Oestrogenic and androgenic activity of triclosan in breast cancer cells

Journal of Applied Toxicology

Volumn 28, Issue 1, 2008, Pages 78-91

  Gee, R H ^a   Charles, A ^a   Taylor, N ^a   Darbre, P D ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Androgen; Antioestrogen; Breast cancer; Endocrine disruption; Oestrogen; Triclosan; Underarm cosmetic

Indexed keywords

ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; TESTOSTERONE; TRICLOSAN;

ANDROGENESIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL STRAIN MCF 7; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL;

ANDROGENS; ANTI-INFECTIVE AGENTS, LOCAL; BINDING, COMPETITIVE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ESTROGENS, NON-STEROIDAL; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; RECEPTORS, ANDROGEN; RESPONSE ELEMENTS; TRICLOSAN;

RATTUS;

EID: 38349077497     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1316     Document Type: Article

References (57)

1. Adolfsson-Erici M, Pettersson M, Parkkonen J, Sturve J. 2002. Triclosan, a commonly used bactericide found in human milk and in the aquatic environment in Sweden. Chemosphere 46: 1485-1489.
2. Allmyr M, Adolfsson-Erici M, McLachlan MS, Sandborgh-Englund G. 2006a. Triclosan in plasma and milk from Swedish nursing mothers and their exposure via personal care products. Sci. Total Environ. 372: 87-93.
3. Allmyr M, McLachlan MS, Sandborgh-Englun G, Adolfsson-Erici M. 2006b. Determination of triclosan as its pentafluorobenzoyl ester in human plasma and milk using electron capture negative ionization mass spectrometry. Anal. Chem. 78: 6542-6546.
4. Aranami K, Readman JW. 2007. Photolytic degradation of triclosan in freshwater and seawater. Chemosphere 66: 1052-1056.
5. Brzozowski AM, Pike ACW, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson JA, Carlquist M. 1997. Molecular basis of agonism and antagonism in the oestrogen receptor. Nature 389: 753-758.
6. Byford JR, Shaw LE, Drew MGB, Pope GS, Sauer MJ, Darbre PD. 2002. Oestrogenic activity of parabens in MCF7 human breast cancer cells. J. Steroid Biochem. Mol. Biol. 80: 49-60.
7. Canosa P, Rodriguez I, Rubi E, Cela R. 2007. Determination of parabens and triclosan in indoor dust using matrix solid-phase dispersion and gas chromatography with tandem mass spectrometry. Anal. Chem. 79: 1675-1681.
8. Cato AC, Miksicek R, Schutz G, Arnemann J, Beato M. 1986. The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J. 5: 2237-2240.
9. Chen J, Ahn KC, Gee NA, Gee SJ, Hammock BD, Lasley BL. 2007. Antiandrogenic properties of parabens and other phenolic containing small molecules in personal care products. Toxicol. Appl. Pharmacol. 221: 278-284.
10. Ciniglia C, Cascone C, Guidice RL, Pinto G, Pollio A. 2005. Application of methods for assessing the geno- and cytotoxicity of triclosan to C. ehrenbergii. J. Hazard Mater. 122: 227-232.
11. Daly RJ, Darbre PD. 1990. Cellular and molecular events in loss of estrogen sensitivity in ZR-75-1 and T-47-D human breast cancer cells. Cancer Res. 50: 5868-5875.
12. Darbre PD. 2006. Environmental oestrogens, cosmetics and breast cancer. Best Practice Res. Clin. Endocrinol. Metab. 20: 121-143.
13. Darbre PD, Byford JR, Shaw LE, Hall S, Coldham NG, Pope GS, Sauer MJ. 2003. Oestrogenic activity of benzylparaben. J. Appl. Toxicol. 23: 43-51.
14. Darbre PD, Byford JR, Shaw LE, Horton RA, Pope GS, Sauer MJ. 2002. Oestrogenic activity of isobutylparaben in vitro and in vivo. J. Appl. Toxicol. 22: 219-226.
15. Darbre PD, Daly RJ. 1989. Effects of oestrogen on human breast cancer cells in culture. Proc. Roy Soc. Edinb. 95B: 119-132.
16. Darbre PD, King RJB. 1988. Steroid hormone regulation of cultured breast cancer cells. In Breast Cancer: Cellular and Molecular Biology, Lippman ME, Dickson RB (eds). Kluwer Academic: Boston; 307-341.
