuclear receptors: Decoding metabolic disease

FEBS Letters

Volumn 582, Issue 1, 2008, Pages 2-9

  Sonoda, Junichiro ^a   Pei, Liming ^a   Evans, Ronald M ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Dyslipidemia; Insulin resistance; Metabolic syndrome; Obesity; Orphan nuclear receptor

Indexed keywords

CELL NUCLEUS RECEPTOR; CHOLESTEROL; FARNESOID X RECEPTOR; INSULIN; LIVER X RECEPTOR; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOIC ACID RECEPTOR; STEROID RECEPTOR; THYROID HORMONE RECEPTOR; TRIACYLGLYCEROL; VITAMIN D RECEPTOR;

CHOLESTEROL METABOLISM; ENDOCRINE FUNCTION; HORMONAL REGULATION; HUMAN; LIPID METABOLISM; METABOLIC DISORDER; MITOCHONDRION; NONHUMAN; NUTRITION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; SHORT SURVEY;

HUMANS; METABOLIC DISEASES; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRIGLYCERIDES;

RODENTIA;

EID: 37349114118     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.11.016     Document Type: Short Survey

References (63)

1. Nagy L., and Schwabe J.W. Mechanism of the nuclear receptor molecular switch. Trends Biochem. Sci. 29 (2004) 317-324
2. Evans R.M. A transcriptional basis for physiology. Nat. Med. 10 (2004) 1022-1026
3. J.M. Maglich, et al. Comparison of complete nuclear receptor sets from the human, Caenorhabditis elegans and Drosophila genomes. Genome Biol. 2 (2001) RESEARCH0029.
4. Evans R.M. The steroid and thyroid hormone receptor superfamily. Science 240 (1988) 889-895
5. Bookout A.L., Jeong Y., Downes M., Yu R.T., Evans R.M., and Mangelsdorf D.J. Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network. Cell 126 (2006) 789-799
6. Yang X., Downes M., Yu R.T., Bookout A.L., He W., Straume M., Mangelsdorf D.J., and Evans R.M. Nuclear receptor expression links the circadian clock to metabolism. Cell 126 (2006) 801-810
7. Barish G.D., Downes M., Alaynick W.A., Yu R.T., Ocampo C.B., Bookout A.L., Mangelsdorf D.J., and Evans R.M. A nuclear receptor atlas: macrophage activation. Mol. Endocrinol. 19 (2005) 2466-2477
8. Pratt W.B., and Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18 (1997) 306-360
9. Rosenfeld M.G., Lunyak V.V., and Glass C.K. Sensors and signals: a coactivator/corepressor/epigenetic code for integrating signal-dependent programs of transcriptional response. Genes Dev. 20 (2006) 1405-1428
10. Li Y., Lambert M.H., and Xu H.E. Activation of nuclear receptors: a perspective from structural genomics. Structure 11 (2003) 741-746
11. Baxter J.D., Webb P., Grover G., and Scanlan T.S. Selective activation of thyroid hormone signaling pathways by GC-1: a new approach to controlling cholesterol and body weight. Trends Endocrinol. Metab. 15 (2004) 154-157
12. Ma Y., et al. Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators. J. Clin. Invest. 116 (2006) 892-904
13. Szanto A., Narkar V., Shen Q., Uray I.P., Davies P.J., and Nagy L. Retinoid X receptors: X-ploring their (patho)physiological functions. Cell Death Differ. 11 Suppl. 2 (2004) S126-S143
14. Shulman A.I., and Mangelsdorf D.J. Retinoid x receptor heterodimers in the metabolic syndrome. N. Engl. J. Med. 353 (2005) 604-615
15. Semple R.K., Chatterjee V.K., and O'Rahilly S. PPAR gamma and human metabolic disease. J. Clin. Invest. 116 (2006) 581-589
16. Lefebvre P., Chinetti G., Fruchart J.C., and Staels B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J. Clin. Invest. 116 (2006) 571-580
17. Kallen J., Schlaeppi J.M., Bitsch F., Delhon I., and Fournier B. Crystal structure of the human RORalpha ligand binding domain in complex with cholesterol sulfate at 2.2 A. J. Biol. Chem. 279 (2004) 14033-14038
