Triclosan reduces the levels of global DNA methylation in HepG2 cells

Chemosphere

Volumn 90, Issue 3, 2013, Pages 1023-1029

  Ma, Huimin ^a   Zheng, Liujin ^a,b   Li, Yuhua ^a   Pan, Shangxia ^a   Hu, Junjie ^a,b   Yu, Zhiqiang ^a   Zhang, Gan ^a   Sheng, Guoying ^a   Fu, Jiamo ^a  

^a GUANGZHOU INSTITUTE OF GEOCHEMISTRY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

8 Hydroxy 2 deoxyguanosine; Epigenotoxicity; Global DNA methylation; HepG2 cells; Triclosan

Indexed keywords

ALKYLATION; DNA; MAMMALS; METHYLATION; TRANSCRIPTION;

8-HYDROXY-2-DEOXYGUANOSINE; DNA METHYLATION; EPIGENOTOXICITY; HEP-G2 CELLS; TRICLOSAN;

CYTOLOGY;

8 HYDROXYDEOXYGUANOSINE; ACETYLCYSTEINE; DNA METHYLTRANSFERASE 1; GENOMIC DNA; MESSENGER RNA; TRICLOSAN;

ANTIMICROBIAL ACTIVITY; ANTIOXIDANT; BIOCHEMISTRY; CYTOLOGY; DNA; DOSE-RESPONSE RELATIONSHIP; GENE EXPRESSION; GENOTOXICITY; METHYLATION; ORGANIC POLLUTANT; PHENOLIC COMPOUND; PUBLIC HEALTH; UARS;

ARTICLE; BIOACCUMULATION; CELL STRAIN HEPG2; CELL VIABILITY; CHEMICAL CARCINOGENESIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA METHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; EPIGENETICS; GENOTOXICITY; HUMAN; HUMAN CELL; PROTEIN DOMAIN; RNA TRANSCRIPTION;

RODENTIA;

EID: 84869882790     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2012.07.063     Document Type: Article

References (25)