17. Darbre P, Page M, King RJB. 1986. Androgen regulation by the long terminal repeat of mouse mammary tumor virus. Mol. Cell. Biol. 6: 2847-2854.
18. Darbre P, Yates J, Curtis SA, King RJB. 1983. Effect of estradiol on human breast cancer cells in culture. Cancer Res. 43: 349-354.
19. Daughton CG, Ternes TA. 1999. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 107: 907-938.
20. Dayan AD. 2007. Risk assessment of triclosan [Irgasan] in human breast milk. Food Chem. Toxicol. 45: 125-129.
21. Fang H, Tong W, Branham WS, Moland CL, Dial SL, Hong H, Xie Q, Perkins R, Owens W, Sheehan DM. 2003. Study of 202 natural, synthetic and environmental chemicals for binding to the androgen receptor. Chem. Res. Toxicol. 16: 1338-1358.
22. Foran CM, Bennett ER, Benson WH. 2000. Developmental evaluation of a potential non-steroidal estrogen: triclosan. Marine Environ. Res. 50: 153-156.
23. Furuya Y, Shirasawa H, Sato N, Watabe Y, Simizu B, Shimazaki J. 1992. Loss of androgen dependency with preservation of functional androgen receptors in androgen-dependent mouse tumor (Shionogi carcinoma 115). J. Steroid Biochem. Mol. Biol. 42: 569-574.
24. Glover JF, Darbre PD. 1989. Multihormone regulation of MMTV-LTR in transfected T-47-D human breast cancer cells. J. Steroid Biochem. 32: 357-363.
25. Gorman C. 1985. High efficiency gene transfer into mammalian cells. In DNA Cloning, Vol II, Glover DM (ed.). IRL: Oxford.
26. Green B, Leake RE. 1987. Steroid Hormones: A Practical Approach. IRL Press: Oxford.
27. Guillette LJ. 2006. Endocrine disrupting contaminants - beyond the dogma. Environ. Health Perspect. 114: 9-12.
28. Harvey PW, Everett DJ. 2006. Regulation of endocrine-disrupting chemicals: Critical overview and deficiencies in toxicology and risk assessment for human health. Best Pract. Res. Clin. Endocrinol. Metab. 20: 145-165.
29. Hihi AK, Wahli W. 1999. Structure and function of the estrogen receptor. In Estrogens and Antiestrogens I, Oettel M, Schillinger E (eds). Springer-Verlag: Berlin; 111-126.
30. Houtman CJ, Van Oostveen AM, Brouwer A, Lamoree MH, Legler J. 2004. Identification of estrogenic compounds in fish bile using bioassay-directed fractionation. Environ. Sci. Technol. 38: 6415-6423.
31. Hovander L, Malmberg T, Athanasiadou M, Athanassiadis I, Rahm S, Bergman A, Klasson Wehler E. 2002. Identification of hydroxylated PCB metabolites and other phenolic halogenated pollutants in human blood plasma. Arch. Environ. Contam. Toxicol. 42: 105-117.
32. Howell SJ, Johnston SRD, Howell A. 2004. The use of selective estrogen receptor modulators and selective estrogen receptor down-regulators in breast cancer. Best Pract. Res. Clin. Endocrinol. Metab. 18: 47-66.
33. Ishibashi H, Matsumura N, Hirano M, Matsuoka M, Shiratsuchi H, Ishibashi Y, Takao Y, Arizono K. 2004. Effects of triclosan on the early life stages and reproduction of medaka Oryzias latipes and induction of hepatic vitellogenin. Aquat. Toxicol. 67: 167-179.
34. Kanetoshi A, Katsura E, Ogawa H, Ohyama T, Kaneshima H, Miura T. 1992. Acute toxicity, percutaneous absorption and effects on hepatic mixed function oxidase activities of 2,4,4′-trichloro-2′-hydroxydiphenyl ether (Irgasan DP300) and its chlorinated derivatives. Arch. Environ. Contam. Toxicol. 23: 91-98.
35. Kolpin DW, Furlong ET, Meyer MT, Thurman EM, Zaugg SD, Barbre LB, Buxton HT. 2002. Pharmaceuticals, hormones and other organic wastewater contaminants in U.S. streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 36: 1202-1211.
36. Lee HB, Peart TE, Svoboda ML. 2005. Determination of endocrine-disrupting phenols, acidic pharmaceuticals, and personal-care products in sewage by solid-phase extraction and gas chromatography-mass spectrometry. J. Chromatogr. 1094: 122-129.
37. Lishman L, Smyth SA, Sarafin K, Kleywegt S, Tioto J, Peart T, Lee B, Servos M, Beland M, Seto P. 2006. Occurrence and reductions of pharmaceuticals and personal care products and estrogens by municipal wastewater treatment plants in Ontario, Canada. Sci. Total Environ. 367: 544-558.