18. Timsit Y.E., and Negishi M. CAR and PXR: the xenobiotic-sensing receptors. Steroids 72 (2007) 231-246
19. Giguere V. To ERR in the estrogen pathway. Trends Endocrinol. Metab. 13 (2002) 220-225
20. Forman B.M. Are those phospholipids in your pocket?. Cell Metab. 1 (2005) 153-155
21. Chrousos G.P., and Kino T. Intracellular glucocorticoid signaling: a formerly simple system turns stochastic. Sci. STKE, 2005 (2005) pe48
22. Seckl J.R. 11beta-hydroxysteroid dehydrogenases: changing glucocorticoid action. Curr. Opin. Pharmacol. 4 (2004) 597-602
23. Opherk C., Tronche F., Kellendonk C., Kohlmuller D., Schulze A., Schmid W., and Schutz G. Inactivation of the glucocorticoid receptor in hepatocytes leads to fasting hypoglycemia and ameliorates hyperglycemia in streptozotocin-induced diabetes mellitus. Mol. Endocrinol. 18 (2004) 1346-1353
24. Thiemermann C. Corticosteroids and cardioprotection. Nat. Med. 8 (2002) 453-455
25. Walker B.R., and Andrew R. Tissue production of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 and metabolic disease. Ann. NY Acad. Sci. 1083 (2006) 165-184
26. Connell J.M., and Davies E. The new biology of aldosterone. J. Endocrinol. 186 (2005) 1-20
27. Funder J.W. Mineralocorticoid-receptor blockade, hypertension and heart failure. Nat. Clin. Pract. Endocrinol. Metab. 1 (2005) 4-5
28. Berger S., et al. Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc. Natl. Acad. Sci. USA 95 (1998) 9424-9429
29. Beggah A.T., et al. Reversible cardiac fibrosis and heart failure induced by conditional expression of an antisense mRNA of the mineralocorticoid receptor in cardiomyocytes. Proc. Natl. Acad. Sci. USA 99 (2002) 7160-7165
30. Cheng S.Y. Thyroid hormone receptor mutations and disease: beyond thyroid hormone resistance. Trends Endocrinol. Metab. 16 (2005) 176-182
31. Johansson L., Rudling M., Scanlan T.S., Lundasen T., Webb P., Baxter J., Angelin B., and Parini P. Selective thyroid receptor modulation by GC-1 reduces serum lipids and stimulates steps of reverse cholesterol transport in euthyroid mice. Proc. Natl. Acad. Sci. USA 102 (2005) 10297-10302
32. Li A.C., and Palinski W. Peroxisome proliferator-activated receptors: how their effects on macrophages can lead to the development of a new drug therapy against atherosclerosis. Annu. Rev. Pharmacol. Toxicol. 46 (2006) 1-39
33. Evans R.M., Barish G.D., and Wang Y.X. PPARs and the complex journey to obesity. Nat. Med. 10 (2004) 355-361
34. Smyth S., and Heron A. Diabetes and obesity: the twin epidemics. Nat. Med. 12 (2006) 75-80
35. Krall R.L. Cardiovascular safety of rosiglitazone. Lancet 369 (2007) 1995-1996
36. Barish G.D., Narkar V.A., and Evans R.M. PPAR delta: a dagger in the heart of the metabolic syndrome. J. Clin. Invest. 116 (2006) 590-597
37. Tontonoz P., and Mangelsdorf D.J. Liver X receptor signaling pathways in cardiovascular disease. Mol. Endocrinol. 17 (2003) 985-993
38. Kalaany N.Y., and Mangelsdorf D.J. LXRS and FXR: the yin and yang of cholesterol and fat metabolism. Annu. Rev. Physiol. 68 (2006) 159-191
39. Mitro N., Mak P.A., Vargas L., Godio C., Hampton E., Molteni V., Kreusch A., and Saez E. The nuclear receptor LXR is a glucose sensor. Nature 445 (2007) 219-223
40. Lee F.Y., Lee H., Hubbert M.L., Edwards P.A., and Zhang Y. FXR, a multipurpose nuclear receptor. Trends Biochem. Sci. 31 (2006) 572-580
41. Bavner A., Sanyal S., Gustafsson J.A., and Treuter E. Transcriptional corepression by SHP: molecular mechanisms and physiological consequences. Trends Endocrinol. Metab. 16 (2005) 478-488