1. Aniagu S.O., Williams T.D., Chipman J.K. Changes in gene expression and assessment of DNA methylation in primary human hepatocytes and HepG2 cells exposed to the environmental contaminants-hexabromocyclododecane and 17-beta oestradiol. Toxicology 2009, 256:143-151.
2. Bogdanovic O., Veenstra G.J.C. DNA methylation and methyl-CpG binding proteins: developmental requirements and function. Chromosoma 2009, 118:549-565.
3. Clouaire T., Stancheva I. Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?. Cell. Mol. Life Sci. 2008, 65:1509-1522.
4. Fang J.L., Stingley R.L., Beland F.A., Harrouk W., Lumpkins D.L., Howard P. Occurrence, efficacy, metabolism, and toxicity of triclosan. J. Environ. Sci. Health. C Environ. Carcinog. Ecotoxicol. Rev. 2010, 28:147-171.
5. Franco R., Schoneveld O., Georgakilas A.G., Panayiotidis M.I. Oxidative stress, DNA methylation and carcinogenesis. Cancer Lett. 2008, 266:6-11.
6. Guerrero-Preston R., Santella R.M., Blanco A., Desai M., Berdasco M., Fraga M. Global DNA hypomethylation in liver cancer cases and controls: a phase I preclinical biomarker development study. Epigenetics 2007, 2:223-226.
7. Hu J.J., Zhang W.B., Ma H.M., Cai Y.M., Sheng G.Y., Fu J.M. Simultaneous determination of 8-hydroxy-2'-deoxyguanosine and 5-methyl-2'-deoxycytidine in DNA sample by high performance liquid chromatography/positive electrospray ionization tandem mass spectrometry. J. Chromatogr. B 2010, 878:2765-2769.
8. Hu J.J., Ma H.M., Zhang W.B., Yu Z.Q., Sheng G.Y., Fu J.M. Effects of benzene and its metabolites on global DNA methylation in human normal hepatic L02 cells. Environ. Toxicol. 2011, 10.1002/tox.20777.
9. Klaunig J.E., Kamendulis L.M., Xu Y. Epigenetic mechanisms of chemical carcinogenesis, carcinogenesis. Hum. Exp. Toxicol. 2000, 19:543-555.
10. Lores M., Llompart M., Sanchez-Prado L., Garcia-Jares C., Cela R. Confirmation of the formation of dichlorodibenzo-p-dioxin in the photodegradation of triclosan by photo-SPME. Anal. Bioanal. Chem. 2005, 381:1294-1298.
11. Ma H.M., Zhang W.B., Hu J.J., Yu Z.Q., Chen Y., Luo Q., Shi X.L., Zhang Y.Y., Song R.F., Zhou Z., Sheng G.Y., Fu J.M. Analysis of global DNA methylation levels in human blood using high-performance liquid chromatography/tandem electrospray ionization mass spectrometry. Eur. J. Mass Spectrom. 2009, 15:555-561.
12. Ma H.M., Zhang W.B., Song R.F., Chen H.Y., Sheng G.Y., Zhou Z., Fu J.M. Characterization of methylated and unmethylated CpG oligodeoxynucleotides by electrospray ionization tandem mass spectrometry. Eur. J. Mass Spectrom. 2005, 11:581-589.
13. Morey S.R., Smiraglia D.J., James S.R., Yu J., Moser M.T., Foster B.A., Karpf A.R. DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Cancer Res. 2006, 66:11659-11667.
14. Murakami H., Sugaya N., Sato M., Imaizumi A., Aburatani S., Horimoto K. Detection of inter-spread repeat sequence in genomic DNA sequence. Genome Inform. 2004, 15:170-179.
15. Phillips J.M., Goodman J.I. Identification of genes that may play critical roles in phenobarbital (PB)-induced liver tumorigenesis due to altered DNA methylation. Toxicol. Sci. 2008, 104:86-99.
16. Rodricks J.V., Swenberg J.A., Borzelleca J.F., Maronpot R.R., Shipp A.M. Triclosan: a critical review of the experimental data and development of margins of safety for consumer products. Crit. Rev. Toxicol. 2010, 40:422-484.
17. Song L.G., James S.R., Kazim L., Karpf A.R. Specific method for the determination of genomic DNA methylation by liquid chromatography-electrospray ionization tandem mass spectrometry. Anal. Chem. 2005, 77:504-510.
18. Suter C.M., Martin D.I., Ward R.L. Hypomethylation of L1 retrotransposons in colorectal cancer and adjacent normal tissue. Int. J. Colorectal. Dis. 2004, 19:95-101.
19. 2+ concentration in rat thymocytes: its relation to oxidative stress. Chemosphere 2012, 86:70-75.
20. Valavanidis A., Vlachogianni T., Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OHdG): a critical biomarker of oxidative stress and carcinogenesis. J. Environ. Sci. Health C 2009, 27:120-139.
21. Valinluck V., Tsai H.H., Rogstad D.K., Burdzy A., Bird A., Sowers L.C. Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). Nucl. Acids Res. 2004, 32:4100-4108.
22. Watson R.E., Goodman J.I. Effects of phenobarbital on DNA methylation in GCrich regions of hepatic DNA from mice that exhibit different levels of susceptibility to liver tumorigenesis. Toxicol. Sci. 2002, 68:51-58.
23. Wilson A.S., Power B.E., Molloy P.L. DNA hypomethylation and human diseases. Biochim. Biophys. Acta 2007, 1775:138-162.
24. Yang A.C., Doshi K.D., Choi S.W., Mason J.B., Mannari R.K., Gharybian V., Luna R., Rashid A., Shen L., Estecio M.R.H., Kantarjian H.M., Garcia-Manero G., Issa J.P.J. DNA methylation changes after 5-aza-2-deoxycytidine therapy in patients with leukemia. Cancer Res. 2006, 66:5495-5503.
25. Yuan J., Lu W.Q., Zou Y.L., Wei W., Zhang C., Xie H., Chen X.M. Influence of aroclor 1254 on benzo(a)Pyrene-induced DNA breakage, oxidative DNA damage, and cytochrome P4501A activity in human hepatoma cell line. Environ. Technol. 2009, 24:327-333.