38. Liu B, Wang Y, Fillgrove KL, Anderson VE. 2002. Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells. Cancer Chemother. Pharmacol. 49: 187-193.
39. Lu S, Archer MC. 2005. Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer. Carcinogenesis 26: 153-157.
40. Matsumura A, Ghosh A, Pope GS, Darbre PD. 2005a. Comparative study of oestrogenic properties of eight phytoestrogens in MCF7 human breast cancer cells. J. Steroid Biochem. Mol. Biol. 94: 431-443.
41. Matsumura N, Ishibashi H, Hirano M, Nagao, Watanabe N, Shiratsuchi H, Kai T, Nishimura T, Kashiwagi A, Arizono K. 2005b. Effects of nonylphenol and triclosan on production of plasma vitellogenin and testosterone in male South African clawed frogs (Xenopus laevis). Biol. Pharm. Bull. 28: 1748-1751.
42. Moss T, Howes D, Williams FM. 2000. Percutaneous penetration and dermal metabolism of triclosan (2,4,4′-trichloro-2′-hydroxydiphenyl ether). Food Chem. Toxicol. 38: 361-370.
43. Nakada N, Tanishima T, Shinohara H, Kiri K, Takada H. 2006. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res. 40: 3297-3303.
44. Nesaretnam K, Corcoran D, Dils RR, Darbre P. 1996. 3,4,3′,4′- Tetrachlorobiphenyl acts as an estrogen in vitro and in vivo. Mol. Endocrinol. 10: 923-936.
45. Osborne CK, Hobbs K, Trent JM. 1987. Biological differences among MCF-7 human breast cancer cell lines from different laboratories. Breast Cancer Res. Treatment 9: 111-121.
46. Parker MG. 1991. Nuclear Hormone Receptors: Molecular Mechanisms, Cellular Functions, Clinical Abnormalities. Academic Press: London; 1-395.
47. Pike ACW. 2006. Lessons learnt from structural studies of the oestrogen receptor. Best Pract. Res. Clin. Endocrinol. Metab. 20: 1-14.
48. Sabaliunas D, Webb SF, Hauk A, Jacob M, Eckhoff WS. 2003. Environmental fate of triclosan in the river Aire basin, UK. Water Res. 37: 3145-3154.
49. Sanchez-Prado L, Llompart M, Lores M, Garcia-Jares C, Bayona JM, Cela R. 2006. Monitoring the photochemical degradation of triclosan in wastewater by UV light and sunlight using solid-phase microextraction. Chemosphere 65: 1338-1347.
50. Sandborgh-Englund G, Adolfsson-Erici M, Odham G, Ekstrand J. 2006. Pharmacokinetics of triclosan following oral ingestion in humans. J. Toxicol. Environ. Health A 69: 1861-1873.
51. Sharpe RM. 2006. Pathways of endocrine disruption during male sexual differentiation and masculinisation. Best Pract. Res. Clin. Endocrinol. Metab. 20: 91-110.
52. Shaw LE, Sadler AJ, Pugazhendhi D, Darbre PD. 2006. Changes in oestrogen receptor-α and -β during progression to acquired resistance to tamoxifen and fulvestrant (Faslodex, ICI 182,780) in MCF7 human breast cancer cells. J. Steroid Biochem. Mol. Biol. 99: 19-32.
53. Soto AM, Maffini MV, Schaeberle CM, Sonnenschein C. 2006. Strengths and weaknesses of in vitro assays for estrogenic and androgenic activity. Best Pract. Res. Clin. Endocrinol. Metab. 20: 15-33.
54. Southern PJ, Berg P. 1982. Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter. J. Mol. Appl. Genet. 1: 327-341.
55. Tamura H, Ishimoto Y, Fujikawa T, Aoyama H, Yoshikawa H, Akamatsu M. 2006. Structural basis for androgen receptor agonists and antagonists: interaction of SPEED 98-listed chemicals and related compounds with the androgen receptor based on an in vitro reporter gene assay and 3D-QSAR. Bioinorg. Med. Chem. 14: 7160-7174.
56. Veldhoen N, Skirrow RC, Osachoff H, Wigmore H, Clapson DJ, Gunderson MP, Van Aggelen G, Helbing CC. 2006. The bactericidal agent triclosan modulates thyroid hormone-associated gene expression and disrupts postembryonic anuran development. Aquat. Toxicol. 80: 217-227.
57. Ying GG, Kookana RS. 2007. Triclosan in wastewaters and biosolids from Australian wastewater plants. Environ. Int. 33: 199-205.