42. Schreiber S.N., Emter R., Hock M.B., Knutti D., Cardenas J., Podvinec M., Oakeley E.J., and Kralli A. The estrogen-related receptor alpha (ERRalpha) functions in PPARgamma coactivator 1alpha (PGC-1alpha)-induced mitochondrial biogenesis. Proc. Natl. Acad. Sci. USA 101 (2004) 6472-6477
43. Mootha V.K., et al. Erralpha and Gabpa/b specify PGC-1alpha-dependent oxidative phosphorylation gene expression that is altered in diabetic muscle. Proc. Natl. Acad. Sci. USA 101 (2004) 6570-6755
44. Lin J., Handschin C., and Spiegelman B.M. Metabolic control through the PGC-1 family of transcription coactivators. Cell Metab. 1 (2005) 361-370
45. Finck B.N., and Kelly D.P. PGC-1 coactivators: inducible regulators of energy metabolism in health and disease. J. Clin. Invest. 116 (2006) 615-622
46. Petersen K.F., and Shulman G.I. Etiology of insulin resistance. Am. J. Med. 119 (2006) S10-S16
47. McGill J.K., and Beal M.F. PGC-1alpha, a new therapeutic target in Huntington's disease?. Cell 127 (2006) 465-468
48. Koo S.H., and Montminy M. In vino veritas: a tale of two sirt1s?. Cell 127 (2006) 1091-1093
49. Lin J., et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell 119 (2004) 121-135
50. Sonoda J., Mehl I.R., Chong L.W., Nofsinger R.R., and Evans R.M. PGC-1beta controls mitochondrial metabolism to modulate circadian activity, adaptive thermogenesis, and hepatic steatosis. Proc. Natl. Acad. Sci. USA 104 (2007) 5223-5228
51. Sonoda J., and Evans R.M. Biological function and mode of action of nuclear xenobiotic receptors. Pure Appl. Chem. (2003) 1733-1742
52. Gupta R.K., and Kaestner K.H. HNF-4alpha: from MODY to late-onset type 2 diabetes. Trends Mol. Med. 10 (2004) 521-524
53. Miura A., et al. Hepatocyte nuclear factor-4alpha is essential for glucose-stimulated insulin secretion by pancreatic beta-cells. J. Biol. Chem. 281 (2006) 5246-5257
54. Gupta R.K., Vatamaniuk M.Z., Lee C.S., Flaschen R.C., Fulmer J.T., Matschinsky F.M., Duncan S.A., and Kaestner K.H. The MODY1 gene HNF-4alpha regulates selected genes involved in insulin secretion. J. Clin. Invest. 115 (2005) 1006-1015
55. Pei L., Waki H., Vaitheesvaran B., Wilpitz D.C., Kurland I.J., and Tontonoz P. NR4A orphan nuclear receptors are transcriptional regulators of hepatic glucose metabolism. Nat. Med. 12 (2006) 1048-1055
56. Pei L., Castrillo A., and Tontonoz P. Regulation of macrophage inflammatory gene expression by the orphan nuclear receptor Nur77. Mol. Endocrinol. 20 (2006) 786-794
57. Bonta P.I., et al. Nuclear receptors Nur77, Nurr1, and NOR-1 expressed in atherosclerotic lesion macrophages reduce lipid loading and inflammatory responses. Arterioscler. Thromb. Vasc. Biol. 26 (2006) 2288-2294
58. Wang L., et al. Orphan receptor small heterodimer partner is an important mediator of glucose homeostasis. Mol. Endocrinol. 20 (2006) 2671-2681
59. Wang L., Liu J., Saha P., Huang J., Chan L., Spiegelman B., and Moore D.D. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2 (2005) 227-238
60. Ramakrishnan S.N., Lau P., Burke L.J., and Muscat G.E. Rev-erbbeta regulates the expression of genes involved in lipid absorption in skeletal muscle cells: evidence for cross-talk between orphan nuclear receptors and myokines. J. Biol. Chem. 280 (2005) 8651-8659
61. Boukhtouche F., Mariani J., and Tedgui A. The "CholesteROR" protective pathway in the vascular system. Arterioscler. Thromb. Vasc. Biol. 24 (2004) 637-643
62. Yu S., and Reddy J.K. Transcription coactivators for peroxisome proliferator-activated receptors. Biochim. Biophys. Acta. 1771 (2007) 936-951
63. Glass C.K., and Ogawa S. Combinatorial roles of nuclear receptors in inflammation and immunity. Nat. Rev. Immunol. 6 (2006) 44-55